66 Matching Annotations
  1. Apr 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
    1
    1. scibot 11 Apr 2024
      RRID:AB_2280448

      DOI: 10.1016/j.isci.2024.109540

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993184/
  3. Nov 2023
  4. www.sciencedirect.com www.sciencedirect.com
    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101285

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    sciencedirect.com/science/article/pii/S2666379123004792
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance
    3
    1. scibot 09 Nov 2023
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      DOI: 10.1177/17590914231206657

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    2. scibot 09 Nov 2023
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      DOI: 10.1177/17590914231206657

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    3. scibot 09 Nov 2023
      RRID:AB_2280448

      DOI: 10.1177/17590914231206657

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621302/
  6. Sep 2023
  7. dx.doi.org dx.doi.org
    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
    1
    1. scibot 14 Sep 2023
      AB_2280448

      DOI: 10.1210/clinem/dgad464

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    dx.doi.org/10.1210/clinem/dgad464
  8. Aug 2023
  9. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
    1
    1. scibot 11 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.015

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    sciencedirect.com/science/article/pii/S1097276523005580
  10. Jul 2023
  11. dx.doi.org dx.doi.org
    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
    1
    1. scibot 29 Jul 2023
      RRID:AB_2280448

      DOI: 10.1210/clinem/dgad413

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    dx.doi.org/10.1210/clinem/dgad413
  12. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
  13. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
    1
    1. scibot 18 Jul 2023
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      DOI: 10.1101/2023.05.18.541123

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    52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
  14. May 2023
  15. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
    1
    1. scibot 06 May 2023
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      DOI: 10.1038/s41467-023-38165-6

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    nature.com/articles/s41467-023-38165-6
  16. Apr 2023
  17. www.sciencedirect.com www.sciencedirect.com
    CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice
    1
    1. scibot 23 Apr 2023
      RRID:AB_2280448

      DOI: 10.1016/j.isci.2023.106524

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    sciencedirect.com/science/article/pii/S2589004223006016
  18. Mar 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
    1
    1. scibot 05 Mar 2023
      RRID:AB_2280448

      DOI: 10.1158/1541-7786.MCR-22-0090

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
  20. Jan 2023
  21. www.sciencedirect.com www.sciencedirect.com
    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
    1
    1. scibot 12 Jan 2023
      RRID:AB_2280448

      DOI: 10.1016/j.celrep.2022.111984

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    sciencedirect.com/science/article/pii/S2211124722018885
  22. Dec 2022
  23. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
    1
    1. scibot 24 Dec 2022
      RRID:AB_2280448

      DOI: 10.1016/j.celrep.2022.111834

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    sciencedirect.com/science/article/pii/S2211124722017260
  24. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
    1
    1. scibot 17 Dec 2022
      RRID:AB_2280448

      DOI: 10.1016/j.cmet.2022.11.012

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    sciencedirect.com/science/article/pii/S1550413122005034
  25. www.sciencedirect.com www.sciencedirect.com
    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
    1
    1. scibot 08 Dec 2022
      RRID:AB_2280448

      DOI: 10.1016/j.celrep.2022.111759

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    sciencedirect.com/science/article/pii/S2211124722016424
  26. Nov 2022
  27. www.sciencedirect.com www.sciencedirect.com
    Simultaneous SGLT2 inhibition and caloric restriction improves insulin resistance and kidney function in OLETF rats
    1
    1. scibot 03 Nov 2022
      RRID:AB_2280448

      DOI: 10.1016/j.mce.2022.111811

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    sciencedirect.com/science/article/pii/S0303720722002593
  28. Aug 2022
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers
    1
    1. scibot 04 Aug 2022
      AB_2280448

      DOI: 10.1111/jnc.15664

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15664
  30. Jun 2022
  31. journals.lww.com journals.lww.com
    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
    1
    1. scibot 24 Jun 2022
      RRID:AB_2280448

      DOI: 10.4103/1673-5374.344840

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    journals.lww.com/nrronline/Fulltext/2023/01000/Icariin_ameliorates_memory_deficits_through.39.aspx
  32. Dec 2021
  33. academic.oup.com academic.oup.com
    Hypothalamic miR-1983 targets insulin receptor beta and the insulin-mediated miR-1983 increase is blocked by metformin
    1
    1. scibot 22 Dec 2021
      RRID:AB_2280448

      DOI: 10.1210/endocr/bqab241

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    academic.oup.com/endo/article/163/1/bqab241/6433013
  34. www.sciencedirect.com www.sciencedirect.com
    TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver
    1
    1. scibot 16 Dec 2021
      RRID:AB_2280448

      DOI: 10.1016/j.cmet.2021.11.013

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    sciencedirect.com/science/article/pii/S1550413121005416
  35. Oct 2021
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling
    1
    1. scibot 23 Oct 2021
      RRID:AB_2280448

      DOI: 10.7554/eLife.70885

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    ncbi.nlm.nih.gov/pmc/articles/PMC8516413/
  37. www.sciencedirect.com www.sciencedirect.com
    Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
    1
    1. scibot 07 Oct 2021
      RRID:AB_2280448

      DOI: 10.1016/j.isci.2021.103151

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    sciencedirect.com/science/article/pii/S2589004221011196
  38. Sep 2021
  39. academic.oup.com academic.oup.com
    Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling
    1
    1. scibot 30 Sep 2021
      RRID:AB_2280448

      DOI: 10.1210/endocr/bqab182

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    academic.oup.com/endo/article/162/11/bqab182/6359854
  40. Aug 2021
  41. www.sciencedirect.com www.sciencedirect.com
    GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
    1
    1. scibot 15 Aug 2021
      RRID:AB_2280448

      DOI: 10.1016/j.celrep.2021.109501

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    sciencedirect.com/science/article/pii/S2211124721009293
  42. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    1. scibot 12 Aug 2021
      RRID:AB_2280448

      DOI: 10.1111/bph.14553

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14553
  43. academic.oup.com academic.oup.com
    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
    1
    1. scibot 08 Aug 2021
      RRID:AB_2280448

      DOI: 10.1210/en.2017-00489

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    academic.oup.com/endo/article/158/10/3399/4037402/Renal-Metabolic-Programming-Is-Linked-to-the
  44. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    1. scibot 03 Aug 2021
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      DOI: 10.1111/bph.14553

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14553
  45. Jul 2021
  46. www.sciencedirect.com www.sciencedirect.com
    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
    1
    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.cell.2018.09.055

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    sciencedirect.com/science/article/pii/S0092867418313060
  47. academic.oup.com academic.oup.com
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    1. scibot 28 Jul 2021
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      DOI: 10.1210/en.2018-00899

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    academic.oup.com/endo/article/160/2/377/5235619
  48. academic.oup.com academic.oup.com
    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
    2
    1. scibot 28 Jul 2021
      AB_2280448

      DOI: 10.1210/en.2017-00657

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    2. scibot 28 Jul 2021
      RRID:AB_2280448

      DOI: 10.1210/en.2017-00657

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    academic.oup.com/endo/article/158/11/3805/4117224
  49. academic.oup.com academic.oup.com
    Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
    2
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      DOI: 10.1210/en.2016-1583

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      IR (3025, AB_2280448)

      DOI: 10.1210/en.2016-1583

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    academic.oup.com/endo/article/157/11/4094/2758329/Glucose-Transporter-4-Facilitates-Insulin
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1210/en.2017-00693

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761602/
  51. Jun 2021
  52. academic.oup.com academic.oup.com
    Endothelial insulin receptors promote VEGF-A signaling via ERK1/2 and sprouting angiogenesis
    1
    1. scibot 29 Jun 2021
      RRID:AB_2280448

      DOI: 10.1210/endocr/bqab104

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    academic.oup.com/endo/article/162/8/bqab104/6284300
  53. academic.oup.com academic.oup.com
    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
    1
    1. scibot 29 Jun 2021
      RRID:AB_2280448

      DOI: 10.1210/endocr/bqab064

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    academic.oup.com/endo/article/162/6/bqab064/6188411
  54. Apr 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference
    1
    1. scibot 29 Apr 2021
      RRID:AB_2280448

      DOI: 10.1016/j.cmet.2020.09.008

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    sciencedirect.com/science/article/pii/S1550413120304861
  56. www.sciencedirect.com www.sciencedirect.com
    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
    1
    1. scibot 29 Apr 2021
      RRID:AB_2280448

      DOI: 10.1016/j.cmet.2020.08.001

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    sciencedirect.com/science/article/pii/S1550413120304149
  57. www.sciencedirect.com www.sciencedirect.com
    The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells
    1
    1. scibot 16 Apr 2021
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      DOI: 10.1016/j.canlet.2020.10.022

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    sciencedirect.com/science/article/pii/S0304383520305498
  58. Feb 2021
  59. www.cell.com www.cell.com
    Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
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  60. Jan 2021
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    Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3
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      DOI: 10.1016/j.celrep.2020.108576

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  62. Oct 2020
  63. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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      DOI: 10.1016/j.celrep.2020.108223

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  64. Sep 2020
  65. www.sciencedirect.com www.sciencedirect.com
    Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats
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      DOI: 10.1016/j.celrep.2020.108207

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  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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      DOI: 10.1111/jnc.14979

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  67. www.jbc.org www.jbc.org
    Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels
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      DOI: 10.1074/jbc.RA119.011840

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  68. academic.oup.com academic.oup.com
    DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice
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      DOI: 10.1210/endocr/bqaa139

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  69. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal rabbit insulin receptor-β

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  70. Jan 2020
  71. elifesciences.org elifesciences.org
    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
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    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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      DOI: 10.1016/j.ebiom.2019.08.033

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  74. academic.oup.com academic.oup.com
    Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
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      DOI: 10.1210/en.2019-00236

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  75. www.sciencedirect.com www.sciencedirect.com
    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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  76. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice
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      DOI: 10.1111/bph.14570

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  77. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.cell.2019.02.030

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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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  79. Nov 2018
  80. www.sciencedirect.com www.sciencedirect.com
    Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
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    Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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  86. academic.oup.com academic.oup.com
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  87. Nov 2017
  88. www.sciencedirect.com www.sciencedirect.com
    Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation
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      Curator: @kaitlinsung

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    Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
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