64 Matching Annotations
  1. May 2024
  2. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
    1
    1. scibot 30 May 2024
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      DOI: 10.1038/s41416-024-02697-5

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    nature.com/articles/s41416-024-02697-5
  3. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
    1
    1. scibot 24 May 2024
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      DOI: 10.1126/scisignal.adh4475

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  4. www.sciencedirect.com www.sciencedirect.com
    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
    1
    1. scibot 23 May 2024
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    sciencedirect.com/science/article/pii/S2211124724005898
  5. Mar 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer
    1
    1. scibot 06 Mar 2024
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  7. Feb 2024
  8. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  9. Jan 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
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  11. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
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  12. Dec 2023
  13. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
    1
    1. scibot 20 Dec 2023
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    sciencedirect.com/science/article/pii/S2589004223026731
  14. www.sciencedirect.com www.sciencedirect.com
    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
    1
    1. scibot 19 Dec 2023
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      DOI: 10.1016/j.devcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1534580723006214
  15. Nov 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  17. Oct 2023
  18. 52.53.155.43 52.53.155.43
    PTEN deletion in spinal pathways via retrograde transduction with AAV-RG enhances forelimb motor recovery after cervical spinal cord injury; Sex differences and late-onset pathophysiologies
    1
    1. scibot 06 Oct 2023
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  19. Sep 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1158/2643-3230.BCD-22-0082

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  21. Aug 2023
  22. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
    1
    1. scibot 11 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.015

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    sciencedirect.com/science/article/pii/S1097276523005580
  23. Jul 2023
  24. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
    2
    1. scibot 18 Jul 2023
      RRID:AB_2253290

      DOI: 10.1101/2023.05.18.541123

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      DOI: 10.1101/2023.05.18.541123

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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
    1
    1. scibot 12 Jul 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328280/
  26. Jun 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1016/j.nbd.2023.106190

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    sciencedirect.com/science/article/pii/S096999612300205X
  28. Apr 2023
  29. www.biorxiv.org www.biorxiv.org
    PTEN deletion in spinal pathways via retrograde transduction with AAV-retro enhances forelimb motor recovery after cervical spinal cord injury; sex differences and late-onset pathophysiologies
    1
    1. scibot 28 Apr 2023
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      DOI: 10.1101/2023.03.20.533502

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    biorxiv.org/content/10.1101/2023.03.20.533502v1
  30. www.sciencedirect.com www.sciencedirect.com
    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
    1
    1. scibot 15 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112377

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    sciencedirect.com/science/article/pii/S2211124723003881
  31. Mar 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
    1
    1. scibot 05 Mar 2023
      RRID:AB_2253290

      DOI: 10.1158/0008-5472.CAN-22-0631

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444962/
  33. Feb 2023
  34. 52.53.155.43 52.53.155.43
    bcd-22-0082-html.html
    1
    1. scibot 11 Feb 2023
      RRID:AB_2253290

      DOI: 10.1158/2643-3230.bcd-22-0082

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  35. Jan 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
    1
    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.xgen.2022.100250

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    sciencedirect.com/science/article/pii/S2666979X22002130
  37. journals.lww.com journals.lww.com
    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
    1
    1. scibot 19 Jan 2023
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      DOI: 10.4103/1673-5374.358606

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    journals.lww.com/nrronline/Fulltext/2023/07000/PTEN_inhibitor_bisperoxovanadium_protects_against.36.aspx
  38. Dec 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage
    1
    1. scibot 13 Dec 2022
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      DOI: 10.4103/1673-5374.346551

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    ncbi.nlm.nih.gov/pmc/articles/PMC9727431/
  40. Sep 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype
    1
    1. scibot 24 Sep 2022
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      DOI: 10.3390/ijms231810311

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    ncbi.nlm.nih.gov/pmc/articles/PMC9499684/
  42. Aug 2022
  43. 52.53.155.43 52.53.155.43
    can-22-0631-html.html
    1
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  44. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
    1
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      DOI: 10.1016/j.brainresbull.2022.08.014

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    sciencedirect.com/science/article/pii/S0361923022002076
  45. Jun 2022
  46. www.sciencedirect.com www.sciencedirect.com
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
    1
    1. scibot 29 Jun 2022
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      DOI: 10.1016/j.celrep.2022.111019

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    sciencedirect.com/science/article/pii/S2211124722008087
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
    1
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  48. May 2022
  49. www.tandfonline.com www.tandfonline.com
    Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
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      DOI: 10.1080/09537104.2022.2026908

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    tandfonline.com/doi/full/10.1080/09537104.2022.2026908
  50. Mar 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
    1
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      DOI: 10.1016/j.molcel.2022.01.029

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  52. Feb 2022
  53. www.tandfonline.com www.tandfonline.com
    Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
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  54. Jan 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury
    1
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      DOI: 10.1016/j.expneurol.2021.113965

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    sciencedirect.com/science/article/pii/S0014488621003733
  56. Nov 2021
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure
    1
    1. scibot 24 Nov 2021
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      DOI: 10.1038/s41419-021-04372-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC8599682/
  58. Sep 2021
  59. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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    sciencedirect.com/science/article/pii/S1097276521007140
  60. Aug 2021
  61. academic.oup.com academic.oup.com
    Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects
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    1. scibot 16 Aug 2021
      RRID:AB_2253290

      DOI: 10.1210/endocr/bqab142

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    academic.oup.com/endo/article/162/10/bqab142/6321973
  62. academic.oup.com academic.oup.com
    Untitled document
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      AB_2253290

      DOI: 10.1210/en.2016-1613

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    academic.oup.com/endo/article/157/12/4641/2758409
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5133353/
  64. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
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      DOI: 10.1016/j.molcel.2017.09.024

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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      RRID:AB_2253290

      DOI: 10.1016/j.molcel.2017.09.024

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  66. Jul 2021
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PTEN knockdown alters dendritic spine/protrusion morphology, not density
    1
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      Anti-PTENMonoclonalRabbitEpitope surrounds amino acid 395 of PTEN sequence1:400Cell Signaling9188AB_2174349

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    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
    2
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      rabbit anti-Pten (1:100, Cell Signaling #9188)

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      rabbit anti-Pten (1:2000, Cell Signaling #9188)

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  69. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock‐down
    1
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      AB_2174349

      DOI: 10.1002/cne.23987

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  70. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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      9188

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  71. May 2021
  72. www.sciencedirect.com www.sciencedirect.com
    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt
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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
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  75. Apr 2021
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    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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      AB_2253290

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  77. Mar 2021
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
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      DOI: 10.1083/jcb.201910041

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  79. Feb 2021
  80. academic.oup.com academic.oup.com
    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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      DOI: 10.1210/endocr/bqaa037

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  81. Sep 2020
  82. www.sciencedirect.com www.sciencedirect.com
    Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
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      DOI: 10.1016/j.celrep.2020.01.052

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  83. www.sciencedirect.com www.sciencedirect.com
    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
    1
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      PTEN

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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1
    1
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      DOI: 10.1038/s41598-020-69698-1

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  85. Jan 2020
  86. www.sciencedirect.com www.sciencedirect.com
    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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      RRID:AB_2253290

      DOI: 10.1016/j.celrep.2019.07.063

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    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
    1
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      RRID:AB_2253290

      DOI: 10.1016/j.ccell.2019.05.003

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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS
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      RRID:AB_2253290

      DOI: 10.7554/eLife.48847

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  89. www.sciencedirect.com www.sciencedirect.com
    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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      RRID:AB_2253290

      DOI: 10.1016/j.cels.2019.11.001

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  90. Nov 2018
  91. www.sciencedirect.com www.sciencedirect.com
    Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer
    1
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      RRID:AB_2253290

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    sciencedirect.com/science/article/pii/S1535610818302617
  92. www.sciencedirect.com www.sciencedirect.com
    Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice
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      RRID:AB_2253290

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    sciencedirect.com/science/article/pii/S0014488618300529
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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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    sciencedirect.com/science/article/pii/S1074761317304855
  94. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
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      RRID:AB_2253290

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    sciencedirect.com/science/article/pii/S1097276517307025
  95. Nov 2017
  96. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
    1
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      AB 2253290 

      Curator: @chewbeccax

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    academic.oup.com/endo/article/157/12/4641/2758409/Developmental-Programming-Insulin-Sensitizer
  97. www.sciencedirect.com www.sciencedirect.com
    Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype
    1
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      AB_2253290

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