Hypothesis

38 Matching Annotations

Sep 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225018139-main-html.html

1
1. scibot 13 Sep 2025
  
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  AB_2225186
  
  DOI: 10.1016
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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52.53.155.43/253550384e171aeac03650972660e6e19e7d73f6/1-s2.0-S2589004225018139-main-html.html
Jun 2025
www.cell.com www.cell.com

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

1
1. scibot 12 Jun 2025
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.xcrm.2025.102163
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00236-8
www.cell.com www.cell.com

Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2025.115831
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00602-3
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

1
1. scibot 16 May 2025
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2025.115625
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling

1
1. scibot 15 Apr 2025
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2025.115527
  
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sciencedirect.com/science/article/pii/S2211124725002980
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk

1
1. scibot 07 Feb 2025
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.cmet.2024.12.011
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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sciencedirect.com/science/article/pii/S1550413124004935
52.53.155.43 52.53.155.43

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

1
1. scibot 06 Feb 2025
  
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  AB_2225186
  
  DOI: 10.1101/2024.09.22.614256
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Sep 2024
dx.doi.org dx.doi.org

Mild Cold Stress at Ambient Temperature Elevates Muscle Calcium Cycling and Exercise Adaptations in Obese Female Mice

1
1. scibot 27 Sep 2024
  
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  AB_2225186
  
  DOI: 10.1210/endocr/bqae102
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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dx.doi.org/10.1210/endocr/bqae102
Feb 2024
www.sciencedirect.com www.sciencedirect.com

Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1

1
1. scibot 27 Feb 2024
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2024.113837
  
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sciencedirect.com/science/article/pii/S2211124724001657
www.sciencedirect.com www.sciencedirect.com

DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling

2
1. scibot 02 Feb 2024
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2024.113713
  
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2. scibot 02 Feb 2024
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2024.113713
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S221112472400041X
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Epinephrine inhibits PI3Kα via the Hippo kinases

1
1. scibot 20 Dec 2023
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2023.113535
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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sciencedirect.com/science/article/pii/S2211124723015474
Jul 2023
www.sciencedirect.com www.sciencedirect.com

GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism

1
1. scibot 21 Jul 2023
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.cmet.2023.06.016
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
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sciencedirect.com/science/article/abs/pii/S1550413123002267
Jun 2023
portlandpress.com portlandpress.com

Akt2 deficiency alleviates oxidative stress in the heart and liver via upregulating SIRT6 during high-fat diet-induced obesity

1
1. scibot 30 Jun 2023
  
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  RRID:AB_2225186
  
  DOI: 10.1042/CS20230433
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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portlandpress.com/clinsci/article/137/10/823/233046/Akt2-deficiency-alleviates-oxidative-stress-in-the
www.sciencedirect.com www.sciencedirect.com

Identification of XAF1 as an endogenous AKT inhibitor

1
1. scibot 29 Jun 2023
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2023.112690
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124723007015
May 2023
www.sciencedirect.com www.sciencedirect.com

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

1
1. scibot 17 May 2023
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.cell.2023.04.026
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867423004221
www.sciencedirect.com www.sciencedirect.com

VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection

1
1. scibot 12 May 2023
  
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  RRID: AB_2225186
  
  DOI: 10.1016/j.celrep.2023.112489
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @sofiakhan13
  
  SciCrunch record: RRID:AB_2225186
  
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sciencedirect.com/science/article/pii/S2211124723005004
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

1
1. scibot 21 Apr 2023
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.cmet.2023.03.021
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1550413123001262
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

1
1. scibot 31 Jul 2022
  
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  RRID:AB_2225186
  
  DOI: 10.3390/ijms23147774
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

1
1. scibot 27 Jul 2022
  
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  RRID:AB_2225186
  
  DOI: 10.1111/febs.16375
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2225186
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

1
1. scibot 16 Mar 2022
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2022.110509
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124722002455
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

1
1. scibot 13 Oct 2021
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2021.109821
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124721012857
academic.oup.com academic.oup.com

The impact of long-term physical inactivity on adipose tissue immunometabolism

1
1. scibot 01 Oct 2021
  
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  RRID:AB_2225186
  
  DOI: 10.1210/clinem/dgab647
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab647/6364151
Sep 2021
www.sciencedirect.com www.sciencedirect.com

KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

1
1. scibot 22 Sep 2021
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.molcel.2021.09.001
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1097276521007358
Jul 2021
jcs.biologists.org jcs.biologists.org

The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3

1
1. scibot 31 Jul 2021
  
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  Akt 2
  
  DOI: 10.1242/jcs.233221
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Missing
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jcs.biologists.org/content/132/20/jcs233221
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

1
1. scibot 06 Apr 2021
  
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  RRID:AB_2225186
  
  DOI: 10.7554/eLife.61313
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7997661/
Feb 2021
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

The insulin‐sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres

1
1. scibot 26 Feb 2021
  
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  AB_2225186
  
  DOI: 10.1113/JP280475
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @scibot
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP280475
Dec 2020
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Insulin‐stimulated glucose uptake partly relies on p21‐activated kinase 2 (PAK2), but not PAK1, in mouse skeletal muscle

1
1. scibot 07 Dec 2020
  
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  AB_2 225 186
  
  DOI: 10.1113/JP280294
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225186
  
  Curator comments: Akt2 (D6G4) Rabbit mAb antibody Cell Signaling Technology Cat# 3063
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP280294
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

1
1. scibot 13 Oct 2020
  
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  RRID:AB_2225186
  
  DOI: 10.7554/eLife.58941
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7541086/
www.sciencedirect.com www.sciencedirect.com

The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

1
1. scibot 08 Oct 2020
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2020.108223
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720312122
Sep 2020
link.springer.com link.springer.com

Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2225186
  
  DOI: 10.1007/s00125-020-05117-4
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225186
  
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  RRIDCUR:Validated RRID:AB_2225186
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link.springer.com/article/10.1007/s00125-020-05117-4
www.sciencedirect.com www.sciencedirect.com

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.celrep.2020.01.080
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225186
  
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  RRIDCUR:Validated RRID:AB_2225186
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sciencedirect.com/science/article/pii/S2211124720301054
www.sciencedirect.com www.sciencedirect.com

Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion

1
1. scibot 12 Sep 2020
  
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  AB_2225186
  
  DOI: 10.1016/j.metabol.2020.154169
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0026049520300330
diabetes.diabetesjournals.org diabetes.diabetesjournals.org

A Single Bout of One-legged Exercise to Local Exhaustion Decreases Insulin Action in Non-exercised Muscle Leading to Decreased Whole-body Insulin Action

1
1. scibot 07 Sep 2020
  
  in Public
  
  AB_2225186
  
  DOI: 10.2337/db19-1010
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2225186
  
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  RRIDCUR:Validated RRID:AB_2225186
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diabetes.diabetesjournals.org/content/69/4/578
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2225186
  
  DOI: 10.1016/j.chembiol.2019.11.014
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Validated
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RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619303964
www.sciencedirect.com www.sciencedirect.com

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2225186
  
  DOI: 10.1016/j.molcel.2019.07.023
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225186
  
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  RRID:AB_2225186 RRIDCUR:Validated
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RRID:AB_2225186

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1097276519305532
www.sciencedirect.com www.sciencedirect.com

Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2225186
  
  DOI: 10.1016/j.immuni.2019.11.015
  
  Resource: (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2225186
  
  What is this?
  
  RRID:AB_2225186 RRIDCUR:Validated
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RRID:AB_2225186

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1074761319304960
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2225186
  
  Resource used:
  
  (Cell Signaling Technology Cat# 3063, RRID:AB_2225186)
  
  SciCrunch record: RRID:AB_2225186
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2225186
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RRID:AB_2225186

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scibot

URL

sciencedirect.com/science/article/pii/S1550413117306204