51 Matching Annotations
  1. Last 7 days
  2. link.springer.com link.springer.com
    Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer’s disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches
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    link.springer.com/article/10.1007/s11011-025-01688-6
  3. Aug 2025
  4. www.sciencedirect.com www.sciencedirect.com
    USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
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    sciencedirect.com/science/article/pii/S2211124725009295
  5. Jun 2025
  6. www.cell.com www.cell.com
    Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier
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    cell.com/cell-reports/fulltext/S2211-1247(25)00602-3
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROUX-en-Y gastric bypass surgery improves metabolic syndrome–related erectile dysfunction in mice via the IRS-1/PI3K/AKT/eNOS pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11134102/
  8. Mar 2025
  9. journals.lww.com journals.lww.com
    The compound... : Neural Regeneration Research
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    journals.lww.com/nrronline/fulltext/2025/11000/the_compound.34.aspx
  10. Feb 2025
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17475
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    sciencedirect.com/science/article/pii/S2666379124006980
  13. Jan 2025
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    PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
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    sciencedirect.com/science/article/pii/S0021925825000869
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
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    pmc.ncbi.nlm.nih.gov/articles/PMC11750134/
  16. Dec 2024
  17. 52.53.155.43 52.53.155.43
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  18. Aug 2024
  19. josr-online.biomedcentral.com josr-online.biomedcentral.com
    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    josr-online.biomedcentral.com/articles/10.1186/s13018-021-02715-9
  20. Jul 2024
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    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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    sciencedirect.com/science/article/pii/S2589004224016924
  22. Jun 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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    ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
  24. May 2024
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  26. Apr 2024
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    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    sciencedirect.com/science/article/pii/S2211124724004601
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    sciencedirect.com/science/article/pii/S2211124724004479
  29. Mar 2024
  30. www.biorxiv.org www.biorxiv.org
    PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
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    biorxiv.org/content/10.1101/2024.03.03.583221v1
  31. Jan 2024
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    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0021925824000176
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10767308/
  34. Dec 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    sciencedirect.com/science/article/pii/S2211124723015474
  36. dx.doi.org dx.doi.org
    Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus
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    dx.doi.org/10.1210/clinem/dgad699
  37. 52.53.155.43 52.53.155.43
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  38. Aug 2023
  39. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  40. 52.53.155.43 52.53.155.43
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  41. Jul 2023
  42. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
  43. Jun 2023
  44. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  45. May 2023
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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  47. Apr 2023
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    Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD
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    sciencedirect.com/science/article/pii/S2211124723003303
  49. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    sciencedirect.com/science/article/pii/S2211124723001997
  51. Jan 2023
  52. journals.lww.com journals.lww.com
    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/PTEN_inhibitor_bisperoxovanadium_protects_against.36.aspx
  53. aacrjournals.org aacrjournals.org
    Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
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    aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
  54. Dec 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    sciencedirect.com/science/article/pii/S1550413122005034
  56. Nov 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
  58. Jul 2022
  59. aacrjournals.org aacrjournals.org
    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
  60. Jun 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  63. Feb 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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    sciencedirect.com/science/article/pii/S2352396422000317
  65. Aug 2021
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6197754/
  67. May 2021
  68. www.sciencedirect.com www.sciencedirect.com
    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    sciencedirect.com/science/article/pii/S1097276520306572
  69. www.cell.com www.cell.com
    LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome
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    cell.com/cell/fulltext/S0092-8674(21)00436-0
  70. Apr 2021
  71. www.sciencedirect.com www.sciencedirect.com
    Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
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    sciencedirect.com/science/article/pii/S1535610821001185
  72. Oct 2020
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
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    onlinelibrary.wiley.com/doi/full/10.1002/cac2.12103
  74. Sep 2020
  75. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
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    pubmed.ncbi.nlm.nih.gov/32997991/
  76. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla
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    onlinelibrary.wiley.com/doi/10.1002/jcp.29862
  77. Jan 2020
  78. www.sciencedirect.com www.sciencedirect.com
    Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase
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  80. Nov 2018
  81. www.sciencedirect.com www.sciencedirect.com
    PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism
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    sciencedirect.com/science/article/pii/S2352396418303712
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC6030672/
  83. Nov 2017
  84. elifesciences.org elifesciences.org
    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
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    elifesciences.org/content/6/e25158