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Sep 2026
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Programmed ribosomal frameshifting triggers translational stress to promote viral replication

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1. scibot 16 Sep 2026
  
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  DOI: 10.1016/j.cell.2026.08.031
  
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Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche

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1. scibot 11 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.117953
  
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54.241.53.176 54.241.53.176

hY3 RNA binds and inhibits ribosomes and modulates the starvation-induced integrated stress response

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1. scibot 03 Sep 2026
  
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  DOI: 10.1093/nar/gkag832
  
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Aug 2026
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Zinc increases stress granule formation by promoting RNA condensation

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1. scibot 27 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117870
  
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sciencedirect.com/science/article/pii/S2211124726009484
54.241.53.176 54.241.53.176

hY3 RNA binds and inhibits ribosomes and modulates the starvation-induced integrated stress response

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1. scibot 26 Aug 2026
  
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  DOI: 10.1093/nar/gkag832
  
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54.241.53.176/8d73ca5c5d8e70a0b171b0889806caeabd6a6882/gkag832-html.html
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AI-driven discovery and validation of a GIPC1 PDZ domain inhibitor for pancreatic ductal adenocarcinoma

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1. scibot 03 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117777
  
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Jul 2026
54.241.53.176 54.241.53.176

huang-et-al-2025-cdk5rap3-mediated-regulation-of-lysosomal-and-er-membrane-proteins-is-pivotal-for-the-survival-and-html.html

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  DOI: 10.1152/ajpcell.00284.2025
  
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54.241.53.176/19603908de2c4d3834b600abd2d3062b6121e6b6/huang-et-al-2025-cdk5rap3-mediated-regulation-of-lysosomal-and-er-membrane-proteins-is-pivotal-for-the-survival-and-html.html
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Translational resistance to amino acid starvation in breast cancer cells revealed by ribosome profiling

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1. scibot 01 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116627
  
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sciencedirect.com/science/article/pii/S2589004226020031
Jun 2026
www.biorxiv.org www.biorxiv.org

Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathies

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1. scibot 26 Jun 2026
  
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  DOI: 10.64898/2026.06.10.731336
  
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biorxiv.org/content/10.64898/2026.06.10.731336v1
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FGF21 reduces ER stress by enhancing the unfolded protein and integrated stress responses through increased sulfide signaling

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1. scibot 17 Jun 2026
  
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  DOI: 10.1016/j.cmet.2026.05.011
  
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May 2026
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RNA length and receptor usage define innate immune recognition across species

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1. scibot 28 May 2026
  
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  DOI: 10.64898/2026.05.21.726451
  
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biorxiv.org/content/10.64898/2026.05.21.726451v1
Apr 2026
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Wntless degradation mediated by CaMKII inhibition drives endoplasmic reticulum stress and apoptosis

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1. scibot 15 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13266901/
Mar 2026
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Gcn2 deficiency triggers anemia and hypoxic intolerance in zebrafish

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117192
  
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sciencedirect.com/science/article/pii/S2211124726002706
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RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.molcel.2026.02.024
  
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sciencedirect.com/science/article/pii/S1097276526001383
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Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117107
  
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sciencedirect.com/science/article/pii/S2211124726001853
Feb 2026
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BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.012
  
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sciencedirect.com/science/article/pii/S1097276526000328
Jan 2026
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Chronic stress antagonizes formation of stress granules

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1. scibot 28 Jan 2026
  
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  DOI: 10.1016/j.isci.2025.114556
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12828549/
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

5′ UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins

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1. scibot 16 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116662
  
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circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116659
  
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Sep 2025
52.53.155.43 52.53.155.43

2025.09.04.674332v2.full-html.html

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1. scibot 18 Sep 2025
  
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  DOI: 10.1101/2025.09.04.674332
  
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Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

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1. scibot 07 Sep 2025
  
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  DOI: 10.4103/NRR.NRR-D-23-01953
  
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Aug 2025
52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM-html.html

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1. scibot 15 Aug 2025
  
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  DOI: 10.1038/s41467-025-56346-3
  
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The Tacrine‐Induced Endoplasmic Reticulum Stress in AChE‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose

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1. scibot 07 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12322807/
Jul 2025
52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM (1)-html.html

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1. scibot 19 Jul 2025
  
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  DOI: 10.1038/s41467-025-56346-3
  
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May 2025
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

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  DOI: 10.4103/NRR.NRR-D-24-00044
  
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FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter

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1. scibot 21 May 2025
  
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  DOI: 10.1210/endocr/bqaf046
  
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De novo serine biosynthesis is protective in mitochondrial disease

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  DOI: 10.1016/j.celrep.2025.115710
  
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Regulation of translation elongation and integrated stress response in heat-shocked neurons

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  DOI: 10.1016/j.celrep.2025.115639
  
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Apr 2025
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Effective recognition of double-stranded RNA does not require activation of cellular inflammation

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  DOI: 10.1126/sciadv.ads6498
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980852/
Mar 2025
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Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

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1. scibot 28 Mar 2025
  
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  DOI: 10.1371/journal.pone.0320157
  
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52.53.155.43 52.53.155.43

1-s2.0-S2589004225003980-main-html.html

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  DOI: 10.1016/j.isci.2025.112138
  
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Feb 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225002901-main-html.html

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.112030
  
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HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

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  DOI: 10.1016/j.celrep.2025.115339
  
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The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

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RIOK3 mediates the degradation of 40S ribosomes

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A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation

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5’-cap-dependent translation as a potent therapeutic target for lethal human squamous cell carcinoma

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eEF2K regulates pain through translational control of BDNF

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IFRD1 is required for maintenance of bladder epithelial homeostasis

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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology

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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

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Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes

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The ribotoxic stress response drives UV-mediated cell death

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BPS Publications

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Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia

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ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling

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miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress

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Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis

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Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

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Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis

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Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis

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A beneficial adaptive role for CHOP in driving cell fate selection during ER stress

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Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

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Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells

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Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes

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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

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Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth

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A beneficial adaptive role for CHOP in driving cell fate selection during ER stress

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EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway

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Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape

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Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome

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Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2

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  DOI: 10.1016/j.molcel.2023.06.020
  
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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

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Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”

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Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes

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KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

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Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination

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Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

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Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

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The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease

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Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions

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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

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Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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Sublethal cytochrome c release generates drug-tolerant persister cells

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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Triangulating variation in the population to define mechanisms for precision management of genetic disease

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A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model

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Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

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Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells

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Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection

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Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

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AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

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Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity

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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

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GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

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ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

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sciencedirect.com/science/article/pii/S2211124721009281
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1
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  DOI: 10.1016/j.cmet.2018.07.012
  
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Acetylation of Cytidine in mRNA Promotes Translation Efficiency

1
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  RRID:AB_2230924
  
  DOI: 10.1016/j.cell.2018.10.030
  
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  DOI: 10.1016/j.neuron.2018.09.044
  
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Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21

1
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  eIF2α
  
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Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers

1
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Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

2
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  AB_2230924
  
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RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs

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  RRID:AB_10695409
  
  DOI: 10.1016/j.molcel.2019.07.029
  
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Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity

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  RRID:AB_10695409
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14306
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Neuronal activity‐dependent local activation of dendritic unfolded protein response promotes expression of brain‐derived neurotrophic factor in cell soma

1
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  RRID:AB_10695409
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14221/full
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Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

1
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Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

1
1. scibot 08 May 2021
  
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m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

1
1. scibot 06 May 2021
  
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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

1
1. scibot 05 May 2021
  
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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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  RRID:AB_2230924
  
  DOI: 10.1016/j.stem.2021.02.008
  
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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

1
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  RRID:AB_2230924
  
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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

1
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  DOI: 10.1016/j.cmet.2020.11.009
  
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Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

1
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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

1
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Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

1
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

1
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  DOI: 10.7554/eLife.63326
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

1
1. scibot 25 Feb 2021
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30836-4
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

1
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  DOI: 10.1016/j.cell.2020.12.024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
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CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

1
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  DOI: 10.7554/eLife.60771
  
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Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway

1
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  RRID:AB_2230924
  
  DOI: 10.3390/nu12123771
  
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GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

1
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  DOI: 10.7554/eLife.62731
  
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Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation

1
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Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

1
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  DOI: 10.1186/s13148-020-00839-z
  
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The integrated stress response induces R-loops and hinders replication fork progression

1
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  DOI: 10.1038/s41419-020-2727-2
  
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Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking

1
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Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia

1
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  DOI: 10.1016/j.chembiol.2020.04.002
  
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Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

1
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  DOI: 10.1038/s41467-019-14085-2
  
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MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system

1
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  DOI: 10.1523/ENEURO.0477-19.2019
  
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eneuro.org/content/7/1/ENEURO.0477-19.2019
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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

1
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  DOI: 10.1016/j.neuron.2019.08.007
  
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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

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Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology

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NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase

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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

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Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

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Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum

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Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice

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High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers

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Tracing MYC Expression for Small Molecule Discovery

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The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

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Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice

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Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

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The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis

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Endoplasmic reticulum stress contributes to the loss of newborn hippocampal neurons after traumatic brain injury

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Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)

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The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

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Translational control of auditory imprinting and structural plasticity by eIF2α

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