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Opposing functions of gut immunomodulatory metabolites on CAR-T therapy

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.004
  
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sciencedirect.com/science/article/pii/S0092867426010731
Jul 2026
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Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0419
  
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aacrjournals.org/cancerres/article/85/18/3416/764453/Mitochondrial-Calcium-Uniporter-Links-Acetyl-CoA
Jun 2026
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Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19

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1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13233774/
Apr 2026
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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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1. scibot 15 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.004
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13159532/
Mar 2026
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Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

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1. scibot 03 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.01.028
  
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sciencedirect.com/science/article/pii/S0092867426001157
Feb 2026
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Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer

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1. scibot 24 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114889
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12925242/
Aug 2025
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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116163
  
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sciencedirect.com/science/article/pii/S2211124725009349
Jul 2025
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Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116032
  
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sciencedirect.com/science/article/pii/S2211124725008034
Jun 2025
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PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer

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1. scibot 24 Jun 2025
  
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  DOI: 10.1016/j.jbc.2025.110406
  
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sciencedirect.com/science/article/pii/S0021925825022562
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Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115888
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12294511/
Mar 2025
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Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma

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1. scibot 07 Mar 2025
  
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  DOI: 10.1016/j.cmet.2025.01.021
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00021-X
Jan 2025
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.002
  
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sciencedirect.com/science/article/pii/S2451945625000029
Nov 2024
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Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to Disease Associated Microglia stage 1

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1. scibot 23 Nov 2024
  
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  DOI: 10.1523/JNEUROSCI.1563-23.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11097271/
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies

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1. scibot 15 Nov 2024
  
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  DOI: 10.1002/advs.202404109
  
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onlinelibrary.wiley.com/doi/full/10.1002/advs.202404109
Sep 2024
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Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114783
  
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sciencedirect.com/science/article/pii/S2211124724011343
Aug 2024
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.cmet.2017.10.006
  
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sciencedirect.com/science/article/pii/S1550413117306186
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Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

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1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114573
  
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cell.com/cell-reports/abstract/S2211-1247(24)00902-1
www.biorxiv.org www.biorxiv.org

In Vitro Budding and Floatation based Enrichment of Mitochondria-derived Vesicles for Proteomics from Rat Heart

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1. scibot 16 Aug 2024
  
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  Pyruvate dehydrogenase
  
  DOI: 10.1101/2024.03.04.583262
  
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biorxiv.org/content/10.1101/2024.03.04.583262v1
Jul 2024
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Hippocampal Warburg effect Mediates Hydrogen Sulfide-Ameliorated Diabetes-Associated Cognitive Dysfunction: Involving Promotion of Hippocampal Synaptic Plasticity

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.neures.2024.07.002
  
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sciencedirect.com/science/article/pii/S0168010224000877
May 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle

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1. scibot 24 May 2024
  
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  DOI: 10.1113/JP285719
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP285719
Apr 2024
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Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114067
  
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sciencedirect.com/science/article/pii/S2211124724003954
Feb 2024
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Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.molmet.2024.101900
  
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sciencedirect.com/science/article/pii/S2212877824000310
Nov 2023
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Omics data integration suggests a potential idiopathic Parkinson’s disease signature

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1. scibot 26 Nov 2023
  
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  DOI: 10.1038/s42003-023-05548-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10662437/
Oct 2023
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Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine

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1. scibot 12 Oct 2023
  
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  DOI: 10.3892/ol.2023.14067
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
Sep 2023
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Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113171
  
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sciencedirect.com/science/article/pii/S221112472301183X
Jul 2023
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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112830
  
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sciencedirect.com/science/article/pii/S2211124723008410
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Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects

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1. scibot 11 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107131
  
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sciencedirect.com/science/article/pii/S2589004223012087
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Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice

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1. scibot 08 Jul 2023
  
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  DOI: 10.1186/s12915-023-01629-8
  
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link.springer.com/article/10.1186/s12915-023-01629-8
Jun 2023
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Acetate controls endothelial-to-mesenchymal transition

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.cmet.2023.05.010
  
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sciencedirect.com/science/article/pii/S1550413123002036
Apr 2023
www.thelancet.com www.thelancet.com

Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.ebiom.2023.104569
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00134-2/abstract
Feb 2023
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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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1. scibot 02 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112033
  
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sciencedirect.com/science/article/pii/S221112472300044X
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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1. scibot 19 Nov 2022
  
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  DOI: 10.1158/2767-9764.crc-22-0256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
Sep 2022
www.nature.com www.nature.com

Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency

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1. scibot 15 Sep 2022
  
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  DOI: 10.1038/s42003-022-03942-4
  
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nature.com/articles/s42003-022-03942-4
Jul 2022
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T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes

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1. scibot 14 Jul 2022
  
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  RRID:AB_2162926
  
  DOI: 10.1210/clinem/dgac378
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac378/6613175
Jun 2022
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Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection

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1. scibot 09 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104447
  
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Dec 2021
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PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

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  AB_2162926
  
  DOI: 10.1186/s12964-021-00794-z
  
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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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  DOI: 10.1016/j.celrep.2021.110063
  
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Jul 2021
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A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism

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  DOI: 10.1016/j.celrep.2019.02.060
  
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

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  DOI: 10.1016/j.cmet.2020.12.003
  
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Local production of lactate, ribose phosphate, and amino acids by human triple-negative breast cancer

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  DOI: 10.1016/j.medj.2021.03.009
  
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FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity

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  DOI: 10.1016/j.celrep.2021.108935
  
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Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses

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  DOI: 10.1016/j.cmet.2017.08.012
  
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Dec 2020
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Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing

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Nov 2020
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Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

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Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

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  DOI: 10.1016/j.cmet.2020.03.017
  
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Jan 2020
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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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  DOI: 10.1038/s41467-019-13086-5
  
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Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival

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  DOI: 10.1074/jbc.RA118.007152
  
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Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

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  DOI: 10.1016/j.cell.2019.05.003
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.04.005
  
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Nov 2018
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Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency

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Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

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1. scibot 05 Nov 2018
  
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Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency

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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

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1. scibot 05 Nov 2018
  
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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Nov 2017
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Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses

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1. scibot 08 Nov 2017
  
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