85 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114119

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    sciencedirect.com/science/article/pii/S2211124724004479
  3. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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    1. scibot 05 Apr 2024
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      DOI: 10.1186/s12958-024-01204-y

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  4. Mar 2024
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
    2
    1. scibot 06 Mar 2024
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    sciencedirect.com/science/article/pii/S1550413124000500
  6. Jan 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    1. scibot 23 Jan 2024
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      DOI: 10.1126/sciadv.adk6524

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.isci.2023.108733

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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    1. scibot 18 Jan 2024
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      DOI: 10.1016/j.isci.2023.108725

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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
  10. Dec 2023
  11. www.sciencedirect.com www.sciencedirect.com
    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
    1
    1. scibot 21 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015309
  12. Sep 2023
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos
    1
    1. scibot 23 Sep 2023
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      DOI: 10.1016/j.xpro.2023.102569

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    ncbi.nlm.nih.gov/pmc/articles/PMC10509694/
  14. Aug 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
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    1. scibot 26 Aug 2023
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      DOI: 10.1016/j.isci.2023.107465

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    ncbi.nlm.nih.gov/pmc/articles/PMC10433125/
  16. Jun 2023
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    Identification of XAF1 as an endogenous AKT inhibitor
    1
    1. scibot 29 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112690

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    sciencedirect.com/science/article/pii/S2211124723007015
  18. 52.53.155.43 52.53.155.43
    Pregnancy-associated steroid effects on insulin sensitivity, adipogenesis and lipogenesis: Role of Wnt/β-catenin pathway
    1
    1. scibot 15 Jun 2023
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      DOI: 10.1210/jendso/bvad076

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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway
    1
    1. scibot 10 Jun 2023
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      DOI: 10.1083/jcb.202208108

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    ncbi.nlm.nih.gov/pmc/articles/PMC9735414/
  20. academic.oup.com academic.oup.com
    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1210/endocr/bqad045

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    academic.oup.com/endo/article/164/6/bqad045/7079002
  21. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16080

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  22. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16073

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16073
  23. Apr 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
    1
    1. scibot 09 Apr 2023
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      DOI: 10.7554/eLife.78629

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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
  25. Feb 2023
  26. www.sciencedirect.com www.sciencedirect.com
    β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence
    1
    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.mito.2022.12.004

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    sciencedirect.com/science/article/pii/S1567724922001088
  27. Jan 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
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    1. scibot 20 Jan 2023
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      DOI: 10.1158/0008-5472.CAN-21-3217

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    ncbi.nlm.nih.gov/pmc/articles/PMC9298960/
  29. Dec 2022
  30. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
    1
    1. scibot 24 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111834

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    sciencedirect.com/science/article/pii/S2211124722017260
  31. Nov 2022
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
    1
    1. scibot 18 Nov 2022
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      DOI: 10.1016/j.isci.2022.105458

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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  33. Oct 2022
  34. www.sciencedirect.com www.sciencedirect.com
    En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
    1
    1. scibot 18 Oct 2022
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      DOI: 10.1016/j.cell.2022.09.031

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    sciencedirect.com/science/article/pii/S0092867422012508
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    KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice
    1
    1. scibot 11 Oct 2022
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      DOI: 10.1016/j.devcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1534580722006372
  36. Aug 2022
  37. www.sciencedirect.com www.sciencedirect.com
    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
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    1. scibot 27 Aug 2022
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      DOI: 10.1016/j.heliyon.2022.e10371

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    sciencedirect.com/science/article/pii/S2405844022016590
  38. www.sciencedirect.com www.sciencedirect.com
    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    1. scibot 22 Aug 2022
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      DOI: 10.1016/j.ccell.2022.07.011

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    sciencedirect.com/science/article/pii/S1535610822003245
  39. Jun 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
    1
    1. scibot 24 Jun 2022
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      DOI: 10.1016/j.cell.2022.05.021

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    sciencedirect.com/science/article/pii/S0092867422006523
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
    1
    1. scibot 07 Jun 2022
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      DOI: 10.1158/2159-8290.CD-21-0209

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  42. Feb 2022
  43. www.sciencedirect.com www.sciencedirect.com
    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    1. scibot 23 Feb 2022
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      DOI: 10.1016/j.molcel.2022.01.022

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    sciencedirect.com/science/article/pii/S1097276522000879
  44. Jan 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Acetylation-dependent regulation of BRAF oncogenic function
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    1. scibot 19 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110250

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    sciencedirect.com/science/article/pii/S2211124721017629
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    Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance
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    1. scibot 13 Jan 2022
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      DOI: 10.1016/j.cmet.2021.12.013

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    sciencedirect.com/science/article/pii/S155041312100632X
  47. Dec 2021
  48. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
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    1. scibot 30 Dec 2021
      RRID:AB_2255933

      DOI: 10.1016/j.isci.2021.103645

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    sciencedirect.com/science/article/pii/S2589004221016151
  49. Oct 2021
  50. www.sciencedirect.com www.sciencedirect.com
    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    1. scibot 06 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109785

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    sciencedirect.com/science/article/pii/S2211124721012444
  51. Aug 2021
  52. www.sciencedirect.com www.sciencedirect.com
    An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver
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      DOI: 10.1016/j.celrep.2021.109569

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    sciencedirect.com/science/article/pii/S2211124721010032
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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      AB_2255933

      DOI: 10.4103/aja.aja_126_18

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    ncbi.nlm.nih.gov/pmc/articles/PMC6628733/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.1016/j.celrep.2018.11.045

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    ncbi.nlm.nih.gov/pmc/articles/PMC6293966/
  55. Jul 2021
  56. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 30 Jul 2021
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      DOI: 10.1002/brb3.1123

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      DOI: 10.1002/brb3.1123

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    onlinelibrary.wiley.com/doi/full/10.1002/brb3.1123
  57. academic.oup.com academic.oup.com
    Selective androgen receptor modulator S42 suppresses prostate cancer cell proliferation
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    1. scibot 29 Jul 2021
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      DOI: 10.1210/en.2018-00099

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      AB_2255933u00a0

      DOI: 10.1210/en.2018-00099

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    academic.oup.com/endo/article/159/4/1774/4850601
  58. www.sciencedirect.com www.sciencedirect.com
    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    1. scibot 14 Jul 2021
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      DOI: 10.1016/j.isci.2021.102724

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    sciencedirect.com/science/article/pii/S2589004221006921
  59. May 2021
  60. journals.plos.org journals.plos.org
    The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism
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      Phospho-AKT Thr308

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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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      RRID:AB_2255933
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    academic.oup.com/endo/article/158/12/4218/4460061
  108. Nov 2017
  109. f1000research.com f1000research.com
    Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity
    1
    1. scibot 08 Nov 2017
      RRID:AB_2255933

      Curator: @patriciaelyse_

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      (Cell Signaling Technology Cat# 2965, RRID:AB_2255933)

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      RRID:AB_2255933 RRIDCUR:Validated
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    f1000research.com/articles/6-1600
  110. academic.oup.com academic.oup.com
    Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice
    1
    1. scibot 08 Nov 2017
      AB_2255933

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 2965, RRID:AB_2255933)

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      RRID:AB_2255933 RRIDCUR:Validated
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    academic.oup.com/endo/article/158/8/2659/3814633/Effects-of-the-Activation-of-Three-Major-Hepatic
  111. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      CSTCat#2965

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2965, RRID:AB_2255933)

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      RRID:AB_2255933
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    sciencedirect.com/science/article/pii/S1074761317302339
  112. www.sciencedirect.com www.sciencedirect.com
    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
    1
    1. scibot 08 Nov 2017
      AB_2255933

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 2965, RRID:AB_2255933)

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      RRID:AB_2255933 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276516308991
  113. www.sciencedirect.com www.sciencedirect.com
    TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1
    1
    1. scibot 08 Nov 2017
      rabbit anti-phospho-Akt (Thr308) monoclonal antibody (1:1500 dilution; Cell Signaling Technology #2965

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 2965, RRID:AB_2255933)

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      RRID:AB_2255933 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0167488916302087