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  1. Apr 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma
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    sciencedirect.com/science/article/pii/S2211124725003675
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996642/
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    Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction
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    Engineered nucleocytosolic vehicles for loading of programmable editors
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  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962402/
  7. 52.53.155.43 52.53.155.43
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    Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure
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  9. Mar 2025
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    ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2666379125001119
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    Antagonistic roles for MITF and TFE3 in melanoma plasticity
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  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes
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    1. scibot 28 Mar 2025
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  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness
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    1. scibot 28 Mar 2025
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  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    1. scibot 27 Mar 2025
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      DOI: 10.1126/sciadv.adi9885

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  15. www.science.org www.science.org
    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
    1
    1. scibot 24 Mar 2025
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    Dual targeting of CXCR4 and EZH2 in endometriosis
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    sciencedirect.com/science/article/pii/S2589004225004031
  17. 52.53.155.43 52.53.155.43
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    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety
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    sciencedirect.com/science/article/pii/S1535610825000583
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    Hypoxia inducible factor-1α drives cancer resistance to cuproptosis
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    1. scibot 07 Mar 2025
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    Increased seizure susceptibility in the collagen-induced arthritis mouse model depends on neuronal IL-1R1
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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  23. Feb 2025
  24. 52.53.155.43 52.53.155.43
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    1. scibot 28 Feb 2025
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    Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism
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    sciencedirect.com/science/article/pii/S1550413125000166
  27. aacrjournals.org aacrjournals.org
    Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment
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      DOI: 10.1158/2159-8290.CD-21-1022

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    aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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    Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution
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  30. 52.53.155.43 52.53.155.43
    Mitochondrial Transplantation: Adaptive Bio-enhancement
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    1. scibot 06 Feb 2025
      Cell Signaling, 4970

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  31. 52.53.155.43 52.53.155.43
    AQP1- A regulatory factor associated with brown adipose tissue-silencing
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    A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
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  33. Jan 2025
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis
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    1. scibot 30 Jan 2025
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    The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models
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  36. www.jbc.org www.jbc.org
    A conserved acetylation switch enables pharmacological control of tubby-like protein stability
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      rabbit anti-beta actin

      DOI: 10.1074/jbc.RA120.015839

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  37. 52.53.155.43 52.53.155.43
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  38. www.nature.com www.nature.com
    Epac2-mediated synaptic insertion of Ca2+-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving
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      DOI: 10.1038/s41386-024-02030-x

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  39. www.sciencedirect.com www.sciencedirect.com
    HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis
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  40. Dec 2024
  41. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
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      DOI: 10.1186/s12915-024-02097-4

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  42. www.biorxiv.org www.biorxiv.org
    Spatial transcriptomics exploration of the primary neuroblastoma microenvironment unveils novel paracrine interactions
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      DOI: 10.1101/2024.12.21.629891

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  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
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      DOI: 10.1093/nar/gkae1105

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    An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel
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      DOI: 10.1016/j.neuron.2024.11.020

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  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and Their Zebrafish Homologs at the Blood-Brain Barrier
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet
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    Proteasome inhibition induces microtubule-dependent changes in nuclear morphology
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    Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1
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    Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3
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    Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors
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    Anti-adipogenic activity of oleoresin from Nigella sativa L. seeds via modulation of PPAR-γ and C/EBP-α expression in 3T3-L1 adipocytes
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    Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
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  57. Nov 2024
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KS-cSCC-1 and KS-cSCC-2: two novel cutaneous squamous cell carcinoma cell lines established from Japanese patients
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    Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors
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  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
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    β2-integrins control HIF1α activation in human neutrophils
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  64. Oct 2024
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    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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  67. Sep 2024
  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pharmacologic activation of activating transcription factor 6 contributes to neuronal survival after spinal cord injury in mice
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    Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing
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    Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function
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    EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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  76. Aug 2024
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    A genetic basis for sex differences in Xp11 translocation renal cell carcinoma
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
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    Chinese medicine Linggui Zhugan formula protects against diabetic kidney disease in close association with inhibition of proteinase 3-mediated podocyte apoptosis in mice
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    Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting heme degradation pathway augments prostate cancer cell sensitivity to docetaxel-induced apoptosis and attenuates migration
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  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Frontiers | The Nonvesicular Sterol Transporter Aster-C Plays a Minor Role in Whole Body Cholesterol Balance
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  97. Jun 2024
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  104. aacrjournals.org aacrjournals.org
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  109. 52.53.155.43 52.53.155.43
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection
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    UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
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    Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  172. Nov 2023
  173. www.sciencedirect.com www.sciencedirect.com
    In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
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    Dual stop codon suppression in mammalian cells with genomically integrated genetic code expansion machinery
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  175. www.sciencedirect.com www.sciencedirect.com
    Tsc2 coordinates neuroprogenitor differentiation
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis
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    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease
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  180. 52.53.155.43 52.53.155.43
    Guanylate Binding Protein 1 (GBP1) modulates proteasomal machinery in ovarian cancer
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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
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    Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function
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    Mast-cell-specific receptor mediates alcohol-withdrawal-associated headache in male mice
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    Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice
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  186. Oct 2023
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells
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    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
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    Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency
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  192. www.science.org www.science.org
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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  193. www.sciencedirect.com www.sciencedirect.com
    Comprehensive quantification of metabolic flux during acute cold stress in mice
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    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria
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  196. Sep 2023
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    Protocol for high-sensitivity western blot on murine hematopoietic stem cells
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    Generation of Novel Immunocompetent Mouse Cell Lines to Model Experimental Metastasis of High-Risk Neuroblastoma
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    TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice
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    Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency
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  201. 52.53.155.43 52.53.155.43
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    STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
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    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    Immunoglobulin G inhibits glucocorticoid-induced osteoporosis through occupation of FcγRI
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  206. Aug 2023
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    Regulation of mitotic clonal expansion and thermogenic pathway are involved in the antiadipogenic effects of cyanidin-3-O-glucoside
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    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis
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    METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy
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    IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy
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