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  1. Last 7 days
  2. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    1. scibot 18 Jul 2024
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      DOI: 10.1126/science.adk0775

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    science.org/doi/10.1126/science.adk0775
  3. Jan 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    1. scibot 25 Jan 2024
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      DOI: 10.1126/sciadv.adi2012

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    2. scibot 23 Jan 2024
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      DOI: 10.1126/sciadv.adi2012

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
  5. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  6. May 2023
  7. www.sciencedirect.com www.sciencedirect.com
    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    1. scibot 25 May 2023
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      DOI: 10.1016/j.celrep.2023.112536

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    sciencedirect.com/science/article/pii/S2211124723005478
  8. Apr 2022
  9. www.sciencedirect.com www.sciencedirect.com
    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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    1. scibot 15 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110670

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    sciencedirect.com/science/article/pii/S2211124722004223
  10. Mar 2022
  11. www.sciencedirect.com www.sciencedirect.com
    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
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    1. scibot 16 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110509

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    sciencedirect.com/science/article/pii/S2211124722002455
  12. Dec 2021
  13. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
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    1. scibot 30 Dec 2021
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      DOI: 10.1016/j.isci.2021.103645

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    sciencedirect.com/science/article/pii/S2589004221016151
  14. Nov 2021
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors
    1
    1. scibot 05 Nov 2021
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      DOI: 10.1158/0008-5472.CAN-20-3232

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    ncbi.nlm.nih.gov/pmc/articles/PMC8137641/
  16. Aug 2021
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 11 Aug 2021
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      DOI: 10.7554/eLife.29241

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    ncbi.nlm.nih.gov/pmc/articles/PMC5589416/
  18. Jul 2021
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer
    1
    1. scibot 29 Jul 2021
      PRAS40

      DOI: 10.1084/jem.20181936

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    ncbi.nlm.nih.gov/pmc/articles/PMC6363423/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 29 Jul 2021
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      DOI: 10.1016/j.cmet.2018.08.013

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    ncbi.nlm.nih.gov/pmc/articles/PMC6331339/
  21. Oct 2020
  22. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    1. scibot 08 Oct 2020
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      DOI: 10.1016/j.celrep.2020.108223

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    pubmed.ncbi.nlm.nih.gov/33027655/
  23. www.sciencedirect.com www.sciencedirect.com
    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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    1. scibot 07 Oct 2020
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      DOI: 10.1016/j.celrep.2020.108230

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    sciencedirect.com/science/article/pii/S2211124720312195
  24. Sep 2020
  25. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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    1. scibot 26 Sep 2020
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      DOI: 10.1111/jnc.14979

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14979
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    1. scibot 26 Sep 2020
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      DOI: 10.1016/j.cell.2020.02.019

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    sciencedirect.com/science/article/pii/S009286742030163X
  27. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
    1
    1. scibot 16 Sep 2020
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      DOI: 10.1096/fj.201902305R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
  28. www.sciencedirect.com www.sciencedirect.com
    Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
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    1. scibot 09 Sep 2020
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      DOI: 10.1016/j.celrep.2020.107780

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    sciencedirect.com/science/article/pii/S2211124720307609
  29. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
    1
    1. scibot 09 Sep 2020
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      DOI: 10.1016/j.celrep.2020.01.080

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    sciencedirect.com/science/article/pii/S2211124720301054
  30. Jan 2020
  31. www.sciencedirect.com www.sciencedirect.com
    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
    1
    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.molcel.2019.07.023

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    sciencedirect.com/science/article/pii/S1097276519305532
  32. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
    1
    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
  33. www.sciencedirect.com www.sciencedirect.com
    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
    1
    1. scibot 13 Jan 2020
      RRID:AB_2225033

      DOI: 10.1016/j.celrep.2019.09.047

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    sciencedirect.com/science/article/pii/S2211124719312355
  34. www.sciencedirect.com www.sciencedirect.com
    Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis
    1
    1. scibot 13 Jan 2020
      RRID:AB_2225033

      DOI: 10.1016/j.cels.2019.11.005

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    sciencedirect.com/science/article/pii/S2405471219303916
  35. Nov 2018
  36. www.sciencedirect.com www.sciencedirect.com
    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
    1
    1. scibot 05 Nov 2018
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      Curator: @evieth

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    sciencedirect.com/science/article/pii/S155041311830514X
  37. Nov 2017
  38. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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    1. scibot 08 Nov 2017
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      Curator: @kaitlinsung

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    elifesciences.org/articles/29241