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BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

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1. scibot 25 Sep 2025
  
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  DOI: 10.1101/2025.05.04.652129
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12248061/
Aug 2025
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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis

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1. scibot 14 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.014
  
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sciencedirect.com/science/article/pii/S153458072500471X
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NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116099
  
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sciencedirect.com/science/article/pii/S2211124725008708
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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.006
  
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sciencedirect.com/science/article/pii/S1535610825003101
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The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.jbc.2025.110561
  
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sciencedirect.com/science/article/pii/S0021925825024123
Jul 2025
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STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models

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1. scibot 17 Jul 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-3833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12260510/
Jun 2025
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Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.cels.2025.101321
  
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sciencedirect.com/science/article/pii/S2405471225001541
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A first-in-class EGFR-directed KRAS G12V selective inhibitor

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.016
  
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sciencedirect.com/science/article/pii/S1535610825002259
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PDF-html.html

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1. scibot 11 Jun 2025
  
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52.53.155.43/3e81ed4154fee0b68ed39cd7c108fb3e26bd25fc/PDF-html.html
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Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.chembiol.2025.05.005
  
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sciencedirect.com/science/article/pii/S2451945625001667
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Amiloride synergizes with EGFR PROTACs and inhibitors to overcome therapeutic resistance in NSCLC

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1. scibot 05 Jun 2025
  
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  DOI: 10.1016/j.bioorg.2025.108641
  
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sciencedirect.com/science/article/pii/S0045206825005218
May 2025
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Genetic biomarker study of sunvozertinib for clinical prognosis and prediction in NSCLC with EGFR exon 20 insertion mutation

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102121
  
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sciencedirect.com/science/article/pii/S2666379125001946
Mar 2025
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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma

1
1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.03.001
  
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sciencedirect.com/science/article/pii/S1097276525001947
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PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD

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1. scibot 13 Mar 2025
  
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  DOI: 10.1016/j.neuron.2025.02.005
  
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sciencedirect.com/science/article/pii/S0896627325001187
Feb 2025
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The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/endocr/bqae136
  
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dx.doi.org/10.1210/endocr/bqae136
Jan 2025
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Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial

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1. scibot 31 Jan 2025
  
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  RRID:AB_2246311
  
  DOI: 10.1016/j.xcrm.2025.101930
  
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sciencedirect.com/science/article/pii/S2666379125000035
Dec 2024
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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

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1. scibot 02 Dec 2024
  
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  RRID:AB_2246311
  
  DOI: 10.1016/j.celrep.2024.115016
  
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sciencedirect.com/science/article/pii/S2211124724013676
Nov 2024
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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981

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1. scibot 15 Nov 2024
  
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  RRID:AB_2246311
  
  DOI: 10.1016/j.isci.2024.111133
  
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sciencedirect.com/science/article/pii/S2589004224023587
52.53.155.43 52.53.155.43

can-24-1817-html.html

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1. scibot 14 Nov 2024
  
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  DOI: 10.1158/0008-5472.can-24-1817
  
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52.53.155.43/65dca824591f5654591dc592fd6476e0cd35e8bf/can-24-1817-html.html
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis

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1. scibot 05 Oct 2024
  
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  RRID:AB_2246311
  
  DOI: 10.1083/jcb.202401167
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
Sep 2024
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An ILK/STAT3 pathway controls glioblastoma stem cell plasticity

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1. scibot 27 Sep 2024
  
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  AB_2246311
  
  DOI: 10.1016/j.devcel.2024.09.003
  
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Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110635
  
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sciencedirect.com/science/article/pii/S2589004224018601
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Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice

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1. scibot 06 Sep 2024
  
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  RRID:AB_2246311
  
  DOI: 10.1210/endocr/bqad133
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10502789/
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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1. scibot 04 Sep 2024
  
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  AB_2246311
  
  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Aug 2024
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A human fetal cerebellar map of the late second trimester reveals developmental molecular characteristics and abnormality in trisomy 21

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1. scibot 21 Aug 2024
  
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  AB_2246311
  
  DOI: 10.1016/j.celrep.2024.114586
  
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sciencedirect.com/science/article/pii/S221112472400915X
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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1. scibot 18 Aug 2024
  
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  AB_2246311
  
  DOI: 10.1016/j.xcrm.2024.101663
  
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sciencedirect.com/science/article/pii/S266637912400377X
breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

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1. scibot 02 Aug 2024
  
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  EGFR
  
  DOI: 10.1186/s13058-020-01374-8
  
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breast-cancer-research.biomedcentral.com/article/10.1186/s13058-020-01374-8
Jun 2024
www.cell.com www.cell.com

Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies

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1. scibot 29 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110068
  
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cell.com/iscience/abstract/S2589-0042(24)01293-8
May 2024
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1-s2.0-S2589004224013270-main-html.html

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.isci.2024.110102
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11342199/
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Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma

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1. scibot 07 May 2024
  
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  4267
  
  DOI: 10.1016/j.ejps.2024.106789
  
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sciencedirect.com/science/article/pii/S0928098724001003
Apr 2024
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EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0434
  
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aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

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1. scibot 22 Mar 2024
  
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  DOI: 10.1038/s41467-024-46284-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
Feb 2024
52.53.155.43 52.53.155.43

can-22-3965-html.html

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1. scibot 23 Feb 2024
  
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  DOI: 10.1158/0008-5472.can-22-3965
  
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52.53.155.43/b267fbdd19a530509c54979d05951e91bb2c0d21/3693-html.html
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IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108984
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10847745/
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Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.devcel.2024.01.010
  
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Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells

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TNIK drives Castration-Resistant Prostate Cancer via phosphorylating EGFR

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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

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Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes

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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma

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can-22-3965-html.html

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The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

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Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor

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can-22-3965-html.html

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CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

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Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes

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Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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Protocol for evaluation of tumor-derived exosome-induced cancer cell metastasis in a mouse model

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Jun 2023
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MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

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How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view

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Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition

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Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma

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Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma

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EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

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Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer

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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

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Histone H3 phospho-regulation by KimH3 in both interphase and mitosis

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Mar 2023
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Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions

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Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers

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Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells

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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

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Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

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Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes

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Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

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Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas

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A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

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GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer

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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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Multi-facet roles of RNA editing in promoting loss-of-function of PODXL in cancer

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Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

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Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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Tissue remodeling by an opportunistic pathogen triggers allergic inflammation

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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

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Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma

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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

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Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells

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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

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Substratum stiffness regulates Erk signaling dynamics through receptor-level control

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EGFR transactivates RON to drive oncogenic crosstalk

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Dietary nitrate supplementation prevents radiotherapy-induced xerostomia

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RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis

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A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Untitled document

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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K

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Untitled document

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ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

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The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

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Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

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Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling

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Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function

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Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors

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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

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Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling

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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

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Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

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ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

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Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models

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Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs

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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

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Proximity Ligation Assay for Detecting Protein‐Protein Interactions and Protein Modifications in Cells and Tissues in Situ

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BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS

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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

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Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

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Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

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Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

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Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

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EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

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Global Analysis of Intercellular Homeodomain Protein Transfer

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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Untitled document

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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  RRID:AB_2246311
  
  DOI: 10.1016/j.ccell.2019.01.020
  
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1. scibot 13 Jan 2020
  
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  RRID:AB_2246311
  
  DOI: 10.1016/j.devcel.2019.03.029
  
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_2246311
  
  DOI: 10.1016/j.stem.2019.01.002
  
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sciencedirect.com/science/article/pii/S1934590919300025
Nov 2018
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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

1
1. scibot 05 Nov 2018
  
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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2246311
  
  Curator: @Jmenke
  
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Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

1
1. scibot 05 Nov 2018
  
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EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

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1. scibot 05 Nov 2018
  
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

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Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer

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1. scibot 05 Nov 2018
  
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europepmc.org europepmc.org

Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.

1
1. scibot 05 Nov 2018
  
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  AB_2246311
  
  Curator: @evieth
  
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europepmc.org/articles/PMC5663478/
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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K

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Nov 2017
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Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

1
1. scibot 08 Nov 2017
  
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Leptin suppresses adenosine triphosphate‐induced impairment of spinal cord astrocytes

1
1. scibot 08 Nov 2017
  
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  Cell Signaling Technology, rabbit monoclonal, 4267S, AB_2246311
  
  Curator: @bandrow
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.23795/full
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EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis

1
1. scibot 08 Nov 2017
  
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  AB_2246311
  
  Curator: @chewbeccax
  
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Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis

1
1. scibot 08 Nov 2017
  
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  AB_2246311
  
  Curator: @gabimpine
  
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