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Comprehensive RNA-binding protein analyses and deep learning uncover genetic constraints and disease associations in protein-RNA interfaces

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.cels.2026.101588
  
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sciencedirect.com/science/article/pii/S2405471226000700
Jan 2026
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BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.010
  
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sciencedirect.com/science/article/pii/S1097276525009840
Dec 2025
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

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1. scibot 03 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.04.012
  
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sciencedirect.com:5037/science/article/pii/S1097276525003156
Aug 2025
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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.08.001
  
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sciencedirect.com/science/article/pii/S1097276525006513
May 2025
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.012
  
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sciencedirect.com:5037/science/article/pii/S1097276525003156
Apr 2025
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Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0785
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962390/
Mar 2025
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Targeted degradation of CDK9 potently disrupts the MYC-regulated network

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.001
  
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sciencedirect.com/science/article/pii/S2451945625000674
Oct 2024
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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

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1. scibot 02 Oct 2024
  
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  AB_2291505
  
  DOI: 10.1016/j.xcrm.2024.101752
  
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sciencedirect.com/science/article/pii/S2666379124004828
Aug 2024
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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.chembiol.2024.07.005
  
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sciencedirect.com/science/article/pii/S2451945624003076
Mar 2024
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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1. scibot 29 Mar 2024
  
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  AB_2291505
  
  DOI: 10.1016/j.molcel.2024.02.032
  
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sciencedirect.com/science/article/pii/S1097276524001758
Jan 2024
www.nature.com www.nature.com

Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

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1. scibot 25 Jan 2024
  
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  RRID:AB_2291505
  
  DOI: 10.1038/s41388-024-02947-z
  
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nature.com/articles/s41388-024-02947-z
Nov 2023
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Selective inhibition of CDK9 in triple negative breast cancer

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1. scibot 25 Nov 2023
  
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  DOI: 10.1038/s41388-023-02892-3
  
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nature.com/articles/s41388-023-02892-3
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

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1. scibot 22 Jul 2023
  
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  RRID:AB_2291505
  
  DOI: 10.1101/2023.06.27.546707
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
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Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation

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1. scibot 13 Jul 2023
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.molcel.2023.06.032
  
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sciencedirect.com/science/article/abs/pii/S1097276523005087
Jul 2022
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AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

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1. scibot 27 Jul 2022
  
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  RRID:AB_2291505
  
  DOI: 10.1111/febs.16375
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
May 2022
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Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells

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1. scibot 26 May 2022
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.cels.2022.04.005
  
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sciencedirect.com/science/article/pii/S2405471222001703
Mar 2022
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Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP

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1. scibot 26 Mar 2022
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.molcel.2022.03.001
  
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sciencedirect.com/science/article/pii/S1097276522002106
Aug 2021
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Untitled document

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1. scibot 13 Aug 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.molcel.2019.01.033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6482433/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 11 Aug 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.molcel.2017.04.027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
Jul 2021
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RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control

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1. scibot 28 Jul 2021
  
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  CDK9
  
  DOI: 10.1016/j.molcel.2019.05.007
  
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  RRID:AB_2291505 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1097276519303600
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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

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1. scibot 22 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109394
  
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sciencedirect.com/science/article/pii/S2211124721007920
Jun 2021
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DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity

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1. scibot 23 Jun 2021
  
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  DOI: 10.1016/j.celrep.2021.109281
  
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sciencedirect.com/science/article/pii/S2211124721006483
May 2021
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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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1. scibot 18 May 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.cell.2021.04.022
  
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sciencedirect.com/science/article/pii/S009286742100502X
Apr 2021
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

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1. scibot 28 Apr 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.celrep.2021.109013
  
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sciencedirect.com/science/article/pii/S2211124721003272
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The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

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1. scibot 15 Apr 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.celrep.2021.108965
  
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  RRID:AB_2291505 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124721002795
Feb 2021
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Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1

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1. scibot 24 Feb 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.celrep.2021.108749
  
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sciencedirect.com/science/article/pii/S2211124721000620
Jan 2021
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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

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1. scibot 07 Jan 2021
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.celrep.2020.108532
  
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sciencedirect.com/science/article/pii/S2211124720315217
Dec 2020
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CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

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1. scibot 24 Dec 2020
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.celrep.2020.108545
  
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sciencedirect.com/science/article/pii/S2211124720315345
Oct 2020
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

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1. scibot 27 Oct 2020
  
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  DOI: 10.1016/j.chembiol.2020.10.001
  
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sciencedirect.com/science/article/pii/S2451945620303809
Sep 2020
www.cell.com www.cell.com

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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1. scibot 17 Sep 2020
  
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  RRID:AB_2291505
  
  DOI: 10.1016/j.molcel.2018.11.006
  
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cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
Jan 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma

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1. scibot 13 Jan 2020
  
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  DOI: 10.1002/jcb.29420
  
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onlinelibrary.wiley.com/doi/10.1002/jcb.29420
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Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.07.013
  
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sciencedirect.com/science/article/pii/S109727651930543X
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Untitled document

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  DOI: 10.1016/j.molcel.2019.01.033
  
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sciencedirect.com/science/article/pii/S109727651930053X
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Untitled document

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  DOI: 10.1016/j.chembiol.2019.02.015
  
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sciencedirect.com/science/article/pii/S2451945619300704
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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  DOI: 10.1016/j.molcel.2018.11.006
  
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  DOI: 10.1016/j.molcel.2018.11.006
  
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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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  DOI: 10.1016/j.molcel.2018.09.031
  
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Nov 2018
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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

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Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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1. scibot 08 Nov 2017
  
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