410 Matching Annotations
  1. Last 7 days
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    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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    1. scibot 10 May 2024
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      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
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    PDZD8 promotes autophagy at ER-Lysosome contact sites to regulate synaptogenesis
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      DOI: 10.1101/2023.10.30.564828

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    ncbi.nlm.nih.gov/pmc/articles/PMC10634952/
  4. May 2024
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    Locus coeruleus norepinephrine contributes to visual-spatial attention by selectively enhancing perceptual sensitivity
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      DOI: 10.1016/j.neuron.2024.04.001

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    sciencedirect.com/science/article/pii/S0896627324002393
  6. Apr 2024
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    Efficient generation of induced pluripotent stem cell lines from healthy donors’ peripheral blood mononuclear cells of different genders
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      RRID:AB_2535813

      DOI: 10.1016/j.scr.2024.103421

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    sciencedirect.com/science/article/pii/S1873506124001193
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.015

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    sciencedirect.com/science/article/pii/S1097276524002259
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    Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptation
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      DOI: 10.1016/j.devcel.2024.03.022

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    sciencedirect.com/science/article/pii/S1534580724001904
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    Plasmodium falciparum Alba6 exhibits DNase activity and participates in stress response
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      RRID:AB_2535813

      DOI: 10.1016/j.isci.2024.109467

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    ncbi.nlm.nih.gov/pmc/articles/PMC10981135/
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    BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing
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      DOI: 10.1016/j.celrep.2024.114025

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    sciencedirect.com/science/article/pii/S221112472400353X
  12. Mar 2024
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    Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides
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      DOI: 10.1016/j.celrep.2024.113984

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      DOI: 10.1016/j.celrep.2024.113984

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    sciencedirect.com/science/article/pii/S2211124724003127
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    Peripheral neuronal activation shapes the microbiome and alters gut physiology
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      DOI: 10.1016/j.celrep.2024.113953

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    sciencedirect.com/science/article/pii/S221112472400281X
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    Rab32 family proteins regulate autophagosomal components recycling
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    1. scibot 21 Mar 2024
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      DOI: 10.1083/jcb.202306040

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      DOI: 10.1083/jcb.202306040

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    rupress.org/jcb/article/223/3/e202306040/276549/Rab32-family-proteins-regulate-autophagosomal
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    Protocol to measure apoptosis-associated speck-like protein containing a CARD specks in human cerebrospinal fluid via imaging flow cytometry
    1
    1. scibot 14 Mar 2024
      RRID:AB_2535813

      DOI: 10.1016/j.xpro.2024.102916

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    sciencedirect.com/science/article/pii/S2666166724000819
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    Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
    2
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      AB_2535813

      DOI: 10.1016/j.nbd.2024.106470

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    sciencedirect.com/science/article/pii/S096999612400069X
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    Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia
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      DOI: 10.1016/j.cmet.2024.02.010

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    sciencedirect.com/science/article/pii/S1550413124000561
  19. Feb 2024
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    Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression
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      DOI: 10.1016/j.celrep.2024.113823

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    sciencedirect.com/science/article/pii/S2211124724001517
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    An iron rheostat controls hematopoietic stem cell fate
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    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.stem.2024.01.011

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    sciencedirect.com/science/article/pii/S1934590924000419
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    Mouse oocytes sequester aggregated proteins in degradative super-organelles
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    1. scibot 21 Feb 2024
      RRID:AB_2535813

      DOI: 10.1016/j.cell.2024.01.031

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    sciencedirect.com/science/article/pii/S0092867424000680
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human iPSC-derived closed-loop cardiac tissue for drug assessment
    1
    1. scibot 11 Feb 2024
      RRID:AB_2535813

      DOI: 10.1016/j.isci.2024.108992

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    ncbi.nlm.nih.gov/pmc/articles/PMC10850789/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO
    1
    1. scibot 08 Feb 2024
      RRID:AB_2535813

      DOI: 10.1016/j.isci.2024.108898

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844825/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterization of a novel variant in the HR1 domain of MFN2 in a patient with ataxia, optic atrophy and sensorineural hearing loss
    1
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      RRID:AB_2535813

      DOI: 10.12688/f1000research.53230.2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10808857/
  26. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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      DOI: 10.1016/j.molcel.2023.12.039

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    sciencedirect.com/science/article/pii/S1097276523010857
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    Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device
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      DOI: 10.1016/j.crmeth.2023.100689

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    sciencedirect.com/science/article/pii/S2667237523003752
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    CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis
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      DOI: 10.1016/j.celrep.2023.113607

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    sciencedirect.com/science/article/pii/S2211124723016194
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    Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk
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    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.stem.2023.12.002

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    sciencedirect.com/science/article/pii/S1934590923004320
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    Generation of three induced pluripotent stem cell lines from individuals with Aicardi-Goutières syndrome caused by a c.3019G>A (p.G1007R) autosomal dominant pathogenic variant in ADAR1
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    1. scibot 07 Jan 2024
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      DOI: 10.1016/j.scr.2023.103299

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    sciencedirect.com/science/article/pii/S1873506123002854
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    Cytoneme signaling provides essential contributions to mammalian tissue patterning
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      DOI: 10.1016/j.cell.2023.12.003

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    sciencedirect.com/science/article/pii/S0092867423013338
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ULK phosphorylation of STX17 controls autophagosome maturation via FLNA
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    1. scibot 05 Jan 2024
      RRID:AB_2535813

      DOI: 10.1083/jcb.202211025

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    ncbi.nlm.nih.gov/pmc/articles/PMC10316704/
  34. Dec 2023
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    Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques
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      DOI: 10.1016/j.isci.2023.108490

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    sciencedirect.com/science/article/pii/S2589004223025671
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    Voluntary wheel running improves molecular and functional deficits in a murine model of facioscapulohumeral muscular dystrophy
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      DOI: 10.1016/j.isci.2023.108632

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    sciencedirect.com/science/article/pii/S2589004223027098
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    The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain
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      DOI: 10.1016/j.celrep.2023.113505

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    sciencedirect.com/science/article/pii/S2211124723015176
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    Protocol for lentivirus-mediated delivery of genes to study neurogenesis and cognitive function in adult rodents
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      DOI: 10.1016/j.xpro.2023.102761

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    sciencedirect.com/science/article/pii/S2666166723007281
  39. Nov 2023
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    Generation of heart and vascular system in rodents by blastocyst complementation
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      DOI: 10.1016/j.devcel.2023.10.008

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    sciencedirect.com/science/article/pii/S153458072300552X
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    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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      DOI: 10.1016/j.celrep.2023.113460

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    sciencedirect.com/science/article/pii/S2211124723014729
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    Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma
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      DOI: 10.1016/j.celrep.2023.113286

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    sciencedirect.com/science/article/pii/S2211124723012986
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    Activated somatostatin interneurons orchestrate memory microcircuits
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      DOI: 10.1016/j.neuron.2023.10.013

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    sciencedirect.com/science/article/pii/S0896627323007699
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    Transitional cell states sculpt tissue topology during lung regeneration
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      DOI: 10.1016/j.stem.2023.10.001

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    sciencedirect.com/science/article/pii/S1934590923003636
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    GABAergic-like dopamine synapses in the brain
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      DOI: 10.1016/j.celrep.2023.113239

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    sciencedirect.com/science/article/pii/S2211124723012512
  46. Oct 2023
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    KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation
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      DOI: 10.1016/j.celrep.2023.113321

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    sciencedirect.com/science/article/pii/S2211124723013335
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells
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    APE1-dependent base excision repair of DNA photodimers in human cells
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    Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states
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  52. Aug 2023
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    A comparative analysis of microglial inducible Cre lines
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    Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
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    An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
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      DOI: 10.1038/s41467-023-40688-x

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    Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction
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    Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
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      DOI: 10.1038/s41467-023-39873-9

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    Senescent cells form nuclear foci that contain the 26S proteasome
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  59. Jul 2023
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    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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  62. Jun 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth
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    Structural plasticity in the entorhinal and perirhinal cortices following hippocampal lesions in rhesus monkeys
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  65. 52.53.155.43 52.53.155.43
    J of Bone Mineral Res - 2023 - Allen - Reduced GS domain serine threonine requirements of Fibrodysplasia Ossificans-html.html
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
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    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system
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    A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors
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    Medulloblastoma and high-grade glioma organoids for drug screening, lineage tracing, co-culture and in vivo assay
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  71. May 2023
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    FriendlyClearMap: an optimized toolkit for mouse brain mapping and analysis
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    The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms
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    Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcineurin associates with centrosomes and regulates cilia length maintenance
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    Immune mechanisms shape the clonal landscape during early progression of prostate cancer
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  77. Apr 2023
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    A tubule-sheet continuum model for the mechanism of nuclear envelope assembly
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    The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation
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    A corneo-retinal hypercitrullination axis underlies ocular injury to nitrogen mustard
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    Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm
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    TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner
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    Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection
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    Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
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    Optineurin provides a mitophagy contact site for TBK1 activation
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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    Hic1 identifies a specialized mesenchymal progenitor population in the embryonic limb responsible for bone superstructure formation
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  88. Mar 2023
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    Efficient Generation of induced Pluripotent Stem Cell lines from Peripheral Blood Mononuclear Cells
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    A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans
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    Nuclease activity of Plasmodium falciparum Alba family protein PfAlba3
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    Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G>A (p.D249N) autosomal dominant mutation in TUBB4A
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    Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines
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    Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy
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    Mechanistic insights into CDCP1 clustering on non-small-cell lung cancer membranes revealed by super-resolution fluorescent imaging
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    EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
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    Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits
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    Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts
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    Peptidyl arginine deiminase 4 deficiency protects against subretinal fibrosis by inhibiting Müller glial hypercitrullination
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    The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum
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    Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks
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    Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutations
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    Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
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    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
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  138. Aug 2022
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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    Non-degradable autophagic vacuoles are indispensable for cell competition
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    Toxic and Phenotypic Effects of AAV_Cre Used to Transduce Mesencephalic Dopaminergic Neurons
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    Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
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    DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential
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    Spatially resolved deconvolution of the fibrotic niche in lung fibrosis
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    EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules
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    Melanopsin retinal ganglion cells mediate light-promoted brain development
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    Glioblastoma hijacks neuronal mechanisms for brain invasion
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    A robust and tunable system for targeted cell ablation in developing embryos
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  149. Jul 2022
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chloral Hydrate Alters Brain Activation Induced by Methamphetamine-Associated Cue and Prevents Relapse
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny
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    Template-independent genome editing in the Pcdh15av−3j mouse, a model of human DFNB23 nonsyndromic deafness
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    Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
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    EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
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    A molecular mechanism for high salt taste in Drosophila
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  157. Jun 2022
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    Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
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    CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development
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    Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation
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  161. May 2022
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    Cone-driven retinal responses are shaped by rod but not cone HCN1
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    Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment
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    An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
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    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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    A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
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    Vocal changes in a zebra finch model of Parkinson’s disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway
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  168. Apr 2022
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    IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming
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    Modular microcircuit organization of the presubicular head-direction map
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    Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
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  174. Mar 2022
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    NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury
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    Melanopsin for precise optogenetic activation of astrocyte-neuron networks
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    AP-4-mediated axonal transport controls endocannabinoid production in neurons
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    Moraxella catarrhalis evades neutrophil oxidative stress responses providing a safer niche for nontypeable Haemophilus influenzae
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  179. Feb 2022
  180. www.sciencedirect.com www.sciencedirect.com
    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility
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    Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
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    A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
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  184. Jan 2022
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    Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing
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    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
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    SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport
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    Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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    A protocol to investigate cellular and circuit mechanisms generating sharp wave ripple oscillations in rodent basolateral amygdala using ex vivo slices
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    CXCL4 drives fibrosis by promoting several key cellular and molecular processes
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  193. Dec 2021
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    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
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  195. Nov 2021
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    CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection
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    Unique Neural Circuit Connectivity of Mouse Proximal, Middle and Distal Colon Defines Regional Colonic Motor Patterns
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    MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients
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    Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy
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    AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
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    Ataxia Telangiectasia iPSC line generated from a patient olfactory biopsy identifies novel disease-causing mutations
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis
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    Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration
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    Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila
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