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Sep 2026
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Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsufficiency in dominant genetic diseases

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1. scibot 04 Sep 2026
  
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  DOI: 10.1016/j.stem.2026.08.004
  
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sciencedirect.com/science/article/pii/S193459092600305X
Aug 2026
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SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

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  DOI: 10.1016/j.celrep.2026.117806
  
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sciencedirect.com/science/article/pii/S2211124726008843
Jul 2026
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Arginine deprivation enhances ASS1-negative glioblastoma radiosensitivity via epigenetic silencing of DNA repair genes

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1. scibot 11 Jul 2026
  
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  DOI: 10.1038/s41419-026-08920-w
  
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54.241.53.176/3b1580221671e68b563bc25b1dd66e50af60765e/s41419-026-08920-w_reference-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes

1
1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117517
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13349233/
Jun 2026
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Tracking mobilization uncovers an evolutionarily conserved mechanism in suppressing mobile genetic elements

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1. scibot 23 Jun 2026
  
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  DOI: 10.1016/j.molcel.2026.05.022
  
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sciencedirect.com/science/article/pii/S1097276526003461
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Multi-tier signaling and chromatin remodeling coordinate microglia inflammatory states and activities associated with demyelination

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1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117569
  
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sciencedirect.com/science/article/pii/S2211124726006479
May 2026
www-cell-com.eproxy.lib.hku.hk www-cell-com.eproxy.lib.hku.hk

Whole-genome doubling drives immune evasion by silencing antigen presentation

1
1. scibot 08 May 2026
  
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  DOI: 10.1016/j.ccell.2026.04.007
  
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www-cell-com.eproxy.lib.hku.hk/cancer-cell/fulltext/S1535-6108(26)00218-7
Feb 2026
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Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.neuron.2025.12.037
  
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sciencedirect.com/science/article/pii/S0896627325009936
Nov 2025
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CUT&Tag overcomes biases of ChIP and establishes chromatin patterns for repetitive genomic loci

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1. scibot 19 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.113757
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12605858/
Oct 2025
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Chromatin state dynamics of autosomes and the B chromosome during spermatogenesis in Pseudococcus viburni

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1. scibot 23 Oct 2025
  
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  DOI: 10.1038/s41437-025-00800-x
  
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nature.com/articles/s41437-025-00800-x
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PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells

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1. scibot 09 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116391
  
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sciencedirect.com/science/article/pii/S2211124725011623
Sep 2025
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Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells

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1. scibot 12 Sep 2025
  
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  DOI: 10.1101/2025.08.20.671247
  
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biorxiv.org/content/10.1101/2025.08.20.671247v1
Jul 2025
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Mitotic slippage causes nuclear instability in polyploid cells

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1. scibot 25 Jul 2025
  
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  DOI: 10.1101/2025.07.21.665898
  
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biorxiv.org/content/10.1101/2025.07.21.665898v1
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β-catenin functions as a molecular adapter for disordered cBAF interactions

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.026
  
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sciencedirect.com/science/article/pii/S1097276525005763
Jun 2025
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Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115917
  
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sciencedirect.com/science/article/pii/S2211124725006886
Dec 2024
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Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.021
  
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sciencedirect.com/science/article/pii/S1097276524009468
Oct 2024
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The chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.celrep.2024.114814
  
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2. scibot 09 Oct 2024
  
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sciencedirect.com/science/article/pii/S2211124724011653
Sep 2024
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Activation of automethylated PRC2 by dimerization on chromatin

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.molcel.2024.08.025
  
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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114739
  
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sciencedirect.com/science/article/pii/S2211124724010908
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Promoter DNA methylation and transcription factor condensation are linked to transcriptional memory in mammalian cells

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cels.2024.08.007
  
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sciencedirect.com/science/article/pii/S2405471224002370
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TGF-β and RAS jointly unmask primed enhancers to drive metastasis

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1. scibot 10 Sep 2024
  
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sciencedirect.com/science/article/pii/S009286742400905X
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GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.006
  
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sciencedirect.com/science/article/pii/S1535610824003052
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers

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1. scibot 18 Aug 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-0398
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11292196/
Jul 2024
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CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A

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1. scibot 30 Jul 2024
  
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  DOI: 10.1007/s00018-024-05285-1
  
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link.springer.com/article/10.1007/s00018-024-05285-1
52.53.155.43 52.53.155.43

Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage

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1. scibot 26 Jul 2024
  
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52.53.155.43/e9c57a9d42b1c2a342f0d34ee7a75c66e8f5b9d0/1-s2.0-S2589004224017322-main-html.html
May 2024
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A chromatin code for limb segment identity in axolotl limb regeneration

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.devcel.2024.05.002
  
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sciencedirect.com/science/article/pii/S1534580724003009
Apr 2024
www.cell.com www.cell.com

Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.015
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(24)00096-1
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An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains

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1. scibot 10 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.015
  
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Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice

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  DOI: 10.1016/j.xcrm.2024.101449
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983034/
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Modular dual-color BiAD sensors for locus-specific readout of epigenome modifications in single cells

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  DOI: 10.1016/j.crmeth.2024.100739
  
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sciencedirect.com/science/article/pii/S266723752400064X
Mar 2024
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Epigenomic tomography for probing spatially defined chromatin state in the brain

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  DOI: 10.1016/j.crmeth.2024.100738
  
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ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.

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1. scibot 07 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109231
  
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sciencedirect.com/science/article/pii/S2589004224004528
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Synthetic reversed sequences reveal default genomic states

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1. scibot 06 Mar 2024
  
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  DOI: 10.1038/s41586-024-07128-2
  
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nature.com/articles/s41586-024-07128-2
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SWI/SNF-dependent genes are defined by their chromatin landscape

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1. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113855
  
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sciencedirect.com/science/article/pii/S2211124724001839
Feb 2024
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PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

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Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo

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EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas

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Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer

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XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells

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Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint

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Epigenetic regulation limits competence of pluripotent stem cell-derived oocytes

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Perturbations in 3D genome organization can promote acquired drug resistance

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Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b-mediated chromatin demethylation

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Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function

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Jun 2023
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DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

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Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

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Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics

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Apr 2023
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Integrative dissection of gene regulatory elements at base resolution

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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

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Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis

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Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-Repression

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Feb 2023
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Bat pluripotent stem cells reveal unusual entanglement between host and viruses

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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation

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Antifungal mechanisms of silver nanoparticles on mycotoxin producing rice false smut fungus

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BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

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Oct 2022
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Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity

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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy

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The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes

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dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region

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An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase

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Interferons reshape the 3D conformation and accessibility of macrophage chromatin

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Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

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Dec 2021
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5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function

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Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus

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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

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Aug 2021
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Evidence of pioneer factor activity of an oncogenic fusion transcription factor

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Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration

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Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation

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N6-methyladenine DNA Modification in Glioblastoma

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An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing

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An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma

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SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

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H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.

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FSHB Transcription is Regulated by a Novel 5’ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism

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Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis

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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population

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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

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H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

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Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

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ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration

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Nucleome Dynamics during Retinal Development

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DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation

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Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State

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Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons

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Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4

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The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain

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Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

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BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome

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Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation

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lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS

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An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells

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Multiscale 3D Genome Rewiring during Mouse Neural Development

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Untitled document

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The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

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Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

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Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts

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Destabilization of B2 RNA by EZH2 Activates the Stress Response

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CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression

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Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons

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Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons

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A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells

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