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  1. Last 7 days
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    PTEN deletion in the adult dentate gyrus induces epilepsy
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    1. scibot 21 Nov 2024
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    sciencedirect.com/science/article/pii/S0969996124003383
  3. Sep 2024
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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    sciencedirect.com/science/article/pii/S1550413124003334
  5. Aug 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY
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  7. Jul 2024
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    Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration
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    sciencedirect.com/science/article/pii/S221112472400843X
  9. May 2024
  10. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
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    1. scibot 23 May 2024
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    sciencedirect.com/science/article/pii/S2211124724005898
  13. Mar 2024
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    Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer
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    sciencedirect.com/science/article/pii/S2451945624000370
  15. Feb 2024
  16. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    1. scibot 27 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  17. Jan 2024
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    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    1. scibot 10 Jan 2024
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  20. Dec 2023
  21. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    sciencedirect.com/science/article/pii/S2589004223026731
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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    1. scibot 19 Dec 2023
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    sciencedirect.com/science/article/pii/S1534580723006214
  23. Nov 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    1. scibot 03 Nov 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  25. Oct 2023
  26. 52.53.155.43 52.53.155.43
    PTEN deletion in spinal pathways via retrograde transduction with AAV-RG enhances forelimb motor recovery after cervical spinal cord injury; Sex differences and late-onset pathophysiologies
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    1. scibot 06 Oct 2023
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  27. Sep 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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    ncbi.nlm.nih.gov/pmc/articles/PMC9975769/
  29. Aug 2023
  30. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    sciencedirect.com/science/article/pii/S1097276523005580
  31. Jul 2023
  32. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
    2
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    52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328280/
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
    1
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    sciencedirect.com/science/article/pii/S096999612300205X
  36. Apr 2023
  37. www.biorxiv.org www.biorxiv.org
    PTEN deletion in spinal pathways via retrograde transduction with AAV-retro enhances forelimb motor recovery after cervical spinal cord injury; sex differences and late-onset pathophysiologies
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    1. scibot 28 Apr 2023
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    biorxiv.org/content/10.1101/2023.03.20.533502v1
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    sciencedirect.com/science/article/pii/S2211124723003881
  39. Mar 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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      DOI: 10.1158/0008-5472.CAN-22-0631

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  41. Feb 2023
  42. 52.53.155.43 52.53.155.43
    bcd-22-0082-html.html
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  43. Jan 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
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    sciencedirect.com/science/article/pii/S2666979X22002130
  45. journals.lww.com journals.lww.com
    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.358606

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    journals.lww.com/nrronline/Fulltext/2023/07000/PTEN_inhibitor_bisperoxovanadium_protects_against.36.aspx
  46. Dec 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage
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    ncbi.nlm.nih.gov/pmc/articles/PMC9727431/
  48. Sep 2022
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC9499684/
  50. Aug 2022
  51. 52.53.155.43 52.53.155.43
    can-22-0631-html.html
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  52. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
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    sciencedirect.com/science/article/pii/S0361923022002076
  53. Jun 2022
  54. www.sciencedirect.com www.sciencedirect.com
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    sciencedirect.com/science/article/pii/S2211124722008087
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  56. May 2022
  57. www.tandfonline.com www.tandfonline.com
    Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
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      DOI: 10.1080/09537104.2022.2026908

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    tandfonline.com/doi/full/10.1080/09537104.2022.2026908
  58. Mar 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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      DOI: 10.1016/j.molcel.2022.01.029

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    sciencedirect.com/science/article/pii/S1097276522001058
  60. Feb 2022
  61. www.tandfonline.com www.tandfonline.com
    Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
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  62. Jan 2022
  63. www.sciencedirect.com www.sciencedirect.com
    Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury
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      DOI: 10.1016/j.expneurol.2021.113965

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    sciencedirect.com/science/article/pii/S0014488621003733
  64. Nov 2021
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure
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      DOI: 10.1038/s41419-021-04372-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC8599682/
  66. Sep 2021
  67. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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      DOI: 10.1016/j.molcel.2021.08.034

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  68. Aug 2021
  69. academic.oup.com academic.oup.com
    Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects
    1
    1. scibot 16 Aug 2021
      RRID:AB_2253290

      DOI: 10.1210/endocr/bqab142

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  70. academic.oup.com academic.oup.com
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      AB_2253290

      DOI: 10.1210/en.2016-1613

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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      AB_2253290

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  72. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
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      RRID:AB_2253290

      DOI: 10.1016/j.molcel.2017.09.024

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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  74. Jul 2021
  75. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PTEN knockdown alters dendritic spine/protrusion morphology, not density
    1
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      Anti-PTENMonoclonalRabbitEpitope surrounds amino acid 395 of PTEN sequence1:400Cell Signaling9188AB_2174349

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
    2
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      rabbit anti-Pten (1:100, Cell Signaling #9188)

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      rabbit anti-Pten (1:2000, Cell Signaling #9188)

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  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock‐down
    1
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      AB_2174349

      DOI: 10.1002/cne.23987

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  78. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
    1
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      9188

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  79. May 2021
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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      RRID:AB_2253290

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    SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt
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      RRID:AB_2253290

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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
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      RRID:AB_2253290

      DOI: 10.1016/j.devcel.2020.04.018

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  83. Apr 2021
  84. www.sciencedirect.com www.sciencedirect.com
    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
    1
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      AB_2253290

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  85. Mar 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
    1
    1. scibot 09 Mar 2021
      RRID:AB_2253290

      DOI: 10.1083/jcb.201910041

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  87. Feb 2021
  88. academic.oup.com academic.oup.com
    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
    1
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      RRID:AB_2253290

      DOI: 10.1210/endocr/bqaa037

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  89. Sep 2020
  90. www.sciencedirect.com www.sciencedirect.com
    Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
    1
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      RRID:AB_2253290

      DOI: 10.1016/j.celrep.2020.01.052

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  91. www.sciencedirect.com www.sciencedirect.com
    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
    1
    1. scibot 04 Sep 2020
      PTEN

      DOI: 10.1016/j.immuni.2018.05.006

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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1
    1
    1. scibot 03 Sep 2020
      RRID:AB_2253290

      DOI: 10.1038/s41598-020-69698-1

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  93. Jan 2020
  94. www.sciencedirect.com www.sciencedirect.com
    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
    1
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      RRID:AB_2253290

      DOI: 10.1016/j.celrep.2019.07.063

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    sciencedirect.com/science/article/pii/S2211124719309672
  95. www.sciencedirect.com www.sciencedirect.com
    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
    1
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      RRID:AB_2253290

      DOI: 10.1016/j.ccell.2019.05.003

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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS
    1
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      RRID:AB_2253290

      DOI: 10.7554/eLife.48847

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  97. www.sciencedirect.com www.sciencedirect.com
    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
    1
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      RRID:AB_2253290

      DOI: 10.1016/j.cels.2019.11.001

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    sciencedirect.com/science/article/pii/S2405471219303874
  98. Nov 2018
  99. www.sciencedirect.com www.sciencedirect.com
    Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer
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      RRID:AB_2253290

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  100. www.sciencedirect.com www.sciencedirect.com
    Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice
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      RRID:AB_2253290

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    sciencedirect.com/science/article/pii/S0014488618300529
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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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      RRID:AB_2253290

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    sciencedirect.com/science/article/pii/S1074761317304855
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
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      RRID:AB_2253290

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  103. Nov 2017
  104. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
    1
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      AB 2253290 

      Curator: @chewbeccax

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    academic.oup.com/endo/article/157/12/4641/2758409/Developmental-Programming-Insulin-Sensitizer
  105. www.sciencedirect.com www.sciencedirect.com
    Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype
    1
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      AB_2253290

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