72 Matching Annotations
  1. Oct 2026
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    Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma
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    sciencedirect.com/science/article/pii/S2211124726010752
  3. Feb 2026
  4. www.science.org www.science.org
    RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity
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    science.org/doi/10.1126/sciadv.aea5932
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12922753/
  6. Jan 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC6 Immunostaining in Conjunction with the Rad51 HRD Assay May Expand PARPi Treatment Eligibility in Patients with HGSOC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833555/
  8. Nov 2025
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    Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope
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    sciencedirect.com/science/article/pii/S1097276525008688
  10. Oct 2025
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    BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR
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    sciencedirect.com/science/article/pii/S221112472501232X
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12493205/
  13. Aug 2025
  14. www.biorxiv.org www.biorxiv.org
    Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients
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    biorxiv.org/content/10.1101/2025.07.29.667411v1
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    PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
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    sciencedirect.com/science/article/pii/S1097276525006045
  16. Jul 2025
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    Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition
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    sciencedirect.com/science/article/pii/S1534580725003636
  18. Apr 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p53 regulates DREAM complex-mediated repression in a p21-independent manner
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000331/
  20. Dec 2024
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    PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress
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    sciencedirect.com/science/article/pii/S2211124724014177
  22. Aug 2024
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    RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
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    sciencedirect.com/science/article/pii/S2211124724009239
  24. Feb 2024
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
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    sciencedirect.com/science/article/pii/S2211124724001062
  26. Oct 2023
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    Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
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    sciencedirect.com/science/article/pii/S2211124723012688
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    An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time
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    sciencedirect.com/science/article/pii/S266637912300424X
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    TERRA R-loops connect and protect sister telomeres in mitosis
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    sciencedirect.com/science/article/pii/S2211124723012470
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    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
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    sciencedirect.com/science/article/pii/S2211124723011567
  31. Jun 2023
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    sciencedirect.com/science/article/pii/S2589004223010283
  33. May 2023
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    sciencedirect.com/science/article/pii/S2211124723004953
  35. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202002810R
  36. Apr 2023
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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    sciencedirect.com/science/article/pii/S1097276523002113
  38. Dec 2022
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    Quantification of protein enrichment at site-specific DNA double-strand breaks by chromatin immunoprecipitation in cultured human cells
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    sciencedirect.com/science/article/pii/S2666166722007973
  40. Aug 2022
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    CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124722011172
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    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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    sciencedirect.com/science/article/pii/S2589004222012160
  43. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124722002777
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8931362/
  46. Jan 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  48. Dec 2021
  49. www.sciencedirect.com www.sciencedirect.com
    EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
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    sciencedirect.com/science/article/pii/S0092867421014276
  50. Aug 2021
  51. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1097276518309456
  52. europepmc.org europepmc.org
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    europepmc.org/articles/PMC6037479/
  53. Jul 2021
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6202423/
  55. May 2021
  56. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202002810R
  57. Apr 2021
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
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    ncbi.nlm.nih.gov/pmc/articles/PMC8153251/
  59. Jan 2021
  60. www.sciencedirect.com www.sciencedirect.com
    RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization
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    sciencedirect.com/science/article/pii/S2211124720316144
  61. www.sciencedirect.com www.sciencedirect.com
    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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    sciencedirect.com/science/article/pii/S1097276520309461
  62. Dec 2020
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    TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A
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    sciencedirect.com/science/article/pii/S2211124720315321
  64. Oct 2020
  65. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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    pubmed.ncbi.nlm.nih.gov/33027668/
  66. Sep 2020
  67. www.sciencedirect.com www.sciencedirect.com
    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
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    sciencedirect.com/science/article/pii/S2211124720308305
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    The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates
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    sciencedirect.com/science/article/pii/S1097276520304007
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    Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination
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    sciencedirect.com/science/article/pii/S2211124720306392
  70. Jan 2020
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    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
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    sciencedirect.com/science/article/pii/S1097276519307683
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    sciencedirect.com/science/article/pii/S2211124719314834
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    sciencedirect.com/science/article/pii/S1097276519305003
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    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
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    sciencedirect.com/science/article/pii/S2211124719308162
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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    sciencedirect.com/science/article/pii/S1535610819303344
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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
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    sciencedirect.com/science/article/pii/S2211124719311854
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    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
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    embopress.org/doi/10.15252/embj.2019102361
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    Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    sciencedirect.com/science/article/pii/S1535610819300546
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    Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways
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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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  87. Nov 2018
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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    sciencedirect.com/science/article/pii/S2211124718312737
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    sciencedirect.com/science/article/pii/S1097276518305586
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    sciencedirect.com/science/article/pii/S1535610818300199
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    SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage
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    sciencedirect.com/science/article/pii/S0960982217316536
  96. Nov 2017
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    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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    sciencedirect.com/science/article/pii/S1097276517304574
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    RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
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    sciencedirect.com/science/article/pii/S1097276517303192
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    A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC5161750/
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    A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming
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    sciencedirect.com/science/article/pii/S0092867416315306