285 Matching Annotations
  1. Jan 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
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    1. scibot 23 Jan 2025
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742192/
  3. www.sciencedirect.com www.sciencedirect.com
    Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma
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    1. scibot 03 Jan 2025
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    sciencedirect.com/science/article/pii/S2589004224028165
  4. Dec 2024
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer
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    1. scibot 21 Dec 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
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    Light-dark shift promotes colon carcinogenesis through accelerated colon aging
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S2589004224027871
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    P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis
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    1. scibot 19 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014475
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
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    1. scibot 13 Dec 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
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    Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells
    1
    1. scibot 06 Dec 2024
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    sciencedirect.com/science/article/pii/S1534580724006725
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    Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
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    1. scibot 02 Dec 2024
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    sciencedirect.com/science/article/pii/S0896627324008006
  11. Nov 2024
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mapping and tracing Grem1+ stromal cells in an ApcMin/+ mouse utilizing cryopreserved intestinal sections prepared via modified Swiss-roll technique
    1
    1. scibot 21 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11574797/
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    Reprogramming of fibroblasts into cancer-associated fibroblasts via IGF2-mediated autophagy promotes metastasis of lung cancer cells
    1
    1. scibot 16 Nov 2024
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    sciencedirect.com/science/article/pii/S2589004224024945
  14. 52.53.155.43 52.53.155.43
    can-24-1703-html.html
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    1. scibot 14 Nov 2024
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
    1
    1. scibot 14 Nov 2024
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    sciencedirect.com/science/article/pii/S2451945624004434
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CircZNF609/miR-324-5p/VDAC1 axis promotes malignant progression of ovarian cancer cells
    1
    1. scibot 10 Nov 2024
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  17. Sep 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial–mesenchymal transition and invasion
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224020005
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    Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma
    1
    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224018601
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    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
    1
    1. scibot 11 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010799
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
    1
    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S009286742400905X
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    Beyond mitochondrial transfer, cell fusion rescues metabolic dysfunction and boosts malignancy in adenoid cystic carcinoma
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010039
  23. www.sciencedirect.com www.sciencedirect.com
    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2666379124004324
  24. Aug 2024
  25. academic.oup.com academic.oup.com
    Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6
    1
    1. scibot 02 Aug 2024
      3195

      DOI: 10.1093/cercor/bhab242

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    academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhab242/6338536
  26. Jul 2024
  27. www.sciencedirect.com www.sciencedirect.com
    Generation and characterization of a human iPSC line expressing EGFP-tagged CDH1, KSCBi002-A-3
    1
    1. scibot 31 Jul 2024
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    sciencedirect.com/science/article/pii/S1873506124002083
  28. www.sciencedirect.com www.sciencedirect.com
    Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells
    1
    1. scibot 31 Jul 2024
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    sciencedirect.com/science/article/pii/S1934590924002534
  29. www.biorxiv.org www.biorxiv.org
    The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
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    1. scibot 30 Jul 2024
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      DOI: 10.1101/2024.07.22.604482

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    biorxiv.org/content/10.1101/2024.07.22.604482v1
  30. 52.53.155.43 52.53.155.43
    Substrate Stiffness Alters Layer Architecture and Biophysics of Human Induced Pluripotent Stem Cells to Modulate their Differentiation Potential
    1
    1. scibot 25 Jul 2024
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  31. www.sciencedirect.com www.sciencedirect.com
    Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.celrep.2021.109363

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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Patterning in stratified epithelia depends on cell–cell adhesion
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    1. scibot 23 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11258421/
  34. www.cell.com www.cell.com
    Regulation of the DLC3 tumor suppressor by a novel phosphoswitch
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    cell.com/iscience/abstract/S2589-0042(24)01428-7
  35. www.cell.com www.cell.com
    Bioengineered human colon organoids with in vivo-like cellular complexity and function
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    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.stem.2024.05.007

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    cell.com/cell-stem-cell/fulltext/S1934-5909(24)00184-X
  36. www.sciencedirect.com www.sciencedirect.com
    Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids
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    sciencedirect.com/science/article/pii/S2589004224015244
  37. Jun 2024
  38. journals.plos.org journals.plos.org
    Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement
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      DOI: 10.1371/journal.pgen.1011326

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  39. www.sciencedirect.com www.sciencedirect.com
    Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus.
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma
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  41. 52.53.155.43 52.53.155.43
    Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration
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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Exocyst Complex is Required for the Trafficking and Delivery of KCa3.1 to the Basolateral Membrane of Polarized Epithelia
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      DOI: 10.1152/ajpcell.00374.2022

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  43. Local file Local file
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      C. Other antibodies used in the study.

      DOI: 10.1101/2022.03.30.486322

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  44. May 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma
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      DOI: 10.1038/s41419-024-06733-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11109141/
  46. www.sciencedirect.com www.sciencedirect.com
    Patterning and folding of intestinal villi by active mesenchymal dewetting
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    sciencedirect.com/science/article/pii/S0092867424004653
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    Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition
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    sciencedirect.com/science/article/pii/S1534580724002971
  48. journals.biologists.com journals.biologists.com
    FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion
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      CST, 3195S

      DOI: 10.1242/dev.201293

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    journals.biologists.com/dev/article/150/6/dev201293/297264/FGF-signaling-regulates-salivary-gland-branching
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
    1
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    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
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  52. Apr 2024
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation
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  61. Mar 2024
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    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
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  63. Feb 2024
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    Depletion of PHLDB2 Suppresses Epithelial–Mesenchymal Transition and Enhances Anti-Tumor Immunity in Head and Neck Squamous Cell Carcinoma
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    Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    OVOL2 induces autophagy-mediated epithelial-mesenchymal transition by the ERK1/2 MAPK signaling in lung adenocarcinoma
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis
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  70. Jan 2024
  71. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis
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    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    Gasdermin-D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway
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  75. Dec 2023
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin
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    A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis
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  84. Nov 2023
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    CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer
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    Protocol for isolation of signet ring cells from human gastric mucosa
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    Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism
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    Highly-parallel production of designer organoids by mosaic patterning of progenitors
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  89. Oct 2023
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
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    In vitro vascularized immunocompetent patient-derived model to test cancer therapies
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  92. Sep 2023
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    Molecular anatomy of adult mouse leptomeninges
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    In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
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    A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling
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    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
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    Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hedgehog regulation of epithelial cell state and morphogenesis in the larynx
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  146. Nov 2022
  147. academic.oup.com academic.oup.com
    CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway
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  148. www.sciencedirect.com www.sciencedirect.com
    Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis
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  149. Oct 2022
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    The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma
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  151. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction
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    Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells
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  155. Aug 2022
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway
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  157. www.sciencedirect.com www.sciencedirect.com
    A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis
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    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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  159. Jul 2022
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding the activated stem cell phenotype of the neonatally maturing pituitary
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    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    Tumorigenic cell selection and substrate rigidity manipulation using 2D and 3D extracellular matrices
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    Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis
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    Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity
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    Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
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  166. Jun 2022
  167. www.sciencedirect.com www.sciencedirect.com
    Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies
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    Lymphatics act as a signaling hub to regulate intestinal stem cell activity
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    Protocols for SARS-CoV-2 infection in primary ocular cells and eye organoids
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  170. May 2022
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys
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    Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens
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  173. Apr 2022
  174. academic.oup.com academic.oup.com
    TNFÉ‘ Antagonist in Combination with PD-1 Blocker to Prevent or Retard Malignant Transformation of B[a]P-induced Chronic Lung Inflammation
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    Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation
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    Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer
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    Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche
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    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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  179. Mar 2022
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    Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer
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    Peritoneal Restoration by Repurposing Vitamin D Inhibits Ovarian Cancer Dissemination via Blockade of the TGF-β1/Thrombospondin-1 Axis
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    Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
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    A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer
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    Protocol for serial organoid formation assay using primary colorectal cancer tissues to evaluate cancer stem cell activity
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    Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition
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    F1000Research Article: Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease.
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    Patterning the embryonic pulmonary mesenchyme
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    DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions
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    Interferon-γ promotes monocyte-mediated lung injury during influenza infection
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    Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin
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  191. Feb 2022
  192. www.sciencedirect.com www.sciencedirect.com
    Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
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    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    A positive feed-forward loop between Fusobacterium nucleatum and ethanol metabolism reprogramming drives laryngeal cancer progression and metastasis
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    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiation induces epithelial to mesenchymal transition via upregulation of PD-L1 in nasopharyngeal carcinoma cell
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  197. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  198. Jan 2022
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    Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity
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  200. Dec 2021
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    Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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    Emergence and patterning dynamics of mouse-definitive endoderm
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    MATISSE: An analysis protocol for combining imaging mass cytometry with fluorescence microscopy to generate single-cell data
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    Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
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    A mechanistic basis for the malignant progression of salivary gland tumors
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  207. Nov 2021
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation
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  211. Oct 2021
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    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
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    Kinase DYRK2 acts as a regulator of autophagy and an indicator of favorable prognosis in gastric carcinoma
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    Proteomic and phosphoproteomic analyses identify liver-related signaling in retinal pigment epithelial cells during EMT
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    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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    The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment
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    Uterine epithelial LIF receptors contribute to implantation chamber formation in blastocyst attachment
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  218. Sep 2021
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    The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
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    Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
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  221. Aug 2021
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    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Entosis is induced by UV radiation.
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    Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads
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    Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium
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      DOI: 10.1096/fj.201900013R

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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    Genomic Function of Estrogen Receptor Beta In Endometriosis
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  233. Jul 2021
  234. academic.oup.com academic.oup.com
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