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186 Matching Annotations

Aug 2025
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MAVS phosphorylation acts as a cellular stress sensor that modulates antiviral immunity

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113256
  
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sciencedirect.com/science/article/pii/S2589004225015172
Jun 2025
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Plinabulin following radiation enhances dendritic cell maturation and checkpoint inhibitor retreatment of relapsed/refractory cancers

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.medj.2025.100752
  
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Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115867
  
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Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.06.001
  
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cell.com/cell/fulltext/S0092-8674(25)00635-X
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Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102198
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281382/
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The human neural cell atlas of Zika virus infection in developing brain tissue

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102189
  
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TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1038/s44319-025-00444-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12116916/
May 2025
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MPXV infection activates cGAS-STING signaling and IFN-I treatment reduces pathogenicity of mpox in CAST/EiJ mice and rhesus macaques

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102135
  
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Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

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1. scibot 20 May 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617599/
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115728
  
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SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074670/
Apr 2025
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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115572
  
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NF-κB signaling directs a program of transient amplifications at innate immune response genes

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1. scibot 18 Apr 2025
  
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  DOI: 10.1101/2025.03.11.641929
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11952383/
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Herpes simplex virus 1 encodes a STING antagonist that can be therapeutically targeted

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1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.xcrm.2025.102051
  
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sciencedirect.com/science/article/pii/S2666379125001247
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TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

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1. scibot 13 Apr 2025
  
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  DOI: 10.1038/s44319-025-00444-2
  
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embopress.org/doi/10.1038/s44319-025-00444-2
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The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

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1. scibot 11 Apr 2025
  
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  DOI: 10.1038/s41556-025-01653-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12081312/
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.005
  
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1097276525002011
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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0834
  
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52.53.155.43/b8eb1cd1446295bdd52d11650093cdf439d34361/PDF-html.html
Mar 2025
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Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115481
  
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sciencedirect.com/science/article/pii/S2211124725002529
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1. scibot 24 Mar 2025
  
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52.53.155.43/089c935c8b8375c73eca3bfe64a1d2170a0cdb88/PDF-html.html
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.014
  
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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115397
  
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Feb 2025
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E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115276
  
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.cell.2025.01.027
  
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Jan 2025
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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.cmet.2024.11.014
  
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BPS Publications

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1. scibot 05 Jan 2025
  
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  DOI: 10.1111/bph.17425
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.17425
Dec 2024
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Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115115
  
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115104
  
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The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

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1. scibot 17 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.017
  
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Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115048
  
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Nov 2024
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Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-0134
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
Oct 2024
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Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.cell.2024.09.024
  
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Aug 2024
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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114608
  
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Jul 2024
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A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.07.003
  
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance

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PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection

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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism

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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers

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The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity

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TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

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N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation

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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

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Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation

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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

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Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

1
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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

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Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

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Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation

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Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products

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Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape

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SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing

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Regulation of STING activity in DNA sensing by ISG15 modification

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TAK1 is an essential kinase for STING trafficking

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ccr-23-0103-html.html

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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

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XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility

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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility

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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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ccr-23-0103-html.html

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Jul 2023
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ccr-23-0103-html.html

1
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Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

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Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production

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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

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The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

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Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses

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Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation

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ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer

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STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion

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The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus

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Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling

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Cancer cell-derived type I interferons instruct tumor monocyte polarization

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Mitochondrial cristae architecture protects against mtDNA release and inflammation

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LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway

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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

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Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity

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Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS

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cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

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May 2022
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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

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DDX41 is required for cGAS-STING activation against DNA virus infection

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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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Protocol to induce and assess cGAS-STING pathway activation in vitro

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Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

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A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis

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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

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MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

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TBK1-METTL3 axis facilitates antiviral immunity

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The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation

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Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA

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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia

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FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer

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Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

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Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

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InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity

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Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

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Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation

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Translation stress and collided ribosomes are co-activators of cGAS

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Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

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TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology

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Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation

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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

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Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

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Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

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Evasion of type-I interferon by SARS-CoV-2

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Disruption of DNA polymerase ζ engages an innate immune response

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MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling

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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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Evasion of type-I interferon by SARS-CoV-2

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Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity

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Reactive oxygen species oxidize STING and suppress interferon production

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  DOI: 10.7554/eLife.57837
  
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ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

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PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

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  DOI: 10.7554/eLife.60637
  
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1

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Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

1
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  RRID:AB_2255663
  
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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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  DOI: 10.1016/j.ccell.2019.11.003
  
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Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

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Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I

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PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

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Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus

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Untitled document

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  DOI: 10.1016/j.cell.2019.03.046
  
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onlinelibrary.wiley.com onlinelibrary.wiley.com

TNF‐α Upregulates IKKε Expression via the Lin28B/let‐7a Pathway to Induce Catecholamine Resistance in Adipocytes

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  DOI: 10.1002/oby.22434
  
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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.029
  
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Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

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  DOI: 10.1016/j.cell.2019.01.039
  
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Nov 2018
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Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

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Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

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Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses

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Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression

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Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

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