25 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High fat diet induced hepatic insulin resistance per se attenuates murine de novo lipogenesis
    1
    1. scibot 14 Nov 2024
      RRID:AB_2258110

      DOI: 10.1016/j.isci.2024.111175

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    pmc.ncbi.nlm.nih.gov/articles/PMC11550620/
  3. Oct 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.xcrm.2024.101752

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    sciencedirect.com/science/article/pii/S2666379124004828
  5. Sep 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
    1
    1. scibot 05 Sep 2024
      RRID:AB_2258110

      DOI: 10.1158/2767-9764.CRC-24-0020

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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  7. Aug 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 21 Aug 2024
      RRID:AB_2258110

      DOI: 10.1126/science.adk0775

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  9. Jul 2024
  10. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 18 Jul 2024
      RRID:AB_2258110

      DOI: 10.1126/science.adk0775

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    science.org/doi/10.1126/science.adk0775
  11. Jan 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
    2
    1. scibot 25 Jan 2024
      RRID:AB_2258110

      DOI: 10.1126/sciadv.adi2012

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    2. scibot 23 Jan 2024
      RRID:AB_2258110

      DOI: 10.1126/sciadv.adi2012

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
  13. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
      RRID:AB_2258110

      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  14. Jun 2022
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity
    1
    1. scibot 07 Jun 2022
      RRID:AB_2258110

      DOI: 10.1016/j.isci.2022.104410

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    ncbi.nlm.nih.gov/pmc/articles/PMC9156944/
  16. Dec 2021
  17. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
    1
    1. scibot 30 Dec 2021
      RRID:AB_2258110

      DOI: 10.1016/j.isci.2021.103645

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    sciencedirect.com/science/article/pii/S2589004221016151
  18. Aug 2021
  19. www.sciencedirect.com www.sciencedirect.com
    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
    1
    1. scibot 04 Aug 2021
      RRID:AB_2258110

      DOI: 10.1016/j.cmet.2021.07.010

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    sciencedirect.com/science/article/pii/S1550413121003260
  20. May 2021
  21. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
    1
    1. scibot 19 May 2021
      RRID:AB_2258110

      DOI: 10.1016/j.celrep.2021.109128

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    sciencedirect.com/science/article/pii/S2211124721004678
  22. Apr 2021
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
    1
    1. scibot 11 Apr 2021
      RRID:AB_2258110

      DOI: 10.1016/j.molcel.2021.01.033

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    ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
  24. Oct 2020
  25. www.sciencedirect.com www.sciencedirect.com
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
    1
    1. scibot 08 Oct 2020
      RRID:AB_2258110

      DOI: 10.1016/j.celrep.2020.108223

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    sciencedirect.com/science/article/pii/S2211124720312122
  26. Sep 2020
  27. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
    1
    1. scibot 17 Sep 2020
      RRID:AB_2258110

      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
    1
    1. scibot 16 Sep 2020
      AB_2258110

      DOI: 10.1111/jnc.14979

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14979
  29. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
    1
    1. scibot 11 Sep 2020
      AB_2258110

      DOI: 10.1096/fj.201902305R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
  30. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
    1
    1. scibot 03 Sep 2020
      RRID:AB_2258110

      DOI: 10.1016/j.cell.2020.02.019

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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  31. Jan 2020
  32. www.sciencedirect.com www.sciencedirect.com
    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
    1
    1. scibot 13 Jan 2020
      RRID:AB_2258110

      DOI: 10.1016/j.molcel.2019.07.023

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    sciencedirect.com/science/article/pii/S1097276519305532
  33. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
    1
    1. scibot 13 Jan 2020
      RRID:AB_2258110

      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
  34. www.sciencedirect.com www.sciencedirect.com
    PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_2258110

      DOI: 10.1016/j.celrep.2019.11.016

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    sciencedirect.com/science/article/pii/S2211124719314871
  35. www.sciencedirect.com www.sciencedirect.com
    Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis
    1
    1. scibot 13 Jan 2020
      RRID:AB_2258110

      DOI: 10.1016/j.cels.2019.11.005

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    sciencedirect.com/science/article/pii/S2405471219303916
  36. www.sciencedirect.com www.sciencedirect.com
    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
    1
    1. scibot 13 Jan 2020
      RRID:AB_2258110

      DOI: 10.1016/j.ebiom.2019.03.014

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    sciencedirect.com/science/article/pii/S2352396419301549
  37. Nov 2018
  38. www.sciencedirect.com www.sciencedirect.com
    Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
    1
    1. scibot 05 Nov 2018
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1550413118305783
  39. www.sciencedirect.com www.sciencedirect.com
    Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
    1
    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1550413117306204