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Pharmacologic interrogation of USP28 cellular function in p53 signaling

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.002
  
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sciencedirect.com/science/article/pii/S2451945625002326
Aug 2025
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PIEZO1 mechanical insensitivity in generalized lymphatic dysplasia with the potential for pharmacological rescue

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113110
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12337661/
Jul 2025
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The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation

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1. scibot 24 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116019
  
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sciencedirect.com/science/article/pii/S2211124725007909
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An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia

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1. scibot 22 Jul 2025
  
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  DOI: 10.1101/2025.07.16.664180
  
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biorxiv.org/content/10.1101/2025.07.16.664180v1
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1-s2.0-S2589004225013719-main-html.html

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  DOI: 10.1016
  
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Jun 2025
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CRAMP1 drives linker histone expression to enable Polycomb repression

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.031
  
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sciencedirect.com/science/article/pii/S1097276525004708
May 2025
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GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.neuron.2025.04.033
  
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sciencedirect.com/science/article/pii/S0896627325003459
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1097276525003156
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The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115656
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00427-9
Apr 2025
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Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction

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  DOI: 10.1016/j.cmet.2025.04.001
  
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sciencedirect.com/science/article/pii/S1550413125002116
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ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

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1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.019
  
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SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115535
  
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A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

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1. scibot 02 Apr 2025
  
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  DOI: 10.7554/eLife.100527
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11952754/
Mar 2025
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Protective ApoE variants support neuronal function by extracting peroxidated lipids

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1. scibot 14 Mar 2025
  
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  DOI: 10.1101/2025.03.05.641722
  
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biorxiv.org/content/10.1101/2025.03.05.641722v1
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115403
  
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sciencedirect.com/science/article/pii/S2211124725001743
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Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115377
  
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sciencedirect.com/science/article/pii/S2211124725001482
Feb 2025
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BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.neuron.2025.01.030
  
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52.53.155.43 52.53.155.43

1-s2.0-S0014488625000482-main-html.html

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.expneurol.2025.115184
  
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52.53.155.43/6a68b8a46fcb77856ed63616fa1014d168ebfdf5/1-s2.0-S0014488625000482-main-html.html
elifesciences.org elifesciences.org

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

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1. scibot 14 Feb 2025
  
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  DOI: 10.7554/eLife.97268
  
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elifesciences.org/articles/97268
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Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115279
  
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Jan 2025
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Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains

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  DOI: 10.1016/j.molcel.2024.12.002
  
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Dec 2024
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START domains generate paralog-specific regulons from a single network architecture

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41467-024-54269-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11564692/
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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.10.010
  
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Mechano-dependent sorbitol accumulation supports biomolecular condensate

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.10.048
  
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Oct 2024
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CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny

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  DOI: 10.1016/j.celrep.2024.114797
  
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Sep 2024
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A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110762
  
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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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  DOI: 10.1016/j.cell.2024.08.036
  
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Aug 2024
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The conformational plasticity of structurally unrelated lipid transport proteins correlates with their mode of action

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  DOI: 10.1371/journal.pbio.3002737
  
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ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

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  DOI: 10.1016/j.celrep.2024.114626
  
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EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development

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  DOI: 10.1002/cne.23933
  
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onlinelibrary.wiley.com/doi/10.1002/cne.23933/full
Jul 2024
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TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging

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1. scibot 25 Jul 2024
  
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  DOI: 10.1080/15548627.2024.2333717
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
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Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114362
  
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cell.com/cell-reports/abstract/S2211-1247(24)00690-9
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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.molcel.2024.06.020
  
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PIIS2589004224017000-html.html

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110475
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11295705/
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Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.crmeth.2024.100816
  
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Evolution of paralogous multicomponent systems for site-specific O-sialylation of flagellin in Gram-negative and Gram-positive bacteria

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Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice

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Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness

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Molecular basis for pH sensing in the KDEL trafficking receptor

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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

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TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves

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Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

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Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells

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Leishmania profilin interacts with actin through an unusual structural mechanism to control cytoskeletal dynamics in parasites

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Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves

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Protocol for detection of in vitro R-loop formation using dot blots

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Gut-liver axis calibrates intestinal stem cell fitness

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SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation

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Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1

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Entorhinohippocampal cholecystokinin modulates spatial learning by facilitating neuroplasticity of hippocampal CA3-CA1 synapses

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p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation

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The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

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A gut meta-interactome map reveals modulation of human immunity by microbiome effectors

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Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts

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Astrocyte lipocalin-2 modestly effects disease severity in a mouse model of multiple sclerosis while reducing mature oligodendrocyte protein and mRNA expression

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MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy

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A co-opted endogenous retroviral envelope promotes cell survival by controlling CTR1-mediated copper transport and homeostasis

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Analyzing the topology of N-linked glycans by PNGase F accessibility assay

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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen

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BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses

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Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease

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Protocol to determine the subcellular localization of protein interactions in murine keratinocytes

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ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines

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A hypometabolic defense strategy against malaria

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Differential Hsp90-dependent gene expression is strain-specific and common among yeast strains

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A tissue injury sensing and repair pathway distinct from host pathogen defense

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Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons

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Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism

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Ultra-rare complement factor 8 coding variants in families with age-related macular degeneration

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Topological regulation of a transmembrane protein by luminal-to-cytosolic retrotranslocation of glycosylated sequence

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A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

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TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions

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Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling

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ERRα attenuates vascular inflammation via enhanced NFκB degradation pathway

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Short photoperiod modulates behavior, cognition and hippocampal neurogenesis in male Japanese quail

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L- and T-type Ca2+ channels dichotomously contribute to... : Neural Regeneration Research

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The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

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The Scaffolding Function of LSD1/KDM1A Reinforces a Negative Feedback Loop to Repress Stem Cell Gene Expression during Primitive Hematopoiesis

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Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists

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Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila

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Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike protein-mediated membrane fusion assay

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Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964

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Structure and mechanism of human cystine exporter cystinosin

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Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

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PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons

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Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing

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Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

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BPS Publications

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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

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Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females With Alzheimer’s Disease Compared to Males

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Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells

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MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

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Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

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Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells

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A superior loading control for the cellular thermal shift assay

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Hexokinase 1 cellular localization regulates the metabolic fate of glucose

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Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

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Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells

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RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin

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Caveolin-1 Peptide Regulates p53-microRNA-34a Feedback in Fibrotic Lung Fibroblasts

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Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

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Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans

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A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

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Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

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Erythrocytosis associated with IgA nephropathy

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TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

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Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic

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Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

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Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

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Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome

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A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function

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p38-mediated cell growth and survival drive rapid embryonic wound repair

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Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation

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FSTL3 Neutralizing Antibodies Enhance Glucose-Responsive Insulin Secretion In Dysfunctional Male Mouse And Human Islets

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Revisiting astrocyte to neuron conversion with lineage tracing in vivo

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Lrp1 is a host entry factor for Rift Valley fever virus

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The amyloid precursor protein is a conserved Wnt receptor

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Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations

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Untitled document

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VEGF/VEGFR2 signaling regulates hippocampal axon branching during development

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The Catalytic Subunit β of PKA Affects Energy Balance and Catecholaminergic Activity

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Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior

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Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development

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Who's in, who's out? Re-evaluation of lipid raft residents

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Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis

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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

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A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development

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A Non-canonical BRCT-Phosphopeptide Recognition Mechanism Underlies RhoA Activation in Cytokinesis

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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

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Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer

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A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

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Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development

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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

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Generation of a WA14 hESC sub-line carrying a hemizygous ABCD1 (C.1696_1710 del) mutation introduced by CRISPR/Cas9 technology

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Ecd promotes U5 snRNP maturation and Prp8 stability

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CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

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Optogenetic investigation of BMP target gene expression diversity

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ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1

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Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis

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Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

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BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain

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GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

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Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

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GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation

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Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

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Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

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Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice

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Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory

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Astrocytic ephrin-B1 controls excitatory-inhibitory balance in developing hippocampus

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Neuronal and synaptic morphological alterations in the hippocampus of cannabinoid receptor type 1 knockout mice

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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

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Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

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Derivation of a human induced pluripotent stem cell line (QBRIi007-A) from a patient carrying a homozygous intronic mutation (c.613-7T>G) in the SLC2A2 gene

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Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila

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Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

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Human CSF monoclonal LGI1 autoantibodies increase neuronal excitability

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Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

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Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis

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The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C

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Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons

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A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

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PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development

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Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome

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Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome

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MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells

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Assessing average somatic CAG repeat instability at the protein level

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UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

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Untitled document

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Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus

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The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C

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Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing

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WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation

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Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation

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Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

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PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

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Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis

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RAPGEF5 Regulates Nuclear Translocation of β-Catenin

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Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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An Atoh1-S193A phospho-mutant allele causes hearing deficits and motor impairment

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YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Amount of fear extinction changes its underlying mechanisms

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PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise

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p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

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Progressive Disorganization of Paranodal Junctions and Compact Myelin Due to Loss of DCC Expression by Oligodendrocytes

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