Hypothesis

29 Matching Annotations

Sep 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225018139-main-html.html

1
1. scibot 13 Sep 2025
  
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  AB_2258110
  
  DOI: 10.1016
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
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52.53.155.43/253550384e171aeac03650972660e6e19e7d73f6/1-s2.0-S2589004225018139-main-html.html
Jul 2025
www.science.org www.science.org

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

1
1. scibot 25 Jul 2025
  
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  RRID:AB_2258110
  
  DOI: 10.1126/science.adm9805
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
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science.org/doi/10.1126/science.adm9805
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

1
1. scibot 16 May 2025
  
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  RRID:AB_2258110
  
  DOI: 10.1158/0008-5472.CAN-24-2220
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @evieth
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

1
1. scibot 10 Dec 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.cell.2024.11.009
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
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sciencedirect.com/science/article/pii/S0092867424013266
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

High fat diet induced hepatic insulin resistance per se attenuates murine de novo lipogenesis

1
1. scibot 14 Nov 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.isci.2024.111175
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11550620/
Oct 2024
www.sciencedirect.com www.sciencedirect.com

Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

1
1. scibot 02 Oct 2024
  
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  AB_2258110
  
  DOI: 10.1016/j.xcrm.2024.101752
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
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sciencedirect.com/science/article/pii/S2666379124004828
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts

1
1. scibot 05 Sep 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1158/2767-9764.CRC-24-0020
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 21 Aug 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
Jul 2024
www.science.org www.science.org

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 18 Jul 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
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science.org/doi/10.1126/science.adk0775
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling

2
1. scibot 25 Jan 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1126/sciadv.adi2012
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110
2. scibot 23 Jan 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1126/sciadv.adi2012
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
www.sciencedirect.com www.sciencedirect.com

Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

1
1. scibot 11 Jan 2024
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.jbc.2024.105641
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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sciencedirect.com/science/article/pii/S0021925824000176
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity

1
1. scibot 07 Jun 2022
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.isci.2022.104410
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9156944/
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Translational and post-translational control of human naïve versus primed pluripotency

1
1. scibot 30 Dec 2021
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.isci.2021.103645
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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sciencedirect.com/science/article/pii/S2589004221016151
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

1
1. scibot 04 Aug 2021
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.cmet.2021.07.010
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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sciencedirect.com/science/article/pii/S1550413121003260
May 2021
www.sciencedirect.com www.sciencedirect.com

Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

1
1. scibot 19 May 2021
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.celrep.2021.109128
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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sciencedirect.com/science/article/pii/S2211124721004678
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

1
1. scibot 11 Apr 2021
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.molcel.2021.01.033
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2258110
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
Oct 2020
www.sciencedirect.com www.sciencedirect.com

The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

1
1. scibot 08 Oct 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.celrep.2020.108223
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S2211124720312122
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.cell.2020.05.053
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRIDCUR:Validated RRID:AB_2258110
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scibot

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sciencedirect.com/science/article/pii/S0092867420306863
onlinelibrary.wiley.com onlinelibrary.wiley.com

Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

1
1. scibot 16 Sep 2020
  
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  AB_2258110
  
  DOI: 10.1111/jnc.14979
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/10.1111/jnc.14979
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

1
1. scibot 11 Sep 2020
  
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  AB_2258110
  
  DOI: 10.1096/fj.201902305R
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

1
1. scibot 03 Sep 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.cell.2020.02.019
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110
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cell.com/cell/fulltext/S0092-8674(20)30163-X
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.molcel.2019.07.023
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519305532
www.sciencedirect.com www.sciencedirect.com

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.chembiol.2019.11.014
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945619303964
www.sciencedirect.com www.sciencedirect.com

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.celrep.2019.11.016
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719314871
www.sciencedirect.com www.sciencedirect.com

Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.cels.2019.11.005
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2405471219303916
www.sciencedirect.com www.sciencedirect.com

New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2258110
  
  DOI: 10.1016/j.ebiom.2019.03.014
  
  Resource: (Cell Signaling Technology Cat# 2997, RRID:AB_2258110)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2258110
  
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  RRID:AB_2258110 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2352396419301549
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2258110
  
  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 2997S, RRID:AB_2258110)
  
  SciCrunch record: RRID:AB_2258110
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2258110 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413118305783
www.sciencedirect.com www.sciencedirect.com

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2258110
  
  Resource used:
  
  (Cell Signaling Technology Cat# 2997S, RRID:AB_2258110)
  
  SciCrunch record: RRID:AB_2258110
  
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sciencedirect.com/science/article/pii/S1550413117306204