102 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    The chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin
    2
    1. scibot 09 Oct 2024
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    sciencedirect.com/science/article/pii/S2211124724011653
  3. Sep 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Activation of automethylated PRC2 by dimerization on chromatin
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.molcel.2024.08.025

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    sciencedirect.com/science/article/pii/S1097276524007020
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    Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation
    1
    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010908
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    Promoter DNA methylation and transcription factor condensation are linked to transcriptional memory in mammalian cells
    1
    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S2405471224002370
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
    1
    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S009286742400905X
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    GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S1535610824003052
  9. Aug 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers
    1
    1. scibot 18 Aug 2024
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      DOI: 10.1158/0008-5472.CAN-24-0398

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    ncbi.nlm.nih.gov/pmc/articles/PMC11292196/
  11. Jul 2024
  12. link.springer.com link.springer.com
    CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A
    1
    1. scibot 30 Jul 2024
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      DOI: 10.1007/s00018-024-05285-1

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    link.springer.com/article/10.1007/s00018-024-05285-1
  13. 52.53.155.43 52.53.155.43
    Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage
    1
    1. scibot 26 Jul 2024
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    52.53.155.43/e9c57a9d42b1c2a342f0d34ee7a75c66e8f5b9d0/1-s2.0-S2589004224017322-main-html.html
  14. May 2024
  15. www.sciencedirect.com www.sciencedirect.com
    A chromatin code for limb segment identity in axolotl limb regeneration
    1
    1. scibot 24 May 2024
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    sciencedirect.com/science/article/pii/S1534580724003009
  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence
    1
    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.stem.2024.03.015

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    sciencedirect.com/science/article/pii/S1934590924000961
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
    1
    1. scibot 10 Apr 2024
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    sciencedirect.com/science/article/pii/S1097276524002259
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101449

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983034/
  20. www.sciencedirect.com www.sciencedirect.com
    Modular dual-color BiAD sensors for locus-specific readout of epigenome modifications in single cells
    1
    1. scibot 02 Apr 2024
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      DOI: 10.1016/j.crmeth.2024.100739

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    sciencedirect.com/science/article/pii/S266723752400064X
  21. Mar 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Epigenomic tomography for probing spatially defined chromatin state in the brain
    1
    1. scibot 21 Mar 2024
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      DOI: 10.1016/j.crmeth.2024.100738

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    sciencedirect.com/science/article/pii/S2667237524000638
  23. www.sciencedirect.com www.sciencedirect.com
    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109231

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      DOI: 10.1016/j.isci.2024.109231

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    sciencedirect.com/science/article/pii/S2589004224004528
  24. www.nature.com www.nature.com
    Synthetic reversed sequences reveal default genomic states
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1038/s41586-024-07128-2

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    nature.com/articles/s41586-024-07128-2
  25. www.sciencedirect.com www.sciencedirect.com
    SWI/SNF-dependent genes are defined by their chromatin landscape
    1
    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113855

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    sciencedirect.com/science/article/pii/S2211124724001839
  26. Feb 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
    1
    1. scibot 28 Feb 2024
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      DOI: 10.1016/j.isci.2024.109152

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879814/
  28. www.sciencedirect.com www.sciencedirect.com
    Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.026

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    sciencedirect.com/science/article/pii/S1097276524000935
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0399

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    ncbi.nlm.nih.gov/pmc/articles/PMC10863487/
  30. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
    1
    1. scibot 07 Feb 2024
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      DOI: 10.1186/s12935-024-03231-6

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    cancerci.biomedcentral.com/articles/10.1186/s12935-024-03231-6
  31. Jan 2024
  32. www.sciencedirect.com www.sciencedirect.com
    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
    1
    1. scibot 05 Jan 2024
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      DOI: 10.1016/j.cell.2023.11.033

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    sciencedirect.com/science/article/pii/S0092867423013193
  33. Dec 2023
  34. www.biorxiv.org www.biorxiv.org
    Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1101/2021.04.21.440825

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    biorxiv.org/content/10.1101/2021.04.21.440825v1
  35. Oct 2023
  36. www.embopress.org www.embopress.org
    Epigenetic regulation limits competence of pluripotent stem cell-derived oocytes
    1
    1. scibot 20 Oct 2023
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      DOI: 10.15252/embj.2023113955

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    embopress.org/doi/10.15252/embj.2023113955
  37. Sep 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Perturbations in 3D genome organization can promote acquired drug resistance
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113124

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    sciencedirect.com/science/article/pii/S2211124723011361
  39. Aug 2023
  40. www.embopress.org www.embopress.org
    Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b-mediated chromatin demethylation
    1
    1. scibot 23 Aug 2023
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      DOI: 10.15252/embj.2023113880

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    embopress.org/doi/10.15252/embj.2023113880
  41. 52.53.155.43 52.53.155.43
    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
    2
    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112914

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    2. scibot 10 Aug 2023
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    52.53.155.43/464fcb14db36fa0ad68672734eea21dbff7f105c/PIIS2211124723009257-html.html
  42. Jun 2023
  43. www.sciencedirect.com www.sciencedirect.com
    DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.cell.2023.05.028

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  44. May 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity
    1
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      DOI: 10.1016/j.cmet.2023.04.015

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    sciencedirect.com/science/article/pii/S1550413123001419
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics
    1
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      DOI: 10.7554/eLife.86273

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    ncbi.nlm.nih.gov/pmc/articles/PMC10181825/
  47. Apr 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Integrative dissection of gene regulatory elements at base resolution
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      DOI: 10.1016/j.xgen.2023.100318

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    sciencedirect.com/science/article/pii/S2666979X23000861
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    A hyper-quiescent chromatin state formed during aging is reversed by regeneration
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      DOI: 10.1016/j.molcel.2023.04.005

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    sciencedirect.com/science/article/pii/S1097276523002496
  50. www.sciencedirect.com www.sciencedirect.com
    Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis
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      DOI: 10.1016/j.celrep.2023.112151

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    sciencedirect.com/science/article/pii/S2211124723001626
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-Repression
    1
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      DOI: 10.1101/2023.03.07.531478

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    ncbi.nlm.nih.gov/pmc/articles/PMC10028926/
  52. Feb 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Bat pluripotent stem cells reveal unusual entanglement between host and viruses
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      DOI: 10.1016/j.cell.2023.01.011

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    sciencedirect.com/science/article/pii/S0092867423000417
  54. Jan 2023
  55. www.cell.com www.cell.com
    Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation
    1
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      DOI: 10.1016/j.cell.2022.12.004

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    cell.com/cell/fulltext/S0092-8674(22)01517-3
  56. Dec 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antifungal mechanisms of silver nanoparticles on mycotoxin producing rice false smut fungus
    1
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      DOI: 10.1016/j.isci.2022.105763

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    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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  59. Oct 2022
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    Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity
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  61. May 2022
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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    L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy
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    The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
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    dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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  71. Jan 2022
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    Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos
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  73. Dec 2021
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    5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function
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    Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
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    Evidence of pioneer factor activity of an oncogenic fusion transcription factor
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    Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration
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    Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation
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    N6-methyladenine DNA Modification in Glioblastoma
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    An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing
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    An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
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  89. Jun 2021
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    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
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    H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.
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  92. May 2021
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    FSHB Transcription is Regulated by a Novel 5’ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism
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    Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis
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    Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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  101. Dec 2020
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    Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis
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    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription
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    4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
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    PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration
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    DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation
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    Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
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    Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
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    Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4
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      DOI: 10.1016/j.stem.2018.12.012

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      DOI: 10.1016/j.molcel.2019.03.018

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  118. Nov 2018
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    The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain
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    Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
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    EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation
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    BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome
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    Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation
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    lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS
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    An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells
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    Multiscale 3D Genome Rewiring during Mouse Neural Development
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  129. Nov 2017
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    The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis
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    Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation
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    Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts
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    Destabilization of B2 RNA by EZH2 Activates the Stress Response
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    CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
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    Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
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    Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
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    A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells
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