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Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression

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  DOI: 10.1016/j.celrep.2025.116234
  
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sciencedirect.com/science/article/pii/S2211124725010058
Aug 2025
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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

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Microcystin-LR hijacks mitochondrial bioenergetics and Wnt crosstalk: Unveiling a novel dual-pathway mechanism for adipogenesis dysregulation in environmental toxicology

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  DOI: 10.1016/j.cbpc.2025.110329
  
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52.53.155.43/3af1c841c2bdd5eb801f1e97e5d21ecf6662ffe6/1-s2.0-S1532045625002108-main-html.html
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1-s2.0-S1532045625002108-main-html.html

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52.53.155.43/4ad8b2adc564ab28a95d5ab5cbd57c41c85e5f0e/1-s2.0-S1532045625002108-main-html.html
Jul 2025
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Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip

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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00317-9
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Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy

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Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice

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  DOI: 10.1101/2025.06.30.662456
  
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biorxiv.org/content/10.1101/2025.06.30.662456v1
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Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction

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  DOI: 10.4103/NRR.NRR-D-24-00999
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12220689/
Jun 2025
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Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation

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ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

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May 2025
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Metabolic and Structural Consequences of GM3 Synthase Deficiency: Insights from an HEK293-T Knockout Model

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1. scibot 21 May 2025
  
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  DOI: 10.3390/biomedicines13040843
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12024672/
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Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

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  DOI: 10.1083/jcb.202403116
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11533445/
Mar 2025
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β-hydroxybutyrate facilitates mitochondrial-derived vesicle biogenesis and improves mitochondrial functions

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cell.com/molecular-cell/abstract/S1097-2765(25)00183-2
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Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

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  DOI: 10.1002/advs.202414260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12021055/
Feb 2025
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Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation

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  DOI: 10.1016/j.stem.2025.01.013
  
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Jan 2025
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Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

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cell.com/cell-metabolism/fulltext/S1550-4131(24)00490-X
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PDF-html.html

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52.53.155.43/764cb087126a42605fa465599969cfdf56a16457/PDF-html.html
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A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

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  DOI: 10.1016/j.celrep.2024.115143
  
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Dec 2024
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Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1

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cell.com/cell-metabolism/fulltext/S1550-4131(24)00413-3
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
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Reactive oxygen species control protein degradation at the mitochondrial import gate

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Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks

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Nov 2024
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GM1 Oligosaccharide Ameliorates Rett Syndrome Phenotypes In Vitro and In Vivo via Trk Receptor Activation

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DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

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  DOI: 10.7554/eLife.96755
  
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elifesciences.org/articles/96755
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DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

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  DOI: 10.7554/eLife.96755.3
  
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elifesciences.org/reviewed-preprints/96755
Oct 2024
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Hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect neurons from cardiac arrest–induced pyroptosis

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  DOI: 10.4103/NRR.NRR-D-23-01922
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11438345/
Sep 2024
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mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes

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Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis

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RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages

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Aug 2024
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Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

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  DOI: 10.1016/j.cell.2024.08.004
  
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cell.com/cell/fulltext/S0092-8674(24)00895-X
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SLC25A48 controls mitochondrial choline import and metabolism

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cell.com/cell-metabolism/fulltext/S1550-4131(24)00281-X
Jul 2024
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Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes

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N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma

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1. scibot 27 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11270646/
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Intracellular tau fragment droplets serve as seeds for tau fibrils

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  DOI: 10.1016/j.str.2024.06.018
  
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation

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  DOI: 10.1016/j.cmet.2024.05.016
  
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels

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Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks

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Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke

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Systemic Phospho-Defective and Phospho-Mimetic Drp1 Mice Exhibit Normal Growth and Development with Altered Anxiety-like Behavior

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BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

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Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease

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Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle

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Rab32 family proteins regulate autophagosomal components recycling

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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

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OPA1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1

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Biallelic pathogenic variants in DNAH3 cause male infertility in humans and mice

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Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

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Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2

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Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis

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OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

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Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

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ULK phosphorylation of STX17 controls autophagosome maturation via FLNA

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End binding-3 inhibitor activates regenerative program in age-related macular degeneration

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Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

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Focused Low-Intensity Pulsed Ultrasound Alleviates Osteoarthritis via Restoring Impaired FUNDC1-Mediated Mitophagy

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Mammalian autophagosomes form from finger-like phagophores

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LINC00116-Encoded Microprotein Mitoregulin Regulates Fatty Acid Metabolism at the Mitochondrial Outer Membrane

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Jul 2023
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Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

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Spatial topology of organelle is a new breast cancer cell classifier

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Jun 2023
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SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux

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Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity

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Effect of Mitophagy in the Formation of Osteomorphs Derived from Osteoclasts

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Optineurin provides a mitophagy contact site for TBK1 activation

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Feb 2023
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Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle

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Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations

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Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification

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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress

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SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2

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Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons

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The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells

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Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis

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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin

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Prevention and Regression of Megamitochondria and Steatosis by Blocking Mitochondrial Fusion in the Liver

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An in vitro system to silence mitochondrial gene expression

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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

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Untitled document

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Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

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Mar 2021
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Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs

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The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells

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Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

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