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Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation

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1. scibot 13 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116286
  
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sciencedirect.com/science/article/pii/S2211124725010575
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A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation

1
1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.006
  
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sciencedirect.com/science/article/pii/S2451945625002594
Jul 2025
www.cell.com www.cell.com

A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner

1
1. scibot 15 Jul 2025
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.chembiol.2025.06.005
  
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cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00200-4
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neonatal NLRP3 Inflammasome Activation Leads to Perineuronal Net Deficits in Early Adulthood

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1. scibot 23 Jun 2025
  
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  RRID:AB_2490202
  
  DOI: 10.1002/dneu.22986
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12179493/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing

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1. scibot 21 May 2025
  
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  RRID:AB_2490202
  
  DOI: 10.3390/ijms26094036
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12071306/
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s44318-025-00412-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome

1
1. scibot 19 Apr 2025
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.114688
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12005378/
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Red blood cells undergo lytic programmed cell death involving NLRP3

1
1. scibot 19 Apr 2025
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.cell.2025.03.039
  
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sciencedirect.com/science/article/pii/S0092867425003897
link.springer.com link.springer.com

Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides

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1. scibot 04 Apr 2025
  
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  RRID:AB_2885199
  
  DOI: 10.1186/s12865-025-00685-9
  
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link.springer.com/article/10.1186/s12865-025-00685-9
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 04 Apr 2025
  
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  RRID:AB_2490202
  
  DOI: 10.1111/bph.70040
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70040
52.53.155.43 52.53.155.43

Lysosome positioning affects NLRP3 inflammasome activation

1
1. scibot 03 Apr 2025
  
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  AB_2490202
  
  DOI: 10.1101/2025.03.21.644552
  
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52.53.155.43/5e725b42faf6f4894ebfb1897ac6165b04d7cac3/PDF-html.html
Mar 2025
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The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

1
1. scibot 29 Mar 2025
  
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  RRID:AB_2885199
  
  DOI: 10.1016/j.celrep.2025.115462
  
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sciencedirect.com/science/article/pii/S2211124725002335
Jan 2025
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A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

1
1. scibot 30 Jan 2025
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.immuni.2025.01.003
  
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sciencedirect.com/science/article/pii/S1074761325000263
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

1
1. scibot 03 Jan 2025
  
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  RRID:AB_2885199
  
  DOI: 10.4103/NRR.NRR-D-23-01799
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11691456/
Nov 2024
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Ethanol modulates astrocyte activation and neuroinflammation via miR-339/NLRP6 inflammasome signaling

1
1. scibot 24 Nov 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.freeradbiomed.2024.11.014
  
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sciencedirect.com/science/article/pii/S089158492401044X
Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

1
1. scibot 09 Oct 2024
  
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  AB_2885199
  
  DOI: 10.1016/j.immuni.2024.09.004
  
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sciencedirect.com/science/article/pii/S1074761324004485
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The emerging role of mesenchymal stem cell–derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

1
1. scibot 02 Oct 2024
  
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  RRID:AB_2490202
  
  DOI: 10.4103/NRR.NRR-D-23-01397
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11438346/
Sep 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 27 Sep 2024
  
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  AB_2490202
  
  DOI: 10.1111/bph.17320
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17320
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation

1
1. scibot 26 Sep 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.114609
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398858/
elifesciences.org elifesciences.org

S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

1
1. scibot 18 Sep 2024
  
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  RRID:AB_2490202
  
  DOI: 10.7554/eLife.94302
  
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elifesciences.org/articles/94302
Jul 2024
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Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation

1
1. scibot 18 Jul 2024
  
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  AB_2490202
  
  DOI: 10.1016/j.isci.2024.110459
  
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sciencedirect.com/science/article/pii/S2589004224016845
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

1
1. scibot 21 Jun 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.cell.2024.05.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
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SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms

1
1. scibot 08 Jun 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.isci.2024.109940
  
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sciencedirect.com/science/article/pii/S2589004224011623
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

1
1. scibot 01 May 2024
  
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  AB_2885199
  
  DOI: 10.1101/2024.04.19.590338
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11042255/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

3′-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome

1
1. scibot 24 Apr 2024
  
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  RRID:AB_2490202
  
  DOI: 10.4103/1673-5374.392887
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034599/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects

1
1. scibot 10 Apr 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.isci.2024.109544
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10995871/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation

2
1. scibot 09 Apr 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.114070
  
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2. scibot 09 Apr 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.114070
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11130711/
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Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis

2
1. scibot 09 Apr 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.xcrm.2024.101503
  
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2. scibot 09 Apr 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.xcrm.2024.101503
  
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sciencedirect.com/science/article/pii/S2666379124001721
Mar 2024
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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

2
1. scibot 12 Mar 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.113935
  
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2. scibot 12 Mar 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.113935
  
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sciencedirect.com/science/article/pii/S2211124724002638
Feb 2024
dx.doi.org dx.doi.org

HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs

1
1. scibot 28 Feb 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1210/endocr/bqae011
  
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dx.doi.org/10.1210/endocr/bqae011
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SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination

1
1. scibot 13 Feb 2024
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2024.113752
  
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sciencedirect.com/science/article/pii/S2211124724000809
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome

1
1. scibot 13 Dec 2023
  
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  RRID:AB_2490202
  
  DOI: 10.1186/s43556-023-00158-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10703753/
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores

1
1. scibot 08 Sep 2023
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.isci.2023.107698
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10480325/
Jun 2023
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1. scibot 30 Jun 2023
  
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  RRID:AB_2490202
  
  DOI: 10.1111/bph.16074
  
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Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases

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  DOI: 10.1016/j.cell.2023.03.036
  
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Mar 2023
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NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro

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BPS Publications

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  DOI: 10.1111/bph.16036
  
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Feb 2023
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Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

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  DOI: 10.1016/j.celrep.2023.112133
  
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

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Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells

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  DOI: 10.1126/sciadv.abn9912
  
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Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35

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Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome

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Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model

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Impaired interferon-γ signaling promotes the development of silicosis

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Jun 2022
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Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination

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  DOI: 10.1111/bph.15838
  
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Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans

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  DOI: 10.1210/endocr/bqac014
  
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academic.oup.com/endo/article/163/4/bqac014/6523230
Mar 2022
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Reconstitution System of NLRP3 Inflammasome in HEK293T Cells

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  DOI: 10.1007/978-1-0716-2144-8_8
  
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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

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Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion

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Leptin Signaling in the Ovary of Diet-Induced Obese Mice Regulates Activation of NOD-Like Receptor Protein 3 Inflammasome

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1. scibot 19 Nov 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8595835/
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Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

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Sacubitril/Valsartan Alleviates Experimental Autoimmune Myocarditis by Inhibiting Th17 Cell Differentiation Independently of the NLRP3 Inflammasome Pathway

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  DOI: 10.3389/fphar.2021.727838
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8479108/
Aug 2021
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Untitled document

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  DOI: 10.1016/j.immuni.2019.02.006
  
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  DOI: 10.1523/JNEUROSCI.3045-16.2017
  
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  DOI: 10.1016/j.celrep.2018.09.071
  
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onlinelibrary.wiley.com/doi/full/10.1002/glia.23568
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Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia

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The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

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The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

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  DOI: 10.1016/j.immuni.2018.04.032
  
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Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation

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sciencedirect.com/science/article/pii/S1097276520305785
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Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

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sciencedirect.com/science/article/pii/S1074761320301680
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Itaconate confers tolerance to late NLRP3 inflammasome activation

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  DOI: 10.1016/j.celrep.2021.108756
  
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Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease

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1. scibot 25 Feb 2021
  
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  DOI: 10.1172/JCI136174
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7410064/
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α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia

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1. scibot 02 Feb 2021
  
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  RRID:AB_2490202
  
  DOI: 10.1002/glia.23970
  
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  DOI: 10.1002/glia.23970
  
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onlinelibrary.wiley.com/doi/10.1002/glia.23970
Dec 2020
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Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

1
1. scibot 22 Dec 2020
  
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  anti-NLRP3
  
  DOI: 10.3390/antiox9121299
  
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mdpi.com/2076-3921/9/12/1299/htm
Nov 2020
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RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

1
1. scibot 24 Nov 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2020.108405
  
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sciencedirect.com/science/article/pii/S2211124720313942
Sep 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1111/jnc.14962
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14962
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

1
1. scibot 25 Sep 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.cell.2020.03.040
  
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sciencedirect.com/science/article/pii/S0092867420303330
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Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2020.107604
  
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sciencedirect.com/science/article/pii/S2211124720305532
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Platelets Fuel the Inflammasome Activation of Innate Immune Cells

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2020.107615
  
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sciencedirect.com/science/article/pii/S2211124720305647
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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2020.02.025
  
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sciencedirect.com/science/article/pii/S2211124720301868
Jan 2020
iovs.arvojournals.org iovs.arvojournals.org

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1167/iovs.18-26360
  
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iovs.arvojournals.org/article.aspx
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HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2019.02.095
  
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sciencedirect.com/science/article/pii/S2211124719302815
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.immuni.2019.02.006
  
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sciencedirect.com/science/article/pii/S107476131930072X
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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

1
1. scibot 13 Jan 2020
  
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  AB_2490202
  
  DOI: 10.1016/j.immuni.2019.04.005
  
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2018.12.047
  
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sciencedirect.com/science/article/pii/S2211124718319776
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia‐induced brain injury

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1111/bph.14673
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14673
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Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2490202
  
  DOI: 10.1016/j.celrep.2018.12.101
  
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sciencedirect.com/science/article/pii/S221112471832076X
Nov 2018
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Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761318303844
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Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118300561
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Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2490202
  
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sciencedirect.com/science/article/pii/S1931312817305504
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Method for the Acute and Rapid Degradation of Endogenous Proteins

2
1. scibot 05 Nov 2018
  
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2. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
Nov 2017
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NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

1
1. scibot 08 Nov 2017
  
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  RRID:AB_2490202
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1097276517306147
www.jneurosci.org www.jneurosci.org

HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation

1
1. scibot 08 Nov 2017
  
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  AB_2490202
  
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jneurosci.org/content/37/13/3599

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