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    STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts
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  6. Nov 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    Mesothelin as a biomarker and potential therapeutic target in rheumatoid arthritis bone destruction
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    Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer’s disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches
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    USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
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    Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier
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    PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
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    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
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    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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  32. May 2024
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    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
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    Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
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  42. Dec 2023
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  49. Jul 2023
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    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD
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  57. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  59. Jan 2023
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  62. Dec 2022
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  64. Nov 2022
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    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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  66. Jul 2022
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    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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  68. Jun 2022
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    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  71. Feb 2022
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  73. Aug 2021
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  75. May 2021
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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  78. Apr 2021
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  80. Oct 2020
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  82. Sep 2020
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  85. Jan 2020
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    Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase
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  88. Nov 2018
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    PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
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  91. Nov 2017
  92. elifesciences.org elifesciences.org
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