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Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis

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1. scibot 06 Sep 2025
  
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  DOI: 10.1038/s41531-025-01077-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12397289/
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ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102336
  
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sciencedirect.com/science/article/pii/S2666379125004094
Aug 2025
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Bifidobacterium animalis suppresses non-small cell lung cancer progression and modulates tumor immunity through indole-3-acetic acid

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116132
  
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sciencedirect.com/science/article/pii/S2211124725009039
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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.007
  
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sciencedirect.com/science/article/pii/S1074761325003164
Jul 2025
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Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.016
  
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sciencedirect.com/science/article/pii/S1074761325002857
Jun 2025
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ILC3s sense gut microbiota through STING to initiate immune tolerance

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.016
  
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sciencedirect.com/science/article/pii/S1074761325002377
May 2025
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Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115623
  
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sciencedirect.com/science/article/pii/S2211124725003948
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Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells

1
1. scibot 16 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.007
  
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sciencedirect.com/science/article/pii/S009286742500409X
Apr 2025
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Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115524
  
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sciencedirect.com/science/article/pii/S2211124725002955
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1. scibot 02 Apr 2025
  
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  DOI: 10.1101/2025.03.25.645229
  
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52.53.155.43/ffe78fc87ac98471413371f69757651fb2a5b49c/PDF-html.html
Mar 2025
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Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.027
  
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sciencedirect.com/science/article/pii/S1074761325000949
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Tracing specificity of immune landscape remodeling associated with distinct anticancer treatments

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.isci.2025.112071
  
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sciencedirect.com/science/article/pii/S2589004225003311
Feb 2025
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

1
1. scibot 11 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
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Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

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1. scibot 11 Feb 2025
  
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  RRID:AB_2564590
  
  DOI: 10.1016/j.ccell.2025.01.004
  
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sciencedirect.com/science/article/pii/S1535610825000224
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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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1. scibot 04 Feb 2025
  
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  RRID:AB_2564590
  
  DOI: 10.1016/j.chembiol.2025.01.004
  
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sciencedirect.com/science/article/pii/S2451945625000042
Jan 2025
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Protocol for isolating and purifying murine liver sinusoidal endothelial cells for in vitro culture and functional assays

1
1. scibot 30 Jan 2025
  
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  RRID:AB_2564590
  
  DOI: 10.1016/j.xpro.2024.103554
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11772955/
Dec 2024
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A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury

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1. scibot 10 Dec 2024
  
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  RRID:AB_2564590
  
  DOI: 10.1016/j.xcrm.2024.101849
  
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sciencedirect.com/science/article/pii/S2666379124006207
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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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1. scibot 10 Dec 2024
  
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  RRID:AB_2564590
  
  DOI: 10.1016/j.cell.2024.11.009
  
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sciencedirect.com/science/article/pii/S0092867424013266
Nov 2024
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Analysis of lipid uptake, storage, and fatty acid oxidation by group 2 innate lymphoid cells

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1. scibot 17 Nov 2024
  
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  AB_2564590
  
  DOI: 10.3389/fimmu.2024.1493848
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532145/
Sep 2024
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Endothelial metabolic control of insulin sensitivity through resident macrophages

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1. scibot 13 Sep 2024
  
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  AB_2564590
  
  DOI: 10.1016/j.cmet.2024.08.008
  
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sciencedirect.com/science/article/pii/S1550413124003358
Aug 2024
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Protocol to examine murine visceral adipose tissue immune cells using fluorescence-based flow cytometry

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1. scibot 21 Aug 2024
  
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  AB_2564590
  
  DOI: 10.1016/j.xpro.2024.103227
  
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sciencedirect.com/science/article/pii/S2666166724003927
Jul 2024
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de057abe614262e4e5c59c6683970ba76047-html.html

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1. scibot 27 Jul 2024
  
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  RRID:AB_2564590
  
  DOI: 10.3389/fmolb.2024.1366259
  
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52.53.155.43/867c9ce570a9187427403edd3cbefccb3f730622/de057abe614262e4e5c59c6683970ba76047-html.html
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Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function

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1. scibot 25 Jul 2024
  
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  AB_2564590
  
  DOI: 10.1016/j.celrep.2024.114506
  
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sciencedirect.com/science/article/pii/S2211124724008350
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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114532
  
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sciencedirect.com/science/article/pii/S2211124724008611
Jun 2024
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Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.ebiom.2024.105170
  
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sciencedirect.com/science/article/pii/S2352396424002056
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Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

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1. scibot 02 Jun 2024
  
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  DOI: 10.7554/eLife.88054
  
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  DOI: 10.7554/eLife.88054
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11132682/
May 2024
www.biorxiv.org www.biorxiv.org

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

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1. scibot 23 May 2024
  
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  DOI: 10.1101/2024.04.28.591518
  
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biorxiv.org/content/10.1101/2024.04.28.591518v1
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DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.isci.2024.109830
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11103367/
Apr 2024
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Disruption of CD47-SIRPα signalling restores inflammatory function in tumour-associated myeloid derived suppressor cells

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109546
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10993187/
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
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Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114007
  
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sciencedirect.com/science/article/pii/S2211124724003358
Feb 2024
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Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.008
  
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sciencedirect.com/science/article/pii/S1074761324000323
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression

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1. scibot 28 Dec 2023
  
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  DOI: 10.1158/0008-5472.CAN-23-1252
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10740391/
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Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.xcrm.2023.101330
  
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sciencedirect.com/science/article/pii/S2666379123005475
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Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

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1. scibot 02 Dec 2023
  
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  RRID:AB_2564590
  
  DOI: 10.1158/0008-5472.CAN-22-2316
  
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Nov 2023
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Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3

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Stress-induced β cell early senescence confers protection against type 1 diabetes

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Aug 2023
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PIIS2211124723009622-html.html

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52.53.155.43 52.53.155.43

can-23-1252-html.html

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Jul 2023
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Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury

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Engineer a double team of short-lived and glucose-sensing bacteria for cancer eradication

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cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

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Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

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Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis

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ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T-Cell Metabolism

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Mar 2023
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T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity

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ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell–mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models

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Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol

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Feb 2023
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Crosstalk between ILC2s and Th2 cells varies among mouse models

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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

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Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

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Isolation of mouse mammary carcinoma-derived macrophages and cancer cells for co-culture assays

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Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development

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T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity

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Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity

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Correlation between circulating innate lymphoid cell precursors and thymic function

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Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

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Dec 2021
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Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

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CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells

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ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

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Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses

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Oct 2021
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Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

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Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges

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Sep 2021
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Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis

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Activating a collaborative innate-adaptive immune response to control metastasis

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Aug 2021
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Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

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Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function

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ncbi.nlm.nih.gov/pmc/articles/PMC8333167/
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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

1
1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.ccell.2021.07.007
  
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sciencedirect.com/science/article/pii/S1535610821003846
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Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

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1. scibot 26 Feb 2021
  
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  DOI: 10.7554/eLife.57495
  
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Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy

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1. scibot 25 Feb 2021
  
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  DOI: 10.1093/hmg/ddaa034
  
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academic.oup.com/hmg/article/29/8/1253/5775613
Sep 2020
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Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.immuni.2020.01.002
  
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Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.03.019
  
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Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.immuni.2020.01.012
  
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Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

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1. scibot 15 Sep 2020
  
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  DOI: 10.7554/eLife.53627
  
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Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

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1. scibot 11 Sep 2020
  
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  DOI: 10.1016/j.cmet.2020.03.002
  
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Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

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  DOI: 10.1016/j.cmet.2020.05.004
  
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Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

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  DOI: 10.1016/j.celrep.2020.107628
  
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Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

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  DOI: 10.1016/j.celrep.2019.12.034
  
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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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1. scibot 15 Aug 2020
  
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  DOI: 10.1016/j.immuni.2020.03.004
  
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sciencedirect.com/science/article/pii/S1074761320301175
Jan 2020
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B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.10.070
  
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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.10.015
  
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Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population

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1. scibot 13 Jan 2020
  
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  RRID:AB_2564590
  
  DOI: 10.1016/j.celrep.2019.11.042
  
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sciencedirect.com/science/article/pii/S2211124719315244
Nov 2018
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Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

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1. scibot 05 Nov 2018
  
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