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Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis

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sciencedirect.com/science/article/pii/S1550413126000161
Jul 2025
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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Jun 2025
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PDF-html.html

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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
May 2025
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration | Molecular Biology of the Cell

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Mar 2025
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Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine

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pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
Feb 2025
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mTORC2 Regulates Actin Polymerization in Auditory Cells

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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
Dec 2024
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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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Oct 2024
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

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ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
Sep 2024
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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming

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Aug 2024
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mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology

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journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
May 2024
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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids

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52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
Mar 2024
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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

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sciencedirect.com/science/article/pii/S2589004224004097
Feb 2024
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mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms

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  DOI: 10.1210/endocr/bqae015
  
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52.53.155.43/6951e0010ae4c14df11b3315f954e81c6a9c88a4/bqae015-html.html
Jul 2023
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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

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sciencedirect.com/science/article/pii/S2211124723007751
Dec 2022
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Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

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  DOI: 10.1126/scisignal.abn2743
  
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science.org/doi/10.1126/scisignal.abn2743
Nov 2022
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mTOR inhibition decreases angiotensin II-induced steroidogenesis in HAC15 human adrenocortical carcinoma cells

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academic.oup.com/endo/article/164/1/bqac185/6793711
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Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells

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  DOI: 10.1210/endocr/bqac170
  
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academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
Nov 2021
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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

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ajpcell.00385.2020-html.html

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Efferocytosis induces macrophage proliferation to help resolve tissue injury

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sciencedirect.com/science/article/pii/S1550413121005271
Sep 2021
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KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

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sciencedirect.com/science/article/pii/S1097276521007358
Jul 2021
jcs.biologists.org jcs.biologists.org

The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3

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jcs.biologists.org/content/132/20/jcs233221
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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May 2021
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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

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Apr 2021
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Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

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sciencedirect.com/science/article/pii/S1550413120304241
Feb 2021
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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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cell.com/cell-reports/abstract/S2211-1247(20)30021-8
Jan 2021
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Impact of WIN site inhibitor on the WDR5 interactome

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  DOI: 10.1016/j.celrep.2020.108636
  
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Nov 2020
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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

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sciencedirect.com/science/article/pii/S2666379120301737
Sep 2020
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Metabolic Control over mTOR-Dependent Diapause-like State

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  DOI: 10.1016/j.devcel.2019.12.018
  
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Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex

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  DOI: 10.1016/j.celrep.2020.107664
  
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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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cell.com/cell-reports/abstract/S2211-1247(20)30021-8
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Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

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  DOI: 10.7554/eLife.51440
  
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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

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  DOI: 10.15252/embr.201949898
  
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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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  DOI: 10.1016/j.immuni.2019.06.007
  
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  DOI: 10.1016/j.celrep.2019.02.052
  
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Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling

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  DOI: 10.1016/j.cmet.2019.03.005
  
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Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

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Systematic Functional Annotation of Somatic Mutations in Cancer

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A Method for the Acute and Rapid Degradation of Endogenous Proteins

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