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Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS

1
1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.045
  
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cell.com/cell/abstract/S0092-8674(25)00908-0
Aug 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits

1
1. scibot 27 Aug 2025
  
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  DOI: 10.1111/jnc.70204
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70204
May 2025
www.sciencedirect.com www.sciencedirect.com

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.039
  
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sciencedirect.com/science/article/pii/S0092867425005094
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Examining the potential involvement of NONO in TDP‐43 proteinopathy in Drosophila

1
1. scibot 24 Jan 2025
  
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  DOI: 10.1111/ejn.16632
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11670437/
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C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity

1
1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115173
  
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sciencedirect.com/science/article/pii/S2211124724015249
Dec 2024
www.biorxiv.org www.biorxiv.org

Lysine deacetylation inhibition reverses TDP-43 mislocalization and in combination with arimoclomol ameliorates neuromuscular pathology

1
1. scibot 21 Dec 2024
  
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  RRID:AB_2200505
  
  DOI: 10.1101/2024.12.15.628528
  
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biorxiv.org/content/10.1101/2024.12.15.628528v1
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of small molecule inhibitors of G3BP-driven stress granule formation

1
1. scibot 30 Jul 2024
  
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  DOI: 10.1083/jcb.202308083
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10824102/
Feb 2024
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Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

2
1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109166
  
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2. scibot 29 Feb 2024
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.isci.2024.109166
  
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sciencedirect.com/science/article/pii/S2589004224003870
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Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice

1
1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.neuron.2024.01.022
  
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sciencedirect.com/science/article/pii/S0896627324000485
Sep 2023
www.sciencedirect.com www.sciencedirect.com

Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43

1
1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.jbc.2023.105272
  
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sciencedirect.com/science/article/pii/S0021925823023001
Jul 2023
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Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

1
1. scibot 22 Jul 2023
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.neuron.2023.06.019
  
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sciencedirect.com/science/article/pii/S0896627323004786
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence

1
1. scibot 24 Jun 2023
  
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  AB_2200505
  
  DOI: 10.12688/f1000research.131852.2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10285334/
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

1
1. scibot 15 Feb 2023
  
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  AB_2200505
  
  DOI: 10.3233/ADR-220056
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
May 2022
www.sciencedirect.com www.sciencedirect.com

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43

1
1. scibot 05 May 2022
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.isci.2022.104273
  
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sciencedirect.com/science/article/pii/S2589004222005430
Jan 2022
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Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis

1
1. scibot 19 Jan 2022
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.neuron.2021.12.019
  
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sciencedirect.com/science/article/pii/S0896627321010369
academic.oup.com academic.oup.com

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia

1
1. scibot 04 Jan 2022
  
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  RRID:AB_2200505
  
  DOI: 10.1093/brain/awab333
  
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academic.oup.com/brain/article/144/12/3710/6491324
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

1
1. scibot 28 Aug 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.molcel.2021.07.038
  
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sciencedirect.com/science/article/pii/S1097276521006225
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

1
1. scibot 16 Aug 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1186/s13024-021-00470-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8353748/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 10 Aug 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1186/s12929-018-0479-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6223059/
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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

1
1. scibot 08 Aug 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.molcel.2017.02.013
  
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sciencedirect.com/science/article/pii/S1097276517301284
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

1
1. scibot 03 Aug 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.molcel.2017.02.013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5364369/
Jul 2021
jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com

Untitled document

1
1. scibot 29 Jul 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1186/s12929-018-0479-4
  
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jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0479-4
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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

1
1. scibot 27 Jul 2021
  
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  AB_2200505
  
  DOI: 10.1016/j.molcel.2017.02.013
  
  Resource: (Proteintech Cat# 12892-1-AP, RRID:AB_2200505)
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1097276517301284
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43

1
1. scibot 14 Jul 2021
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.isci.2021.102733
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8259439/
May 2021
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function

1
1. scibot 04 May 2021
  
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  AB_2200505
  
  DOI: 10.1096/fj.202100087R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100087R
Sep 2020
link.springer.com link.springer.com

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2200505
  
  DOI: 10.1186/s40478-020-00965-y
  
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  Curator: @Naa003
  
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  RRID:AB_2200505 RRIDCUR:Validated
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link.springer.com/article/10.1186/s40478-020-00965-y
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BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain

1
1. scibot 13 Sep 2020
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.cels.2020.03.003
  
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  Curator: @ethanbadger
  
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  RRIDCUR:Validated RRID:AB_2200505
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sciencedirect.com/science/article/pii/S2405471220301095
Jan 2020
www.nature.com www.nature.com

C9-ALS/FTD-linked proline–arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2200505
  
  DOI: 10.1038/s41419-019-1983-5
  
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  RRID:AB_2200505 RRIDCUR:Validated
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nature.com/articles/s41419-019-1983-5
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2200505
  
  DOI: 10.7554/eLife.39578
  
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  Curator: @evieth
  
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  RRID:AB_2200505 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6426440/
www.sciencedirect.com www.sciencedirect.com

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2200505
  
  DOI: 10.1016/j.neuron.2019.02.038
  
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  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2200505
  
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  RRID:AB_2200505 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627319301734
Nov 2018
onlinelibrary.wiley.com onlinelibrary.wiley.com

Differential toxicity of TAR DNA‐binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2200505
  
  Curator: @Jmenke
  
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  (Proteintech Group Cat# 12892-1-AP, RRID:AB_2200505)
  
  SciCrunch record: RRID:AB_2200505
  
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  RRID:AB_2200505 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14465
Nov 2017
www.sciencedirect.com www.sciencedirect.com

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

1
1. scibot 08 Nov 2017
  
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  RRID:AB_2200505
  
  Curator: @Jmenke
  
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  RRID:AB_2200505 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627317306475
elifesciences.org elifesciences.org

Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106

2
1. scibot 08 Nov 2017
  
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  AB_2200505
  
  Curator: @gabimpine
  
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  (Proteintech Group Cat# 12892-1-AP, RRID:AB_2200505)
  
  SciCrunch record: RRID:AB_2200505
  
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  RRID:AB_2200505 RRIDCUR:Validated
2. scibot 08 Nov 2017
  
  in Public
  
  AB_2200505
  
  Curator: @chewbeccax
  
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  (Proteintech Group Cat# 12892-1-AP, RRID:AB_2200505)
  
  SciCrunch record: RRID:AB_2200505
  
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  RRID:AB_2200505 RRIDCUR:Validated
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Tags

RRIDCUR:Validated

RRID:AB_2200505

Annotators

scibot

URL

elifesciences.org/content/6/e19032