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Dot1 triggers a conserved ribophagy signal to govern ribosome quality and longevity by methylating Rpl12

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cell.com/molecular-cell/abstract/S1097-2765(26)00743-4
Nov 2026
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Mesothelin-induced lysosomal biogenesis sustains neutrophil longevity to drive brain metastasis

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RAStoERK: A reference interaction atlas for insights into signaling and disease

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sciencedirect.com/science/article/pii/S2211124726012805
Oct 2026
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RanGAP1 coordinates the ER-lamina interface to drive de novo nuclear envelope reassembly in mouse embryos

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1. scibot 29 Oct 2026
  
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  DOI: 10.1126/sciadv.aef7931
  
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Macrophage Migration Inhibitory Factor Inhibitor ISO-1 Attenuates Anesthesia/Surgery-Induced Cognitive Impairment in Aged Mice: Association with NLRP3 Inflammasome Inhibition

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link.springer.com/article/10.1007/s11064-026-04928-y
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Mitochondrial transfer protects against cisplatin-induced hearing loss by fumarate-mediated activation of mitophagy

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A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization

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sciencedirect.com/science/article/pii/S2211124726011046
Sep 2026
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Lactate couples metabolic state to necroptosis across pathological and physiological conditions

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The spindle-associated antisense RNA ARHGEF17-AS1 functionally contributes to mitotic spindle integrity

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Cohesin preservation across mitosis contributes to restart transcription via Cdk9-mediated activation of RNAPol2

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Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance

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sciencedirect.com/science/article/pii/S2666379126004696
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Viral infection activates the IRF1-BAK axis to drive mitochondria-derived inflammation

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GPX3 suppresses lung adenocarcinoma progression through HSPB1 ubiquitination and Hippo pathway activation

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sciencedirect.com/science/article/pii/S2211124726010016
Aug 2026
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ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway

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Torsins organize CLCC1 assembly to safeguard ER bilayer and lipid homeostasis

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sciencedirect.com/science/article/pii/S1097276526005034
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A progressive reduction in basal phosphorylation of glutamate receptors along postweaning development accompanies maturation of hippocampal theta-burst-induced LTP

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1. scibot 04 Aug 2026
  
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  DOI: 10.64898/2026.07.30.741885
  
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biorxiv.org/content/10.64898/2026.07.30.741885v1
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Astaxanthin Activates PI3K/AKT and AMPK Signaling to Alleviate Oxidative Stress and Improve Mouse Oocyte In Vitro Maturation

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1. scibot 04 Aug 2026
  
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sciencedirect.com/science/article/pii/S0093691X26003110
Jul 2026
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Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers

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1. scibot 30 Jul 2026
  
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MYC-Mediated USP39 Upregulation Stabilizes SRSF1 in Pancreatic Cancer

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  DOI: 10.1158/1541-7786.MCR-25-1104
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13355883/
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The tRNA-Derived Fragment tRF-E Promotes Ferroptosis in Hepatocellular Carcinoma to Suppress Tumor Progression

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1. scibot 12 Jul 2026
  
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aacrjournals.org/cancerres/article/86/13/3233/786155/The-tRNA-Derived-Fragment-tRF-E-Promotes
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Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production

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aacrjournals.org/cancerres/article/85/20/3930/766090/Exon-Skipping-of-Ste20-Like-Kinase-Enhances
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Immunotherapy-based combination remodels the immunosuppressive microenvironment and enhances efficacy in advanced SMARCA4-deficient non-small cell lung cancer

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sciencedirect.com/science/article/pii/S0304383526004660
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Early melatonin supplementation partially delays gastrointestinal aging

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sciencedirect.com/science/article/pii/S0925443926002073
Jun 2026
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NAT10-dependent N4-acetylcytidine reprograms R-loops and promotes cancer stem cell growth

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May 2026
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A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity

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5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling

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Gut Mycobiota-Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction-Associated Steatotic Liver Disease

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  DOI: 10.1002/advs.202514830
  
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Apr 2026
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Proteomic and lipidomic analyses reveal molecular subtypes and potential targets in early-stage lung adenocarcinoma among non-smokers

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Mar 2026
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Early HMGB1 Inhibition Reduces Hippocampal Injury During Adolescence in a Young Mouse Model of Radiation-Induced Brain Injury

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pmc.ncbi.nlm.nih.gov/articles/PMC12946357/
Feb 2026
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Microbial-derived 3-phenylpropionic acid orchestrates immune-progenitor cell crosstalk to promote beige adipogenesis and energy expenditure

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A nuclear isoform of hydroxyacyl-COA dehydrogenase inhibits tumor progression in colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12860641/
Jan 2026
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Chronic stress antagonizes formation of stress granules

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  DOI: 10.1016/j.isci.2025.114556
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12828549/
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Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle

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  DOI: 10.1083/jcb.202404025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11737348/
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PDCD5 promotes substrate release from the TRiC complex in cilia and flagella

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  DOI: 10.1016/j.molcel.2025.12.012
  
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sciencedirect.com/science/article/pii/S1097276525009864
Dec 2025
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Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade

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Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival

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Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis

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Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism

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RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation

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Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression

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A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma

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A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells

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IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma

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Exogenous H2S reduces oxidative stress induced by lipid mixture in HepG2 cells through USP22/SIRT1 axis

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BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

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Lysosome positioning affects NLRP3 inflammasome activation

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Induction of MASH-like pathogenesis in the Nwd1−/− mouse liver

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Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

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Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds

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HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

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Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling

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Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining

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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

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Vitamin D alleviates HFD-induced hepatic fibrosis by inhibiting DNMT1 to affect the TGFβ1/Smad3 pathway

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DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

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DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

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Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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enhanced_autophagic_clearance_of_amyloid___via.25-html.html

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Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson’s disease

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A TBK1-independent primordial function of STING in lysosomal biogenesis

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gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination

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Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway

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Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma

1
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METTL3 regulates cartilage development and homeostasis by affecting Lats1 mRNA stability in an m6A-YTHDF2-dependent manner

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cell.com/cell-reports/fulltext/S2211-1247(24)00864-7
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A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma

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Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice

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Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification

1
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PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1

1
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Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma

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Jun 2024
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Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

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May 2024
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Induction of NASH in the Nwd1−/− mouse liver via SERCA2-dependent endoplasmic reticulum stress

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2024.02.09.579580v1.full-html.html

2
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Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation

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Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia

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Impaired Response to Mismatch Novelty in the Li2+-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs

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Postweaning Development Influences Endogenous VPAC1 Modulation of LTP Induced by Theta-Burst Stimulation: A Link to Maturation of the Hippocampal GABAergic System

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Mar 2024
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Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

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Characterization of novel PHEX variants in X-linked hypophosphatemic rickets and genotype-PHEX activity correlation

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RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma

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Biallelic pathogenic variants in DNAH3 cause male infertility in humans and mice

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Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers

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Solobacterium moorei promotes the progression of adenomatous polyps by causing inflammation and disrupting the intestinal barrier

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Postweaning development influences endogenous VPAC1 modulation of LTP induced by theta-burst stimulation: a link to maturation of the hippocampal GABAergic system?

1
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Impaired response to mismatch novelty in the Li2+-pilocarpine rat model of TLE: correlation with hippocampal monoaminergic inputs

1
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Multiple reorganizations of the lateral elements of the synaptonemal complex facilitate homolog segregation in Bombyx mori oocytes

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Dec 2023
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Hexamethylene amiloride synergizes with venetoclax to induce lysosome-dependent cell death in acute myeloid leukemia

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SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

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Oct 2023
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Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development

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Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5

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Aug 2023
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Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer

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Estrogen receptor alpha (ESR1) regulates uterine epithelial lineage specification and homeostasis

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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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Contribution of Inwardly Rectifying Potassium Channel 4.1 in Orofacial Neuropathic Pain: Regulation of Pannexin 3 via the Reactive Oxygen Species-Activated P38 MAPK Signal Pathway

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HOXA11 promotes lymphatic metastasis of gastric cancer via transcriptional activation of TGFβ1

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Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD

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Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway

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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity?

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VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection

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Piezo1 suppression reduces demyelination after... : Neural Regeneration Research

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Progesterone prevents HGSOC by promoting precancerous cell pyroptosis via inducing fibroblast paracrine

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Unusually severe muscular dystrophy upon in-frame deletion of the dystrophin rod domain and lack of compensation by membrane-localized utrophin

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Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

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SYTL5 promotes papillary thyroid carcinoma progression by enhancing activation of the NF-κB signaling pathway

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Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation

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TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation

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Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome

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Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy

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Opposing reduced VPAC1 and enhanced VPAC2 VIP receptors in the hippocampus of the Li2+-pilocarpine rat model of temporal lobe epilepsy

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A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis

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Cholesterol determines the cytosolic entry and seeded aggregation of tau

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In vitro and in vivo assay of the ER lipid scramblase TMEM41B

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Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11

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Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch

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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

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Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors

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A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h

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Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

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MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway

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Untitled document

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Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

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AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

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Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108071
  
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sciencedirect.com/science/article/pii/S2211124720310561
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The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

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1. scibot 10 Sep 2020
  
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  RRID:AB_2210206
  
  DOI: 10.7554/eLife.53459
  
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elifesciences.org/articles/53459
Jan 2020
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Myocardial Adipose Triglyceride Lipase Overexpression Protects against Burn-Induced Cardiac Lipid Accumulation and Injury

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1. scibot 13 Jan 2020
  
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  RRID:AB_2210206
  
  DOI: 10.1155/2019/6428924
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6541965/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury

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1. scibot 13 Jan 2020
  
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  RRID:AB_2210206
  
  DOI: 10.1111/jnc.14827
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14827
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Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia

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1. scibot 13 Jan 2020
  
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  RRID:AB_2210206
  
  DOI: 10.1074/jbc.RA118.006425
  
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jbc.org/content/294/35/12921.full
Nov 2018
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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

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1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1535610818300102

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