Hypothesis

19 Matching Annotations

Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

The Alzheimer’s disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states

1
1. scibot 23 Dec 2025
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.neuron.2025.11.022
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com:5037/science/article/pii/S0896627325008955
Jul 2025
www.cell.com www.cell.com

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice

1
1. scibot 10 Jul 2025
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.stem.2025.06.006
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

cell.com/cell-stem-cell/fulltext/S1934-5909(25)00228-0
Apr 2025
elifesciences.org elifesciences.org

Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

1
1. scibot 19 Apr 2025
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.7554/eLife.100581
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

elifesciences.org/articles/100581
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

1
1. scibot 21 Dec 2024
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1101/2024.07.17.603931
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11275733/
Oct 2024
www.biorxiv.org www.biorxiv.org

Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1101/2024.09.25.614811
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

biorxiv.org/content/10.1101/2024.09.25.614811v1
Aug 2024
jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com

Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

1
1. scibot 02 Aug 2024
  
  in Public
  
  MAB17291
  
  DOI: 10.1186/s12974-021-02276-y
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2208679
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:AB_2208679

Annotators

scibot

URL

jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02276-y
May 2024
www.sciencedirect.com www.sciencedirect.com

Distinct roles of TREM2 in central nervous system cancers and peripheral cancers

1
1. scibot 24 May 2024
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.ccell.2024.05.001
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610824001624
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias

1
1. scibot 16 Mar 2024
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1038/s44319-024-00077-x
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10933458/
Feb 2024
www.embopress.org www.embopress.org

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias

1
1. scibot 15 Feb 2024
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1038/s44319-024-00077-x
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

embopress.org/doi/10.1038/s44319-024-00077-x
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Priming of macrophage by glycosphingolipids from extracellular vesicles facilitates immune tolerance for embryo-maternal crosstalk

1
1. scibot 22 Nov 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.devcel.2023.09.012
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580723005117
Oct 2023
52.53.155.43 52.53.155.43

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias

1
1. scibot 13 Oct 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1101/2023.06.14.544924
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

52.53.155.43/5afe577c269e488702b5f7086020251c9f5e047d/2023.06.14.544924v1.full-html.html
Sep 2023
www.sciencedirect.com www.sciencedirect.com

A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease

1
1. scibot 29 Sep 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.stem.2023.07.006
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1934590923002515
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders

1
1. scibot 09 Jun 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.celrep.2023.112629
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S221112472300640X
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Modulation of microglial metabolism facilitates regeneration in demyelination

1
1. scibot 22 Apr 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.isci.2023.106588
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S258900422300665X
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

1
1. scibot 23 Feb 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.celrep.2023.112133
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124723001444
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

1
1. scibot 28 Jan 2023
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.immuni.2022.11.013
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761322006033
Jul 2021
www.cell.com www.cell.com

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID: AB_2208679
  
  DOI: 10.1016/j.cell.2019.05.056
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679
Visit annotations in context

Tags

RRID:AB_2208679

Annotators

scibot

URL

cell.com/cell/fulltext/S0092-8674(19)30627-0
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

1
1. scibot 09 Dec 2020
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1093/hmg/ddaa209
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:AB_2208679

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7689298/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2208679
  
  DOI: 10.1016/j.neuron.2019.12.007
  
  Resource: (R and D Systems Cat# MAB17291, RRID:AB_2208679)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2208679
  
  What is this?
  
  RRID:AB_2208679 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:AB_2208679

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0896627319310499