91 Matching Annotations
  1. Sep 2024
  2. www.sciencedirect.com www.sciencedirect.com
    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    sciencedirect.com/science/article/pii/S2589004224021059
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    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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    1. scibot 05 Sep 2024
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      DOI: 10.1016/j.immuni.2024.08.008

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    sciencedirect.com/science/article/pii/S1074761324004072
  4. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    sciencedirect.com/science/article/pii/S2211124724010143
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    M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival
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    1. scibot 02 Aug 2024
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    tandfonline.com/doi/full/10.1080/15548627.2021.1938912
  7. May 2024
  8. www.cell.com www.cell.com
    Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion
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    1. scibot 30 May 2024
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    cell.com/cell-reports/abstract/S2211-1247(24)00611-9
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    Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation
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      Cell SignallingCat# 2965S

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    sciencedirect.com/science/article/pii/S1074761324002280
  10. Apr 2024
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    sciencedirect.com/science/article/pii/S2211124724004479
  12. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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  13. Mar 2024
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    sciencedirect.com/science/article/pii/S1550413124000500
  15. Jan 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    1. scibot 23 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    1. scibot 20 Jan 2024
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    1. scibot 18 Jan 2024
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  19. Dec 2023
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    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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    1. scibot 21 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015309
  21. Sep 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos
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    1. scibot 23 Sep 2023
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      DOI: 10.1016/j.xpro.2023.102569

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    ncbi.nlm.nih.gov/pmc/articles/PMC10509694/
  23. Aug 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
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    1. scibot 26 Aug 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10433125/
  25. Jun 2023
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    Identification of XAF1 as an endogenous AKT inhibitor
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    sciencedirect.com/science/article/pii/S2211124723007015
  27. 52.53.155.43 52.53.155.43
    Pregnancy-associated steroid effects on insulin sensitivity, adipogenesis and lipogenesis: Role of Wnt/β-catenin pathway
    1
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      DOI: 10.1210/jendso/bvad076

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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway
    1
    1. scibot 10 Jun 2023
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      DOI: 10.1083/jcb.202208108

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    ncbi.nlm.nih.gov/pmc/articles/PMC9735414/
  29. academic.oup.com academic.oup.com
    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
    1
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      RRID:AB_2255933

      DOI: 10.1210/endocr/bqad045

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    academic.oup.com/endo/article/164/6/bqad045/7079002
  30. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16080

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  31. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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      DOI: 10.1111/bph.16073

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16073
  32. Apr 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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      DOI: 10.7554/eLife.78629

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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
  34. Feb 2023
  35. www.sciencedirect.com www.sciencedirect.com
    β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence
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      DOI: 10.1016/j.mito.2022.12.004

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    sciencedirect.com/science/article/pii/S1567724922001088
  36. Jan 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
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      DOI: 10.1158/0008-5472.CAN-21-3217

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    ncbi.nlm.nih.gov/pmc/articles/PMC9298960/
  38. Dec 2022
  39. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    1. scibot 24 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111834

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    sciencedirect.com/science/article/pii/S2211124722017260
  40. Nov 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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      DOI: 10.1016/j.isci.2022.105458

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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  42. Oct 2022
  43. www.sciencedirect.com www.sciencedirect.com
    En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
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      DOI: 10.1016/j.cell.2022.09.031

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    sciencedirect.com/science/article/pii/S0092867422012508
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    KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice
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      DOI: 10.1016/j.devcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1534580722006372
  45. Aug 2022
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    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
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      DOI: 10.1016/j.heliyon.2022.e10371

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    sciencedirect.com/science/article/pii/S2405844022016590
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    sciencedirect.com/science/article/pii/S1535610822003245
  48. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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      DOI: 10.1016/j.cell.2022.05.021

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    sciencedirect.com/science/article/pii/S0092867422006523
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    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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      DOI: 10.1158/2159-8290.CD-21-0209

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  51. Feb 2022
  52. www.sciencedirect.com www.sciencedirect.com
    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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      DOI: 10.1016/j.molcel.2022.01.022

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    sciencedirect.com/science/article/pii/S1097276522000879
  53. Jan 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Acetylation-dependent regulation of BRAF oncogenic function
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    sciencedirect.com/science/article/pii/S2211124721017629
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    Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance
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      DOI: 10.1016/j.cmet.2021.12.013

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    sciencedirect.com/science/article/pii/S155041312100632X
  56. Dec 2021
  57. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
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      DOI: 10.1016/j.isci.2021.103645

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    sciencedirect.com/science/article/pii/S2589004221016151
  58. Oct 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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      DOI: 10.1016/j.celrep.2021.109785

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    sciencedirect.com/science/article/pii/S2211124721012444
  60. Aug 2021
  61. www.sciencedirect.com www.sciencedirect.com
    An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver
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      DOI: 10.1016/j.celrep.2021.109569

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    sciencedirect.com/science/article/pii/S2211124721010032
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    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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    sciencedirect.com/science/article/pii/S0092867418300412
  111. www.sciencedirect.com www.sciencedirect.com
    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
    1
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      RRID:AB_2255933

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    sciencedirect.com/science/article/pii/S1097276518301084
  112. www.sciencedirect.com www.sciencedirect.com
    Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress
    1
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      RRID:AB_2255933

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    sciencedirect.com/science/article/pii/S1934590918301644
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
    1
    1. scibot 05 Nov 2018
      RRID:AB_2255933

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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
    1
    1. scibot 05 Nov 2018
      rabbit anti-p-AKT (T308) (1:2000, Cell Signaling #2965)

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5824782/
  115. www.sciencedirect.com www.sciencedirect.com
    Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_2255933

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    sciencedirect.com/science/article/pii/S1534580717307359
  116. academic.oup.com academic.oup.com
    Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation
    1
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      AB_2255933

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    academic.oup.com/endo/article/158/12/4218/4460061
  117. Nov 2017
  118. f1000research.com f1000research.com
    Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity
    1
    1. scibot 08 Nov 2017
      RRID:AB_2255933

      Curator: @patriciaelyse_

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    f1000research.com/articles/6-1600
  119. academic.oup.com academic.oup.com
    Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice
    1
    1. scibot 08 Nov 2017
      AB_2255933

      Curator: @kaitlinsung

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    academic.oup.com/endo/article/158/8/2659/3814633/Effects-of-the-Activation-of-Three-Major-Hepatic
  120. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      CSTCat#2965

      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S1074761317302339
  121. www.sciencedirect.com www.sciencedirect.com
    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
    1
    1. scibot 08 Nov 2017
      AB_2255933

      Curator: @kaitlinsung

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      RRID:AB_2255933 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276516308991
  122. www.sciencedirect.com www.sciencedirect.com
    TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1
    1
    1. scibot 08 Nov 2017
      rabbit anti-phospho-Akt (Thr308) monoclonal antibody (1:1500 dilution; Cell Signaling Technology #2965

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S0167488916302087