121 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    1. scibot 11 Apr 2024
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    sciencedirect.com/science/article/pii/S2352396424001348
  3. Mar 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113900

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      DOI: 10.1016/j.celrep.2024.113900

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    sciencedirect.com/science/article/pii/S2211124724002286
  5. Feb 2024
  6. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 16 Feb 2024
      RRID:AB_2225340

      DOI: 10.1111/bph.16283

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16283
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    1. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  8. Jan 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bruton’s Tyrosine Kinase Inhibitors With Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
    1
    1. scibot 05 Jan 2024
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      DOI: 10.1158/1535-7163.MCT-22-0642

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762339/
  11. Dec 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.xcrm.2023.101341

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    sciencedirect.com/science/article/pii/S266637912300558X
  13. 52.53.155.43 52.53.155.43
    mct-22-0642 (1)-html.html
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    1. scibot 01 Dec 2023
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  14. Nov 2023
  15. www.sciencedirect.com www.sciencedirect.com
    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101286

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    sciencedirect.com/science/article/pii/S2666379123004809
  16. www.sciencedirect.com www.sciencedirect.com
    Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113417

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    sciencedirect.com/science/article/pii/S2211124723014298
  17. Oct 2023
  18. www.sciencedirect.com www.sciencedirect.com
    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.ccell.2023.09.001

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    sciencedirect.com/science/article/pii/S1535610823003185
  19. Jul 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
    1
    1. scibot 06 Jul 2023
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      DOI: 10.1158/0008-5472.CAN-22-0945

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812901/
  21. Jun 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
    1
    1. scibot 24 Jun 2023
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      DOI: 10.1016/j.isci.2023.107028

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    ncbi.nlm.nih.gov/pmc/articles/PMC10285549/
  23. www.sciencedirect.com www.sciencedirect.com
    Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.isci.2023.106999

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    sciencedirect.com/science/article/pii/S2589004223010763
  24. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  25. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16069

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16069
  26. May 2023
  27. www.sciencedirect.com www.sciencedirect.com
    A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation
    1
    1. scibot 10 May 2023
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      DOI: 10.1016/j.ebiom.2023.104594

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    sciencedirect.com/science/article/pii/S2352396423001597
  28. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
    1
    1. scibot 06 May 2023
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      DOI: 10.1038/s41467-023-38165-6

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    nature.com/articles/s41467-023-38165-6
  29. Apr 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP
    1
    1. scibot 28 Apr 2023
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      DOI: 10.1016/j.isci.2023.106538

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    sciencedirect.com/science/article/pii/S2589004223006156
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.isci.2023.106639

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    sciencedirect.com/science/article/pii/S2589004223007162
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    Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112434

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    sciencedirect.com/science/article/pii/S221112472300445X
  33. www.sciencedirect.com www.sciencedirect.com
    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
    1
    1. scibot 19 Apr 2023
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      DOI: 10.1016/j.cmet.2023.03.019

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    sciencedirect.com/science/article/pii/S1550413123001249
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    Identification of a comprehensive alternative splicing function during epithelial-mesenchymal transition
    1
    1. scibot 13 Apr 2023
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      DOI: 10.1016/j.isci.2023.106517

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    sciencedirect.com/science/article/pii/S2589004223005941
  35. Mar 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
    1
    1. scibot 03 Mar 2023
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      DOI: 10.1016/j.ccell.2023.02.004

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    sciencedirect.com/science/article/pii/S1535610823000326
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
    1
    1. scibot 03 Mar 2023
      RRID:AB_225340

      DOI: 10.1111/jnc.15764

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15764
  38. Feb 2023
  39. www.sciencedirect.com www.sciencedirect.com
    PIMT regulates Hepatic Gluconeogenesis in Mice
    1
    1. scibot 25 Feb 2023
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      DOI: 10.1016/j.isci.2023.106120

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    sciencedirect.com/science/article/pii/S2589004223001979
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    β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence
    1
    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.mito.2022.12.004

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    sciencedirect.com/science/article/pii/S1567724922001088
  41. Jan 2023
  42. www.sciencedirect.com www.sciencedirect.com
    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
    1
    1. scibot 21 Jan 2023
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      DOI: 10.1016/j.celrep.2023.112012

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    sciencedirect.com/science/article/pii/S2211124723000232
  43. Dec 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bistable insulin response: The win-win solution for glycemic control
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    1. scibot 02 Dec 2022
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      DOI: 10.1016/j.isci.2022.105561

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    ncbi.nlm.nih.gov/pmc/articles/PMC9708922/
  45. 52.53.155.43 52.53.155.43
    can-22-0945-html.html
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    1. scibot 01 Dec 2022
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      DOI: 10.1158/0008-5472.CAN-22-0945

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  46. Oct 2022
  47. journals.lww.com journals.lww.com
    Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research
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    1. scibot 08 Oct 2022
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      DOI: 10.4103/1673-5374.344952

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    journals.lww.com/nrronline/Fulltext/2023/04000/Siponimod_exerts_neuroprotective_effects_on_the.29.aspx
  48. Aug 2022
  49. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
    1
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      DOI: 10.1016/j.celrep.2022.111267

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    sciencedirect.com/science/article/pii/S2211124722010853
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PH domain-mediated autoinhibition and oncogenic activation of Akt
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    1. scibot 31 Aug 2022
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      DOI: 10.7554/eLife.80148

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    ncbi.nlm.nih.gov/pmc/articles/PMC9417420/
  51. www.cell.com www.cell.com
    Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
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      DOI: 10.1016/j.stem.2022.08.002

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    cell.com/cell-stem-cell/fulltext/S1934-5909(22)00338-1
  52. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis
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      DOI: 10.1016/j.celrep.2022.111204

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    sciencedirect.com/science/article/pii/S221112472201021X
  53. www.sciencedirect.com www.sciencedirect.com
    S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway
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      DOI: 10.1016/j.celrep.2022.111194

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    sciencedirect.com/science/article/pii/S2211124722010117
  54. www.sciencedirect.com www.sciencedirect.com
    HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution
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      DOI: 10.1016/j.celrep.2022.111136

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    sciencedirect.com/science/article/pii/S2211124722009457
  55. Jul 2022
  56. www.sciencedirect.com www.sciencedirect.com
    PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis
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      DOI: 10.1016/j.celrep.2022.111125

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    sciencedirect.com/science/article/pii/S2211124722009317
  57. Jun 2022
  58. www.sciencedirect.com www.sciencedirect.com
    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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      DOI: 10.1016/j.molcel.2022.06.005

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  60. Apr 2022
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    L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy
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    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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  63. Mar 2022
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  66. Feb 2022
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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    Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice
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  72. Dec 2021
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    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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  75. academic.oup.com academic.oup.com
    Regulation of AKT signaling in mouse uterus
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  76. Nov 2021
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    MiR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA
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    Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice
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  79. Oct 2021
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    Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
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    Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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  87. Jul 2021
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  91. Jun 2021
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  93. May 2021
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    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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  100. Mar 2021
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells
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  103. Feb 2021
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    Intravenous Administration of Triptonide Attenuates CFA-Induced Pain Hypersensitivity by Inhibiting DRG AKT Signaling Pathway in Mice
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    (+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma
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  107. atm.amegroups.com atm.amegroups.com
    MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro
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  108. Jan 2021
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    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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  110. Dec 2020
  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Functional inhibition of heat shock protein 70 by VER‐155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism
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      AKT (pan) (11E7) rabbit mAb

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    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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  113. Oct 2020
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    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance
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  115. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
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    Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla
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    GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
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    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
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    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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    Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats
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  126. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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    Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
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      Rabbit anti-AKT pan (11EZ)

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    Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes
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    Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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  131. Jan 2020
  132. elifesciences.org elifesciences.org
    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
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    Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet
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    GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
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      DOI: 10.1016/j.stem.2019.06.004

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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation
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      AB_2225340

      DOI: 10.1152/ajpendo.00050.2018

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    Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide
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    Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
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    12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
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    Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice
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      RRID:AB_2225340

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    Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition
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      DOI: 10.1111/bph.14652

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    Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
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  144. Nov 2018
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    Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor
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    Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
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    Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress
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  154. Nov 2017
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    Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
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    Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice
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    EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis
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    Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats
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      AB_2225340

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 4685, RRID:AB_2225340)

      SciCrunch record: RRID:AB_2225340

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2225340 RRIDCUR:Validated
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    link.springer.com/article/10.1007/s12035-017-0538-y
  159. www.sciencedirect.com www.sciencedirect.com
    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
    1
    1. scibot 08 Nov 2017
      AB_2225340

      Curator: @kaitlinsung

      Resource used:

      (Cell Signaling Technology Cat# 4685, RRID:AB_2225340)

      SciCrunch record: RRID:AB_2225340

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2225340 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276516308991