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39 Matching Annotations

Sep 2025
rupress.org rupress.org

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

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1. scibot 16 Sep 2025
  
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  DOI: 10.1084/jem.20250185
  
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rupress.org/jem/article/222/11/e20250185/278317/Autoimmune-disease-risk-gene-ANKRD55-promotes-TH17
Jul 2025
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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.011
  
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sciencedirect.com/science/article/pii/S1535610825002612
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.xgen.2025.100782
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SIKs regulate HDAC7 stabilization and cytokine recall in late-stage T cell effector differentiation

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1. scibot 22 Dec 2024
  
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  DOI: 10.4049/jimmunol.2300248
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10842463/
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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1. scibot 11 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111311
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.114984
  
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sciencedirect.com/science/article/pii/S2211124724013354
May 2024
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Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.024
  
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sciencedirect.com/science/article/pii/S1074761324002292
Oct 2023
www.cell.com www.cell.com

CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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1. scibot 28 Oct 2023
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.cmet.2023.09.012
  
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cell.com/cell-metabolism/fulltext/S1550-4131(23)00368-6
Jun 2023
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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.ccell.2023.05.015
  
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sciencedirect.com/science/article/pii/S1535610823001824
May 2023
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LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation

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1. scibot 12 May 2023
  
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  DOI: 10.1016/j.molcel.2023.04.017
  
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sciencedirect.com/science/article/pii/S1097276523002885
onlinelibrary.wiley.com onlinelibrary.wiley.com

Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

1
1. scibot 05 May 2023
  
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  RRID:AB_2198327
  
  DOI: 10.1002/cac2.12332
  
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onlinelibrary.wiley.com/doi/10.1002/cac2.12332
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

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1. scibot 16 Mar 2023
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.isci.2023.106251
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10005909/
Nov 2022
www.cell.com www.cell.com

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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1. scibot 10 Nov 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.celrep.2022.111498
  
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cell.com/cell-reports/abstract/S2211-1247(22)01348-1
Oct 2022
www.nature.com www.nature.com

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

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1. scibot 16 Oct 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1038/s41467-022-33749-0
  
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nature.com/articles/s41467-022-33749-0
Sep 2022
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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1. scibot 24 Sep 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.ccell.2022.08.015
  
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sciencedirect.com/science/article/pii/S1535610822003798
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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1. scibot 01 Jun 2022
  
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  RRID:AB_2198327
  
  DOI: 10.3389/fphar.2022.848957
  
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  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
May 2022
link.springer.com link.springer.com

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

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1. scibot 05 May 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1186/s13024-022-00526-y
  
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link.springer.com/article/10.1186/s13024-022-00526-y
Mar 2022
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Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

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1. scibot 26 Mar 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.cub.2022.02.058
  
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sciencedirect.com/science/article/pii/S0960982222003281
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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

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1. scibot 18 Mar 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.xcrm.2022.100554
  
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sciencedirect.com/science/article/pii/S266637912200060X
Jan 2022
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Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

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1. scibot 12 Jan 2022
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.isci.2021.103697
  
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sciencedirect.com/science/article/pii/S2589004221016679
Sep 2021
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Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

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1. scibot 18 Sep 2021
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.cmet.2021.08.014
  
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sciencedirect.com/science/article/pii/S1550413121003776
Jul 2021
www.jbc.org www.jbc.org

The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export

1
1. scibot 29 Jul 2021
  
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  LKB1
  
  DOI: 10.1074/jbc.RA119.007848
  
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jbc.org/content/294/30/11597.full
Feb 2021
www.cell.com www.cell.com

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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1. scibot 25 Feb 2021
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.molcel.2020.12.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30900-X
Dec 2020
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Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

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1. scibot 07 Dec 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.celrep.2020.108444
  
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sciencedirect.com/science/article/pii/S2211124720314339
Sep 2020
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Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism

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1. scibot 16 Sep 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.chom.2020.01.028
  
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sciencedirect.com/science/article/pii/S1931312820300718
Jan 2020
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.immuni.2019.06.007
  
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sciencedirect.com/science/article/pii/S1074761319302778
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

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1. scibot 13 Jan 2020
  
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  AB_2198327
  
  DOI: 10.1016/j.molcel.2019.08.028
  
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sciencedirect.com/science/article/pii/S1097276519306835
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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.cmet.2019.05.018
  
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  RRID:AB_2198327 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S155041311930258X
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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.molcel.2019.08.021
  
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  RRID:AB_2198327 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519306604
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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.celrep.2019.10.117
  
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  RRID:AB_2198327 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719314500
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Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.celrep.2019.05.020
  
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  RRID:AB_2198327 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S221112471930631X
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.cmet.2019.03.012
  
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sciencedirect.com/science/article/pii/S155041311930141X
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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

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1. scibot 13 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.molcel.2019.04.003
  
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sciencedirect.com/science/article/pii/S1097276519302734
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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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1. scibot 12 Jan 2020
  
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  RRID:AB_2198327
  
  DOI: 10.1016/j.cmet.2018.10.005
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1550413118306375
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

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1. scibot 05 Nov 2018
  
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  RRID:AB_2198327
  
  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 3047, RRID:AB_2198327)
  
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  RRID:AB_2198327 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610818303696
onlinelibrary.wiley.com onlinelibrary.wiley.com

Antagonizing peroxisome proliferator‐activated receptor γ facilitates M1‐to‐M2 shift of microglia by enhancing autophagy via the LKB1–AMPK signaling pathway

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2198327
  
  Curator: @anp055
  
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  (Cell Signaling Technology Cat# 3047, RRID:AB_2198327)
  
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  RRID:AB_2198327 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/full/10.1111/acel.12774
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LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2198327
  
  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 3047, RRID:AB_2198327)
  
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  RRID:AB_2198327 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276518301096
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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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1. scibot 05 Nov 2018
  
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  RRID:AB_2198327
  
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  (Cell Signaling Technology Cat# 3047, RRID:AB_2198327)
  
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  RRID:AB_2198327
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sciencedirect.com/science/article/pii/S1097276517308845