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Aug 2025
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice

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  DOI: 10.1016/j.celrep.2025.116130
  
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sciencedirect.com/science/article/pii/S2211124725009015
Jul 2025
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Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer

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  DOI: 10.1158/1535-7163.MCT-24-0289
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695182/
Jun 2025
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Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102198
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281382/
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The human neural cell atlas of Zika virus infection in developing brain tissue

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  DOI: 10.1016/j.xcrm.2025.102189
  
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sciencedirect.com/science/article/pii/S2666379125002629
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

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1. scibot 18 Jun 2025
  
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Epigenetic changes and serotype-specific responses of alveolar type II epithelial cells to Streptococcus pneumoniae in resolving influenza A virus infection

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  DOI: 10.1186/s12964-025-02284-y
  
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Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection

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1. scibot 14 Jun 2025
  
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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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1. scibot 03 Jun 2025
  
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sciencedirect.com/science/article/pii/S1074761325002274
May 2025
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Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.redox.2025.103670
  
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sciencedirect.com/science/article/pii/S2213231725001831
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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1. scibot 17 May 2025
  
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sciencedirect.com/science/article/pii/S2211124725004991
Apr 2025
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Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission

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1. scibot 15 Apr 2025
  
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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1. scibot 09 Apr 2025
  
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sciencedirect.com/science/article/pii/S1074761325001244
Mar 2025
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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1. scibot 11 Mar 2025
  
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sciencedirect.com/science/article/pii/S2211124725001743
Feb 2025
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Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

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1. scibot 26 Feb 2025
  
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  DOI: 10.1084/jem.20231486
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11338319/
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Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115310
  
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sciencedirect.com/science/article/pii/S2211124725000816
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

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1. scibot 11 Feb 2025
  
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  DOI: 10.7554/eLife.100197
  
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elifesciences.org/articles/100197
Jan 2025
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

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1. scibot 24 Jan 2025
  
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  DOI: 10.7554/eLife.100197.2
  
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elifesciences.org/reviewed-preprints/100197
Dec 2024
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RNA sensing induced by chromosome missegregation augments anti-tumor immunity

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.025
  
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sciencedirect.com/science/article/pii/S109727652400950X
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Regulation of human interferon signaling by transposon exonization

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  DOI: 10.1016/j.cell.2024.11.016
  
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sciencedirect.com/science/article/pii/S0092867424013333
Nov 2024
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Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

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sciencedirect.com/science/article/pii/S0092867424012017
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
Oct 2024
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Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon

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  DOI: 10.1016/j.cmet.2024.09.002
  
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sciencedirect.com/science/article/pii/S1550413124003668
Sep 2024
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Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages

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1. scibot 26 Sep 2024
  
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

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1. scibot 25 Sep 2024
  
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Aug 2024
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Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

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1. scibot 02 Aug 2024
  
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jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
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TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic β-Cell

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Jul 2024
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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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1. scibot 24 Jul 2024
  
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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism

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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
Jun 2024
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The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies

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  DOI: 10.1016/j.immuni.2024.05.017
  
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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  DOI: 10.1016/j.celrep.2024.114289
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
May 2024
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TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity

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1. scibot 23 May 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.cell.2024.04.025
  
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Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114246
  
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Viral mimicry and memory deficits upon microglial deletion of ATRX

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1. scibot 16 May 2024
  
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  DOI: 10.1101/2024.05.07.592875
  
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Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

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PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages

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MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C

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Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system

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Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration

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Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome

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Oncostatin M signaling drives cancer-associated skeletal muscle wasting

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PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages

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PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

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Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription

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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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Balancing macrophage polarization via stem cell-derived apoptotic bodies for diabetic wound healing

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Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs

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Alleviation of monocyte exhaustion by BCG derivative mycolic acid

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Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients

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XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

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PIM kinases regulate early human Th17 cell differentiation

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SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

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PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5

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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response

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NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages

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ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

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Journal of Neurochemistry - 2023 - Kamte-html.html

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

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Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling

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Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway

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Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis

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Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

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Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models

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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling

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Mitochondrial cristae architecture protects against mtDNA release and inflammation

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Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

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The target antigen determines the mechanism of acquired resistance to T cell-based therapies

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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

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Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction

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A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

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Intracellular infection and immune system cues rewire adipocytes to acquire immune function

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PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

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Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

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Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner

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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

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IL-27/IL-27RA signaling may modulate inflammation and progression of benign prostatic hyperplasia via suppressing the LPS/TLR4 pathway

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Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase

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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

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IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation

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CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response

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Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis

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Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC

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Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.

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Translation stress and collided ribosomes are co-activators of cGAS

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PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

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Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

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Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities

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A case of Luscan-Lumish syndrome: Possible involvement of enhanced GH signaling

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Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2′3′-Cyclic GMP–AMP and Cisplatin under Steady State and Inflammation

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates

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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

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sciencedirect.com/science/article/pii/S1074761321001205
Mar 2021
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Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

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1. scibot 11 Mar 2021
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.canlet.2021.03.004
  
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sciencedirect.com/science/article/pii/S0304383521001087
Feb 2021
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BPS Publications

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1. scibot 27 Feb 2021
  
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  RRID:AB_2198300
  
  DOI: 10.1111/bph.15330
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15330
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Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

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1. scibot 27 Feb 2021
  
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  RRID:AB_2198300
  
  DOI: 10.3390/antiox10020334
  
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mdpi.com/2076-3921/10/2/334
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The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

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1. scibot 25 Feb 2021
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.immuni.2020.06.023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7362873/
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Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma

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1. scibot 24 Feb 2021
  
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  RRID:AB_2198300
  
  DOI: 10.1002/jcp.29555
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.29555
Sep 2020
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

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1. scibot 16 Sep 2020
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.immuni.2020.03.016
  
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sciencedirect.com/science/article/pii/S1074761320301291
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Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain

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1. scibot 12 Sep 2020
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.celrep.2020.107777
  
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sciencedirect.com/science/article/pii/S2211124720307579
Jan 2020
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198289
  
  DOI: 10.1016/j.immuni.2019.06.007
  
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sciencedirect.com/science/article/pii/S1074761319302778
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CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198300
  
  DOI: 10.7554/eLife.46012
  
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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.ccell.2018.10.006
  
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IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.cmet.2019.01.006
  
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

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1. scibot 12 Jan 2020
  
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  RRID:AB_2198300
  
  DOI: 10.1016/j.molcel.2019.02.038
  
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sciencedirect.com/science/article/pii/S1097276519301492
Nov 2018
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Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

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1. scibot 05 Nov 2018
  
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The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)

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1. scibot 05 Nov 2018
  
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  RRID:AB_2198300
  
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sciencedirect.com/science/article/pii/S0165572817303703

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