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Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

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1. scibot 26 Jun 2026
  
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  DOI: 10.7554/eLife.109518
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13290227/
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Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes

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sciencedirect.com/science/article/pii/S1074761326002281
Apr 2026
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Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer

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aacrjournals.org/mct/article/25/4/662/776472/Targeting-Tumor-Microenvironment-Derived-NRG1-HER2
Feb 2026
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Covalent modification of a glutamic acid inspired by HaloTag technology

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1. scibot 07 Feb 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12864978/
Dec 2025
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Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice

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sciencedirect.com:5037/science/article/pii/S1550413125005261
Oct 2025
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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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sciencedirect.com/science/article/pii/S2211124725011532
Sep 2025
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OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

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sciencedirect.com/science/article/pii/S155041312500381X
Feb 2025
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TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion

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Nov 2024
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The roles of mTORC1 in parathyroid gland function in chronic kidney disease‐induced secondary hyperparathyroidism: Evidence from male genetic mouse models and clinical data

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1. scibot 26 Nov 2024
  
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Aug 2024
journals.physiology.org journals.physiology.org

mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology

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1. scibot 02 Aug 2024
  
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journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
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EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics

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1. scibot 02 Aug 2024
  
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  anti‐phospho‐S6
  
  DOI: 10.15252/embr.202050835
  
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embopress.org/doi/full/10.15252/embr.202050835
May 2024
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Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis

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1. scibot 03 May 2024
  
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  DOI: 10.1101/2024.01.08.574551
  
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biorxiv.org/content/10.1101/2024.01.08.574551v1
Oct 2023
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A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113260
  
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sciencedirect.com/science/article/pii/S221112472301272X
Aug 2023
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Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy

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sciencedirect.com/science/article/pii/S2211124723010495
Jul 2023
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GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107341
  
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sciencedirect.com/science/article/pii/S2589004223014189
May 2023
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Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

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  DOI: 10.1016/j.xcrm.2022.100680
  
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sciencedirect.com/science/article/pii/S2666379122002166
Apr 2023
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.neuron.2023.04.006
  
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sciencedirect.com/science/article/pii/S0896627323002684
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Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways

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  DOI: 10.1016/j.celrep.2023.112434
  
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sciencedirect.com/science/article/pii/S221112472300445X
Dec 2022
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Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

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1. scibot 13 Dec 2022
  
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  DOI: 10.1126/scisignal.abn2743
  
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science.org/doi/10.1126/scisignal.abn2743
Nov 2022
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mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

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  DOI: 10.1038/s41467-022-34763-y
  
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nature.com/articles/s41467-022-34763-y
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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  DOI: 10.1016/j.crmeth.2022.100271
  
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sciencedirect.com/science/article/pii/S2667237522001485
Jul 2022
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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

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sciencedirect.com/science/article/pii/S1550413122003023
Jun 2022
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Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

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ncbi.nlm.nih.gov/pmc/articles/PMC9183236/
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A single vomeronasal receptor promotes intermale aggression through dedicated hypothalamic neurons

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  DOI: 10.1016/j.neuron.2022.05.002
  
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sciencedirect.com/science/article/pii/S089662732200410X
Nov 2021
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ajpcell.00385.2020-html.html

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52.53.155.43/fcc41b1e6a5d6b11282a20b711b4d6b99930c8bb/ajpcell.00385.2020-html.html
Jul 2021
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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6331339/
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ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors

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  DOI: 10.1016/j.xcrm.2021.100350
  
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sciencedirect.com/science/article/pii/S2666379121001993
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Gut-microbiota-targeted diets modulate human immune status

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cell.com/cell/fulltext/S0092-8674(21)00754-6
Jan 2021
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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  DOI: 10.1016/j.cell.2020.12.024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
Nov 2020
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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  DOI: 10.7554/eLife.55994
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation

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Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

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  DOI: 10.1016/j.celrep.2019.12.090
  
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Zonation of Pancreatic Acinar Cells in Diabetic Mice

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  DOI: 10.1016/j.celrep.2020.108043
  
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Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice

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  DOI: 10.1016/j.celrep.2020.107835
  
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sciencedirect.com/science/article/pii/S2211124720308160
Jan 2020
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Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

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  DOI: 10.1016/j.cub.2019.06.018
  
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Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

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  DOI: 10.1016/j.immuni.2019.10.001
  
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Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

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PI3K inhibitors protect against glucocorticoid-induced skin atrophy

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  DOI: 10.1016/j.ebiom.2019.01.055
  
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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Untitled document

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Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

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Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice

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