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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44318-026-00783-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13270093/
Apr 2026
aacrjournals.org aacrjournals.org

Harnessing senolytics and PARP inhibition to expand the antitumor activity of CDK4/6 inhibitors in prostate cancer

1
1. scibot 07 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-24-0903
  
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aacrjournals.org/mct/article/24/12/1959/768323/Harnessing-Senolytics-and-PARP-Inhibition-to
Mar 2026
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Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

1
1. scibot 06 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117051
  
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sciencedirect.com/science/article/pii/S2211124726001294
Nov 2025
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A role for human senataxin in contending with pausing and backtracking during transcript elongation

1
1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.molcel.2025.10.019
  
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sciencedirect.com/science/article/pii/S1097276525008603
Jul 2025
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TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

1
1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.009
  
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sciencedirect.com/science/article/pii/S109727652500509X
Apr 2025
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Protocol for optimizing culture conditions for ex vivo activation during CRISPR-Cas9 gene editing in human hematopoietic stem and progenitor cells

1
1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.xpro.2025.103722
  
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sciencedirect.com/science/article/pii/S2666166725001285
Mar 2025
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

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1. scibot 20 Mar 2025
  
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  RRID:AB_2180847
  
  DOI: 10.1002/advs.202410718
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
Nov 2024
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A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells

1
1. scibot 14 Nov 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.xcrm.2024.101823
  
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sciencedirect.com/science/article/pii/S2666379124005949
Jun 2024
www.cell.com www.cell.com

CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

1
1. scibot 29 Jun 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.isci.2024.109978
  
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cell.com/iscience/abstract/S2589-0042(24)01200-8
May 2024
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Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

1
1. scibot 16 May 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2024.114205
  
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sciencedirect.com/science/article/pii/S2211124724005333
Apr 2024
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Unprocessed genomic uracil as a source of DNA replication stress in cancer cells

1
1. scibot 30 Apr 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2024.04.004
  
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sciencedirect.com/science/article/pii/S109727652400282X
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

2
1. scibot 09 Apr 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2024.114064
  
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2. scibot 09 Apr 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2024.114064
  
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sciencedirect.com/science/article/pii/S2211124724003929
Jan 2024
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Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

1
1. scibot 19 Jan 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.xcrm.2023.101376
  
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sciencedirect.com/science/article/pii/S2666379123006055
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Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair

1
1. scibot 09 Jan 2024
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2023.113656
  
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sciencedirect.com/science/article/pii/S2211124723016674
Dec 2023
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FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination

1
1. scibot 20 Dec 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2023.113523
  
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sciencedirect.com/science/article/pii/S2211124723015358
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Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells

1
1. scibot 19 Dec 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.chembiol.2023.11.008
  
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sciencedirect.com/science/article/pii/S2451945623004233
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IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors

1
1. scibot 16 Dec 2023
  
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  AB_2180847
  
  DOI: 10.1016/j.molcel.2023.11.022
  
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sciencedirect.com/science/article/pii/S109727652300967X
Nov 2023
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Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

1
1. scibot 04 Nov 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.isci.2023.108169
  
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sciencedirect.com/science/article/pii/S2589004223022460
Oct 2023
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Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer

1
1. scibot 01 Oct 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2023.113144
  
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sciencedirect.com/science/article/pii/S2211124723011567
Sep 2023
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Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction

1
1. scibot 30 Sep 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2023.113176
  
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sciencedirect.com/science/article/pii/S2211124723011889
Jul 2023
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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

1
1. scibot 21 Jul 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2023.112805
  
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sciencedirect.com/science/article/pii/S2211124723008161
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

1
1. scibot 21 Jul 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2023.06.025
  
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sciencedirect.com/science/article/pii/S1097276523004720
Mar 2023
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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination

1
1. scibot 28 Mar 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2023.112296
  
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sciencedirect.com/science/article/pii/S2211124723003078
Jan 2023
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SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses

1
1. scibot 26 Jan 2023
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2023.01.003
  
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sciencedirect.com/science/article/pii/S1097276523000035
Dec 2022
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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

1
1. scibot 01 Dec 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2022.11.008
  
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sciencedirect.com/science/article/pii/S109727652201070X
Nov 2022
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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

1
1. scibot 16 Nov 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.celrep.2022.111670
  
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sciencedirect.com/science/article/pii/S2211124722015443
Aug 2022
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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

1
1. scibot 22 Aug 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.ccell.2022.07.012
  
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sciencedirect.com/science/article/pii/S1535610822003257
Jun 2022
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Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

1
1. scibot 30 Jun 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.devcel.2022.06.003
  
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sciencedirect.com/science/article/pii/S1534580722004129
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A function for Ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

1
1. scibot 17 Jun 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.isci.2022.104536
  
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sciencedirect.com/science/article/pii/S2589004222008070
May 2022
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

1
1. scibot 25 May 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2022.04.031
  
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sciencedirect.com/science/article/pii/S109727652200394X
Apr 2022
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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

1
1. scibot 21 Apr 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2022.03.030
  
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sciencedirect.com/science/article/pii/S1097276522002684
Mar 2022
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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

1
1. scibot 02 Mar 2022
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2022.01.020
  
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sciencedirect.com/science/article/pii/S1097276522000855
Nov 2021
www.cell.com www.cell.com

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

1
1. scibot 30 Nov 2021
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.molcel.2021.11.002
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
Sep 2021
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

1
1. scibot 25 Sep 2021
  
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  RRID:AB_2180847
  
  DOI: 10.1016/j.xcrm.2021.100394
  
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  DOI: 10.7554/eLife.38771
  
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Jul 2021
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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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  DOI: 10.1016/j.molcel.2021.06.016
  
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Jun 2021
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ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

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May 2021
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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

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Homology-directed repair protects the replicating genome from metabolic assaults

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  DOI: 10.1016/j.devcel.2021.01.011
  
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Mar 2021
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Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

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Feb 2021
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CARM1 regulates replication fork speed and stress response by stimulating PARP1

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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Jan 2021
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

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Dec 2020
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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

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WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

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Sep 2020
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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability

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Jan 2020
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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

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RPA Phosphorylation Inhibits DNA Resection

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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Untitled document

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Nov 2018
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Untitled document

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Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

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Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

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Nov 2017
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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

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