519 Matching Annotations
  1. Jul 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons
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    1. scibot 09 Jul 2022
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      DOI: 10.1016/j.scitotenv.2022.157134

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    sciencedirect.com/science/article/pii/S0048969722042310
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    Impaired interferon-γ signaling promotes the development of silicosis
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    1. scibot 08 Jul 2022
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      DOI: 10.1016/j.isci.2022.104647

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    sciencedirect.com/science/article/pii/S2589004222009191
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    EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
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    1. scibot 06 Jul 2022
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      DOI: 10.1016/j.celrep.2022.111031

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    sciencedirect.com/science/article/pii/S2211124722008257
  5. Jun 2022
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
    1
    1. scibot 29 Jun 2022
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      DOI: 10.1016/j.molcel.2022.06.003

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    sciencedirect.com/science/article/pii/S1097276522005391
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    TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells
    1
    1. scibot 29 Jun 2022
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      DOI: 10.1016/j.molcel.2022.06.002

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    sciencedirect.com/science/article/pii/S109727652200538X
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    Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes
    1
    1. scibot 29 Jun 2022
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      DOI: 10.1016/j.celrep.2022.111011

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    sciencedirect.com/science/article/pii/S2211124722008002
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    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
    1
    1. scibot 22 Jun 2022
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      DOI: 10.1016/j.isci.2022.104561

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    sciencedirect.com/science/article/pii/S2589004222008331
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    Lymphatics act as a signaling hub to regulate intestinal stem cell activity
    1
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      DOI: 10.1016/j.stem.2022.05.007

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    sciencedirect.com/science/article/pii/S1934590922002077
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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
    1
    1. scibot 22 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110991

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    sciencedirect.com/science/article/pii/S221112472200777X
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    Stub1 maintains proteostasis of master transcription factors in embryonic stem cells
    1
    1. scibot 09 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110919

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    sciencedirect.com/science/article/pii/S2211124722006969
  13. www.nature.com www.nature.com
    A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
    1
    1. scibot 04 Jun 2022
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      DOI: 10.1038/s41556-022-00918-8

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    nature.com/articles/s41556-022-00918-8
  14. academic.oup.com academic.oup.com
    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
    1
    1. scibot 03 Jun 2022
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      DOI: 10.1210/clinem/dgac270

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac270/6577152
  15. May 2022
  16. www.eneuro.org www.eneuro.org
    Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice
    1
    1. scibot 26 May 2022
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      DOI: 10.1523/ENEURO.0133-22.2022

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    eneuro.org/content/9/3/ENEURO.0133-22.2022
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
    1
    1. scibot 26 May 2022
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      DOI: 10.1016/j.celrep.2022.110838

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    sciencedirect.com/science/article/pii/S2211124722006118
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
    1
    1. scibot 20 May 2022
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      DOI: 10.1016/j.molcel.2022.04.030

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    sciencedirect.com/science/article/pii/S1097276522003938
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    Gold(III)-P-chirogenic complex induce mitochondrial dysfunction in triple-negative breast cancer
    1
    1. scibot 19 May 2022
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      DOI: 10.1016/j.isci.2022.104340

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    sciencedirect.com/science/article/pii/S2589004222006113
  20. www.sciencedirect.com www.sciencedirect.com
    Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1)
    1
    1. scibot 19 May 2022
      RRID:AB_2242334

      DOI: 10.1016/j.scr.2022.102815

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    sciencedirect.com/science/article/pii/S1873506122001647
  21. www.nature.com www.nature.com
    Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
    1
    1. scibot 17 May 2022
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      DOI: 10.1038/s41467-022-30363-y

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    nature.com/articles/s41467-022-30363-y
  22. www.sciencedirect.com www.sciencedirect.com
    MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1
    1
    1. scibot 13 May 2022
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      DOI: 10.1016/j.isci.2022.104279

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    sciencedirect.com/science/article/pii/S2589004222005491
  23. www.sciencedirect.com www.sciencedirect.com
    A novel spinal neuron connection for heat sensation
    1
    1. scibot 13 May 2022
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      DOI: 10.1016/j.neuron.2022.04.021

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    sciencedirect.com/science/article/pii/S089662732200366X
  24. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
    1
    1. scibot 05 May 2022
      RRID:AB_2242334

      DOI: 10.1186/s13024-022-00526-y

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    link.springer.com/article/10.1186/s13024-022-00526-y
  25. link.springer.com link.springer.com
    Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
    1
    1. scibot 03 May 2022
      RRID:AB_2242334

      DOI: 10.1007/s11064-022-03612-1

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    link.springer.com/article/10.1007/s11064-022-03612-1
  26. Apr 2022
  27. www.sciencedirect.com www.sciencedirect.com
    Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice
    1
    1. scibot 28 Apr 2022
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      DOI: 10.1016/j.isci.2022.104241

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    sciencedirect.com/science/article/pii/S2589004222005119
  28. www.sciencedirect.com www.sciencedirect.com
    Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
    1
    1. scibot 28 Apr 2022
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      DOI: 10.1016/j.immuni.2022.04.001

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    sciencedirect.com/science/article/pii/S1074761322001728
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110752

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    ncbi.nlm.nih.gov/pmc/articles/PMC9099058/
  30. www.sciencedirect.com www.sciencedirect.com
    Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110747

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    sciencedirect.com/science/article/pii/S2211124722005113
  31. academic.oup.com academic.oup.com
    Deletion of Gdf15 reduces ER stress-induced beta cell apoptosis and diabetes
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1210/endocr/bqac030

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    academic.oup.com/endo/article/163/5/bqac030/6548945
  32. www.sciencedirect.com www.sciencedirect.com
    Generation and characterization of a genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A)
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.scr.2022.102792

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    sciencedirect.com/science/article/pii/S1873506122001416
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    Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization
    1
    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110719

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    sciencedirect.com/science/article/pii/S2211124722004806
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    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
    1
    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110712

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    sciencedirect.com/science/article/pii/S2211124722004739
  35. aacrjournals.org aacrjournals.org
    Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET
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    1. scibot 16 Apr 2022
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      DOI: 10.1158/0008-5472.CAN-20-0821

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    aacrjournals.org/cancerres/article/82/8/1534/694341/Loss-of-KMT5C-Promotes-EGFR-Inhibitor-Resistance
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    VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
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      DOI: 10.1016/j.devcel.2022.03.012

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    sciencedirect.com/science/article/pii/S1534580722002064
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    POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function
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      DOI: 10.1016/j.celrep.2022.110642

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    sciencedirect.com/science/article/pii/S2211124722003941
  38. aacrjournals.org aacrjournals.org
    DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
    1
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      DOI: 10.1158/1535-7163.MCT-21-0554

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    aacrjournals.org/mct/article/21/4/635/689570/DS-7300a-a-DNA-Topoisomerase-I-Inhibitor-DXd-Based
  39. Mar 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
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      DOI: 10.1016/j.cmet.2022.02.012

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    sciencedirect.com/science/article/pii/S1550413122000845
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    Caveolin-1 Peptide Regulates p53-microRNA-34a Feedback in Fibrotic Lung Fibroblasts
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      DOI: 10.1016/j.isci.2022.104022

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    sciencedirect.com/science/article/pii/S2589004222002929
  42. www.sciencedirect.com www.sciencedirect.com
    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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      DOI: 10.1016/j.celrep.2022.110541

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    sciencedirect.com/science/article/pii/S2211124722002820
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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      DOI: 10.1016/j.isci.2022.104009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8927994/
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota–brain axis
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    1. scibot 22 Mar 2022
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      DOI: 10.1111/jnc.14709

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14709
  45. www.embopress.org www.embopress.org
    Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation
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      DOI: 10.15252/embr.202154027

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    Nitric oxide regulates adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells
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    5-HT3Rs Maintain Hippocampal LTP in a CB1R-GABAA-Dependent Manner for Spatial Memory
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Emodin inhibits the proliferation and migration of B16F10 cells and induces their apoptosis
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    Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
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    RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair
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    Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis
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    The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
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    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    Chronic neuronal excitation leads to dual metaplasticity in the signaling for structural long-term potentiation
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    MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1
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  65. Dec 2021
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    PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer
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    Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
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    TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver
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    Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation
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  74. Nov 2021
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    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
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    MiR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA
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    β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME
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    Secretory mouse quiescin sulfhydryl oxidase 1 aggregates defected human and mouse spermatozoa in vitro and in vivo
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    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
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    Beta 2 Adrenergic Receptor Antagonist Propranolol and Opioidergic Receptor Antagonist Naltrexone Produce Synergistic Effects on Breast Cancer Growth Prevention by Acting on Cancer Cells and Immune Environment in a Preclinical Model of Breast Cancer
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    A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
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    Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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    Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells
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    Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
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    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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    Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice
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    Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Contribute to Neuronal Cell Loss in an Animal Model of Multiple Sclerosis
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  117. Jul 2021
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    Combination of an engineered Lactococcus lactis expressing CXCL12 with light-emitting diode yellow light as a treatment for scalded skin in mice
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    TACC3 Regulates Microtubule Plus-End Dynamics and Cargo Transport in Interphase Cells
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    Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats
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  123. www.nature.com www.nature.com
    Dominant-negative ATF5 rapidly depletes survivin in tumor cells
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    A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype
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    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
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    A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication
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    Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
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      AB_2242334u00a0

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      u03b2-actin (3700, AB_2242334)

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    Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells
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      DOI: 10.1016/j.molcel.2017.09.022

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    Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis
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    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
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    Modulation of Akt vs Stat3 activity by the focal adhesion kinase in non-neoplastic mouse fibroblasts
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    The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
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  145. May 2021
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    MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease
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    Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
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    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
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    R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
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    HIFα regulates developmental myelination independent of autocrine Wnt signaling
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    Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses
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  202. Nov 2020
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    CTCF-Mediated Genome Architecture Regulates the Dosage of Mitotically Stable Mono-allelic Expression of Autosomal Genes
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    Heterotrimeric G‐protein, Gi1, is involved in the regulation of proliferation, neuronal migration and dendrite morphology during cortical development in vivo
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    A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control
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