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Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis

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1. scibot 09 Sep 2026
  
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  DOI: 10.1016/j.devcel.2026.08.008
  
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sciencedirect.com/science/article/pii/S1534580726003199
Jul 2026
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Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.cell.2026.07.006
  
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2026.07.11.737985.full-html.html

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1. scibot 22 Jul 2026
  
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  DOI: 10.64898/2026.07.11.737985
  
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54.241.53.176/abdd4fd49c7ff7fe062e3f7e97d1cb52de6bbb37/2026.07.11.737985.full-html.html
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MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0021
  
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aacrjournals.org/cancerres/article/86/1/146/771172/MEN1-Promotes-Ferroptosis-by-Disrupting-CD44
Jun 2026
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Cyclin-dependent kinase-9 and oxidative phosphorylation inhibition overcome ibrutinib resistance in mantle cell lymphoma

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1. scibot 24 Jun 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0818
  
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aacrjournals.org/cancerrescommun/article/6/5/1192/785363/Cyclin-Dependent-Kinase-9-and-Oxidative
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CFP1 promotes B cell class switch recombination through the regulation of S region germline transcription and proliferation

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1. scibot 07 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116255
  
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sciencedirect.com/science/article/pii/S2589004226016305
Feb 2026
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Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression

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1. scibot 27 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117028
  
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sciencedirect.com/science/article/pii/S2211124726001063
Sep 2025
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Bicoid-nucleosome competition sets a concentration threshold for transcription constrained by genome replication

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1. scibot 20 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116121
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12425142/
Aug 2025
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Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.006
  
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sciencedirect.com/science/article/pii/S1097276525006070
Jun 2025
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
May 2025
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U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation

1
1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.021
  
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sciencedirect.com/science/article/pii/S1097276525003636
Mar 2025
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Targeted degradation of CDK9 potently disrupts the MYC-regulated network

1
1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.001
  
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sciencedirect.com/science/article/pii/S2451945625000674
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Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

1
1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.007
  
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sciencedirect.com/science/article/pii/S1097276525001339
Feb 2025
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Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer

1
1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115267
  
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sciencedirect.com/science/article/pii/S2211124725000385
Dec 2024
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TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome

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1. scibot 21 Dec 2024
  
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  AB_2167468
  
  DOI: 10.1016/j.molcel.2024.11.007
  
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sciencedirect.com/science/article/pii/S1097276524009122
Nov 2024
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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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1. scibot 21 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.018
  
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sciencedirect.com/science/article/pii/S0092867424012005
Jul 2024
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.06.012
  
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sciencedirect.com/science/article/pii/S153561082400237X
pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com

Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis

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1. scibot 23 Jul 2024
  
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  DOI: 10.1002/path.6325
  
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pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6325
May 2024
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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

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1. scibot 09 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114211
  
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sciencedirect.com/science/article/pii/S2211124724005394
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MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.neuron.2024.04.007
  
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sciencedirect.com/science/article/pii/S0896627324002459
Mar 2024
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Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113964
  
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sciencedirect.com/science/article/pii/S2211124724002924
Feb 2024
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Persistence of backtracking by human RNA polymerase II

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1. scibot 13 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.019
  
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sciencedirect.com/science/article/pii/S1097276524000558
Dec 2023
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A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.chembiol.2023.11.009
  
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sciencedirect.com/science/article/pii/S2451945623004245
Oct 2023
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Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis

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1. scibot 14 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.108079
  
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sciencedirect.com/science/article/pii/S2589004223021569
Sep 2023
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Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

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1. scibot 06 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107630
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10475482/
Apr 2023
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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.neuron.2023.01.022
  
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sciencedirect.com/science/article/pii/S0896627323000727
Aug 2022
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SPT6 functions in transcriptional pause/release via PAF1C recruitment

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1. scibot 10 Aug 2022
  
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  DOI: 10.1016/j.molcel.2022.06.037
  
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sciencedirect.com/science/article/pii/S1097276522006554
Jul 2022
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RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis

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  DOI: 10.1016/j.celrep.2022.111071
  
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sciencedirect.com/science/article/pii/S2211124722008695
Mar 2022
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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

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1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.molcel.2022.02.013
  
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sciencedirect.com/science/article/pii/S1097276522001186
Sep 2021
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SPT5 stabilization of promoter-proximal RNA polymerase II

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1. scibot 04 Sep 2021
  
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  DOI: 10.1016/j.molcel.2021.08.006
  
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sciencedirect.com/science/article/pii/S1097276521006468
Jul 2021
www.embopress.org www.embopress.org

CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

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1. scibot 30 Jul 2021
  
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  CTD of PolII largest subunit
  
  DOI: 10.15252/embr.201948058
  
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embopress.org/doi/10.15252/embr.201948058
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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

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1. scibot 22 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109394
  
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sciencedirect.com/science/article/pii/S2211124721007920
Mar 2021
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Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma

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1. scibot 17 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108870
  
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sciencedirect.com/science/article/pii/S2211124721001844
Feb 2021
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Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1

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1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.celrep.2021.108749
  
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sciencedirect.com/science/article/pii/S2211124721000620
Jan 2020
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The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.06.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6907403/
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Untitled document

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  RRID:AB_2167468
  
  DOI: 10.1016/j.cell.2019.02.030
  
  Resource: (Cell Signaling Technology Cat# 2629, RRID:AB_2167468)
  
  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S0092867419302132
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CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

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1. scibot 12 Jan 2020
  
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  RRID:AB_2167468
  
  DOI: 10.1016/j.immuni.2019.01.021
  
  Resource: (Cell Signaling Technology Cat# 2629, RRID:AB_2167468)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2167468
  
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  RRID:AB_2167468 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761319300445