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    6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model
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  3. Apr 2024
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    Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum
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    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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  7. Mar 2024
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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    Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model
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  14. Feb 2024
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    IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
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    Stromal-derived MAOB promotes prostate cancer growth and progression
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    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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    Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
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    Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
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  21. Jan 2024
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    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    Metformin inhibits cell proliferation and ACTH secretion in AtT20 cells via regulating the MAPK pathway
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    Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration
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    Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism
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  30. Nov 2023
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism
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    Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway
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    Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
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  36. Oct 2023
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    EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
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    Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
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    Mechanochemical coupling of MGF mediates periodontal regeneration
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  40. Sep 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury
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    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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  45. Jul 2023
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    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-γ-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation
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    Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
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    Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice
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    Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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    Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
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    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
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    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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    Identification of a Novel Axon Regeneration Role for Non-Canonical Wnt Signaling in the Adult Retina After Injury
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  98. Jul 2022
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    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
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    Manipulating bovine granulosa cell energy metabolism limits inflammation
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    Transmissible ER stress between macrophages and tumor cells configures tumor microenvironment
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    Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway
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  103. Jun 2022
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    Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
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    Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  108. May 2022
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    Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition
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    SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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  114. Mar 2022
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    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  119. Feb 2022
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    Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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  123. Jan 2022
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    The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
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    Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
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    Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua
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  127. Dec 2021
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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  130. Nov 2021
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    Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors
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    Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics
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  136. Oct 2021
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    Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity
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  138. Sep 2021
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    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  142. Aug 2021
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    Entosis is induced by UV radiation.
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    ErbB4 mediates amyloid β-induced neurotoxicity through JNK/tau pathway activation: implications for Alzheimer’s disease
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    Rewiring of the ubiquitinated proteome determines ageing in C. elegans
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    Crosstalk control and limits of physiological c-Jun N-terminal kinase activity for cell viability and neurite stability in differentiated PC12 cells - ScienceDirect
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  149. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mitogen‐activated protein kinase signaling mediates opioid‐induced presynaptic NMDA receptor activation and analgesic tolerance
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    MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo
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    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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    ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,
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    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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  174. May 2021
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  186. Mar 2021
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    Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
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  194. Dec 2020
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    Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism
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  198. Nov 2020
  199. www.frontiersin.org www.frontiersin.org
    Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway
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    Lysophosphatidic acid induces thrombospondin‐1 production in primary cultured rat cortical astrocytes
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    Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-κB Signaling
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  203. Oct 2020
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    IL‐1/IL‐1R signaling induced by all‐trans‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium
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    The p38 signaling pathway mediates the TGF‐β1‐induced increase in type I collagen deposition in human granulosa cells
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  206. Sep 2020
  207. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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    Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation
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    The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
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    Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
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      DOI: 10.1523/JNEUROSCI.2994-18.2019

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    Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus
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      DOI: 10.3389/fnagi.2020.00192

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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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      DOI: 10.1016/j.celrep.2020.01.054

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      DOI: 10.1111/bph.14959

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    KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species‐mediated apoptosis
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      DOI: 10.1002/jcp.29743

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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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      Anti-JNK

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    FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c‐Jun axis
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      DOI: 10.1002/jcp.29942

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    Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
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      DOI: 10.1016/j.celrep.2020.107731

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  219. Jan 2020
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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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      DOI: 10.1016/j.immuni.2019.11.013

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    CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
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    The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation
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    Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor
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      DOI: 10.7554/eLife.44502

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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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    Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade
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      DOI: 10.3389/fncel.2019.00399

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    Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents
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    Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR
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    GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
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    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
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    MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells
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    Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors
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    Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3
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    CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress
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    Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells
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      DOI: 10.1002/jcp.28246

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