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Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion

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  DOI: 10.1126/sciadv.aeb8564
  
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science.org/doi/10.1126/sciadv.aeb8564
Jul 2026
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Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion

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pmc.ncbi.nlm.nih.gov/articles/PMC13353423/
Mar 2026
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VGLL4 modulates Paneth cells and sustains intestinal homeostasis

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1. scibot 18 Mar 2026
  
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  DOI: 10.1038/s44319-026-00699-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12979657/
Jul 2025
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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

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  DOI: 10.1016/j.cell.2025.05.041
  
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sciencedirect.com/science/article/pii/S0092867425006282
May 2025
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CapdevilaCastillo_columbia_0054D_18600-html.html

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52.53.155.43/defa13d4e31bf105e951133a04f91af42d68a175/CapdevilaCastillo_columbia_0054D_18600-html.html
Apr 2025
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Dual states of murine Bmi1-expressing intestinal stem cells drive epithelial development utilizing non-canonical Wnt signaling

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sciencedirect.com/science/article/pii/S1534580725001777
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Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

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  DOI: 10.7554/eLife.97144
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11996175/
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Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell

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  DOI: 10.1016/j.stem.2025.03.005
  
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sciencedirect.com/science/article/pii/S1934590925000955
Mar 2025
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Vagal pathway activation links chronic stress to decline in intestinal stem cell function

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1. scibot 24 Mar 2025
  
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  DOI: 10.1016/j.stem.2025.02.016
  
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sciencedirect.com/science/article/pii/S1934590925000840
Feb 2025
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LPA5-Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation

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1. scibot 13 Feb 2025
  
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  DOI: 10.1152/ajpgi.00269.2023
  
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52.53.155.43/978c5dfff0426cc212e73bbfea0ae45a47f47f85/yun-et-al-2024-lpa5-dependent-signaling-regulates-regeneration-of-the-intestinal-epithelium-following-irradiation-html.html
Dec 2024
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Maternal gut microbiota influence stem cell function in offspring

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.stem.2024.10.003
  
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sciencedirect.com/science/article/pii/S1934590924003655
Sep 2024
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Paneth cell TNF signaling induces gut bacterial translocation and sepsis

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  DOI: 10.1016/j.chom.2024.08.007
  
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sciencedirect.com/science/article/pii/S1931312824003147
Aug 2024
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Table 3 Antibodies/Staining substrates used in studies

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1. scibot 02 Aug 2024
  
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  DOI: 10.1038/s41596-021-00658-3
  
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nature.com/articles/s41596-021-00658-3/tables/3
Jun 2024
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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells

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1. scibot 07 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.001
  
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sciencedirect.com/science/article/pii/S0092867424004914
May 2024
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Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.devcel.2024.05.001
  
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sciencedirect.com/science/article/pii/S1534580724002995
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Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.018
  
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sciencedirect.com/science/article/pii/S1074761324002231
Apr 2024
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.003
  
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sciencedirect.com/science/article/pii/S1934590924000845
Feb 2024
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Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity

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1. scibot 07 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.002
  
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sciencedirect.com/science/article/pii/S107476132400027X
Aug 2023
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Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells

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1. scibot 29 Aug 2023
  
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  DOI: 10.1016/j.stem.2023.07.013
  
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sciencedirect.com/science/article/pii/S1934590923002588
May 2023
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M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

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  DOI: 10.1016/j.immuni.2023.04.002
  
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sciencedirect.com/science/article/pii/S107476132300170X
Apr 2023
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Smooth muscle contributes to the development and function of a layered intestinal stem cell niche

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  DOI: 10.1016/j.devcel.2023.02.012
  
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sciencedirect.com/science/article/pii/S1534580723000709
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Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche

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  DOI: 10.1016/j.stem.2023.03.004
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10134073/
Jan 2023
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A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

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sciencedirect.com/science/article/pii/S1934590922004921
Dec 2022
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Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations

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  DOI: 10.7554/eLife.80682
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9708068/
Nov 2022
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A dietary change to a high-fat diet initiates a rapid adaptation of the intestine

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  DOI: 10.1016/j.celrep.2022.111641
  
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sciencedirect.com/science/article/pii/S2211124722015121
May 2022
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Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models

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1. scibot 20 May 2022
  
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  DOI: 10.1016/j.xpro.2022.101411
  
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Dec 2021
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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

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  DOI: 10.7554/eLife.69729
  
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Generation of mixed murine organoids to model cellular interactions

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  DOI: 10.1016/j.xpro.2021.100997
  
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sciencedirect.com/science/article/pii/S2666166721007036
Oct 2021
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Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases

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  DOI: 10.1038/s41596-021-00607-0
  
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nature.com/articles/s41596-021-00607-0
Sep 2021
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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

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  DOI: 10.1016/j.stem.2021.09.004
  
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sciencedirect.com/science/article/pii/S1934590921003805
Aug 2021
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Untitled document

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  DOI: 10.1016/j.immuni.2018.09.013
  
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sciencedirect.com/science/article/pii/S107476131830428X
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.108
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6391775/
Jul 2021
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Untitled document

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  DOI: 10.1016/j.stem.2016.11.001
  
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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

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  DOI: 10.1016/j.cell.2018.10.008
  
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sciencedirect.com/science/article/pii/S0092867418313163
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Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

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1. scibot 29 Jul 2021
  
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  DOI: 10.1186/s12915-018-0527-2
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0527-2
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Quantitative Proteomics of Intestinal Mucosa From Male Mice Lacking Intestinal Epithelial Insulin Receptors

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1. scibot 28 Jul 2021
  
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A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting

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Mapping Development of the Human Intestinal Niche at Single-Cell Resolution

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Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

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Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition

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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

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Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

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Exploring the human lacrimal gland using organoids and single-cell sequencing

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A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis

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Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

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Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

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Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

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Grading TESI: Crypt and villus formation in tissue-engineered small intestine alters with stem/progenitor cell source | American Journal of Physiology-Gastrointestinal and Liver Physiology

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Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

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T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

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Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

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Untitled document

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Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

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Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

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YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

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Nov 2017
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Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

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Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity

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Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

1
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Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells

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