44 Matching Annotations
  1. Jun 2026
  2. www.biorxiv.org www.biorxiv.org
    SMAD4 loss drives cancer chromosomal instability through transcription-replication conflict-induced replication stress
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    biorxiv.org/content/10.64898/2025.12.17.694873v1
  3. Oct 2025
  4. www.science.org www.science.org
    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    science.org/doi/10.1126/sciadv.adw4618
  5. Jul 2025
  6. www.nature.com www.nature.com
    Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases
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    nature.com/articles/s41419-025-07812-9
  7. Apr 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996177/
  9. Sep 2024
  10. www.sciencedirect.com www.sciencedirect.com
    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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    sciencedirect.com/science/article/pii/S0092867424009115
  11. Aug 2024
  12. www.embopress.org www.embopress.org
    DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
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    embopress.org/doi/full/10.15252/embr.202153658
  13. Apr 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
  15. Jan 2024
  16. www.sciencedirect.com www.sciencedirect.com
    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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    sciencedirect.com/science/article/pii/S1097276523010869
  17. www.sciencedirect.com www.sciencedirect.com
    Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair
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    sciencedirect.com/science/article/pii/S2211124723016674
  18. Dec 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells
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    sciencedirect.com/science/article/pii/S2451945623004233
  20. Jul 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    sciencedirect.com/science/article/pii/S1097276523004720
  22. 52.53.155.43 52.53.155.43
    GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner
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    52.53.155.43/82562d81b2014f2e2d5c134f5e9ab42cec01f29a/embr.202256437-html.html
  23. Apr 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
  25. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    science.org/doi/10.1126/sciadv.ade7997
  26. Mar 2023
  27. www.sciencedirect.com www.sciencedirect.com
    HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
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    sciencedirect.com/science/article/pii/S2211124723002954
  28. Aug 2022
  29. www.sciencedirect.com www.sciencedirect.com
    RAD51 protects human cells from transcription-replication conflicts
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    sciencedirect.com/science/article/pii/S1097276522007067
  30. Apr 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
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    sciencedirect.com/science/article/pii/S2589004222004126
  32. www.sciencedirect.com www.sciencedirect.com
    MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
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    sciencedirect.com/science/article/pii/S2211124722003503
  33. Mar 2022
  34. www.embopress.org www.embopress.org
    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    embopress.org/doi/abs/10.15252/embj.2021110145
  35. www.sciencedirect.com www.sciencedirect.com
    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    sciencedirect.com/science/article/pii/S153458072200079X
  36. Dec 2021
  37. www.sciencedirect.com www.sciencedirect.com
    Assessing kinetics and recruitment of DNA repair factors using high content screens
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    sciencedirect.com/science/article/pii/S2211124721016764
  38. www.sciencedirect.com www.sciencedirect.com
    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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    sciencedirect.com/science/article/pii/S2211124721015710
  39. Aug 2021
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5426901/
  41. Feb 2021
  42. www.sciencedirect.com www.sciencedirect.com
    AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
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    sciencedirect.com/science/article/pii/S2211124721000267
  43. Jan 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
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    sciencedirect.com/science/article/pii/S2211124720316697
  45. Nov 2020
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC7671687/
  47. Sep 2020
  48. www.sciencedirect.com www.sciencedirect.com
    The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
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    sciencedirect.com/science/article/pii/S2211124720309700
  49. Jan 2020
  50. www.sciencedirect.com www.sciencedirect.com
    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    sciencedirect.com/science/article/pii/S2211124719314834
  51. www.sciencedirect.com www.sciencedirect.com
    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    sciencedirect.com/science/article/pii/S1097276519305003
  52. www.sciencedirect.com www.sciencedirect.com
    Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer
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    sciencedirect.com/science/article/pii/S0092867419306300
  53. www.sciencedirect.com www.sciencedirect.com
    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    sciencedirect.com/science/article/pii/S1097276519308044
  54. www.embopress.org www.embopress.org
    The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
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    embopress.org/doi/10.15252/embj.2019102361
  55. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1097276518310062
  56. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1097276519301042
  57. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124719301706
  58. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1097276519303168
  59. Nov 2018
  60. www.sciencedirect.com www.sciencedirect.com
    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    sciencedirect.com/science/article/pii/S1097276518307858
  61. www.sciencedirect.com www.sciencedirect.com
    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
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    sciencedirect.com/science/article/pii/S1097276518301424
  62. Nov 2017
  63. www.sciencedirect.com www.sciencedirect.com
    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    sciencedirect.com/science/article/pii/S1097276517306184
  64. www.sciencedirect.com www.sciencedirect.com
    A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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    sciencedirect.com/science/article/pii/S1535610817303549
  65. www.sciencedirect.com www.sciencedirect.com
    Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug
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    sciencedirect.com/science/article/pii/S2405471217303319
  66. www.sciencedirect.com www.sciencedirect.com
    RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
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    sciencedirect.com/science/article/pii/S1097276517303192
  67. www.sciencedirect.com www.sciencedirect.com
    NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
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    sciencedirect.com/science/article/pii/S1097276517300424