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A decline in skeletal muscle NOX4 abrogates adaptive homeostasis and exacerbates ageing

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1. scibot 03 Apr 2026
  
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  DOI: 10.64898/2026.03.27.714615
  
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biorxiv.org/content/10.64898/2026.03.27.714615v1
Mar 2026
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Di-(2-ethylhexyl) terephthalate promotes breast cancer progression: Multi-omics integrated experimental validation

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sciencedirect.com/science/article/pii/S0009279726001109
Feb 2026
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The Prolyl Isomerase PIN1 Impacts Fibroblast Differentiation States and Crosstalk in Pancreatic Cancer

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1. scibot 19 Feb 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-3437
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12912258/
Jan 2026
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Differential contribution of TFE3 isoforms to cell motility and invasion

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1. scibot 31 Jan 2026
  
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  DOI: 10.1038/s44319-025-00659-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12852735/
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A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

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1. scibot 23 Jan 2026
  
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  DOI: 10.1111/acel.70352
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12816977/
Dec 2025
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misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html

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1. scibot 16 Dec 2025
  
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  DOI: 10.6084/m9.figshare.30317422
  
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54.241.53.176/7d61701eda67e5c30e5b80a91af04eaa9e6cd528/misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html
Sep 2025
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Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116320
  
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sciencedirect.com/science/article/pii/S2211124725010915
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PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region

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1. scibot 16 Sep 2025
  
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  DOI: 10.1186/s12929-025-01185-z
  
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jbiomedsci.biomedcentral.com/articles/10.1186/s12929-025-01185-z
Aug 2025
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p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia

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1. scibot 05 Aug 2025
  
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  DOI: 10.1093/brain/awaf084
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12316007/
Jul 2025
52.53.155.43 52.53.155.43

2025.07.14.664742v1.full-html.html

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1. scibot 25 Jul 2025
  
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  DOI: 10.1101/2025.07.14.664742
  
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52.53.155.43/0ddeb0d5c1e9d78409db30015477d90afb34bbce/2025.07.14.664742v1.full-html.html
Jun 2025
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Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112843
  
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sciencedirect.com/science/article/pii/S2589004225011046
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1-s2.0-S258900422501226X-main-html.html

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112965
  
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52.53.155.43/d1f78810f1eafd7cac950f9c8a5713f79fe4d700/1-s2.0-S258900422501226X-main-html.html
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TBX3 advances the developmental chromatin landscape toward the hepatic fate

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.devcel.2025.05.014
  
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sciencedirect.com/science/article/pii/S1534580725003259
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1158/0008-5472.can-24-0859
  
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52.53.155.43/9cdde814e7de824838c1017824753184462e213e/PDF-html.html
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Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.isci.2024.108903
  
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sciencedirect.com/science/article/pii/S258900422400124X
Apr 2025
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Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities

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1. scibot 17 Apr 2025
  
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  DOI: 10.1158/1541-7786.MCR-24-0958
  
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aacrjournals.org/mcr/article/23/4/327/754237/Exploring-B7-H4-s-Role-in-Prostate-Cancer-Dormancy
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ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

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1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.019
  
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sciencedirect.com/science/article/pii/S0092867425002922
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Cleavage of the TrkB-FL receptor during epileptogenesis: insights from a kainic acid-induced model of epilepsy and human samples

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.phrs.2025.107707
  
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sciencedirect.com/science/article/pii/S104366182500132X
Mar 2025
biosignaling.biomedcentral.com biosignaling.biomedcentral.com

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

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1. scibot 06 Mar 2025
  
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  DOI: 10.1186/s12964-025-02115-0
  
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biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02115-0
Feb 2025
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Small-molecule inhibitor BAY synergizes with gemcitabine through AHR inhibition in pancreatic cancer cells

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1. scibot 21 Feb 2025
  
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  DOI: 10.1016/j.bcp.2025.116798
  
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sciencedirect.com/science/article/pii/S0006295225000607
Jan 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 10 Jan 2025
  
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  DOI: 10.1158/1541-7786.mcr-24-0958
  
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52.53.155.43/57f7b91c9dd53b655db1714a662edada3a9f9e82/PDF-html.html
Dec 2024
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Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples

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1. scibot 28 Dec 2024
  
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  DOI: 10.1101/2024.12.18.628660
  
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biorxiv.org/content/10.1101/2024.12.18.628660v1
Sep 2024
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BPS Publications

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1. scibot 28 Sep 2024
  
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  DOI: 10.1111/bph.17319
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17319
Jul 2024
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Identification of the main barriers to Ku accumulation in chromatin

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1. scibot 30 Jul 2024
  
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  AB_2536381
  
  DOI: 10.1016/j.celrep.2024.114538
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11411529/
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Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.crmeth.2024.100816
  
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cell.com/cell-reports-methods/abstract/S2667-2375(24)00181-4
May 2024
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p75NTR upregulation following perinatal hypoxia leads to deficits in parvalbumin-expressing GABAergic cell maturation, cortical activity and cognitive abilities in adult mice

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1. scibot 03 May 2024
  
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  DOI: 10.1101/2024.01.16.574659
  
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biorxiv.org/content/10.1101/2024.01.16.574659v1
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Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.neuron.2024.04.006
  
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sciencedirect.com/science/article/pii/S0896627324002447
Apr 2024
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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

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1. scibot 10 Apr 2024
  
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  DOI: 10.1038/s41593-024-01615-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11088998/
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Efficacy of the induced pluripotent stem cell derived and engineered CD276-targeted CAR-NK cells against human esophageal squamous cell carcinoma

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  DOI: 10.3389/fimmu.2024.1337489
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10985341/
Mar 2024
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Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins

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  DOI: 10.1016/j.isci.2024.109136
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951640/
Feb 2024
aacrjournals.org aacrjournals.org

Exosomal lncRNA NEAT1 inhibits NK cell activity to promote multiple myeloma cell immune escape via an EZH2/PBX1 axis

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1. scibot 24 Feb 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0282
  
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aacrjournals.org/mcr/article/22/2/125/733692/Exosomal-lncRNA-NEAT1-Inhibits-NK-Cell-Activity-to
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EHD2 regulates plasma membrane integrity and downstream insulin receptor signalling events

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1. scibot 08 Feb 2024
  
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  DOI: 10.1091/mbc.E23-03-0078
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10846623/
Jan 2024
www.molbiolcell.org www.molbiolcell.org

EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events

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1. scibot 12 Jan 2024
  
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  DOI: 10.1091/mbc.E23-03-0078
  
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molbiolcell.org/doi/10.1091/mbc.E23-03-0078
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CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

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1. scibot 07 Jan 2024
  
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  DOI: 10.1016/j.celrep.2023.113626
  
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sciencedirect.com/science/article/pii/S2211124723016376
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe

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mcr-23-0282-html.html

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Nov 2023
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Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice

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Oct 2023
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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

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Sep 2023
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Natural mutations of human XDH promote the nitrite (NO2−)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?

2
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  DOI: 10.1016/j.redox.2023.102864
  
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Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

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Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome

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  DOI: 10.15252/embr.202357233
  
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Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation

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Jul 2023
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates

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  DOI: 10.7554/eLife.78695
  
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May 2023
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Plasma membrane preassociation drives β-arrestin coupling to receptors and activation

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Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells

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Apr 2023
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Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: a novel mechanism to promote redox health?

1
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  DOI: 10.1101/2023.03.24.533749
  
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Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

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Feb 2023
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Protein Kinase A Activation Alleviates Cataract Formation via Increased Gap Junction Intercellular Communication

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Prophylaxis and treatment of SARS-CoV-2 infection by an ACE2 receptor decoy in a preclinical animal model

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ncbi.nlm.nih.gov/pmc/articles/PMC9886562/
Jan 2023
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PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells

1
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Nov 2022
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LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus

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Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964

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Sep 2022
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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Aug 2022
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Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons

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Jul 2022
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EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes

1
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Apr 2022
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High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction

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Feb 2022
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Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

1
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  DOI: 10.7554/eLife.68677
  
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PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

2
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Jan 2022
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Histone deacetylase HDAC2 regulates microRNA-125a expression in neuroblastoma

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Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models

1
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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

1
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  DOI: 10.1126/sciadv.abl4988
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8673768/
Dec 2021
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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

1
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  DOI: 10.1126/sciadv.abl4988
  
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SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

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Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner

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  DOI: 10.1096/fj.202100832R
  
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Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7

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Nov 2021
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A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function

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  DOI: 10.1242/jcs.259075
  
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DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity

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Genomic and “Polyomic” Studies of Cardiovascular and Inflammatory Diseases: miR-125 family regulates XIRP1 and FIH in response to myocardial infarction

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Systematic Functional Annotation of Somatic Mutations in Cancer

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A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome (APC/C) activity resulting in microcephaly, psychomotor retardation and epilepsy

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Targeting senescent cells improves functional recovery after spinal cord injury

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Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling

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Pericentromeric Satellite III transcripts induce etoposide resistance

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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

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Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells

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Deciphering the signaling network of breast cancer improves drug sensitivity prediction

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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

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Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

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A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation

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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

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Multisystem Progeroid Syndrome With Lipodystrophy, Cardiomyopathy, and Nephropathy Due to an LMNA p.R349W Variant

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Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation

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An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

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An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model

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Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

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Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

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Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

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The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

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Effects of acute aerobic, resistance and combined exercises on 24-h glucose variability and skeletal muscle signalling responses in type 1 diabetics

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Sex differences in hypothalamic–pituitary–adrenal axis regulation after chronic unpredictable stress

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Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

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miR-125 family regulates XIRP1 and FIH in response to myocardial infarction | Physiological Genomics

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

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Stimulation of Hair Growth by Small Molecules that Activate Autophagy

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Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen

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  DOI: 10.1016/j.chom.2019.08.017
  
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A protein quality control pathway regulated by linear ubiquitination

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  DOI: 10.15252/embj.2018100730
  
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Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores

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  DOI: 10.1016/j.molcel.2019.11.017
  
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CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus

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  DOI: 10.1016/j.celrep.2019.09.037
  
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p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex

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  DOI: 10.1523/JNEUROSCI.2881-18.2019
  
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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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  DOI: 10.1016/j.stem.2018.12.013
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.019
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.093
  
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Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

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  DOI: 10.1016/j.celrep.2019.02.056
  
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Untitled document

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  DOI: 10.1016/j.molcel.2019.04.021
  
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Untitled document

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  DOI: 10.1016/j.neuron.2019.01.022
  
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Untitled document

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  DOI: 10.1016/j.neuron.2019.02.036
  
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Nov 2018
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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine

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academic.oup.com/endo/article/159/6/2421/4990770
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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1

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1. scibot 05 Nov 2018
  
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Splicing Activation by Rbfox Requires Self-Aggregation through Its Tyrosine-Rich Domain

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  AB_2536381
  
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Proteasome Activation by Small Molecules

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1. scibot 08 Nov 2017
  
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Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment

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1. scibot 08 Nov 2017
  
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A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes

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1. scibot 08 Nov 2017
  
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Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection

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onlinelibrary.wiley.com/doi/10.1111/jnc.14064/full

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