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Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation

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  DOI: 10.1016/j.celrep.2026.117739
  
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sciencedirect.com/science/article/pii/S221112472600817X
Jun 2026
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LRP1 activated by AT2 cell-secreted MDK inhibits fibrotic ferroptosis in idiopathic pulmonary fibrosis

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sciencedirect.com/science/article/pii/S2589004226015877
Apr 2026
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Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility

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Mar 2026
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Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes

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  DOI: 10.1016/j.neuron.2026.02.003
  
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sciencedirect.com/science/article/pii/S0896627326000863
Feb 2026
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2026.02.12.705597.full-html.html

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54.241.53.176/14f3a07ece1e475cb953a541f0cfe26481a8aa41/2026.02.12.705597.full-html.html
Oct 2025
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Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid

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DUSP14 suppresses ferroptosis and promotes tumor progression of triple-negative breast cancer

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Sep 2025
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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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Aug 2025
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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sciencedirect.com/science/article/pii/S1535610825003186
Jul 2025
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Conserved biochemical activity and function of phosphatidylinositol 5-phosphate 4-kinase regulates growth and development

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  DOI: 10.1242/jcs.263881
  
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dx.doi.org/10.1242/jcs.263881
May 2025
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.chom.2025.05.004
  
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sciencedirect.com/science/article/pii/S1931312825001830
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Activation of an antifungal pathway in Yersinia pseudotuberculosis by chitin-receptor-mediated fungal recognition

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  DOI: 10.1016/j.cub.2025.04.072
  
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sciencedirect.com/science/article/pii/S096098222500569X
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.009
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12160003/
Jul 2024
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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1. scibot 30 Jul 2024
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
May 2024
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Polyphosphate attachment to lysine repeats is a non-covalent protein modification

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  DOI: 10.1016/j.molcel.2024.03.028
  
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sciencedirect.com/science/article/pii/S1097276524002776
Feb 2024
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Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

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1. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109075
  
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sciencedirect.com/science/article/pii/S2589004224002967
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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

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  DOI: 10.1016/j.cell.2024.01.004
  
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cell.com/cell/fulltext/S0092-8674(24)00006-0
Jan 2024
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In silico protein interaction screening uncovers DONSON’s role in replication initiation

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1. scibot 24 Jan 2024
  
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  DOI: 10.1126/science.adi3448
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
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A quantitative model for virus uncoating predicts influenza A infectivity

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  DOI: 10.1016/j.celrep.2023.113558
  
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sciencedirect.com/science/article/pii/S221112472301570X
Nov 2023
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Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation

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  DOI: 10.1016/j.celrep.2023.113358
  
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Sep 2023
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Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

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sciencedirect.com/science/article/pii/S096921262300326X
Aug 2023
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In silico protein interaction screening uncovers DONSON’s role in replication initiation

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science.org/doi/10.1126/science.adi3448
May 2023
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IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance

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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

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Nov 2022
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Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin

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sciencedirect.com/science/article/pii/S1097276522010607
Apr 2022
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CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

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  DOI: 10.1016/j.cell.2022.03.005
  
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Mar 2022
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Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases

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sciencedirect.com/science/article/pii/S1097276522002192
Nov 2021
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MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal

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sciencedirect.com/science/article/pii/S2211124721014261
Jul 2021
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Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation

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  DOI: 10.1016/j.celrep.2021.109343
  
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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

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1. scibot 10 Jul 2021
  
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  DOI: 10.1038/s41598-021-92408-4
  
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nature.com/articles/s41598-021-92408-4
May 2021
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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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  DOI: 10.1016/j.devcel.2020.08.006
  
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Sep 2020
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The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

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  DOI: 10.1016/j.celrep.2020.107547
  
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Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

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  DOI: 10.7554/eLife.55828
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7324161/
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A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

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1. scibot 04 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.03.031
  
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sciencedirect.com/science/article/pii/S0092867420303238
Jan 2020
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Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.07.005
  
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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

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  DOI: 10.1016/j.molcel.2018.12.001
  
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Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector

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  DOI: 10.1016/j.molcel.2019.03.028
  
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  DOI: 10.1016/j.cell.2019.02.013
  
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LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling

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SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

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Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer

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Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

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Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

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CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue

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SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding

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