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Jul 2026
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Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior

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  DOI: 10.1016/j.isci.2026.116615
  
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Apr 2026
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1-s2.0-S2589004226010953-main-html.html

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Ets1-dependent Mek-Erk signaling drives adipose tissue macrophage anti-inflammatory polarization to ameliorates insulin resistance

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Feb 2026
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2026.02.11.705361v1.full-html.html

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54.241.53.176/5c618bd82011554652ee37be2d6b5f0590a656fa/2026.02.11.705361v1.full-html.html
May 2025
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Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A

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pmc.ncbi.nlm.nih.gov/articles/PMC12038057/
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S2212877825000584-main-html.html

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Ceramide-induced FGF13 impairs systemic metabolic health

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sciencedirect.com/science/article/pii/S1550413125001056
Mar 2025
52.53.155.43 52.53.155.43

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  DOI: 10.1210/endocr/bqaf051
  
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52.53.155.43/53309e2192e51912992203fea9560cdb3f219267/bqaf051-html.html
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Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

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biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02115-0
Feb 2025
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Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance

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The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

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  DOI: 10.1210/endocr/bqae136
  
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Dec 2024
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FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology

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  DOI: 10.1016/j.cmet.2024.11.001
  
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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  DOI: 10.1016/j.celrep.2024.114984
  
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Proteolethargy is a pathogenic mechanism in chronic disease

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  DOI: 10.1016/j.cell.2024.10.051
  
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sciencedirect.com/science/article/pii/S0092867424012741
Sep 2024
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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114746
  
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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

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1. scibot 10 Sep 2024
  
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Jul 2024
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Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice

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1. scibot 18 Jul 2024
  
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  DOI: 10.1210/endocr/bqae069
  
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dx.doi.org/10.1210/endocr/bqae069
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Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin

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  DOI: 10.1016/j.celrep.2024.114491
  
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sciencedirect.com/science/article/pii/S2211124724008209
Jun 2024
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Insulin and leptin oscillations license food-entrained browning and metabolic flexibility

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sciencedirect.com/science/article/pii/S2211124724007186
May 2024
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Contrasting consequences of podocyte IGF1R inhibition

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ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
Apr 2024
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Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1

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  DOI: 10.1016/j.isci.2024.109540
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10993184/
Nov 2023
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HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

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Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance

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  DOI: 10.1177/17590914231206657
  
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  DOI: 10.1177/17590914231206657
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10621302/
Sep 2023
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Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis

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Aug 2023
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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  DOI: 10.1016/j.molcel.2023.07.015
  
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Jul 2023
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Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus

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  DOI: 10.1210/clinem/dgad413
  
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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  DOI: 10.1016/j.celrep.2023.112868
  
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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  DOI: 10.1101/2023.05.18.541123
  
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May 2023
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Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

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  DOI: 10.1038/s41467-023-38165-6
  
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nature.com/articles/s41467-023-38165-6
Apr 2023
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CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice

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  DOI: 10.1016/j.isci.2023.106524
  
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Mar 2023
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Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

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  DOI: 10.1158/1541-7786.MCR-22-0090
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
Jan 2023
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SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2

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  DOI: 10.1016/j.celrep.2022.111984
  
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Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111834
  
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Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

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The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC

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Simultaneous SGLT2 inhibition and caloric restriction improves insulin resistance and kidney function in OLETF rats

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Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers

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Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research

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Hypothalamic miR-1983 targets insulin receptor beta and the insulin-mediated miR-1983 increase is blocked by metformin

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TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver

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A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

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Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

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Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling

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GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

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Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams

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Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

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Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism

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Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts

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Endothelial insulin receptors promote VEGF-A signaling via ERK1/2 and sprouting angiogenesis

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CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice

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Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

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The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells

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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats

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Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

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Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels

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DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice

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  DOI: 10.1210/endocr/bqaa139
  
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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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  monoclonal rabbit insulin receptor-β
  
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Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

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Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling

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  DOI: 10.1016/j.celrep.2019.08.092
  
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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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  DOI: 10.1016/j.ebiom.2019.08.033
  
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Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice

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  DOI: 10.1210/en.2019-00236
  
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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice

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Untitled document

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  DOI: 10.1016/j.cell.2019.02.030
  
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Lysosome Positioning Influences mTORC2 and AKT Signaling

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  DOI: 10.1016/j.molcel.2019.05.009
  
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Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

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Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

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A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network

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COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Untitled document

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Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation

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Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

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