Hypothesis

31 Matching Annotations

Sep 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225018139-main-html.html

1
1. scibot 13 Sep 2025
  
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  AB_2225033
  
  DOI: 10.1016
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
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52.53.155.43/253550384e171aeac03650972660e6e19e7d73f6/1-s2.0-S2589004225018139-main-html.html
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

1
1. scibot 11 Feb 2025
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.xcrm.2025.101943
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

1
1. scibot 10 Dec 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.cell.2024.11.009
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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sciencedirect.com/science/article/pii/S0092867424013266
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

High fat diet induced hepatic insulin resistance per se attenuates murine de novo lipogenesis

1
1. scibot 14 Nov 2024
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.isci.2024.111175
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11550620/
Aug 2024
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

1
1. scibot 22 Aug 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.cell.2020.02.019
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
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cell.com/cell/fulltext/S0092-8674(20)30163-X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 21 Aug 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
Jul 2024
www.science.org www.science.org

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 18 Jul 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
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science.org/doi/10.1126/science.adk0775
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling

2
1. scibot 25 Jan 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1126/sciadv.adi2012
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
2. scibot 23 Jan 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1126/sciadv.adi2012
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
www.sciencedirect.com www.sciencedirect.com

Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

1
1. scibot 11 Jan 2024
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.jbc.2024.105641
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
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sciencedirect.com/science/article/pii/S0021925824000176
May 2023
www.sciencedirect.com www.sciencedirect.com

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

1
1. scibot 25 May 2023
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2023.112536
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
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sciencedirect.com/science/article/pii/S2211124723005478
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model

1
1. scibot 15 Apr 2022
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2022.110670
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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sciencedirect.com/science/article/pii/S2211124722004223
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

1
1. scibot 16 Mar 2022
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2022.110509
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
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sciencedirect.com/science/article/pii/S2211124722002455
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Translational and post-translational control of human naïve versus primed pluripotency

1
1. scibot 30 Dec 2021
  
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  RRID:AB_2225033
  
  DOI: 10.1016/j.isci.2021.103645
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
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sciencedirect.com/science/article/pii/S2589004221016151
Nov 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors

1
1. scibot 05 Nov 2021
  
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  RRID:AB_2225033
  
  DOI: 10.1158/0008-5472.CAN-20-3232
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
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ncbi.nlm.nih.gov/pmc/articles/PMC8137641/
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 11 Aug 2021
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.7554/eLife.29241
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5589416/
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

1
1. scibot 29 Jul 2021
  
  in Public
  
  PRAS40
  
  DOI: 10.1084/jem.20181936
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Missing RRID:AB_2225033
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RRID:AB_2225033

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6363423/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.cmet.2018.08.013
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033
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ncbi.nlm.nih.gov/pmc/articles/PMC6331339/
Oct 2020
www.sciencedirect.com www.sciencedirect.com

The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

1
1. scibot 08 Oct 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2020.108223
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S2211124720312122
www.sciencedirect.com www.sciencedirect.com

The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

1
1. scibot 07 Oct 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2020.108230
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Validated RRID:AB_2225033
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S2211124720312195
Sep 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1111/jnc.14979
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Validated RRID:AB_2225033
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RRID:AB_2225033

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onlinelibrary.wiley.com/doi/10.1111/jnc.14979
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.cell.2020.02.019
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Validated RRID:AB_2225033
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

URL

cell.com/cell/fulltext/S0092-8674(20)30163-X
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1096/fj.201902305R
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Validated RRID:AB_2225033
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RRID:AB_2225033

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scibot

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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
www.sciencedirect.com www.sciencedirect.com

Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2020.107780
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Validated RRID:AB_2225033
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720307609
www.sciencedirect.com www.sciencedirect.com

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2020.01.080
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRIDCUR:Validated RRID:AB_2225033
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S2211124720301054
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.molcel.2019.07.023
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S1097276519305532
www.sciencedirect.com www.sciencedirect.com

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.chembiol.2019.11.014
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619303964
www.sciencedirect.com www.sciencedirect.com

CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.celrep.2019.09.047
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S2211124719312355
www.sciencedirect.com www.sciencedirect.com

Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2225033
  
  DOI: 10.1016/j.cels.2019.11.005
  
  Resource: (Cell Signaling Technology Cat# 2691, RRID:AB_2225033)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225033
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S2405471219303916
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2225033
  
  Curator: @evieth
  
  Resource used:
  
  (Cell Signaling Technology Cat# 2691S, RRID:AB_2225033)
  
  SciCrunch record: RRID:AB_2225033
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

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sciencedirect.com/science/article/pii/S155041311830514X
Nov 2017
elifesciences.org elifesciences.org

Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:AB_2225033
  
  Curator: @kaitlinsung
  
  Resource used:
  
  (Cell Signaling Technology Cat# 2691S, RRID:AB_2225033)
  
  SciCrunch record: RRID:AB_2225033
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2225033 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2225033

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scibot

URL

elifesciences.org/articles/29241