49 Matching Annotations
  1. Last 7 days
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    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    1. scibot 30 Apr 2024
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    sciencedirect.com/science/article/pii/S109727652400282X
  3. Apr 2024
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    sciencedirect.com/science/article/pii/S2211124724003929
  5. Jan 2024
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    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    1
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    sciencedirect.com/science/article/pii/S2666379123006055
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    Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair
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      DOI: 10.1016/j.celrep.2023.113656

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    sciencedirect.com/science/article/pii/S2211124723016674
  8. Dec 2023
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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    sciencedirect.com/science/article/pii/S2211124723015358
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    Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells
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      DOI: 10.1016/j.chembiol.2023.11.008

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    sciencedirect.com/science/article/pii/S2451945623004233
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    IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
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    sciencedirect.com/science/article/pii/S109727652300967X
  12. Nov 2023
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
    1
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      DOI: 10.1016/j.isci.2023.108169

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    sciencedirect.com/science/article/pii/S2589004223022460
  14. Oct 2023
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    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
    1
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      DOI: 10.1016/j.celrep.2023.113144

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    sciencedirect.com/science/article/pii/S2211124723011567
  16. Sep 2023
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    Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction
    1
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      DOI: 10.1016/j.celrep.2023.113176

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    sciencedirect.com/science/article/pii/S2211124723011889
  18. Jul 2023
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    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
    1
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      DOI: 10.1016/j.celrep.2023.112805

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    sciencedirect.com/science/article/pii/S2211124723008161
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
    1
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.025

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    sciencedirect.com/science/article/pii/S1097276523004720
  21. Mar 2023
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  23. Jan 2023
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.molcel.2023.01.003

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    sciencedirect.com/science/article/pii/S1097276523000035
  25. Dec 2022
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    POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
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      DOI: 10.1016/j.molcel.2022.11.008

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    sciencedirect.com/science/article/pii/S109727652201070X
  27. Nov 2022
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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      DOI: 10.1016/j.celrep.2022.111670

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    sciencedirect.com/science/article/pii/S2211124722015443
  29. Aug 2022
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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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      DOI: 10.1016/j.ccell.2022.07.012

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    sciencedirect.com/science/article/pii/S1535610822003257
  31. Jun 2022
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
    1
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      DOI: 10.1016/j.devcel.2022.06.003

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    sciencedirect.com/science/article/pii/S1534580722004129
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    A function for Ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission
    1
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      DOI: 10.1016/j.isci.2022.104536

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    sciencedirect.com/science/article/pii/S2589004222008070
  34. May 2022
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
    1
    1. scibot 25 May 2022
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      DOI: 10.1016/j.molcel.2022.04.031

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    sciencedirect.com/science/article/pii/S109727652200394X
  36. Apr 2022
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
    1
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      DOI: 10.1016/j.molcel.2022.03.030

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    sciencedirect.com/science/article/pii/S1097276522002684
  38. Mar 2022
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    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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    sciencedirect.com/science/article/pii/S1097276522000855
  40. Nov 2021
  41. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
  42. Sep 2021
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    CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
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      DOI: 10.1016/j.xcrm.2021.100394

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    sciencedirect.com/science/article/pii/S2666379121002524
  44. Aug 2021
  45. europepmc.org europepmc.org
    Untitled document
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      DOI: 10.7554/eLife.38771

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    europepmc.org/articles/PMC6037479/
  46. Jul 2021
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
    1
    1. scibot 09 Jul 2021
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      DOI: 10.1016/j.molcel.2021.06.016

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    sciencedirect.com/science/article/pii/S1097276521004962
  48. Jun 2021
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
    1
    1. scibot 18 Jun 2021
      RRID:AB_2180847

      DOI: 10.1016/j.isci.2021.102534

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    ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
  50. May 2021
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.04.031

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    sciencedirect.com/science/article/pii/S1097276520302732
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    Homology-directed repair protects the replicating genome from metabolic assaults
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      DOI: 10.1016/j.devcel.2021.01.011

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    sciencedirect.com/science/article/pii/S1534580721000691
  53. Mar 2021
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    Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies
    1
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      DOI: 10.1016/j.molcel.2020.12.030

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    sciencedirect.com/science/article/pii/S1097276520309515
  55. Feb 2021
  56. www.sciencedirect.com www.sciencedirect.com
    CARM1 regulates replication fork speed and stress response by stimulating PARP1
    1
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      DOI: 10.1016/j.molcel.2020.12.010

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    sciencedirect.com/science/article/pii/S1097276520309023
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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      DOI: 10.1016/j.molcel.2021.01.004

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    sciencedirect.com/science/article/pii/S1097276521000046
  58. Jan 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
    1
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      RRID:AB_2180847

      DOI: 10.1016/j.molcel.2020.12.025

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    sciencedirect.com/science/article/pii/S1097276520309461
  60. Dec 2020
  61. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
    1
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      RRID:AB_2180847

      DOI: 10.1016/j.molcel.2020.12.006

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    sciencedirect.com/science/article/pii/S1097276520308984
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    WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
    1
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      RRID:AB_2180847

      DOI: 10.1016/j.celrep.2020.108469

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    sciencedirect.com/science/article/pii/S2211124720314583
  63. Sep 2020
  64. www.sciencedirect.com www.sciencedirect.com
    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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    1. scibot 23 Sep 2020
      RRID:AB_2180847

      DOI: 10.1016/j.celrep.2020.107983

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    sciencedirect.com/science/article/pii/S2211124720309682
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    Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability
    1
    1. scibot 17 Sep 2020
      RRID:AB_2180847

      DOI: 10.1016/j.stem.2019.12.013

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    sciencedirect.com/science/article/pii/S1934590919305715
  66. Jan 2020
  67. www.sciencedirect.com www.sciencedirect.com
    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
    1
    1. scibot 13 Jan 2020
      RRID:AB_2180847

      DOI: 10.1016/j.celrep.2019.06.043

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    sciencedirect.com/science/article/pii/S2211124719308162
  68. www.sciencedirect.com www.sciencedirect.com
    RPA Phosphorylation Inhibits DNA Resection
    1
    1. scibot 13 Jan 2020
      RRID:AB_2180847

      DOI: 10.1016/j.molcel.2019.05.005

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    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_2180847

      DOI: 10.1016/j.molcel.2019.10.008

      Resource: (Bethyl Cat# A300-246A, RRID:AB_2180847)

      Curator: @ethanbadger

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      RRID:AB_2180847 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276519307683
  70. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_2180847

      DOI: 10.1016/j.molcel.2019.04.010

      Resource: (Bethyl Cat# A300-246A, RRID:AB_2180847)

      Curator: @ethanbadger

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      RRID:AB_2180847 RRIDCUR:Validated
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  71. Nov 2018
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:AB_2180847

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    ncbi.nlm.nih.gov/pmc/articles/PMC6037479/
  73. www.sciencedirect.com www.sciencedirect.com
    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_2180847

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      (Bethyl Cat# A300-246A, RRID:AB_2180847)

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      RRID:AB_2180847
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    sciencedirect.com/science/article/pii/S1535610818301818
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
    1
    1. scibot 05 Nov 2018
      RRID:AB_2180847

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      (Bethyl Cat# A300-246A, RRID:AB_2180847)

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    sciencedirect.com/science/article/pii/S1535610818300199
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    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
    1
    1. scibot 05 Nov 2018
      RRID:AB_2180847

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      (Bethyl Cat# A300-246A, RRID:AB_2180847)

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  76. Nov 2017
  77. www.sciencedirect.com www.sciencedirect.com
    Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
    1
    1. scibot 08 Nov 2017
      RRID:AB_2180847

      Curator: @Jmenke

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    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
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    1. scibot 08 Nov 2017
      AB_2180847

      Curator: @Zeljana_Babic

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      (Bethyl Cat# A300-246A, RRID:AB_2180847)

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    Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
    1
    1. scibot 08 Nov 2017
      AB_2180847

      Curator: @Zeljana_Babic

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      (Bethyl Cat# A300-246A, RRID:AB_2180847)

      SciCrunch record: RRID:AB_2180847

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      RRID:AB_2180847 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517300552