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  1. Last 7 days
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    Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis
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    sciencedirect.com/science/article/pii/S2352396424001373
  3. Apr 2024
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    Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α
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    AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer
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  6. Mar 2024
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    PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication
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    sciencedirect.com/science/article/pii/S2451945624000783
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    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
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    sciencedirect.com/science/article/pii/S109727652400176X
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    Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning
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    A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development
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    sciencedirect.com/science/article/pii/S2211124724002456
  11. Feb 2024
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    Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons
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    sciencedirect.com/science/article/pii/S2589004224003870
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    SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA
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    Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
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    Zn2+-dependent functional switching of ERp18, an ER-resident thioredoxin-like protein
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  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cullin-RING E3 ubiquitin ligase 4 regulates neurite morphogenesis during neurodevelopment
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    A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin-treated rats
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  18. Jan 2024
  19. 52.53.155.43 52.53.155.43
    FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement
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    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
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    The YBX3 RNA-binding protein post-transcriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells
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    1. scibot 07 Jan 2024
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    sciencedirect.com/science/article/pii/S0021925823026315
  22. Dec 2023
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    Genome-wide classification of epigenetic activity reveals regions of enriched heritability in immune-related traits
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    sciencedirect.com/science/article/pii/S2666979X23003130
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    Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
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    ncbi.nlm.nih.gov/pmc/articles/PMC10723426/
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    Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron
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    Activity-regulated cytoskeletal-associated protein (Arc) in presynaptic terminals and extracellular vesicles in hippocampal synapses
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      DOI: 10.3389/fnmol.2023.1225533

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    ncbi.nlm.nih.gov/pmc/articles/PMC10658193/
  27. Nov 2023
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    Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling
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    sciencedirect.com/science/article/pii/S2589004223025282
  29. www.sciencedirect.com www.sciencedirect.com
    Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus
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  30. link.springer.com link.springer.com
    Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats
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      DOI: 10.1007/s00210-023-02795-w

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  31. www.nature.com www.nature.com
    SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase
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      DOI: 10.1038/s41467-023-43027-2

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    nature.com/articles/s41467-023-43027-2
  32. Oct 2023
  33. www.biorxiv.org www.biorxiv.org
    Parkinson’s-linked LRRK2-G2019S derails AMPAR trafficking, mobility and composition in striatum with cell-type and subunit specificity
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      DOI: 10.1101/2023.10.13.562231

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    biorxiv.org/content/10.1101/2023.10.13.562231v1
  34. www.cell.com www.cell.com
    Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain
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    cell.com/iscience/abstract/S2589-0042(23)02087-4
  35. Aug 2023
  36. 52.53.155.43 52.53.155.43
    Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function
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      DOI: 10.1016/j.celrep.2023.112947

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  37. link.springer.com link.springer.com
    SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
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      DOI: 10.1007/s00125-023-05979-4

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  38. www.sciencedirect.com www.sciencedirect.com
    Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4+ T cells
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      DOI: 10.3389/fimmu.2023.1107397

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    ncbi.nlm.nih.gov/pmc/articles/PMC10407399/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
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      DOI: 10.1158/2159-8290.CD-22-1396

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    ncbi.nlm.nih.gov/pmc/articles/PMC10401075/
  41. www.sciencedirect.com www.sciencedirect.com
    Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity
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      DOI: 10.1016/j.celrep.2023.112846

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    sciencedirect.com/science/article/pii/S2211124723008574
  42. Jul 2023
  43. www.sciencedirect.com www.sciencedirect.com
    A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins
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    Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior
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  45. 52.53.155.43 52.53.155.43
    cd-22-0411-html.html
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      DOI: 10.1158/2159-8290.cd-22-0411

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  46. Jun 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
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    Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO
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    Clinical impact of androgen receptor-suppressing miR-146b expression in papillary thyroid cancer aggressiveness
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      DOI: 10.1210/clinem/dgad279

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  50. May 2023
  51. www.nature.com www.nature.com
    Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs
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    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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    Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain
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    BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses
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    Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation
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    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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  58. Mar 2023
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
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    Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection
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    Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
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  63. Feb 2023
  64. academic.oup.com academic.oup.com
    Non-coding mutations in a thyroid hormone receptor gene that impair cone photoreceptor function
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    Prostaglandins limit nuclear actin to control nucleolar function during oogenesis
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    Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study
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  67. Jan 2023
  68. www.embopress.org www.embopress.org
    C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1
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    Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamics of CLIMP-63 S-acylation control ER morphology
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    The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
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    Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
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  73. Dec 2022
  74. www.sciencedirect.com www.sciencedirect.com
    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia
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  76. Nov 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
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    Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis
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    Nna1, Essential for Purkinje Cell Survival, Is also Associated with Emotion and Memory
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    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
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    The Citrus Flavonoid Nobiletin Downregulates Angiopoietin-like Protein 3 (ANGPTL3) Expression and Exhibits Lipid-Modulating Effects in Hepatic Cells and Adult Zebrafish Models
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  82. Oct 2022
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    Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice
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    Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
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    Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism
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    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
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  87. Sep 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small molecule SJ572946 activates BAK to initiate apoptosis
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    Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD
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    Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
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    The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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  92. Aug 2022
  93. www.sciencedirect.com www.sciencedirect.com
    CRISPR engineered mouse embryonic stem cells with Sox2-tdTomato and Gata6-GFP knock-in for endoderm differentiation
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    Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation
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    Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment
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  96. Jul 2022
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Self-assembly of pericentriolar material in interphase cells lacking centrioles
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    Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells
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  100. Jun 2022
  101. journals.physiology.org journals.physiology.org
    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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  102. May 2022
  103. www.sciencedirect.com www.sciencedirect.com
    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Redox profiles of Amyotrophic Lateral Sclerosis lymphoblasts with or without known SOD1 mutations
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    Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth
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  106. Apr 2022
  107. pubs.acs.org pubs.acs.org
    Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones
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    Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis
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    Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats
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    Vascular Biology and Microcirculation: Maternal systemic vascular dysfunction in a primate model of defective uterine spiral artery remodeling
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    YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia
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  112. Mar 2022
  113. www.embopress.org www.embopress.org
    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation
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    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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    A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
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    Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases
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  118. www.nature.com www.nature.com
    White matter integrity in mice requires continuous myelin synthesis at the inner tongue
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  119. Feb 2022
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    Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy
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    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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    Unconcerted conformational changes in Arp2/3 complex integrate multiple activating signals to assemble functional actin networks
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  123. Jan 2022
  124. elifesciences.org elifesciences.org
    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
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    miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence
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    Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals
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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    The portrait of liver cancer is shaped by mitochondrial genetics
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  129. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models
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  130. Dec 2021
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Usher syndrome Type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish
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  132. www.sciencedirect.com www.sciencedirect.com
    14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice
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    Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production
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    Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A
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  136. Nov 2021
  137. www.sciencedirect.com www.sciencedirect.com
    The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function
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  138. Oct 2021
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    Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing
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    The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics
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  144. Sep 2021
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    Real-time monitoring of deformed wing virus-infected bee foraging behavior following histone deacetylase inhibitor treatment
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    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
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    The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells
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  150. Aug 2021
  151. www.sciencedirect.com www.sciencedirect.com
    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
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    Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function
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    Sequential oncogenic mutations influence cell competition
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  157. www.jneurosci.org www.jneurosci.org
    Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis
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    The GABAA Receptor β Subunit Is Required for Inhibitory Transmission
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plasma Rich in Growth Factors Promotes Autophagy in ARPE19 Cells in Response to Oxidative Stress Induced by Blue Light
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    A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
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    Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity
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  174. Jul 2021
  175. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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      mouse monoclonal anti-actin

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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz255/5613690
  176. link.springer.com link.springer.com
    TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain
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  178. www.nature.com www.nature.com
    ABCC9 -related Intellectual disability Myopathy Syndrome is a K ATP channelopathy with loss-of-function mutations in ABCC9
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      anti-α actin

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  179. www.jneurosci.org www.jneurosci.org
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  180. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  181. www.sciencedirect.com www.sciencedirect.com
    cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis
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      mouse anti-Actin Clone C4

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  182. www.embopress.org www.embopress.org
    VAP‐SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function
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      mouse anti‐actin

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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
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    Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization
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  187. www.jneurosci.org www.jneurosci.org
    Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation
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  191. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Participation of the dentate‐rubral pathway in the kindling model of epilepsy
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    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response
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    p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino
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    LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes
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    An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein
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  205. May 2021
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    Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis
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    Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines
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    RNA degradation is required for the germ-cell to maternal transition in Drosophila
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    Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
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    Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
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    Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML
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    Pro-inflammatory Cytokine Interleukin 1β Disrupts β cell Circadian Clock Function and Regulation of Insulin Secretion
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    Inhibition of miR-155 potentially protects Lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway
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    Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells
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    Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat
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    Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis
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    A Non-canonical BRCT-Phosphopeptide Recognition Mechanism Underlies RhoA Activation in Cytokinesis
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    Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle
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    p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
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    IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery
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    Maternal Systemic Vascular Dysfunction in a Primate Model of Defective Uterine Spiral Artery Remodeling
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    Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress
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    Protease-mediated processing of Argonaute proteins controls small RNA association
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  225. Mar 2021
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    Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-γ-Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus
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    Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
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    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells
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  229. Feb 2021
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    PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels
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