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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience

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  DOI: 10.1016/j.immuni.2026.06.002
  
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sciencedirect.com/science/article/pii/S1074761326002530
Jun 2026
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SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism

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sciencedirect.com/science/article/pii/S2211124726006224
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A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer

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  DOI: 10.1016/j.molcel.2026.05.005
  
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sciencedirect.com/science/article/pii/S1097276526003114
May 2026
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Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson’s Disease Knockin Mice

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1. scibot 28 May 2026
  
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  DOI: 10.1007/s11064-026-04762-2
  
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link.springer.com/article/10.1007/s11064-026-04762-2
Apr 2026
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A subcellular map of translational machinery composition and regulation at the single-molecule level

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1. scibot 25 Apr 2026
  
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  DOI: 10.1126/science.adn2623
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13102253/
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Wntless degradation mediated by CaMKII inhibition drives endoplasmic reticulum stress and apoptosis

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  DOI: 10.1016/j.celrep.2026.117256
  
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1-s2.0-S2589004226010862-main-html.html

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1. scibot 11 Apr 2026
  
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54.241.53.176/be028d43344bab6907bc9e771fd88e2dec1a0cd7/1-s2.0-S2589004226010862-main-html.html
Mar 2026
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Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102694
  
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sciencedirect.com/science/article/pii/S2666379126001114
Feb 2026
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Extracellular vesicles and their RNA cargo facilitate bidirectional cross-kingdom communication between human and bacterial cells

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1. scibot 25 Feb 2026
  
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  DOI: 10.1080/19490976.2026.2630482
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12928640/
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Dual-action strategy to reprogram chaperone activity for α-synuclein aggregate clearance in Parkinson's disease

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1. scibot 05 Feb 2026
  
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Jan 2026
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1-s2.0-S2589004226001653-main-html.html

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54.241.53.176/f82d02e43842eed6dc34b60b0d5cbb8ddeacb8e1/1-s2.0-S2589004226001653-main-html.html
Oct 2025
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pORF3-driven biogenesis of lipid droplets facilitates HEV infectivity

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1. scibot 09 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116406
  
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Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity

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1. scibot 08 Oct 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-0904
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12495980/
Sep 2025
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Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

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1. scibot 16 Sep 2025
  
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  DOI: 10.1084/jem.20250185
  
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rupress.org/jem/article/222/11/e20250185/278317/Autoimmune-disease-risk-gene-ANKRD55-promotes-TH17
Aug 2025
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Extracellular vesicle manufacture via FACTORY: fully automated collection technology and optimum machinery for clinical translational applications

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  DOI: 10.1016/j.tibtech.2025.06.020
  
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sciencedirect.com/science/article/pii/S0167779925002598
Jul 2025
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Extracellular vesicles and their RNA cargo facilitate bidirectional cross-kingdom communication between human and bacterial cells

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1. scibot 22 Jul 2025
  
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  DOI: 10.1101/2025.07.10.664124
  
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biorxiv.org/content/10.1101/2025.07.10.664124v1
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CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

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1. scibot 17 Jul 2025
  
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  DOI: 10.1016/j.molcel.2019.01.037
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6450717/
May 2025
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Human Amniotic Fluid-Derived Exosomes Alleviate Neuropathic Pain by Inducing an Anti-Inflammatory Transition in Microglia

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1. scibot 29 May 2025
  
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  DOI: 10.1096/fj.202500334R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500334R
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Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102090
  
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sciencedirect.com/science/article/pii/S2666379125001636
Feb 2025
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GEVSod2 Powder: A Modified Product Based on Biovesicles Functioned in Air Pollution PM2.5-Induced Cardiopulmonary Injury

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1. scibot 15 Feb 2025
  
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  DOI: 10.34133/research.0609
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11822167/
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Novel Pannexin 1 isoform is increased in cancer

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.09.612143
  
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52.53.155.43/248e2b0e257da849dadde63c071f77bcede2b26b/2024.09.09.612143v3.full-html.html
Dec 2024
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Epstein-Barr viral product-containing exosome facilitates LIF-associated immunosuppressive polarization of macrophage in nasopharyngeal carcinoma

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1. scibot 03 Dec 2024
  
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  DOI: 10.1101/2024.11.25.625317
  
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biorxiv.org/content/10.1101/2024.11.25.625317v1
Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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1. scibot 09 Oct 2024
  
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sciencedirect.com/science/article/pii/S1074761324004485
Sep 2024
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Zika virus NS3 drives the assembly of a viroplasm-like structure

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1. scibot 29 Sep 2024
  
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  DOI: 10.1101/2024.09.16.613201
  
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biorxiv.org/content/10.1101/2024.09.16.613201v1
Aug 2024
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Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo

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1. scibot 25 Aug 2024
  
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  DOI: 10.1007/s12035-024-04425-9
  
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link.springer.com/article/10.1007/s12035-024-04425-9
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

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1. scibot 02 Aug 2024
  
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  DOI: 10.3390/diagnostics11060917
  
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mdpi.com/2075-4418/11/6/917/htm
Jul 2024
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Atg8/LC3 controls systemic nutrient surplus signaling in flies and humans

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  DOI: 10.1016/j.cub.2024.06.005
  
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564418938-html.html

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  DOI: 10.1016/j.chembiol.2018.05.003
  
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52.53.155.43/40ec25098151b2e43571dd4d5aa80f6bfa4e0409/564418938-html.html
Jun 2024
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FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

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1. scibot 28 Jun 2024
  
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  DOI: 10.1002/advs.202404822
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202404822
molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

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  DOI: 10.1186/s12943-024-02034-7
  
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molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-02034-7
May 2024
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NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for melanoma tumor growth

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1. scibot 23 May 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0445
  
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aacrjournals.org/mcr/article/22/4/386/741848/NRAS-Mutant-Dictates-AHCYL1-Governed-ER-Calcium
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Generation and enrichment of cerebellar GABAergic interneurons from human induced pluripotent stem cells and intracellular calcium measurements

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.xpro.2024.102936
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11101973/
Apr 2024
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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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1. scibot 19 Apr 2024
  
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  DOI: 10.1016/j.immuni.2024.03.021
  
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sciencedirect.com/science/article/pii/S1074761324001420
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Vascular endothelial cells derived exosomes synergize with curcumin to prevent osteoporosis development

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1. scibot 18 Apr 2024
  
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Jan 2024
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Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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Nov 2023
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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

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Acylation of MLKL impacts its function in necroptosis

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Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis

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May 2023
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Extension of the DNAJB2a isoform in a dominant neuromyopathy family

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Feb 2023
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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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HRS regulates small extracellular vesicle PD-L1 secretion and is associated with anti-PD-1 treatment efficacy

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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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Exosomes mediated fibrogenesis in dilated cardiomyopathy through a MicroRNA pathway

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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

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Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity

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Role for <i>N</i>-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity.

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

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Target protein localization and its impact on PROTAC-mediated degradation

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Aug 2022
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Ubiquitination of phosphatidylethanolamine in organellar membranes

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Proteomics of serum exosomes identified fibulin-1 as a... : Neural Regeneration Research

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Jun 2022
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Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

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Mar 2022
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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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Feb 2022
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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

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Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity

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Dec 2021
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Methods to separate nuclear soluble fractions reflecting localizations in living cells

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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

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GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

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Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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Aug 2021
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McCarthy_Trehalose manuscript-table 1 (AJP Heart & Circ)

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ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

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McCarthy_Trehalose manuscript-table 1 (AJP Heart & Circ)

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Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis

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Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

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Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release

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Jun 2021
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A role for the ribosome-associated complex in activation of the IRE1 branch of UPR

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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

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Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

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A High-Density Human Mitochondrial Proximity Interaction Network

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Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis

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Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

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  anti-calnexin
  
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G protein-regulated endocytic trafficking of adenylyl cyclase type 9

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Isolation and characterization of extracellular vesicle subpopulations from tissues

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Jan 2021
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs

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N‐linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1

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  DOI: 10.1096/fj.202001544R
  
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Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation

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  DOI: 10.1038/s41598-020-64718-6
  
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Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

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Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease

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G protein-regulated endocytic trafficking of adenylyl cyclase type 9

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Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling

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  Calnexin
  
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Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5

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  DOI: 10.1016/j.celrep.2019.07.066
  
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Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

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Untitled document

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CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

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  DOI: 10.1016/j.molcel.2019.01.037
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6450717/
Nov 2018
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Untitled document

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Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II

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Untitled document

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nature.com/articles/s41419-018-0871-8
Nov 2017
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Isolation and Identification of ER Associated Proteins with Unique Expression Changes Specific to the V144D SPTLC1 Mutations in HSN-I

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omicsonline.org/open-access/isolation-and-identification-of-er-associated-proteins-with-unique-expressionchanges-specific-to-the-v144d-sptlc1-mutations-in-hsn-2161-1009-1000248.php

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