90 Matching Annotations
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    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
  3. Oct 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485380/
  5. Jul 2025
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    An in vivo screen identifies NAT10 as a master regulator of brain metastasis
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    science.org/doi/10.1126/sciadv.ads6021
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    Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
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    52.53.155.43/baf73dc4816d69ae4de3fa32641dfd7bd010d8a5/Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
  8. Jun 2025
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    An optimised Bcl-3 inhibitor for melanoma treatment
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.17467
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    Pyruvate kinase M2 (PKM2) tetramerization protects against hepatic stellate cell activation and liver fibrosis
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    sciencedirect.com/science/article/pii/S0002944020303722
  11. May 2025
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    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12055001/
  13. Apr 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11174043/
  15. Mar 2025
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    An in vivo screen identifies NAT10 as a master regulator of brain metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11939035/
  17. Jan 2025
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    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    sciencedirect.com/science/article/pii/S2451945624005166
  19. Nov 2024
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11475318/
  21. Sep 2024
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    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    link.springer.com/article/10.1007/s12035-024-04504-x
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    UA influences the progression of breast cancer via the AhR/p27Kip1/cyclin E pathway
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    sciencedirect.com/science/article/pii/S2211124724011136
  25. Aug 2024
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    BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11320024/
  27. Jul 2024
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    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293357/
  30. Jun 2024
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    Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
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    link.springer.com/article/10.1038/s41388-024-03081-6
  32. May 2024
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    Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
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    sciencedirect.com/science/article/pii/S1535610824001636
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    TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT
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  35. Apr 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
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    Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
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  38. Mar 2024
  39. www.nature.com www.nature.com
    Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
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    SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    sciencedirect.com/science/article/pii/S2211124724002031
  42. Feb 2024
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    Sphingolipid metabolism controls mammalian heart regeneration
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  44. Jan 2024
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    Mechanism of GW117 antidepressant action: melatonin receptor-mediated regulation of sleep rhythm
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  46. Dec 2023
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
  48. Nov 2023
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    Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14
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    Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124723014201
  51. Aug 2023
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    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
  53. Jul 2023
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    sciencedirect.com/science/article/pii/S2666379123002483
  55. May 2023
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    Modeling breast cancer proliferation, drug synergies, and alternating therapies
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    sciencedirect.com/science/article/pii/S2211124722008750
  58. Feb 2023
  59. aacrjournals.org aacrjournals.org
    Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
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    aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
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    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
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    Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
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  62. Jan 2023
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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  64. Nov 2022
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    Intracellular TMEM16A is necessary for myogenesis of skeletal muscle
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    Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
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  67. Sep 2022
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    TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3
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    sciencedirect.com/science/article/pii/S2211124722012529
  69. Aug 2022
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    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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  71. Jul 2022
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  74. Mar 2022
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    Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch
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  76. Dec 2021
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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    ncbi.nlm.nih.gov/pmc/articles/PMC8670743/
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    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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  79. Oct 2021
  80. mct.aacrjournals.org mct.aacrjournals.org
    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
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    Proteome-wide mapping of short-lived proteins in human cells
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  82. Sep 2021
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    Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
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  84. Aug 2021
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  86. Jul 2021
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    BPS Publications
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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    link.springer.com/article/10.1186/s40659-019-0268-x
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    Midkine promotes articular chondrocyte proliferation through the MK-LRP1-nucleolin signaling pathway
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    SARNP, a participant in mRNA splicing and export, negatively regulates E‐cadherin expression via interaction with pinin
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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.29073
  92. Jun 2021
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    Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction
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  94. May 2021
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
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    Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
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  98. Feb 2021
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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  100. Jan 2021
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    A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy
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    link.springer.com/article/10.1007/s10637-020-01042-w
  102. Nov 2020
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    p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound
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    link.springer.com/article/10.1007/s10571-020-01006-x
  104. Oct 2020
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    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  107. Sep 2020
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species‐mediated apoptosis
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    Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Long noncoding RNA SOX2OT promotes the proliferation of pancreatic cancer by binding to FUS
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    GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma
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  114. Jan 2020
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    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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    MicroRNA‐487a‐3p functions as a new tumor suppressor in prostate cancer by targeting CCND1
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    onlinelibrary.wiley.com/doi/10.1002/jcp.29078
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    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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    Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity
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    De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma
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  122. Nov 2018
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate
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    PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
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    NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis
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    Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
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    sciencedirect.com/science/article/pii/S1535610817304646
  128. academic.oup.com academic.oup.com
    Canonical Wnt/β-Catenin Signaling Regulates Postnatal Mouse Epididymal Development But Does Not Affect Epithelial Cell Differentiation
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    academic.oup.com/endo/article/158/12/4286/4344851
  129. Nov 2017
  130. www.sciencedirect.com www.sciencedirect.com
    Differential Wnt signaling activity limits epithelial gland development to the anti-mesometrial side of the mouse uterus - ScienceDirect
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    sciencedirect.com/science/article/pii/S0012160616308314
  131. www.jneurosci.org www.jneurosci.org
    TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
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    jneurosci.org/content/37/7/1772
  132. academic.oup.com academic.oup.com
    Maternal Low Protein Isocaloric Diet Suppresses Pancreatic β-Cell Proliferation in Mouse Offspring via miR-15b
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    academic.oup.com/endo/article/157/12/4782/2758433/Maternal-Low-Protein-Isocaloric-Diet-Suppresses
  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The antiviral cytokine interferon‐gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23987/full