124 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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    1. scibot 15 Nov 2024
      RRID:AB_2238583

      DOI: 10.1016/j.isci.2024.111133

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    pmc.ncbi.nlm.nih.gov/articles/PMC11544388/
  3. Sep 2024
  4. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    1. scibot 27 Sep 2024
      RRID:AB_2238583

      DOI: 10.1093/hmg/ddae135

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    dx.doi.org/10.1093/hmg/ddae135
  5. www.sciencedirect.com www.sciencedirect.com
    RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
    1
    1. scibot 14 Sep 2024
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      DOI: 10.1016/j.molcel.2024.08.023

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    sciencedirect.com/science/article/pii/S1097276524007007
  6. 52.53.155.43 52.53.155.43
    Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
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    1. scibot 05 Sep 2024
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      DOI: 10.1101/2024.07.26.605278

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    52.53.155.43/76e736f0a40c1a2ebb10a21ddca6aa06b484cb52/2024.07.26.605278v1.full-html.html
  7. Aug 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 13 Aug 2024
      AB_22238583

      DOI: 10.1126/science.adk0775

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  9. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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    1. scibot 02 Aug 2024
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      DOI: 10.1016/j.molcel.2020.11.008

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  10. May 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry
    1
    1. scibot 30 May 2024
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      DOI: 10.1016/j.xpro.2024.103082

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    sciencedirect.com/science/article/pii/S2666166724002478
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
    1
    1. scibot 17 May 2024
      RRID:AB_2238583

      DOI: 10.1158/1078-0432.CCR-23-1763

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094420/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
    1
    1. scibot 03 May 2024
      RRID:AB_2238583

      DOI: 10.7554/eLife.89100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  14. Mar 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
    1
    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate
    1
    1. scibot 23 Mar 2024
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      DOI: 10.7554/eLife.89015

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    ncbi.nlm.nih.gov/pmc/articles/PMC10957176/
  17. Feb 2024
  18. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.08.23.554263

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    52.53.155.43/d64025fcba7405c73976a9e0dc65e9989e0d835f/2023.08.23.554263v1.full-html.html
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
    1
    1. scibot 03 Feb 2024
      RRID:AB_2238583

      DOI: 10.1016/j.isci.2024.108843

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9
    1
    1. scibot 03 Feb 2024
      RRID:AB_13

      DOI: 10.1016/j.isci.2024.108857

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    ncbi.nlm.nih.gov/pmc/articles/PMC10830855/
  21. Jan 2024
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
    1
    1. scibot 06 Jan 2024
      RRID:AB_2238583

      DOI: 10.1016/j.jbc.2023.105619

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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  23. Dec 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
    1
    1. scibot 06 Dec 2023
      RRID:AB_2238583

      DOI: 10.7554/eLife.80944

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    ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
  25. Nov 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
    1
    1. scibot 29 Nov 2023
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      DOI: 10.1016/j.isci.2023.108278

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    sciencedirect.com/science/article/pii/S2589004223023556
  27. www.sciencedirect.com www.sciencedirect.com
    PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
    1
    1. scibot 28 Nov 2023
      RRID:AB_2238583

      DOI: 10.1016/j.cmet.2023.11.001

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    sciencedirect.com/science/article/abs/pii/S1550413123004114
  28. www.sciencedirect.com www.sciencedirect.com
    CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
    1
    1. scibot 02 Nov 2023
      RRID:AB_2238583

      DOI: 10.1016/j.celrep.2023.113306

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    sciencedirect.com/science/article/pii/S2211124723013189
  29. www.sciencedirect.com www.sciencedirect.com
    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
    1
    1. scibot 02 Nov 2023
      RRID:AB_2238583

      DOI: 10.1016/j.celrep.2023.113269

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    sciencedirect.com/science/article/pii/S2211124723012810
  30. Oct 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
    1
    1. scibot 05 Oct 2023
      RRID:AB_2238583

      DOI: 10.7554/eLife.85898

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    ncbi.nlm.nih.gov/pmc/articles/PMC10541180/
  32. Aug 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
    1
    1. scibot 25 Aug 2023
      RRID:AB_2238583

      DOI: 10.1016/j.celrep.2023.113032

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    sciencedirect.com/science/article/pii/S2211124723010434
  34. www.sciencedirect.com www.sciencedirect.com
    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
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    1. scibot 18 Aug 2023
      RRID:AB_2238583

      DOI: 10.1016/j.molcel.2023.07.017

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    sciencedirect.com/science/article/abs/pii/S1097276523005609
  35. Jul 2023
  36. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
    1
    1. scibot 27 Jul 2023
      RRID:AB_2238583

      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
  37. Jun 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
    1
    1. scibot 29 Jun 2023
      RRID:AB_2238583

      DOI: 10.1016/j.neuron.2023.05.033

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    sciencedirect.com/science/article/pii/S0896627323004348
  39. www.sciencedirect.com www.sciencedirect.com
    Regulation of RNG105/caprin1 dynamics by pathogenic cytoplasmic FUS and TDP-43 in neuronal RNA granules modulates synaptic loss
    1
    1. scibot 09 Jun 2023
      RRID:AB_2238583

      DOI: 10.1016/j.heliyon.2023.e17065

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    sciencedirect.com/science/article/pii/S2405844023042731
  40. www.sciencedirect.com www.sciencedirect.com
    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
    1
    1. scibot 08 Jun 2023
      RRID:AB_2238583

      DOI: 10.1016/j.xcrm.2023.101073

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    sciencedirect.com/science/article/pii/S2666379123001921
  41. May 2023
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
    1
    1. scibot 05 May 2023
      RRID:AB_2238583

      DOI: 10.1002/mc.23284

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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  43. www.sciencedirect.com www.sciencedirect.com
    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.celrep.2022.111085

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    sciencedirect.com/science/article/pii/S2211124722008877
  44. Apr 2023
  45. www.sciencedirect.com www.sciencedirect.com
    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.isci.2023.106578

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    sciencedirect.com/science/article/pii/S2589004223006557
  46. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    1. scibot 21 Apr 2023
      RRID:AB_2238583

      DOI: 10.1016/j.cmet.2023.03.021

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    sciencedirect.com/science/article/pii/S1550413123001262
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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      DOI: 10.1016/j.xcrm.2023.101002

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    sciencedirect.com/science/article/pii/S266637912300112X
  48. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational dynamics in a model peptidergic system
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      DOI: 10.1016/j.mcpro.2023.100544

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    sciencedirect.com/science/article/pii/S1535947623000543
  49. Feb 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Injury primes mutation-bearing astrocytes for dedifferentiation in later life
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      DOI: 10.1016/j.cub.2023.02.013

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    sciencedirect.com/science/article/pii/S0960982223001525
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostaglandins limit nuclear actin to control nucleolar function during oogenesis
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      DOI: 10.3389/fcell.2023.1072456

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    ncbi.nlm.nih.gov/pmc/articles/PMC9981675/
  52. Jan 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma
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      DOI: 10.1158/0008-5472.CAN-21-1222

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    ncbi.nlm.nih.gov/pmc/articles/PMC9359717/
  54. 52.53.155.43 52.53.155.43
    SSRN-id4201001-html.html
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      DOI: 10.2139/ssrn.4201001

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    52.53.155.43/36d292ba6a35036ba493fd13dd1895996b7f9f6e/SSRN-id4201001-html.html
  55. Dec 2022
  56. www.sciencedirect.com www.sciencedirect.com
    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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      DOI: 10.1016/j.celrep.2022.111821

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    sciencedirect.com/science/article/pii/S2211124722017132
  57. Nov 2022
  58. www.nature.com www.nature.com
    mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
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      DOI: 10.1038/s41467-022-34763-y

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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  61. Sep 2022
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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  64. aacrjournals.org aacrjournals.org
    Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
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    Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
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  67. Jun 2022
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    Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle
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  71. May 2022
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    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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    Regulation of GTPase function by autophosphorylation
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    DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions
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    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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  79. Feb 2022
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    A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice
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  81. Jan 2022
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  83. Dec 2021
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
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    Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy
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  86. Nov 2021
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    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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  88. Sep 2021
  89. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia
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    Oncogene-dependent sloppiness in mRNA translation
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  91. Aug 2021
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    Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis
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  94. Jul 2021
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    Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
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    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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    Protein synthetic machinery and mRNA in regenerating tips of spinal cord axons in lamprey
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      anti-rpS6 monoclonal antibody (Cell Signaling Technology, Danvers, MA; #2317; 54D2, 1:1,000)

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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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  99. Jun 2021
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  101. May 2021
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways
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  106. Apr 2021
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    Coordinate regulation of the senescent state by selective autophagy
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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  110. Mar 2021
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    Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
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  112. Feb 2021
  113. www.nature.com www.nature.com
    Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy
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      anti-S6

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  114. Jan 2021
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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  116. Dec 2020
  117. www.sciencedirect.com www.sciencedirect.com
    Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth
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    PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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  134. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal mouse S6 ribosomal protein

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  136. Jan 2020
  137. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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    Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
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    Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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  149. Nov 2018
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy
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    mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
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    Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  162. Nov 2017
  163. www.sciencedirect.com www.sciencedirect.com
    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
    1
    1. scibot 08 Nov 2017
      RRID:AB_2238583

      Curator: @Jmenke

      Resource used:

      (Cell Signaling Technology Cat# 2317, RRID:AB_2238583)

      SciCrunch record: RRID:AB_2238583

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2238583 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1550413117304904
  164. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
    1
    1. scibot 08 Nov 2017
      RRID:AB_2238583

      Curator: @Jmenke

      Resource used:

      (Cell Signaling Technology Cat# 2317, RRID:AB_2238583)

      SciCrunch record: RRID:AB_2238583

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2238583 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580717305968
  165. www.sciencedirect.com www.sciencedirect.com
    Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
    1
    1. scibot 08 Nov 2017
      Mouse anti-S6Cell Signaling2317

      Curator: @Jmenke

      Resource used:

      (Cell Signaling Technology Cat# 2317, RRID:AB_2238583)

      SciCrunch record: RRID:AB_2238583

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2238583 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1550413117301717
  166. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
    1
    1. scibot 08 Nov 2017
      AB_2238583

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2317, RRID:AB_2238583)

      SciCrunch record: RRID:AB_2238583

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2238583 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517304914
  167. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
    1
    1. scibot 08 Nov 2017
      AB_2238583

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2317, RRID:AB_2238583)

      SciCrunch record: RRID:AB_2238583

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2238583 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517303945
  168. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
    1
    1. scibot 08 Nov 2017
      AB_2238583

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 2317, RRID:AB_2238583)

      SciCrunch record: RRID:AB_2238583

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2238583 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S009286741631460X