88 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.chembiol.2024.10.008

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    sciencedirect.com/science/article/pii/S2451945624004434
  3. Sep 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
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    1. scibot 25 Sep 2024
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      DOI: 10.1038/s41417-024-00809-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11405271/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
    1
    1. scibot 18 Sep 2024
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      DOI: 10.1038/s41523-024-00687-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11401886/
  6. Jul 2024
  7. www.cell.com www.cell.com
    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.chembiol.2024.06.012

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    cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00273-3
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    Paradoxical activation of c-Src as a drug-resistant mechanism
    2
    1. scibot 03 Jul 2024
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      DOI: 10.1016/j.celrep.2021.108876

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    2. scibot 03 Jul 2024
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      DOI: 10.1016/j.celrep.2021.108876

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    sciencedirect.com/science/article/pii/S221112472100190X
  9. Jun 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization
    1
    1. scibot 13 Jun 2024
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      DOI: 10.1007/s00403-024-03032-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11161541/
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo
    1
    1. scibot 06 Jun 2024
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      DOI: 10.1002/dneu.22950

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    onlinelibrary.wiley.com/doi/10.1002/dneu.22950
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    FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114297

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    sciencedirect.com/science/article/pii/S2211124724006259
  13. May 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells
    1
    1. scibot 30 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11126613/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway
    1
    1. scibot 23 May 2024
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      DOI: 10.1016/j.isci.2024.109829

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    ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATG9B regulates bacterial internalization via actin rearrangement
    1
    1. scibot 05 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11066431/
  17. Apr 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling
    1
    1. scibot 28 Apr 2024
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      DOI: 10.7554/eLife.94265

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    ncbi.nlm.nih.gov/pmc/articles/PMC11045221/
  19. Mar 2024
  20. www.sciencedirect.com www.sciencedirect.com
    IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF
    2
    1. scibot 28 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113989

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      DOI: 10.1016/j.celrep.2024.113989

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    sciencedirect.com/science/article/pii/S2211124724003176
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice
    1
    1. scibot 13 Mar 2024
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      DOI: 10.1016/j.ynstr.2024.100621

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    pmc.ncbi.nlm.nih.gov/articles/PMC10955429/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells
    1
    1. scibot 03 Mar 2024
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      DOI: 10.3389/fncel.2024.1357499

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    ncbi.nlm.nih.gov/pmc/articles/PMC10902920/
  23. Feb 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation
    1
    1. scibot 10 Feb 2024
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      DOI: 10.1096/fj.202201088R

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    ncbi.nlm.nih.gov/pmc/articles/PMC10586062/
  25. Jan 2024
  26. 52.53.155.43 52.53.155.43
    Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer
    1
    1. scibot 12 Jan 2024
      RRID:AB_2269034

      DOI: 10.1210/jendso/bvae001

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    52.53.155.43/1275268acb8a22f11b9f453254726460ddb0b773/bvae001-html.html
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
    1
    1. scibot 10 Jan 2024
      AB_2269034

      DOI: 10.1158/1078-0432.CCR-23-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  28. Dec 2023
  29. www.biorxiv.org www.biorxiv.org
    Together, Neuropilin 1 and Neuropilin 2 direct α5 integrin trafficking through GTPase-activating-protein p120RasGAP in endothelial cells to promote fibronectin fibrillogenesis
    1
    1. scibot 02 Dec 2023
      RRID:AB_2269034

      DOI: 10.1101/2023.11.28.568967

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    biorxiv.org/content/10.1101/2023.11.28.568967v1
  30. Nov 2023
  31. www.sciencedirect.com www.sciencedirect.com
    PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis
    1
    1. scibot 28 Nov 2023
      RRID:AB_2269034

      DOI: 10.1016/j.celrep.2023.113414

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    sciencedirect.com/science/article/pii/S2211124723014262
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis
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    1. scibot 02 Nov 2023
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      DOI: 10.7554/eLife.89141

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    ncbi.nlm.nih.gov/pmc/articles/PMC10615368/
  33. Oct 2023
  34. aiche.onlinelibrary.wiley.com aiche.onlinelibrary.wiley.com
    Mechanochemical coupling of MGF mediates periodontal regeneration
    1
    1. scibot 09 Oct 2023
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      DOI: 10.1002/btm2.10603

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    aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10603
  35. www.sciencedirect.com www.sciencedirect.com
    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.neuron.2023.08.012

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    sciencedirect.com/science/article/pii/S0896627323006232
  36. Sep 2023
  37. academic.oup.com academic.oup.com
    bvad117-html.html
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    1. scibot 20 Sep 2023
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      DOI: 10.1210/jendso/bvad117

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    2. scibot 20 Sep 2023
      RRID:AB_2269034

      DOI: 10.1210/jendso/bvad117

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    academic.oup.com/jes/article/7/10/bvad117/7274808
  38. Jul 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors
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    1. scibot 29 Jul 2023
      RRID:AB_2269034

      DOI: 10.1016/j.isci.2023.107302

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    sciencedirect.com/science/article/pii/S2589004223013792
  40. Jun 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.cmet.2023.05.007

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    sciencedirect.com/science/article/pii/S1550413123001845
  42. 52.53.155.43 52.53.155.43
    Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis
    1
    1. scibot 16 Jun 2023
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      DOI: 10.1053/j.gastro.2023.05.039

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    52.53.155.43/6547da8aa0b8d7e491fdd14880a12803f28db0ef/1-s2.0-S0016508523008120-main-html.html
  43. www.sciencedirect.com www.sciencedirect.com
    Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α
    1
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      DOI: 10.1016/j.molcel.2023.05.008

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    sciencedirect.com/science/article/pii/S1097276523003325
  44. May 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    1. scibot 26 May 2023
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      DOI: 10.1016/j.ccell.2023.04.018

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    sciencedirect.com/science/article/pii/S1535610823001629
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex
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      DOI: 10.1016/j.isci.2023.106240

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    sciencedirect.com/science/article/pii/S2589004223003176
  48. www.sciencedirect.com www.sciencedirect.com
    Identification of a comprehensive alternative splicing function during epithelial-mesenchymal transition
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      DOI: 10.1016/j.isci.2023.106517

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    sciencedirect.com/science/article/pii/S2589004223005941
  49. Mar 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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      DOI: 10.1371/journal.pone.0281063

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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      DOI: 10.1016/j.celrep.2023.112188

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    sciencedirect.com/science/article/pii/S2211124723001997
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    Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis
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      DOI: 10.1016/j.celrep.2023.112164

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    sciencedirect.com/science/article/pii/S2211124723001754
  53. Feb 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
    1
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      DOI: 10.1016/j.cmet.2023.01.011

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    sciencedirect.com/science/article/pii/S1550413123000116
  55. Jan 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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      DOI: 10.1016/j.stem.2022.12.010

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    sciencedirect.com/science/article/pii/S1934590922004945
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
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      DOI: 10.1158/1535-7163.MCT-21-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC9630827/
  58. www.sciencedirect.com www.sciencedirect.com
    A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration
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  59. Dec 2022
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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  61. Oct 2022
  62. www.nature.com www.nature.com
    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
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  63. Sep 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis
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    Exploring the target scope of KEAP1 E3 ligase-based PROTACs
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  66. Aug 2022
  67. journals.plos.org journals.plos.org
    Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions
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      DOI: 10.1371/journal.pbio.3001759

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  68. Jul 2022
  69. www.sciencedirect.com www.sciencedirect.com
    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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  70. May 2022
  71. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice
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  72. Apr 2022
  73. www.sciencedirect.com www.sciencedirect.com
    Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice
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  74. Mar 2022
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer
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  76. Feb 2022
  77. www.sciencedirect.com www.sciencedirect.com
    LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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  79. link.springer.com link.springer.com
    Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
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  80. www.sciencedirect.com www.sciencedirect.com
    βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer
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  81. Jan 2022
  82. www.sciencedirect.com www.sciencedirect.com
    GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries
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  84. Dec 2021
  85. link.springer.com link.springer.com
    PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD
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  86. Oct 2021
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1
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  88. www.sciencedirect.com www.sciencedirect.com
    Biosensors based on peptide exposure show single molecule conformations in live cells
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  89. Sep 2021
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    Senescent immune cells release grancalcin to promote skeletal aging
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  91. Jul 2021
  92. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways
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      FAK

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    Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF
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      DOI: 10.1016/j.expneurol.2018.11.002

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    Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
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    Modulation of Akt vs Stat3 activity by the focal adhesion kinase in non-neoplastic mouse fibroblasts
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      Cell-signalling technology Cat. #3285

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  96. Jun 2021
  97. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
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    Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis
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  99. May 2021
  100. mcr.aacrjournals.org mcr.aacrjournals.org
    Adaptor protein ShcD/SHC4 interacts with Tie2 receptor to synergistically promote glioma cell invasion
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    Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
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  102. Apr 2021
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    CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
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  104. Mar 2021
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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      DOI: 10.1016/j.devcel.2020.11.017

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  106. www.sciencedirect.com www.sciencedirect.com
    Paradoxical activation of c-Src as a drug-resistant mechanism
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    A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration
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  108. Feb 2021
  109. www.cell.com www.cell.com
    Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms
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  110. Dec 2020
  111. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
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      total-FAK

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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptation of endothelial cells to shear stress under atheroprone conditions by modulating internalization of vascular endothelial cadherin and vinculin
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  113. Sep 2020
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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      RRID:AB_10829239

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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling
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      DOI: 10.7554/eLife.57617

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  116. link.springer.com link.springer.com
    Targeting the Tie2–α v β 3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
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      RRID:AB_10694068

      DOI: 10.1186/s12915-018-0557-9

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  117. Jan 2020
  118. jcs.biologists.org jcs.biologists.org
    Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling
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    1. scibot 13 Jan 2020
      AB_2269034

      DOI: 10.1242/jcs.202580

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

      Curator: @Naa003

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      RRID:AB_2269034 RRIDCUR:Validated
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    jcs.biologists.org/content/131/3/jcs202580
  119. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling
    1
    1. scibot 13 Jan 2020
      RRID:AB_2269034

      DOI: 10.1111/bph.14813

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

      Curator: @Naa003

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      RRID:AB_2269034 RRIDCUR:Validated
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14813
  120. www.sciencedirect.com www.sciencedirect.com
    Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6
    1
    1. scibot 13 Jan 2020
      RRID:AB_2269034

      DOI: 10.1016/j.expneurol.2019.113088

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S0014488619302353
  121. www.sciencedirect.com www.sciencedirect.com
    A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
    1
    1. scibot 13 Jan 2020
      RRID:AB_2269034

      DOI: 10.1016/j.celrep.2019.06.036

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

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    sciencedirect.com/science/article/pii/S2211124719308022
  122. www.sciencedirect.com www.sciencedirect.com
    γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A
    1
    1. scibot 13 Jan 2020
      RRID:AB_10694068

      DOI: 10.1016/j.molcel.2019.09.007

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S1097276519306926
  123. www.sciencedirect.com www.sciencedirect.com
    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
    1
    1. scibot 13 Jan 2020
      AB_2269034

      DOI: 10.1016/j.ccell.2019.05.003

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S1535610819302417
  124. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_2269034

      DOI: 10.1016/j.ccell.2019.01.009

      Resource: (Cell Signaling Technology Cat# 3285, RRID:AB_2269034)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S1535610819300431
  125. Nov 2018
  126. academic.oup.com academic.oup.com
    Insulinlike Growth Factor–Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance
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    1. scibot 05 Nov 2018
      AB_2269034

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      RRID:AB_2269034
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    academic.oup.com/endo/article/159/2/696/4657266
  127. Nov 2017
  128. www.sciencedirect.com www.sciencedirect.com
    Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
    1
    1. scibot 08 Nov 2017
      AB_2269034

      Curator: @chewbeccax

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      RRID:AB_2269034 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1934590917301376