150 Matching Annotations
  1. Feb 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Dual-action strategy to reprogram chaperone activity for α-synuclein aggregate clearance in Parkinson's disease
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    sciencedirect.com/science/article/pii/S0141813026006562
  3. Jan 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12807472/
  5. www.biorxiv.org www.biorxiv.org
    NF1 Loss Remodels Tumor Niches for Immune Evasion
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    biorxiv.org/content/10.64898/2026.01.11.698818v1
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    Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma
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    sciencedirect.com/science/article/pii/S2589004225028251
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural Communication Between C-Peptide and Insulin Within the Proinsulin Molecule
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    pmc.ncbi.nlm.nih.gov/articles/PMC12786736/
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    DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function
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    sciencedirect.com/science/article/pii/S1550413125005406
  9. Dec 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role of Sec61α2 Translocon in Insulin Biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11579409/
  11. Oct 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11496028/
  13. www.sciencedirect.com www.sciencedirect.com
    Adipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing β-adrenergic signaling and lipolysis
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    sciencedirect.com/science/article/pii/S2211124725012161
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The role of the lysine histone methylase KMT2D in chronic myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12481891/
  15. Sep 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/pdf/can-24-3904.pdf
  19. Aug 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12341233/
  21. Jul 2025
  22. www.cell.com www.cell.com
    High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
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    cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
  23. Jun 2025
  24. 52.53.155.43 52.53.155.43
    PDF-html.html
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
  27. May 2025
  28. www.sciencedirect.com www.sciencedirect.com
    A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction
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    sciencedirect.com/science/article/pii/S1074761325002225
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
  30. Apr 2025
  31. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
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    sciencedirect.com/science/article/pii/S1074761325001244
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    RAF1 kinase contributes to autophagic lysosome reformation
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    sciencedirect.com/science/article/pii/S221112472500261X
  33. Jan 2025
  34. www.sciencedirect.com www.sciencedirect.com
    Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies
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    Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome
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    sciencedirect.com/science/article/pii/S1934590924004478
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668527/
  37. Nov 2024
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
  39. Sep 2024
  40. www.sciencedirect.com www.sciencedirect.com
    Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function
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    sciencedirect.com/science/article/pii/S2211124724011343
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
  42. www.sciencedirect.com www.sciencedirect.com
    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610824003179
  43. elifesciences.org elifesciences.org
    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
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    elifesciences.org/content/6/e25158
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    sciencedirect.com/science/article/pii/S2211124724010726
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    mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
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    sciencedirect.com/science/article/pii/S2666379124004385
  46. www.sciencedirect.com www.sciencedirect.com
    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
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    sciencedirect.com/science/article/pii/S0092867424009048
  47. www.sciencedirect.com www.sciencedirect.com
    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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    sciencedirect.com/science/article/pii/S2666379124004324
  48. Aug 2024
  49. www.sciencedirect.com www.sciencedirect.com
    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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  50. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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  51. Jul 2024
  52. www.sciencedirect.com www.sciencedirect.com
    Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes
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  53. May 2024
  54. journals.asm.org journals.asm.org
    Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum
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    journals.asm.org/doi/10.1128/mbio.00299-24
  55. Apr 2024
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
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    ncbi.nlm.nih.gov/pmc/articles/PMC11014585/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum
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    ncbi.nlm.nih.gov/pmc/articles/PMC11005342/
  58. Mar 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10955614/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  61. www.sciencedirect.com www.sciencedirect.com
    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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  62. www.sciencedirect.com www.sciencedirect.com
    Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
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    sciencedirect.com/science/article/pii/S1535610824000485
  63. Feb 2024
  64. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
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    cancerci.biomedcentral.com/articles/10.1186/s12935-024-03231-6
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798623/
  66. Jan 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10187264/
  68. www.sciencedirect.com www.sciencedirect.com
    DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
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    sciencedirect.com/science/article/pii/S0092867423014381
  69. www.sciencedirect.com www.sciencedirect.com
    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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  70. Dec 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring
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    ncbi.nlm.nih.gov/pmc/articles/PMC10692727/
  72. Sep 2023
  73. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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  74. Aug 2023
  75. 52.53.155.43 52.53.155.43
    Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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  77. 52.53.155.43 52.53.155.43
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  78. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  80. Jul 2023
  81. www.sciencedirect.com www.sciencedirect.com
    Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
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  82. www.nature.com www.nature.com
    Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice
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    nature.com/articles/s41467-023-39715-8
  83. www.sciencedirect.com www.sciencedirect.com
    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
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  84. Jun 2023
  85. www.sciencedirect.com www.sciencedirect.com
    Nutrient-dependent regulation of β-cell proinsulin content
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  86. www.sciencedirect.com www.sciencedirect.com
    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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  87. May 2023
  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    onlinelibrary.wiley.com/doi/10.1002/cac2.12332
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  90. Apr 2023
  91. www.sciencedirect.com www.sciencedirect.com
    Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue
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    sciencedirect.com/science/article/pii/S2589004223006296
  92. www.sciencedirect.com www.sciencedirect.com
    VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms
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    Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction
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  94. Mar 2023
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10025096/
  96. www.sciencedirect.com www.sciencedirect.com
    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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  97. Feb 2023
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
  99. Jan 2023
  100. www.sciencedirect.com www.sciencedirect.com
    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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    sciencedirect.com/science/article/pii/S2211124723000487
  101. Dec 2022
  102. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    embopress.org/doi/10.15252/embj.2022111961
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9794981/
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  105. Sep 2022
  106. www.sciencedirect.com www.sciencedirect.com
    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    sciencedirect.com/science/article/pii/S2211124722012694
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9271144/
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    Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma
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  109. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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    link.springer.com/article/10.1007/s00401-022-02491-8
  110. Aug 2022
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    sciencedirect.com/science/article/pii/S2211124722010774
  112. Jun 2022
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    Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
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    sciencedirect.com/science/article/pii/S2352345X22000972
  114. www.sciencedirect.com www.sciencedirect.com
    ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
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    sciencedirect.com/science/article/pii/S2211124722006878
  115. May 2022
  116. www.sciencedirect.com www.sciencedirect.com
    Protocol to induce and assess cGAS-STING pathway activation in vitro
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    sciencedirect.com/science/article/pii/S2666166722002647
  117. Apr 2022
  118. www.sciencedirect.com www.sciencedirect.com
    Functional elements of the cis-regulatory lincRNA-p21
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  119. link.springer.com link.springer.com
    In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1
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    link.springer.com/article/10.1007/s11064-022-03570-8
  120. Mar 2022
  121. www.sciencedirect.com www.sciencedirect.com
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