34 Matching Annotations
  1. Apr 2026
  2. aacrjournals.org aacrjournals.org
    Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer
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    aacrjournals.org/mct/article/25/4/662/776472/Targeting-Tumor-Microenvironment-Derived-NRG1-HER2
  3. Feb 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Leveraging menstrual effluent (ME) to investigate vitamin D and human decidualization, a potential link with fertility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12933435/
  5. Jan 2026
  6. www.sciencedirect.com www.sciencedirect.com
    Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
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    sciencedirect.com/science/article/pii/S2666379125006512
  7. Nov 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
  9. Oct 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12508894/
  11. Sep 2025
  12. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225018139-main-html.html
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    52.53.155.43/253550384e171aeac03650972660e6e19e7d73f6/1-s2.0-S2589004225018139-main-html.html
  13. Jul 2025
  14. www.science.org www.science.org
    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
  15. May 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  17. Dec 2024
  18. www.sciencedirect.com www.sciencedirect.com
    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
  19. Nov 2024
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High fat diet induced hepatic insulin resistance per se attenuates murine de novo lipogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11550620/
  21. Oct 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    sciencedirect.com/science/article/pii/S2666379124004828
  23. Sep 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  25. Aug 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  27. Jul 2024
  28. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    science.org/doi/10.1126/science.adk0775
  29. Jan 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
  31. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0021925824000176
  32. Jun 2022
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9156944/
  34. Dec 2021
  35. www.sciencedirect.com www.sciencedirect.com
    Translational and post-translational control of human naïve versus primed pluripotency
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    sciencedirect.com/science/article/pii/S2589004221016151
  36. Aug 2021
  37. www.sciencedirect.com www.sciencedirect.com
    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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    sciencedirect.com/science/article/pii/S1550413121003260
  38. May 2021
  39. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    sciencedirect.com/science/article/pii/S2211124721004678
  40. Apr 2021
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
  42. Oct 2020
  43. www.sciencedirect.com www.sciencedirect.com
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    sciencedirect.com/science/article/pii/S2211124720312122
  44. Sep 2020
  45. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    sciencedirect.com/science/article/pii/S0092867420306863
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14979
  47. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
  48. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  49. Jan 2020
  50. www.sciencedirect.com www.sciencedirect.com
    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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    sciencedirect.com/science/article/pii/S1097276519305532
  51. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    sciencedirect.com/science/article/pii/S2451945619303964
  52. www.sciencedirect.com www.sciencedirect.com
    PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
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    sciencedirect.com/science/article/pii/S2211124719314871
  53. www.sciencedirect.com www.sciencedirect.com
    Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis
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    sciencedirect.com/science/article/pii/S2405471219303916
  54. www.sciencedirect.com www.sciencedirect.com
    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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    sciencedirect.com/science/article/pii/S2352396419301549
  55. Nov 2018
  56. www.sciencedirect.com www.sciencedirect.com
    Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
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    sciencedirect.com/science/article/pii/S1550413118305783
  57. www.sciencedirect.com www.sciencedirect.com
    Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
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    sciencedirect.com/science/article/pii/S1550413117306204