78 Matching Annotations
  1. Last 7 days
  2. www.nature.com www.nature.com
    Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming
    1
    1. scibot 26 May 2022
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      DOI: 10.1038/s41598-022-12188-3

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    nature.com/articles/s41598-022-12188-3
  3. Mar 2022
  4. www.sciencedirect.com www.sciencedirect.com
    A cell-sorting-based protocol for cell cycle small-scale ChIP sequencing
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    1. scibot 18 Mar 2022
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      DOI: 10.1016/j.xpro.2022.101243

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    sciencedirect.com/science/article/pii/S266616672200123X
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    The PAF1 complex promotes 3′ processing of pervasive transcripts
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      DOI: 10.1016/j.celrep.2022.110519

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    sciencedirect.com/science/article/pii/S2211124722002558
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    dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region
    1
    1. scibot 02 Mar 2022
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    sciencedirect.com/science/article/pii/S221112472200184X
  7. Feb 2022
  8. www.sciencedirect.com www.sciencedirect.com
    EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells
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    1. scibot 23 Feb 2022
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      DOI: 10.1016/j.molcel.2022.01.015

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    sciencedirect.com/science/article/pii/S1097276522000582
  9. Jan 2022
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome
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    1. scibot 22 Jan 2022
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      DOI: 10.1038/s41467-021-27899-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC8758698/
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    Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis
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    1. scibot 19 Jan 2022
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      DOI: 10.1016/j.neuron.2021.12.019

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    sciencedirect.com/science/article/pii/S0896627321010369
  12. Dec 2021
  13. www.nature.com www.nature.com
    KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
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      DOI: 10.1038/s41467-021-27502-2

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    nature.com/articles/s41467-021-27502-2
  14. reader.elsevier.com reader.elsevier.com
    Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells
    1
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    reader.elsevier.com/reader/sd/pii/S2211124721015497
  15. Nov 2021
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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      DOI: 10.1016/j.molcel.2021.10.017

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    sciencedirect.com/science/article/pii/S1097276521009096
  17. Oct 2021
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    Collective regulation of chromatin modifications predicts replication timing during cell cycle
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      DOI: 10.1016/j.celrep.2021.109799

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    sciencedirect.com/science/article/pii/S2211124721012596
  19. Aug 2021
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    TooManyPeaks identifies drug-resistant-specific regulatory elements from single-cell leukemic epigenomes
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    sciencedirect.com/science/article/pii/S2211124721010093
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules
    1
    1. scibot 19 Aug 2021
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      DOI: 10.1016/j.isci.2021.102928

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    ncbi.nlm.nih.gov/pmc/articles/PMC8321697/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evidence of pioneer factor activity of an oncogenic fusion transcription factor
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    1. scibot 17 Aug 2021
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      DOI: 10.1016/j.isci.2021.102867

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    ncbi.nlm.nih.gov/pmc/articles/PMC8346656/
  23. www.sciencedirect.com www.sciencedirect.com
    Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.devcel.2021.07.003

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    sciencedirect.com/science/article/pii/S1534580721005591
  24. academic.oup.com academic.oup.com
    Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB
    1
    1. scibot 14 Aug 2021
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      DOI: 10.1210/endocr/bqab069

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    academic.oup.com/endo/article/162/7/bqab069/6213400
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    Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration
    1
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      DOI: 10.1016/j.stem.2018.07.016

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    sciencedirect.com/science/article/pii/S1934590918303527
  26. Jul 2021
  27. mcr.aacrjournals.org mcr.aacrjournals.org
    Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins
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    1. scibot 31 Jul 2021
      anti-H3K27Ac

      DOI: 10.1158/1541-7786.MCR-19-0747

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    mcr.aacrjournals.org/content/17/11/2208
  28. www.sciencedirect.com www.sciencedirect.com
    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
    1
    1. scibot 29 Jul 2021
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      DOI: 10.1016/j.stem.2019.08.017

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    sciencedirect.com/science/article/pii/S1934590919303844
  29. May 2021
  30. academic.oup.com academic.oup.com
    FSHB Transcription is Regulated by a Novel 5’ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism
    1
    1. scibot 10 May 2021
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      DOI: 10.1210/endocr/bqaa181

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    academic.oup.com/endo/article/162/1/bqaa181/5917511
  31. www.sciencedirect.com www.sciencedirect.com
    Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.molcel.2020.12.047

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    sciencedirect.com/science/article/pii/S1097276520309898
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    Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA
    1
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    sciencedirect.com/science/article/pii/S1097276520303865
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    The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
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      DOI: 10.1016/j.immuni.2020.07.012

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    sciencedirect.com/science/article/pii/S1074761320303198
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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
    1
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    sciencedirect.com/science/article/pii/S1534580720303506
  35. Apr 2021
  36. www.sciencedirect.com www.sciencedirect.com
    Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S0092867420309387
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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    sciencedirect.com/science/article/pii/S153561082030369X
  38. www.sciencedirect.com www.sciencedirect.com
    Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics
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      DOI: 10.1016/j.molcel.2021.01.031

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    sciencedirect.com/science/article/pii/S1097276521000514
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
    1
    1. scibot 13 Apr 2021
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      DOI: 10.1016/j.molcel.2021.03.032

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    ncbi.nlm.nih.gov/pmc/articles/PMC8153251/
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    Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution
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      DOI: 10.1016/j.celrep.2021.108927

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    sciencedirect.com/science/article/pii/S2211124721002412
  41. Feb 2021
  42. www.sciencedirect.com www.sciencedirect.com
    An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells
    1
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      DOI: 10.1016/j.xpro.2021.100358

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    sciencedirect.com/science/article/pii/S2666166721000654
  43. elifesciences.org elifesciences.org
    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
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      DOI: 10.7554/eLife.59067

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    elifesciences.org/articles/59067
  44. Dec 2020
  45. www.sciencedirect.com www.sciencedirect.com
    Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis
    1
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      DOI: 10.1016/j.celrep.2020.108473

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    sciencedirect.com/science/article/pii/S2211124720314625
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness
    1
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      DOI: 10.7554/eLife.61965

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    ncbi.nlm.nih.gov/pmc/articles/PMC7704108/
  47. Nov 2020
  48. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
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      DOI: 10.1016/j.celrep.2020.108366

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    pubmed.ncbi.nlm.nih.gov/33176148/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription
    1
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      DOI: 10.7554/eLife.53550

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    ncbi.nlm.nih.gov/pmc/articles/PMC7641585/
  50. Oct 2020
  51. www.sciencedirect.com www.sciencedirect.com
    G9a Plays Distinct Roles in Maintaining DNA Methylation, Retrotransposon Silencing, and Chromatin Looping
    1
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      DOI: 10.1016/j.celrep.2020.108315

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    sciencedirect.com/science/article/pii/S2211124720313048
  52. Sep 2020
  53. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder
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      DOI: 10.1016/j.stem.2020.09.001

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    pubmed.ncbi.nlm.nih.gov/32991838/
  54. elifesciences.org elifesciences.org
    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
    1
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      DOI: 10.7554/eLife.54993

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    elifesciences.org/articles/54993
  55. www.sciencedirect.com www.sciencedirect.com
    MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
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      DOI: 10.1016/j.ccell.2020.05.001

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    sciencedirect.com/science/article/pii/S153561082030218X
  56. www.sciencedirect.com www.sciencedirect.com
    Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
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    Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation
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    ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase
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    MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells
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    Circadian Entrainment Triggers Maturation of Human In Vitro Islets
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
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    Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers
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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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    HUMAN TROPHOBLAST DIFFERENTIATION IS ASSOCIATED WITH PROFOUND GENE REGULATORY AND EPIGENETIC CHANGES
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    A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
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    FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
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    Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice
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    Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
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    Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition
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  75. Nov 2018
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
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    Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
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    Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression
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    Transcription Elongation Can Affect Genome 3D Structure
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    Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
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    AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
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    Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells
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    SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation
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    Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity
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    The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling
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    Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms
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  89. Nov 2017
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    Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
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    Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation
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    Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
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    Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts
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    Resolving Heart Regeneration by Replacement Histone Profiling
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    Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
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    RNA Binding to CBP Stimulates Histone Acetylation and Transcription
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    Histone Acetylome-wide Association Study of Autism Spectrum Disorder
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