69 Matching Annotations
  1. Apr 2024
  2. aacrjournals.org aacrjournals.org
    miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1158/1541-7786.MCR-23-0676

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    aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
  3. www.sciencedirect.com www.sciencedirect.com
    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.020

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    sciencedirect.com/science/article/pii/S1534580724001886
  4. Mar 2024
  5. www.sciencedirect.com www.sciencedirect.com
    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    2. scibot 06 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
  6. www.sciencedirect.com www.sciencedirect.com
    Alternative splicing decouples local from global PRC2 activity
    2
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.011

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    2. scibot 06 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.011

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    sciencedirect.com/science/article/pii/S1097276524001308
  7. Feb 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.026

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    sciencedirect.com/science/article/pii/S1097276524000935
  9. Jan 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer
    1
    1. scibot 06 Jan 2024
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      DOI: 10.1016/j.cmet.2023.12.003

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    sciencedirect.com/science/article/pii/S1550413123004552
  11. Jul 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
    1
    1. scibot 06 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.007

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    sciencedirect.com/science/article/pii/S1097276523004306
  13. Jun 2023
  14. www.sciencedirect.com www.sciencedirect.com
    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
    1
    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107115

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    sciencedirect.com/science/article/pii/S2589004223011926
  15. www.sciencedirect.com www.sciencedirect.com
    METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
    1
    1. scibot 22 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112650

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    sciencedirect.com/science/article/pii/S2211124723006617
  16. May 2023
  17. journals.plos.org journals.plos.org
    Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC
    1
    1. scibot 04 May 2023
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      DOI: 10.1371/journal.pbio.3002038

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    journals.plos.org/plosbiology/article
  18. Apr 2023
  19. www.sciencedirect.com www.sciencedirect.com
    PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1
    1
    1. scibot 08 Apr 2023
      RRID:AB_2196850

      DOI: 10.1016/j.molcel.2023.03.018

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    sciencedirect.com/science/article/pii/S1097276523002083
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gain of chromosome 1q perturbs a competitive endogenous RNA network to promote melanoma metastasis
    1
    1. scibot 04 Apr 2023
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      DOI: 10.1158/0008-5472.CAN-22-0283

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    ncbi.nlm.nih.gov/pmc/articles/PMC9971359/
  21. Jan 2023
  22. www.nature.com www.nature.com
    Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
    1
    1. scibot 19 Jan 2023
      RRID:AB_2196850

      DOI: 10.1038/s41556-022-01056-x

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    nature.com/articles/s41556-022-01056-x
  23. www.mdpi.com www.mdpi.com
    Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent
    1
    1. scibot 04 Jan 2023
      RRID:AB_2196850

      DOI: 10.3390/cancers15010208

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    mdpi.com/2072-6694/15/1/208
  24. Dec 2022
  25. www.sciencedirect.com www.sciencedirect.com
    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
    1
    1. scibot 08 Dec 2022
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      DOI: 10.1016/j.molcel.2022.11.010

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    sciencedirect.com/science/article/pii/S1097276522010991
  26. academic.oup.com academic.oup.com
    Dual Acting Peptides Target EZH2 and AR: a New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer
    1
    1. scibot 03 Dec 2022
      RRID:AB_2196850

      DOI: 10.1210/endocr/bqac180

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    academic.oup.com/endo/article/164/1/bqac180/6775160
  27. Oct 2022
  28. www.sciencedirect.com www.sciencedirect.com
    p300/CBP sustains Polycomb silencing by non-enzymatic functions
    1
    1. scibot 07 Oct 2022
      RRID:AB_2196850

      DOI: 10.1016/j.molcel.2022.09.005

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    sciencedirect.com/science/article/pii/S1097276522008942
  29. Sep 2022
  30. www.sciencedirect.com www.sciencedirect.com
    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
    1
    1. scibot 22 Sep 2022
      RRID:AB_2196850

      DOI: 10.1016/j.celrep.2022.111363

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    sciencedirect.com/science/article/pii/S2211124722011950
  31. www.sciencedirect.com www.sciencedirect.com
    Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
    1
    1. scibot 15 Sep 2022
      RRID:AB_2196850

      DOI: 10.1016/j.isci.2022.105013

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    sciencedirect.com/science/article/pii/S2589004222012858
  32. May 2022
  33. www.sciencedirect.com www.sciencedirect.com
    NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
    1
    1. scibot 12 May 2022
      RRID:AB_2196850

      DOI: 10.1016/j.molcel.2022.04.015

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    sciencedirect.com/science/article/pii/S1097276522003264
  34. Feb 2022
  35. www.sciencedirect.com www.sciencedirect.com
    Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing
    1
    1. scibot 16 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110357

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    sciencedirect.com/science/article/pii/S2211124722000766
  36. www.cell.com www.cell.com
    Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110332

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    2. scibot 09 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110332

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    cell.com/cell-reports/fulltext/S2211-1247(22)00048-1
  37. Oct 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Reprogramming CBX8-PRC1 function with a positive allosteric modulator
    1
    1. scibot 29 Oct 2021
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      DOI: 10.1016/j.chembiol.2021.10.003

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    sciencedirect.com/science/article/pii/S2451945621004372
  39. Aug 2021
  40. www.sciencedirect.com www.sciencedirect.com
    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
    1
    1. scibot 04 Aug 2021
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      DOI: 10.1016/j.ccell.2018.10.014

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    sciencedirect.com/science/article/pii/S153561081830480X
  41. Jul 2021
  42. www.sciencedirect.com www.sciencedirect.com
    Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas
    1
    1. scibot 29 Jul 2021
      RRID: 2196850

      DOI: 10.1016/j.celrep.2019.10.083

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    sciencedirect.com/science/article/pii/S2211124719314056
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.celrep.2018.11.035

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    ncbi.nlm.nih.gov/pmc/articles/PMC6342284/
  44. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.celrep.2018.11.035

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    sciencedirect.com/science/article/pii/S2211124718317984
  45. Jun 2021
  46. www.sciencedirect.com www.sciencedirect.com
    BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation
    1
    1. scibot 30 Jun 2021
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      DOI: 10.1016/j.molcel.2021.06.020

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    sciencedirect.com/science/article/pii/S1097276521005001
  47. May 2021
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.09.028

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    ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
  49. Apr 2021
  50. www.sciencedirect.com www.sciencedirect.com
    Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation
    1
    1. scibot 22 Apr 2021
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      DOI: 10.1016/j.molcel.2021.03.038

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    sciencedirect.com/science/article/pii/S1097276521002331
  51. www.sciencedirect.com www.sciencedirect.com
    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
    1
    1. scibot 17 Apr 2021
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      DOI: 10.1016/j.ccell.2020.05.022

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    sciencedirect.com/science/article/pii/S1535610820302725
  52. Feb 2021
  53. www.sciencedirect.com www.sciencedirect.com
    Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
    1
    1. scibot 28 Feb 2021
      RRID:AB_2196850

      DOI: 10.1016/j.cell.2020.11.012

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    sciencedirect.com/science/article/pii/S0092867420315294
  54. www.sciencedirect.com www.sciencedirect.com
    Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells
    1
    1. scibot 24 Feb 2021
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      DOI: 10.1016/j.molcel.2020.11.044

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    sciencedirect.com/science/article/pii/S1097276520308868
  55. Nov 2020
  56. www.sciencedirect.com www.sciencedirect.com
    H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation
    1
    1. scibot 25 Nov 2020
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      DOI: 10.1016/j.celrep.2020.108390

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    sciencedirect.com/science/article/pii/S2211124720313796
  57. Oct 2020
  58. www.embopress.org www.embopress.org
    Critical regulation of a NDIME/MEF2C axis in embryonic stem cell neural differentiation and autism
    1
    1. scibot 11 Oct 2020
      AB_2196850

      DOI: 10.15252/embr.202050283

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    embopress.org/doi/abs/10.15252/embr.202050283
  59. Sep 2020
  60. www.sciencedirect.com www.sciencedirect.com
    A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin
    1
    1. scibot 17 Sep 2020
      RRID:AB_2196850

      DOI: 10.1016/j.molcel.2019.12.019

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    sciencedirect.com/science/article/pii/S1097276519309499
  61. www.sciencedirect.com www.sciencedirect.com
    PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway
    1
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      RRID:AB_2196850

      DOI: 10.1016/j.celrep.2020.108147

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    sciencedirect.com/science/article/pii/S2211124720311360
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
    1
    1. scibot 08 Sep 2020
      RRID:AB_2196850

      DOI: 10.1126/sciadv.aaz6699

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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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  64. Jan 2020
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    PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration
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    Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression
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    PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation
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    Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation
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    PRC1 Catalytic Activity Is Central to Polycomb System Function
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    Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis
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    PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression
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    A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2
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    Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  82. Nov 2018
  83. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium
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    Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
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    A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
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    MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts
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    Capturing the Onset of PRC2-Mediated Repressive Domain Formation
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells
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    A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs
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  92. Nov 2017
  93. elifesciences.org elifesciences.org
    PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
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