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Evaluating Endometrial Response to Human Chorionic Gonadotropin: Alterations in Epigenetic Regulation and Extracellular Vesicle Cargo of Endometrial Stromal Cells

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1. scibot 06 Sep 2025
  
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  DOI: 10.1093/hropen/hoaf051
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12408481/
Aug 2025
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Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.014
  
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sciencedirect.com/science/article/pii/S109727652500615X
Jul 2025
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Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.neuron.2025.06.016
  
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sciencedirect.com/science/article/pii/S089662732500474X
Jun 2025
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RNA m6A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors

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  DOI: 10.1016/j.celrep.2025.115802
  
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sciencedirect.com/science/article/pii/S221112472500573X
May 2025
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

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1. scibot 22 May 2025
  
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N-acetyltransferase 10 promotes glioblastoma malignancy via mRNA stabilization of Jumonji and AT-rich interaction domain containing 2

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.jbc.2025.108544
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12152616/
Mar 2025
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Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs

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1. scibot 23 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.014
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00145-5
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Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee

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1. scibot 07 Mar 2025
  
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  DOI: 10.1016/j.stem.2025.02.002
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00041-4
Oct 2024
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

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1. scibot 02 Oct 2024
  
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  DOI: 10.1158/2159-8290.CD-20-0461
  
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aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
Sep 2024
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Activation of automethylated PRC2 by dimerization on chromatin

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.molcel.2024.08.025
  
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sciencedirect.com/science/article/pii/S1097276524007020
Jul 2024
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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.molcel.2020.09.028
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
Apr 2024
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miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0676
  
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aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.devcel.2024.03.020
  
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sciencedirect.com/science/article/pii/S1534580724001886
Mar 2024
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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

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1. scibot 07 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109188
  
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2. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109188
  
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sciencedirect.com/science/article/pii/S2589004224004097
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Alternative splicing decouples local from global PRC2 activity

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1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.011
  
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2. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.011
  
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sciencedirect.com/science/article/pii/S1097276524001308
Feb 2024
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Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo

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1. scibot 22 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.026
  
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sciencedirect.com/science/article/pii/S1097276524000935
Jan 2024
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Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer

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1. scibot 06 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.003
  
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sciencedirect.com/science/article/pii/S1550413123004552
Jul 2023
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.007
  
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sciencedirect.com/science/article/pii/S1097276523004306
Jun 2023
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An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer

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1. scibot 27 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107115
  
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sciencedirect.com/science/article/pii/S2589004223011926
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METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells

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  DOI: 10.1016/j.celrep.2023.112650
  
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sciencedirect.com/science/article/pii/S2211124723006617
May 2023
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Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC

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1. scibot 04 May 2023
  
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  DOI: 10.1371/journal.pbio.3002038
  
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journals.plos.org/plosbiology/article
Apr 2023
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PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

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1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.03.018
  
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sciencedirect.com/science/article/pii/S1097276523002083
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Gain of chromosome 1q perturbs a competitive endogenous RNA network to promote melanoma metastasis

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1. scibot 04 Apr 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-0283
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9971359/
Jan 2023
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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

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1. scibot 19 Jan 2023
  
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  DOI: 10.1038/s41556-022-01056-x
  
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nature.com/articles/s41556-022-01056-x
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Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent

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1. scibot 04 Jan 2023
  
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  DOI: 10.3390/cancers15010208
  
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mdpi.com/2072-6694/15/1/208
Dec 2022
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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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1. scibot 08 Dec 2022
  
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  DOI: 10.1016/j.molcel.2022.11.010
  
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sciencedirect.com/science/article/pii/S1097276522010991
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Dual Acting Peptides Target EZH2 and AR: a New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer

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1. scibot 03 Dec 2022
  
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  DOI: 10.1210/endocr/bqac180
  
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academic.oup.com/endo/article/164/1/bqac180/6775160
Oct 2022
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p300/CBP sustains Polycomb silencing by non-enzymatic functions

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  DOI: 10.1016/j.molcel.2022.09.005
  
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sciencedirect.com/science/article/pii/S1097276522008942
Sep 2022
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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

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1. scibot 22 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111363
  
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sciencedirect.com/science/article/pii/S2211124722011950
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Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters

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1. scibot 15 Sep 2022
  
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  DOI: 10.1016/j.isci.2022.105013
  
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sciencedirect.com/science/article/pii/S2589004222012858
May 2022
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

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1. scibot 12 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.015
  
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sciencedirect.com/science/article/pii/S1097276522003264
Feb 2022
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Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing

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1. scibot 16 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110357
  
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sciencedirect.com/science/article/pii/S2211124722000766
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Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis

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1. scibot 11 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110332
  
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2. scibot 09 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110332
  
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cell.com/cell-reports/fulltext/S2211-1247(22)00048-1
Oct 2021
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Reprogramming CBX8-PRC1 function with a positive allosteric modulator

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

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Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

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H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

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Critical regulation of a NDIME/MEF2C axis in embryonic stem cell neural differentiation and autism

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway

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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling

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PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

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Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

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DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation

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PRC1 Catalytic Activity Is Central to Polycomb System Function

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Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

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PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression

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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

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Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium

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Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency

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A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

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MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts

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Capturing the Onset of PRC2-Mediated Repressive Domain Formation

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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

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The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells

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A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

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PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

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