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Nov 2026
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Innate sensor responses set a supra-unitary threshold for viral replication

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1. scibot 05 Nov 2026
  
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sciencedirect.com/science/article/pii/S0092867426012158
Oct 2026
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SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening

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  DOI: 10.1016/j.cell.2026.09.021
  
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sciencedirect.com/science/article/pii/S0092867426011232
Aug 2026
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STING deficiency does not rescue short telomere-mediated aging phenotypes and longevity in TERC- or TERT-telomerase deficient mice

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1. scibot 28 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117786
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13506677/
Jun 2026
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Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity

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  DOI: 10.1016/j.celrep.2026.117601
  
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sciencedirect.com/science/article/pii/S2211124726006790
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Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages

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  DOI: 10.1038/s44319-026-00793-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13260819/
Feb 2026
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Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.010
  
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sciencedirect.com/science/article/pii/S1097276526000304
Oct 2025
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IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

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  DOI: 10.1016/j.celrep.2025.116336
  
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sciencedirect.com/science/article/pii/S2211124725011076
Sep 2025
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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  DOI: 10.1016/j.immuni.2025.07.024
  
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sciencedirect.com/science/article/pii/S1074761325003334
Aug 2025
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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  DOI: 10.1016/j.devcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S153458072500499X
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116130
  
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sciencedirect.com/science/article/pii/S2211124725009015
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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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1. scibot 12 Aug 2025
  
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  DOI: 10.1038/s41467-025-62379-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12335601/
Feb 2025
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RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.013
  
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sciencedirect.com/science/article/pii/S1550413125000130
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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.004
  
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sciencedirect.com/science/article/pii/S2451945625000042
Dec 2024
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RNA sensing induced by chromosome missegregation augments anti-tumor immunity

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.025
  
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sciencedirect.com/science/article/pii/S109727652400950X
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Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111384
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11634986/
Nov 2024
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
Sep 2024
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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110893
  
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sciencedirect.com/science/article/pii/S2589004224021187
Aug 2024
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.08.006
  
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sciencedirect.com/science/article/pii/S1097276524006609
Jun 2024
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An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors

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  DOI: 10.1038/s44320-024-00040-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148061/
May 2024
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TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity

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1. scibot 23 May 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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  DOI: 10.1016/j.redox.2024.103202
  
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sciencedirect.com/science/article/pii/S2213231724001800
Apr 2024
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ISGylation by HERCs facilitates STING activation

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  DOI: 10.1016/j.celrep.2024.114135
  
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sciencedirect.com/science/article/pii/S2211124724004637
Nov 2023
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SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

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1. scibot 30 Nov 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0265
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
Sep 2023
www.biorxiv.org www.biorxiv.org

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

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1. scibot 30 Sep 2023
  
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  DOI: 10.1101/2023.09.25.559255
  
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biorxiv.org/content/10.1101/2023.09.25.559255v1
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STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

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1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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sciencedirect.com/science/article/pii/S2211124723011191
Mar 2023
europepmc.org europepmc.org

Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112303
  
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europepmc.org/article/med/36952341
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UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS

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  DOI: 10.1016/j.celrep.2023.112272
  
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europepmc.org/article/med/36943869
Feb 2023
www.cell.com www.cell.com

Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma

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  DOI: 10.1016/j.celrep.2023.112127
  
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cell.com/cell-reports/fulltext/S2211-1247(23)00138-9
Jan 2023
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Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response

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1. scibot 05 Jan 2023
  
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  DOI: 10.1016/j.molcel.2022.12.007
  
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sciencedirect.com/science/article/pii/S1097276522011649
Sep 2022
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.015
  
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sciencedirect.com/science/article/pii/S1535610822003798
Jul 2022
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Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer

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1. scibot 31 Jul 2022
  
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  DOI: 10.1158/2767-9764.CRC-21-0139
  
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aacrjournals.org/cancerrescommun/article/2/7/706/707154/Potent-Stimulation-of-the-Androgen-Receptor
Jan 2022
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
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SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.ebiom.2021.103808
  
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Native-PAGE analysis of protein aggregation upon viral infection in mouse macrophages

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Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

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The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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Untitled document

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TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

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Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

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Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

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IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling

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Untitled document

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

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Nov 2017
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Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

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