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Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC

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  DOI: 10.1016/j.celrep.2026.117797
  
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sciencedirect.com/science/article/pii/S2211124726008752
Apr 2026
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Cinobufotalin reduces glioblastoma resistance to temozolomide by inhibiting the CCL5-mediated PI3K/Akt/mTOR signaling pathway

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  DOI: 10.21037/tcr-2025-aw-2546
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13067027/
Mar 2026
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FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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  DOI: 10.1016/j.xcrm.2026.102686
  
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sciencedirect.com/science/article/pii/S2666379126001035
Feb 2026
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A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma

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  DOI: 10.1016/j.xcrm.2026.102622
  
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sciencedirect.com/science/article/pii/S266637912600039X
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FAM65A, as a potential predictor of prognosis, promotes colorectal cancer progression via activating Ras/ERK/RSK signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC12874459/
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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sciencedirect.com/science/article/pii/S2211124726000197
Jan 2026
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Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway

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1. scibot 31 Jan 2026
  
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  DOI: 10.1038/s41598-025-33774-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12852878/
Dec 2025
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CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis

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  DOI: 10.3389/fonc.2025.1671797
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12672324/
Sep 2025
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Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

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1. scibot 07 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12407559/
Aug 2025
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EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines

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1. scibot 05 Aug 2025
  
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  DOI: 10.1186/s41065-025-00517-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12315303/
Jul 2025
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Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-0133
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695179/
May 2025
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1-s2.0-S2589004225008958-main-html.html

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1. scibot 18 May 2025
  
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  AB_2227948
  
  DOI: 10.1016/j.isci.2025.112634
  
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52.53.155.43/3124e289592a3629f97e02aa5117cdb2659dc765/1-s2.0-S2589004225008958-main-html.html
Nov 2024
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PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms

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1. scibot 10 Nov 2024
  
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  DOI: 10.21037/tcr-24-1974
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11543057/
Jul 2024
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation

1
1. scibot 24 Jul 2024
  
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  AB_2227948
  
  DOI: 10.1016/j.cmet.2024.05.016
  
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sciencedirect.com/science/article/pii/S155041312400192X
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Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis

1
1. scibot 23 Jul 2024
  
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  AB_2227948
  
  DOI: 10.1016/j.isci.2024.110382
  
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sciencedirect.com/science/article/pii/S2589004224016079
Dec 2023
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Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia

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1. scibot 02 Dec 2023
  
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  DOI: 10.1007/s11064-023-04057-w
  
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link.springer.com/article/10.1007/s11064-023-04057-w
Sep 2023
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ALKBH5-mediated m6A modification of HS3ST3B1-IT1 prevents osteoarthritis progression

1
1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107838
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10518728/
Jun 2023
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METTL3-mediated m6A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis

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1. scibot 07 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112589
  
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sciencedirect.com/science/article/pii/S2211124723006009
Apr 2023
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Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis

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  DOI: 10.1016/j.bcp.2023.115523
  
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sciencedirect.com/science/article/pii/S0006295223001144
Mar 2023
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Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates

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  DOI: 10.1016/j.devcel.2023.02.006
  
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sciencedirect.com/science/article/pii/S1534580723000485
Feb 2023
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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

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  DOI: 10.1016/j.cmet.2023.01.011
  
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sciencedirect.com/science/article/pii/S1550413123000116
Jan 2023
52.53.155.43 52.53.155.43

Global cancer statistics, 2012

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  AB_2227948
  
  DOI: 10.3322/caac.21262
  
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52.53.155.43/a02c96445d7922530f409187fd9f1b81c5a72867/SSRN-id4278954-html.html
Oct 2022
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FBXL6 depletion restrains clear cell renal cell carcinoma progression

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1. scibot 05 Oct 2022
  
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  DOI: 10.1016/j.tranon.2022.101550
  
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sciencedirect.com/science/article/pii/S1936523322002091
Aug 2022
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MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.brainresbull.2022.08.014
  
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sciencedirect.com/science/article/pii/S0361923022002076
Jun 2022
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A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism

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1. scibot 25 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104591
  
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sciencedirect.com/science/article/pii/S258900422200863X
Apr 2022
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Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer

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1. scibot 30 Apr 2022
  
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  DOI: 10.1038/s41418-022-01007-x
  
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nature.com/articles/s41418-022-01007-x
Mar 2022
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury

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1. scibot 26 Mar 2022
  
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  DOI: 10.1096/fj.202101555RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202101555RR
Aug 2021
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Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells

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1. scibot 24 Aug 2021
  
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  DOI: 10.1016/j.phymed.2021.153711
  
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sciencedirect.com/science/article/pii/S0944711321002543
Apr 2021
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TUFM is involved in Alzheimer’s disease‐like pathologies that are associated with ROS

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1. scibot 02 Apr 2021
  
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  DOI: 10.1096/fj.202002461R
  
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faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202002461R
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression

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1. scibot 21 Mar 2021
  
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  DOI: 10.1016/j.ebiom.2021.103283
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7957119/
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The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells

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1. scibot 17 Mar 2021
  
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  DOI: 10.3892/etm.2021.9748
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7885062/
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Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence

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1. scibot 03 Mar 2021
  
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  DOI: 10.1096/fj.202001855RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001855RR