139 Matching Annotations
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    1. scibot 26 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824001284
  3. Mar 2024
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    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    sciencedirect.com/science/article/pii/S2211124724002730
  5. Feb 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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    1. scibot 21 Feb 2024
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      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  7. Jan 2024
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    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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    1. scibot 19 Jan 2024
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    sciencedirect.com/science/article/pii/S2589004224000294
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276523010298
  10. Nov 2023
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
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    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
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    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
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    Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products
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    1. scibot 02 Nov 2023
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    sciencedirect.com/science/article/abs/pii/S0003986123003077
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    Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape
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  16. Oct 2023
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    SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing
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    1. scibot 28 Oct 2023
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    Regulation of STING activity in DNA sensing by ISG15 modification
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    1. scibot 27 Oct 2023
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    TAK1 is an essential kinase for STING trafficking
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  20. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
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    1. scibot 07 Oct 2023
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  21. Sep 2023
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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  23. Aug 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
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      DOI: 10.1126/sciadv.adg5211

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    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
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    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
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  27. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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  28. 52.53.155.43 52.53.155.43
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  29. Jul 2023
  30. 52.53.155.43 52.53.155.43
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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    Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production
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  33. Jun 2023
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    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    sciencedirect.com/science/article/pii/S2589004223011677
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    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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    sciencedirect.com/science/article/pii/S0092867423005913
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    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001733
  39. May 2023
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    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
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    sciencedirect.com/science/article/pii/S2589004223008350
  41. Apr 2023
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    sciencedirect.com/science/article/pii/S2666379123001349
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    Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
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    sciencedirect.com/science/article/pii/S2589004223006909
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    sciencedirect.com/science/article/pii/S1534580723001314
  45. Mar 2023
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    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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    sciencedirect.com/science/article/pii/S1074761323000894
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    sciencedirect.com/science/article/pii/S2211124723003170
  48. europepmc.org europepmc.org
    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
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      DOI: 10.1016/j.celrep.2023.112275

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    europepmc.org/article/med/36943864
  49. Dec 2022
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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      DOI: 10.1016/j.chembiol.2022.11.012

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    sciencedirect.com/science/article/pii/S2451945622004184
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    sciencedirect.com/science/article/pii/S2211124722016527
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    Mitochondrial cristae architecture protects against mtDNA release and inflammation
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      DOI: 10.1016/j.celrep.2022.111774

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    sciencedirect.com/science/article/pii/S2211124722016576
  53. Nov 2022
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    LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
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  58. Oct 2022
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    Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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  61. Sep 2022
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    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
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  63. Aug 2022
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    DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
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  65. Jul 2022
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  68. Jun 2022
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    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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  71. May 2022
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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  77. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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  79. Mar 2022
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    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  82. Feb 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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    The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  89. Dec 2021
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    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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  91. Nov 2021
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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  94. Aug 2021
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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  108. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  111. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
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  113. www.nature.com www.nature.com
    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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  114. Jun 2021
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    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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    Translation stress and collided ribosomes are co-activators of cGAS
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  117. May 2021
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    Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation
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  125. Apr 2021
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    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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      rabbit anti‐TBK1

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    Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation
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  130. Mar 2021
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    Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback
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  132. Feb 2021
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    Evasion of type-I interferon by SARS-CoV-2
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    Disruption of DNA polymerase ζ engages an innate immune response
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  135. Jan 2021
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    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
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    The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling
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  138. Oct 2020
  139. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    Evasion of type-I interferon by SARS-CoV-2
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  141. Sep 2020
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    Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
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    Reactive oxygen species oxidize STING and suppress interferon production
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    ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway
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    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages
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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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  151. Jan 2020
  152. www.sciencedirect.com www.sciencedirect.com
    Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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  155. www.sciencedirect.com www.sciencedirect.com
    Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
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  156. www.sciencedirect.com www.sciencedirect.com
    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
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      DOI: 10.1016/j.celrep.2019.07.081

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  157. www.sciencedirect.com www.sciencedirect.com
    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
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      DOI: 10.1016/j.celrep.2019.08.085

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  158. www.sciencedirect.com www.sciencedirect.com
    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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      DOI: 10.1016/j.immuni.2019.11.015

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  159. www.sciencedirect.com www.sciencedirect.com
    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
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      DOI: 10.1016/j.celrep.2019.04.071

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  160. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.cell.2019.03.046

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  161. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TNF‐α Upregulates IKKε Expression via the Lin28B/let‐7a Pathway to Induce Catecholamine Resistance in Adipocytes
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      DOI: 10.1002/oby.22434

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  162. www.sciencedirect.com www.sciencedirect.com
    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      DOI: 10.1016/j.molcel.2019.05.006

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  163. www.sciencedirect.com www.sciencedirect.com
    NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
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      DOI: 10.1016/j.chom.2019.02.013

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  166. www.sciencedirect.com www.sciencedirect.com
    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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      DOI: 10.1016/j.cell.2019.01.039

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  167. Nov 2018
  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
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  169. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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  170. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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  172. www.sciencedirect.com www.sciencedirect.com
    Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
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    sciencedirect.com/science/article/pii/S1074761318300931
  173. Nov 2017
  174. www.sciencedirect.com www.sciencedirect.com
    Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
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      Curator: @chewbeccax

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  175. www.sciencedirect.com www.sciencedirect.com
    Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression
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      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S193459091630457X
  176. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
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      AB_2255663

      Curator: @Zeljana_Babic

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