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Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44319-026-00793-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13260819/
Feb 2026
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Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.010
  
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sciencedirect.com/science/article/pii/S1097276526000304
Oct 2025
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IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116336
  
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sciencedirect.com/science/article/pii/S2211124725011076
Sep 2025
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.07.024
  
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sciencedirect.com/science/article/pii/S1074761325003334
Aug 2025
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S153458072500499X
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116130
  
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sciencedirect.com/science/article/pii/S2211124725009015
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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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1. scibot 12 Aug 2025
  
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  DOI: 10.1038/s41467-025-62379-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12335601/
Feb 2025
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RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.013
  
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sciencedirect.com/science/article/pii/S1550413125000130
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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.004
  
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sciencedirect.com/science/article/pii/S2451945625000042
Dec 2024
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RNA sensing induced by chromosome missegregation augments anti-tumor immunity

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.025
  
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Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111384
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11634986/
Nov 2024
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
Sep 2024
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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110893
  
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sciencedirect.com/science/article/pii/S2589004224021187
Aug 2024
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.08.006
  
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sciencedirect.com/science/article/pii/S1097276524006609
Jun 2024
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An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors

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1. scibot 09 Jun 2024
  
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  DOI: 10.1038/s44320-024-00040-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148061/
May 2024
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TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity

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1. scibot 23 May 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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2. scibot 23 May 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.redox.2024.103202
  
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sciencedirect.com/science/article/pii/S2213231724001800
Apr 2024
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ISGylation by HERCs facilitates STING activation

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1. scibot 23 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114135
  
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sciencedirect.com/science/article/pii/S2211124724004637
Nov 2023
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SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

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1. scibot 30 Nov 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0265
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
Sep 2023
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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

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1. scibot 30 Sep 2023
  
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  DOI: 10.1101/2023.09.25.559255
  
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biorxiv.org/content/10.1101/2023.09.25.559255v1
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STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

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1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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sciencedirect.com/science/article/pii/S2211124723011191
Mar 2023
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Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING

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1. scibot 28 Mar 2023
  
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  RRID:AB_225566
  
  DOI: 10.1016/j.celrep.2023.112303
  
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europepmc.org/article/med/36952341
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UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS

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1. scibot 23 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112272
  
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europepmc.org/article/med/36943869
Feb 2023
www.cell.com www.cell.com

Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma

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  DOI: 10.1016/j.celrep.2023.112127
  
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cell.com/cell-reports/fulltext/S2211-1247(23)00138-9
Jan 2023
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Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response

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1. scibot 05 Jan 2023
  
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  DOI: 10.1016/j.molcel.2022.12.007
  
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sciencedirect.com/science/article/pii/S1097276522011649
Sep 2022
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.015
  
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sciencedirect.com/science/article/pii/S1535610822003798
Jul 2022
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Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer

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1. scibot 31 Jul 2022
  
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  DOI: 10.1158/2767-9764.CRC-21-0139
  
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aacrjournals.org/cancerrescommun/article/2/7/706/707154/Potent-Stimulation-of-the-Androgen-Receptor
Jan 2022
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
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SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.ebiom.2021.103808
  
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sciencedirect.com/science/article/pii/S2352396421006022
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Native-PAGE analysis of protein aggregation upon viral infection in mouse macrophages

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1. scibot 11 Jan 2022
  
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  DOI: 10.1016/j.xpro.2021.101080
  
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sciencedirect.com/science/article/pii/S2666166721007863
Oct 2021
elifesciences.org elifesciences.org

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

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1. scibot 23 Oct 2021
  
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  DOI: 10.7554/eLife.72328
  
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elifesciences.org/articles/72328
Sep 2021
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The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

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1. scibot 22 Sep 2021
  
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  DOI: 10.1016/j.celrep.2021.109731
  
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sciencedirect.com/science/article/pii/S2211124721011803
Aug 2021
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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.026
  
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sciencedirect.com/science/article/pii/S0092867421008850
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Untitled document

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1. scibot 09 Aug 2021
  
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  RRID:AB_2199749
  
  DOI: 10.1016/j.celrep.2018.10.057
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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sciencedirect.com/science/article/pii/S2211124718316462
Apr 2021
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TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

1
1. scibot 29 Apr 2021
  
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  RRID:AB_2199749
  
  DOI: 10.1016/j.cmet.2020.10.010
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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sciencedirect.com/science/article/pii/S155041312030543X
Jan 2021
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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

1
1. scibot 08 Jan 2021
  
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  RRID:AB_2199749
  
  DOI: 10.1016/j.celrep.2020.108586
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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  RRIDCUR:Validated RRID:AB_2199749
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sciencedirect.com/science/article/pii/S2211124720315758
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

1
1. scibot 17 Dec 2020
  
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  RRID:AB_2199749
  
  DOI: 10.1016/j.celrep.2019.03.098
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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  RRIDCUR:Validated RRID:AB_2199749
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ncbi.nlm.nih.gov/pmc/articles/PMC7733315/
Sep 2020
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2199749
  
  DOI: 10.1016/j.celrep.2020.03.056
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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sciencedirect.com/science/article/pii/S2211124720303703
rupress.org rupress.org

Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2199749
  
  DOI: 10.1083/jcb.201912144
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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rupress.org/jcb/article/219/9/e201912144/151863/Critical-role-of-mitochondrial-ubiquitination-and
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling

1
1. scibot 03 Sep 2020
  
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  TBK1
  
  DOI: 10.1111/jcmm.15774
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
  Curator: @Naa003
  
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  RRID:AB_2199749 RRIDCUR:Missing
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pubmed.ncbi.nlm.nih.gov/32858764/
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2199749
  
  DOI: 10.1016/j.celrep.2019.03.098
  
  Resource: (Cell Signaling Technology Cat# 3013, RRID:AB_2199749)
  
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sciencedirect.com/science/article/pii/S2211124719304371
Nov 2018
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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2199749
  
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sciencedirect.com/science/article/pii/S0092867418309693
Nov 2017
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Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

1
1. scibot 08 Nov 2017
  
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  RRID:AB_2199749
  
  Curator: @Jmenke
  
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  RRID:AB_2199749 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276517306536