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Aug 2025
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Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression

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  DOI: 10.1186/s12967-025-06920-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12341233/
Jul 2025
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
Jun 2025
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52.53.155.43/39661a60067369c81e4f8c30deffb29c14ec6c80/PDF-html.html
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RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

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pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
May 2025
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A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

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sciencedirect.com/science/article/pii/S1074761325002225
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De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

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1. scibot 20 May 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
Apr 2025
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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sciencedirect.com/science/article/pii/S1074761325001244
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RAF1 kinase contributes to autophagic lysosome reformation

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sciencedirect.com/science/article/pii/S221112472500261X
Jan 2025
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Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies

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sciencedirect.com/science/article/pii/S0378874125000765
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Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

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  DOI: 10.1016/j.stem.2024.12.007
  
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sciencedirect.com/science/article/pii/S1934590924004478
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Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

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1. scibot 04 Jan 2025
  
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  DOI: 10.7554/eLife.100205
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11668527/
Nov 2024
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Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer

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1. scibot 08 Nov 2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
Sep 2024
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Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114783
  
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sciencedirect.com/science/article/pii/S2211124724011343
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GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

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  DOI: 10.1016/j.celrep.2024.114606
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
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Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.018
  
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sciencedirect.com/science/article/pii/S1535610824003179
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SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

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1. scibot 25 Sep 2024
  
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  AB_2121214
  
  DOI: 10.7554/eLife.25158
  
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elifesciences.org/content/6/e25158
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Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114721
  
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sciencedirect.com/science/article/pii/S2211124724010726
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mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101717
  
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sciencedirect.com/science/article/pii/S2666379124004385
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

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sciencedirect.com/science/article/pii/S2666379124004324
Aug 2024
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Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

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  DOI: 10.1016/j.celrep.2024.114663
  
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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  DOI: 10.1016/j.xcrm.2024.101663
  
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sciencedirect.com/science/article/pii/S266637912400377X
Jul 2024
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Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes

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  DOI: 10.1016/j.cmet.2024.07.005
  
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May 2024
journals.asm.org journals.asm.org

Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum

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1. scibot 24 May 2024
  
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  DOI: 10.1128/mbio.00299-24
  
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journals.asm.org/doi/10.1128/mbio.00299-24
Apr 2024
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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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1. scibot 30 Apr 2024
  
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  DOI: 10.1101/2024.04.02.587836
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11014585/
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Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum

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1. scibot 13 Apr 2024
  
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  DOI: 10.1128/mbio.00299-24
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11005342/
Mar 2024
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Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis

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  DOI: 10.1002/pro.4949
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10955614/
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Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma

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  DOI: 10.1158/1535-7163.MCT-23-0025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
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Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice

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  DOI: 10.1016/j.celrep.2024.113875
  
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  DOI: 10.1016/j.celrep.2024.113875
  
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sciencedirect.com/science/article/pii/S2211124724002031
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Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells

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  DOI: 10.1016/j.ccell.2024.02.004
  
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  DOI: 10.1016/j.ccell.2024.02.004
  
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sciencedirect.com/science/article/pii/S1535610824000485
Feb 2024
cancerci.biomedcentral.com cancerci.biomedcentral.com

Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer

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1. scibot 07 Feb 2024
  
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  DOI: 10.1186/s12935-024-03231-6
  
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cancerci.biomedcentral.com/articles/10.1186/s12935-024-03231-6
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Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function

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1. scibot 01 Feb 2024
  
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  AB_2233307
  
  DOI: 10.1371/journal.ppat.1011926
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798623/
Jan 2024
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Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

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1. scibot 26 Jan 2024
  
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  DOI: 10.1101/2023.05.04.539399
  
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DNA-guided transcription factor cooperativity shapes face and limb mesenchyme

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Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

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Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring

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Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment

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Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling

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Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

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mct-23-0025 (1)-html.html

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

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Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer

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Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

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Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons

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Nutrient-dependent regulation of β-cell proinsulin content

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The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

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Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue

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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction

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Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

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Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

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N-acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells

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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

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The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells

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Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

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Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma

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Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo

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Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

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Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice

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ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

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Protocol to induce and assess cGAS-STING pathway activation in vitro

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Functional elements of the cis-regulatory lincRNA-p21

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In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1

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Mucus sialylation determines intestinal host-commensal homeostasis

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Gold(I)-Catalyzed Intramolecular Hydrothiophenylation of N-Thiophen-3-yl Alkynylamides for Accessing Thieno[3,2-b]pyridine-5(4H)-ones: Development of F-Actin Specific Fluorescent Probes

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Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

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Inhibition of extracellular vesicle-associated MMP2 abrogates intercellular hepatic miR-122 transfer to liver macrophages and curtails inflammation

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome

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Untitled document

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Untitled document

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Untitled document

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BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

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Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II - Md Al Rahim, Shabarish Thatipamula, Giulio M. Pasinetti, Mir Ahamed Hossain, 2021

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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

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Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

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The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

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Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Isolation and characterization of extracellular vesicles produced by cell lines

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A novel HDAC6 inhibitor improves myelination of Schwann cells in a model of Charcot‐Marie‐Tooth disease type 1A

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance

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Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

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A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism

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Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

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MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

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p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

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FOXD3 Regulates VISTA Expression in Melanoma

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Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4

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TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

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CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

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Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis

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Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co‐chaperone STI1

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The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

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Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

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Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

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Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

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A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer

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Untitled document

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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Untitled document

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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

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SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

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A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms

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PPARδ Promotes Running Endurance by Preserving Glucose

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An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

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