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Jun 2026
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CDC20 promotes prostate cancer progression via modulating c-MYC and PI3K-AKT signaling

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1. scibot 21 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116409
  
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sciencedirect.com/science/article/pii/S2589004226017840
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PI3Kα inhibitor and degrader inavolisib can co-opt FGFR2 to enhance responses in patients with PIK3CA-mutated solid tumors and in preclinical models

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1. scibot 19 Jun 2026
  
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  DOI: 10.1158/1078-0432.CCR-25-1459
  
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aacrjournals.org/clincancerres/article/32/1/56/771272/PI3K-Inhibitor-and-Degrader-Inavolisib-Can-Co-opt
May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Activin A enhances neurofunctional recovery following traumatic spinal cord injury by inhibiting autophagy

1
1. scibot 29 May 2026
  
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  DOI: 10.4103/NRR.NRR-D-24-01021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13211839/
Apr 2026
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PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

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1. scibot 09 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-1126
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13056290/
Feb 2026
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MEDAG functions as an A-kinase-anchoring protein in adipocytes

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.02.001
  
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sciencedirect.com/science/article/pii/S1097276526000961
Dec 2025
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Akt2 regulates autophagy and osteogenesis in diabetic osteoporosis via PI3K/AKT/mTOR signaling axis

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.bone.2025.117770
  
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sciencedirect.com/science/article/pii/S8756328225003825
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STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts

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1. scibot 18 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116703
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12990061/
54.241.53.176 54.241.53.176

s12974-025-03648-4_reference-html.html

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1. scibot 16 Dec 2025
  
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  DOI: 10.1186/s12974-025-03648-4
  
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54.241.53.176/a44cc0e7569e6d3c1fa351bb4696d083040f2f89/s12974-025-03648-4_reference-html.html
54.241.53.176 54.241.53.176

1-s2.0-S258900422502646X-main-html.html

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114385
  
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54.241.53.176/93de8e6290387b0a29b7a2c9729bf4f9de57ced1/1-s2.0-S258900422502646X-main-html.html
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

1
1. scibot 15 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4501
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
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Mesothelin as a biomarker and potential therapeutic target in rheumatoid arthritis bone destruction

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102430
  
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sciencedirect.com/science/article/pii/S2666379125005038
Sep 2025
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Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer’s disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches

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1. scibot 03 Sep 2025
  
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  DOI: 10.1007/s11011-025-01688-6
  
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link.springer.com/article/10.1007/s11011-025-01688-6
Aug 2025
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USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24

1
1. scibot 15 Aug 2025
  
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  RRID:AB_2165248
  
  DOI: 10.1016/j.celrep.2025.116158
  
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sciencedirect.com/science/article/pii/S2211124725009295
Jun 2025
www.cell.com www.cell.com

Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115831
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00602-3
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ROUX-en-Y gastric bypass surgery improves metabolic syndrome–related erectile dysfunction in mice via the IRS-1/PI3K/AKT/eNOS pathway

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1. scibot 11 Jun 2025
  
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  RRID:AB_2165248
  
  DOI: 10.1093/sexmed/qfae029
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11134102/
Mar 2025
journals.lww.com journals.lww.com

The compound... : Neural Regeneration Research

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1. scibot 06 Mar 2025
  
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  DOI: 10.4103/NRR.NRR-D-23-01890
  
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journals.lww.com/nrronline/fulltext/2025/11000/the_compound.34.aspx
Feb 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 20 Feb 2025
  
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  RRID:AB_2165248
  
  DOI: 10.1111/bph.17475
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17475
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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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1. scibot 07 Feb 2025
  
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  RRID:AB_2165248
  
  DOI: 10.1016/j.xcrm.2024.101927
  
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sciencedirect.com/science/article/pii/S2666379124006980
Jan 2025
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PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

1
1. scibot 28 Jan 2025
  
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  RRID:AB_2165248
  
  DOI: 10.1016/j.jbc.2025.108239
  
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sciencedirect.com/science/article/pii/S0021925825000869
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

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1. scibot 23 Jan 2025
  
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  DOI: 10.7554/eLife.94420
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11750134/
Dec 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224028670-main-html.html

1
1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111640
  
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52.53.155.43/5c36597ef844ded17f85575515b051ce997d7e64/1-s2.0-S2589004224028670-main-html.html
Aug 2024
josr-online.biomedcentral.com josr-online.biomedcentral.com

Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway

1
1. scibot 02 Aug 2024
  
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  4249
  
  DOI: 10.1186/s13018-021-02715-9
  
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josr-online.biomedcentral.com/articles/10.1186/s13018-021-02715-9
Jul 2024
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PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110467
  
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sciencedirect.com/science/article/pii/S2589004224016924
Jun 2024
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Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta

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  DOI: 10.1016/j.isci.2024.109921
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
May 2024
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The Janus kinase 1 is critical for pancreatic cancer initiation and progression

1
1. scibot 14 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114202
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
Apr 2024
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Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect

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1. scibot 24 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114132
  
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sciencedirect.com/science/article/pii/S2211124724004601
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A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

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  DOI: 10.1016/j.celrep.2024.114119
  
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sciencedirect.com/science/article/pii/S2211124724004479
Mar 2024
www.biorxiv.org www.biorxiv.org

PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

1
1. scibot 21 Mar 2024
  
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  DOI: 10.1101/2024.03.03.583221
  
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biorxiv.org/content/10.1101/2024.03.03.583221v1
Jan 2024
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Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

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  DOI: 10.1016/j.jbc.2024.105641
  
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sciencedirect.com/science/article/pii/S0021925824000176
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Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma

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  DOI: 10.1158/1078-0432.CCR-23-1317
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10767308/
Dec 2023
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Epinephrine inhibits PI3Kα via the Hippo kinases

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  DOI: 10.1016/j.celrep.2023.113535
  
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sciencedirect.com/science/article/pii/S2211124723015474
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Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus

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1. scibot 15 Dec 2023
  
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  DOI: 10.1210/clinem/dgad699
  
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dx.doi.org/10.1210/clinem/dgad699
52.53.155.43 52.53.155.43

ccr-23-1317-html.html

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  DOI: 10.1158/1078-0432.ccr-23-1317
  
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52.53.155.43/eb06d63ced7d6b4d34065d25e0eab223f52bfb41/ccr-23-1317-html.html
Aug 2023
www.sciencedirect.com www.sciencedirect.com

PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

1
1. scibot 11 Aug 2023
  
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  RRID:AB_2165248
  
  DOI: 10.1016/j.molcel.2023.07.015
  
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sciencedirect.com/science/article/pii/S1097276523005580
52.53.155.43 52.53.155.43

BPS Publications

1
1. scibot 01 Aug 2023
  
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  DOI: 10.1111/bph.16202
  
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52.53.155.43/d8c850c315bd1ef9a1794152cac296a4123affe5/British J Pharmacology - 2023 - Wang - Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3-html.html
Jul 2023
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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Jun 2023
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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

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May 2023
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Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma

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Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD

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FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

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Jan 2023
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PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research

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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells

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Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

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Jul 2022
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Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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Jun 2022
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Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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Feb 2022
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Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression

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Aug 2021
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Untitled document

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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cell.com/cell/fulltext/S0092-8674(21)00436-0
Apr 2021
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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma

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onlinelibrary.wiley.com/doi/full/10.1002/cac2.12103
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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

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Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla

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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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Untitled document

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PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism

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Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase

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ncbi.nlm.nih.gov/pmc/articles/PMC6030672/
Nov 2017
elifesciences.org elifesciences.org

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

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