30 Matching Annotations
  1. Feb 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
    1
    1. scibot 27 Feb 2024
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2024.113837

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    sciencedirect.com/science/article/pii/S2211124724001657
  3. www.sciencedirect.com www.sciencedirect.com
    DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling
    2
    1. scibot 02 Feb 2024
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2024.113713

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    2. scibot 02 Feb 2024
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2024.113713

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    sciencedirect.com/science/article/pii/S221112472400041X
  4. Dec 2023
  5. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
    1
    1. scibot 20 Dec 2023
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2023.113535

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    sciencedirect.com/science/article/pii/S2211124723015474
  6. Jul 2023
  7. www.sciencedirect.com www.sciencedirect.com
    GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
    1
    1. scibot 21 Jul 2023
      RRID:AB_2225186

      DOI: 10.1016/j.cmet.2023.06.016

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    sciencedirect.com/science/article/abs/pii/S1550413123002267
  8. Jun 2023
  9. portlandpress.com portlandpress.com
    Akt2 deficiency alleviates oxidative stress in the heart and liver via upregulating SIRT6 during high-fat diet-induced obesity
    1
    1. scibot 30 Jun 2023
      RRID:AB_2225186

      DOI: 10.1042/CS20230433

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    portlandpress.com/clinsci/article/137/10/823/233046/Akt2-deficiency-alleviates-oxidative-stress-in-the
  10. www.sciencedirect.com www.sciencedirect.com
    Identification of XAF1 as an endogenous AKT inhibitor
    1
    1. scibot 29 Jun 2023
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2023.112690

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    sciencedirect.com/science/article/pii/S2211124723007015
  11. May 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
    1
    1. scibot 17 May 2023
      RRID:AB_2225186

      DOI: 10.1016/j.cell.2023.04.026

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    sciencedirect.com/science/article/pii/S0092867423004221
  13. www.sciencedirect.com www.sciencedirect.com
    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
    1
    1. scibot 12 May 2023
      RRID: AB_2225186

      DOI: 10.1016/j.celrep.2023.112489

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    sciencedirect.com/science/article/pii/S2211124723005004
  14. Apr 2023
  15. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
    1
    1. scibot 21 Apr 2023
      RRID:AB_2225186

      DOI: 10.1016/j.cmet.2023.03.021

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    sciencedirect.com/science/article/pii/S1550413123001262
  16. Jul 2022
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
    1
    1. scibot 31 Jul 2022
      RRID:AB_2225186

      DOI: 10.3390/ijms23147774

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    ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
    1
    1. scibot 27 Jul 2022
      RRID:AB_2225186

      DOI: 10.1111/febs.16375

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    ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
  19. Mar 2022
  20. www.sciencedirect.com www.sciencedirect.com
    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
    1
    1. scibot 16 Mar 2022
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2022.110509

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    sciencedirect.com/science/article/pii/S2211124722002455
  21. Oct 2021
  22. www.sciencedirect.com www.sciencedirect.com
    Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation
    1
    1. scibot 13 Oct 2021
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2021.109821

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    sciencedirect.com/science/article/pii/S2211124721012857
  23. academic.oup.com academic.oup.com
    The impact of long-term physical inactivity on adipose tissue immunometabolism
    1
    1. scibot 01 Oct 2021
      RRID:AB_2225186

      DOI: 10.1210/clinem/dgab647

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab647/6364151
  24. Sep 2021
  25. www.sciencedirect.com www.sciencedirect.com
    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
    1
    1. scibot 22 Sep 2021
      RRID:AB_2225186

      DOI: 10.1016/j.molcel.2021.09.001

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    sciencedirect.com/science/article/pii/S1097276521007358
  26. Jul 2021
  27. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
    1
    1. scibot 31 Jul 2021
      Akt 2

      DOI: 10.1242/jcs.233221

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    jcs.biologists.org/content/132/20/jcs233221
  28. Apr 2021
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
    1
    1. scibot 06 Apr 2021
      RRID:AB_2225186

      DOI: 10.7554/eLife.61313

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    ncbi.nlm.nih.gov/pmc/articles/PMC7997661/
  30. Feb 2021
  31. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    The insulin‐sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres
    1
    1. scibot 26 Feb 2021
      AB_2225186

      DOI: 10.1113/JP280475

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP280475
  32. Dec 2020
  33. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Insulin‐stimulated glucose uptake partly relies on p21‐activated kinase 2 (PAK2), but not PAK1, in mouse skeletal muscle
    1
    1. scibot 07 Dec 2020
      AB_2 225 186

      DOI: 10.1113/JP280294

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      Curator comments: Akt2 (D6G4) Rabbit mAb antibody Cell Signaling Technology Cat# 3063

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP280294
  34. Oct 2020
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
    1
    1. scibot 13 Oct 2020
      RRID:AB_2225186

      DOI: 10.7554/eLife.58941

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    ncbi.nlm.nih.gov/pmc/articles/PMC7541086/
  36. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
    1
    1. scibot 08 Oct 2020
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2020.108223

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    pubmed.ncbi.nlm.nih.gov/33027655/
  37. Sep 2020
  38. link.springer.com link.springer.com
    Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity
    1
    1. scibot 17 Sep 2020
      RRID:AB_2225186

      DOI: 10.1007/s00125-020-05117-4

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    link.springer.com/article/10.1007/s00125-020-05117-4
  39. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
    1
    1. scibot 16 Sep 2020
      RRID:AB_2225186

      DOI: 10.1016/j.celrep.2020.01.080

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    sciencedirect.com/science/article/pii/S2211124720301054
  40. www.sciencedirect.com www.sciencedirect.com
    Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion
    1
    1. scibot 12 Sep 2020
      AB_2225186

      DOI: 10.1016/j.metabol.2020.154169

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    sciencedirect.com/science/article/pii/S0026049520300330
  41. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    A Single Bout of One-legged Exercise to Local Exhaustion Decreases Insulin Action in Non-exercised Muscle Leading to Decreased Whole-body Insulin Action
    1
    1. scibot 07 Sep 2020
      AB_2225186

      DOI: 10.2337/db19-1010

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    diabetes.diabetesjournals.org/content/69/4/578
  42. Jan 2020
  43. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
    1
    1. scibot 13 Jan 2020
      RRID:AB_2225186

      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
  44. www.sciencedirect.com www.sciencedirect.com
    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
    1
    1. scibot 13 Jan 2020
      RRID:AB_2225186

      DOI: 10.1016/j.molcel.2019.07.023

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    sciencedirect.com/science/article/pii/S1097276519305532
  45. www.sciencedirect.com www.sciencedirect.com
    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
    1
    1. scibot 13 Jan 2020
      RRID:AB_2225186

      DOI: 10.1016/j.immuni.2019.11.015

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    sciencedirect.com/science/article/pii/S1074761319304960
  46. Nov 2018
  47. www.sciencedirect.com www.sciencedirect.com
    Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
    1
    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1550413117306204