Hypothesis

52 Matching Annotations

Aug 2025
52.53.155.43 52.53.155.43

2025.07.28.667160v1.full-html.html

1
1. scibot 05 Aug 2025
  
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  AB_2289606
  
  DOI: 10.1101/2025.07.28.667160
  
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52.53.155.43/969a14b205ba775788b5b53d9d63a84942cc91b4/2025.07.28.667160v1.full-html.html
May 2025
www.sciencedirect.com www.sciencedirect.com

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

1
1. scibot 20 May 2025
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.immuni.2025.04.029
  
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sciencedirect.com/science/article/pii/S107476132500192X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Engineering ARMMs for improved intracellular delivery of CRISPR-Cas9

1
1. scibot 19 May 2025
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.vesic.2025.100082
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12245188/
www.sciencedirect.com www.sciencedirect.com

Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease

1
1. scibot 17 May 2025
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.immuni.2025.04.018
  
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sciencedirect.com/science/article/pii/S1074761325001815
Apr 2025
elifesciences.org elifesciences.org

APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

1
1. scibot 24 Apr 2025
  
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  RRID:AB_2289606
  
  DOI: 10.7554/eLife.100968
  
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elifesciences.org/articles/100968
Dec 2024
www.science.org www.science.org

ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75NTR and induction of amyloid precursor protein

2
1. scibot 20 Dec 2024
  
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  AB_2289606
  
  DOI: 10.1126/scisignal.adn2616
  
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2. scibot 20 Dec 2024
  
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  AB_32136
  
  DOI: 10.1126/scisignal.adn2616
  
  Resource: None
  
  Curator: @inessasarian
  
  SciCrunch record: RRID:AB_2289606
  
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  RRIDCUR:Unresolved RRID:AB_2289606
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science.org/doi/10.1126/scisignal.adn2616
Nov 2024
journals.lww.com journals.lww.com

Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

1
1. scibot 07 Nov 2024
  
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  RRID:AB_2289606
  
  DOI: 10.4103/NRR.NRR-D-23-01633
  
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journals.lww.com/nrronline/fulltext/2026/04000/the_cullin3_ring_e3_ubiquitin_ligase_complex_and.44.aspx
52.53.155.43 52.53.155.43

enhanced_autophagic_clearance_of_amyloid___via.25-html.html

1
1. scibot 07 Nov 2024
  
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  AB_2289606
  
  DOI: 10.4103/nrr.nrr-d-23-01633
  
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52.53.155.43/f837a450e4d673727102c6a319547882bc299234/enhanced_autophagic_clearance_of_amyloid___via.25-html.html
Aug 2024
www.sciencedirect.com www.sciencedirect.com

Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes

1
1. scibot 22 Aug 2024
  
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  AB_2289606
  
  DOI: 10.1016/j.immuni.2024.07.019
  
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sciencedirect.com/science/article/pii/S1074761324003686
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

1
1. scibot 23 Jul 2024
  
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  RRID:AB_2289606
  
  DOI: 10.7554/eLife.90690
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11259434/
May 2024
www.mdpi.com www.mdpi.com

Transcranial Magneto-Acoustic Stimulation Protects Synaptic Rehabilitation from Amyloid-Beta Plaques via Regulation of Microglial Functions

1
1. scibot 03 May 2024
  
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  RRID:AB_2289606
  
  DOI: 10.3390/ijms25094651
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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mdpi.com/1422-0067/25/9/4651
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

1
1. scibot 28 Oct 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2023.113240
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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sciencedirect.com/science/article/pii/S2211124723012524
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Visualizing Wallerian degeneration in the corticospinal tract after sensorimotor cortex ischemia in mice

1
1. scibot 20 Oct 2023
  
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  RRID:AB_2289606
  
  DOI: 10.4103/1673-5374.380903
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10581571/
Sep 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Plk2 promotes synaptic destabilization through disruption of N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation

1
1. scibot 06 Sep 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1111/jnc.15948
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15948
Aug 2023
www.sciencedirect.com www.sciencedirect.com

Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease

1
1. scibot 05 Aug 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.neuron.2023.07.005
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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sciencedirect.com/science/article/pii/S0896627323005135
Jul 2023
www.sciencedirect.com www.sciencedirect.com

Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment

1
1. scibot 13 Jul 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2023.112774
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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sciencedirect.com/science/article/pii/S2211124723007854
www.sciencedirect.com www.sciencedirect.com

Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice

1
1. scibot 06 Jul 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.neuron.2023.06.002
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0896627323004373
Jun 2023
www.sciencedirect.com www.sciencedirect.com

ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer’s disease-like mouse model

1
1. scibot 16 Jun 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2023.112624
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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sciencedirect.com/science/article/pii/S2211124723006356
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4

1
1. scibot 12 Apr 2023
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.neuron.2023.03.024
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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sciencedirect.com/science/article/abs/pii/S0896627323002209
Mar 2023
journals.lww.com journals.lww.com

Inhibiting 5-hydroxytryptamine receptor 3 alleviates... : Neural Regeneration Research

1
1. scibot 11 Mar 2023
  
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  RRID:AB_2289606
  
  DOI: 10.4103/1673-5374.366492
  
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journals.lww.com/nrronline/Fulltext/2023/09000/Inhibiting_5_hydroxytryptamine_receptor_3.30.aspx
Oct 2022
www.sciencedirect.com www.sciencedirect.com

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

1
1. scibot 20 Oct 2022
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.cell.2022.09.030
  
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sciencedirect.com/science/article/pii/S0092867422012491
Sep 2022
www.sciencedirect.com www.sciencedirect.com

Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models

1
1. scibot 08 Sep 2022
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2022.111312
  
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sciencedirect.com/science/article/pii/S2211124722011366
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk

1
1. scibot 26 Aug 2022
  
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  RRID:AB_2289606
  
  DOI: 10.3389/fnagi.2022.896522
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9395645/
Jul 2022
www.sciencedirect.com www.sciencedirect.com

Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice

1
1. scibot 13 Jul 2022
  
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  AB_2289606
  
  DOI: 10.1016/j.celrep.2022.111062
  
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sciencedirect.com/science/article/pii/S2211124722008609
Jun 2022
journals.lww.com journals.lww.com

Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research

1
1. scibot 24 Jun 2022
  
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  RRID:AB_2289606
  
  DOI: 10.4103/1673-5374.344840
  
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journals.lww.com/nrronline/Fulltext/2023/01000/Icariin_ameliorates_memory_deficits_through.39.aspx
Apr 2022
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 28 Apr 2022
  
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  RRID:AB_2289606
  
  DOI: 10.1111/bph.15836
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15836
Jan 2022
www.sciencedirect.com www.sciencedirect.com

The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease

1
1. scibot 19 Jan 2022
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2021.110262
  
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sciencedirect.com/science/article/pii/S2211124721017745
Nov 2021
www.sciencedirect.com www.sciencedirect.com

Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

1
1. scibot 19 Nov 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.neuron.2021.10.036
  
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sciencedirect.com/science/article/pii/S0896627321008667
Aug 2021
www.nature.com www.nature.com

Untitled document

1
1. scibot 03 Aug 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1038/s41598-019-39494-7
  
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nature.com/articles/s41598-019-39494-7
www.sciencedirect.com www.sciencedirect.com

Increased P2×2 receptors induced by amyloid-β peptide participates in the neurotoxicity in alzheimer’s disease

1
1. scibot 03 Aug 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.biopha.2021.111968
  
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sciencedirect.com/science/article/pii/S0753332221007502
Jul 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Who's in, who's out? Re-evaluation of lipid raft residents

1
1. scibot 02 Jul 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1111/jnc.15446
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15446
Jun 2021
www.liebertpub.com www.liebertpub.com

Antisense Oligonucleotide-Induced Amyloid Precursor Protein Splicing Modulation as a Therapeutic Approach for Dutch-Type Cerebral Amyloid Angiopathy

1
1. scibot 05 Jun 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1089/nat.2021.0005
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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liebertpub.com/doi/abs/10.1089/nat.2021.0005
Mar 2021
www.tandfonline.com www.tandfonline.com

Ketogenic diet protects myelin and axons in diffuse axonal injury

2
1. scibot 15 Mar 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1080/1028415X.2021.1875300
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @bandrow
  
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  RRID:AB_2289606
2. scibot 10 Mar 2021
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1080/1028415X.2021.1875300
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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tandfonline.com/doi/full/10.1080/1028415X.2021.1875300
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity

1
1. scibot 26 Feb 2021
  
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  RRID:AB_2289606
  
  DOI: 10.1016/j.jbc.2021.100469
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
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  RRIDCUR:Validated RRID:AB_2289606
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sciencedirect.com/science/article/pii/S0021925821002428
portlandpress.com portlandpress.com

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

1
1. scibot 25 Feb 2021
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1042/BSR20200435
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @scibot
  
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portlandpress.com/bioscirep/article/40/4/BSR20200435/222674/The-cellular-expression-and-proteolytic-processing
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

1
1. scibot 07 Jan 2021
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2020.108588
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
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  RRID:AB_2289606 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720315771
Dec 2020
www.cell.com www.cell.com

APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival

1
1. scibot 19 Dec 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1016/j.neuron.2020.08.011
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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  SciCrunch record: RRID:AB_2289606
  
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  RRIDCUR:Validated RRID:AB_2289606
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cell.com/neuron/abstract/S0896-6273(20)30642-5
www.sciencedirect.com www.sciencedirect.com

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

1
1. scibot 16 Dec 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1016/j.cels.2020.11.007
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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  RRIDCUR:Validated RRID:AB_2289606
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sciencedirect.com/science/article/pii/S2405471220304580
link.springer.com link.springer.com

Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons

1
1. scibot 11 Dec 2020
  
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  RRID:AB_2289606
  
  DOI: 10.1186/s13024-020-00419-y
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
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  RRIDCUR:Validated RRID:AB_2289606
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link.springer.com/article/10.1186/s13024-020-00419-y
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2020.107719
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2289606
  
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  RRID:AB_2289606 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720306963
www.sciencedirect.com www.sciencedirect.com

Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing

1
1. scibot 25 Sep 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2020.107689
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2289606
  
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  RRIDCUR:Validated RRID:AB_2289606
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sciencedirect.com/science/article/pii/S2211124720306422
www.sciencedirect.com www.sciencedirect.com

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1016/j.celrep.2020.107796
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2289606
  
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  RRID:AB_2289606 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720307774
onlinelibrary.wiley.com onlinelibrary.wiley.com

Necrostatin‐1 prevents the proapoptotic protein Bcl‐2/adenovirus E1B 19‐kDa interacting protein 3 from integration into mitochondria

1
1. scibot 15 Sep 2020
  
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  RRID:AB_2289606
  
  DOI: 10.1111/jnc.14993
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2289606
  
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  RRIDCUR:Validated RRID:AB_2289606
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onlinelibrary.wiley.com/doi/10.1111/jnc.14993
link.springer.com link.springer.com

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease

1
1. scibot 12 Sep 2020
  
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  RRID:AB_2289606
  
  DOI: 10.1186/s40478-020-01013-5
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2289606
  
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  RRID:AB_2289606 RRIDCUR:Validated
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link.springer.com/article/10.1186/s40478-020-01013-5
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 03 Sep 2020
  
  in Public
  
  APP
  
  DOI: 10.1111/bph.15131
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2289606
  
  Curator comments: Amyloid beta precursor protein antibody [Y188] Abcam Cat# ab32136
  
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  RRID:AB_2289606 RRIDCUR:Missing
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15131
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1

1
1. scibot 03 Sep 2020
  
  in Public
  
  APP
  
  DOI: 10.1038/s41419-020-2663-1
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2289606
  
  Curator comments: Amyloid beta precursor protein antibody [Y188] Abcam Cat# ab32136
  
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  RRID:AB_2289606 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC7303181/
Aug 2020
elifesciences.org elifesciences.org

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

1
1. scibot 14 Aug 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.7554/eLife.52612
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2289606
  
  Curator comments: Abcam Cat# ab32136, Amyloid beta precursor protein antibody [Y188]
  
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  RRID:AB_2289606
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elifesciences.org/articles/52612
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1038/s41598-019-39494-7
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2289606
  
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  RRID:AB_2289606 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6391466/
www.jneurosci.org www.jneurosci.org

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2289606
  
  DOI: 10.1523/JNEUROSCI.1280-17.2018
  
  Resource: (Abcam Cat# ab32136, RRID:AB_2289606)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2289606
  
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  RRID:AB_2289606 RRIDCUR:Validated
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jneurosci.org/content/38/18/4288
Nov 2018
onlinelibrary.wiley.com onlinelibrary.wiley.com

The conformational epitope for a new Aβ42 protofibril‐selective antibody partially overlaps with the peptide N‐terminal region

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2289606
  
  Resource used:
  
  (Abcam Cat# ab32136, RRID:AB_2289606)
  
  SciCrunch record: RRID:AB_2289606
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2289606
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onlinelibrary.wiley.com/doi/10.1111/jnc.14211/full