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Microglia-mediated protection against Alzheimer’s disease pathology and detrimental effects in white matter revealed by Ptpn6 deletion

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.neuron.2026.02.023
  
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sciencedirect.com/science/article/pii/S0896627326001285
Mar 2026
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MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer’s disease

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1. scibot 18 Mar 2026
  
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  DOI: 10.3389/fimmu.2026.1694824
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12971419/
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MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration

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1. scibot 18 Mar 2026
  
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  DOI: 10.1038/s41467-026-69189-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12976283/
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Active immunization with bacteriophage AP205 VLPs results in reduced amyloid load and microgliosis in 5xFAD female mice

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  DOI: 10.1007/s00210-025-04739-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12935789/
Feb 2026
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Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature

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1. scibot 19 Feb 2026
  
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  DOI: 10.1016/j.cell.2026.01.024
  
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sciencedirect.com/science/article/pii/S009286742600111X
Jan 2026
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Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.020
  
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sciencedirect.com/science/article/pii/S0092867425014333
Dec 2025
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Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain

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  DOI: 10.1016/j.xcrm.2025.102535
  
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sciencedirect.com:5037/science/article/pii/S2666379125006081
Nov 2025
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Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging

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1. scibot 29 Nov 2025
  
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sciencedirect.com:5037/science/article/pii/S2211124725013968
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Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease

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1. scibot 07 Nov 2025
  
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  DOI: 10.7554/eLife.105347
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12585179/
Oct 2025
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Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease

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1. scibot 23 Oct 2025
  
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  DOI: 10.1016/j.neuron.2024.12.025
  
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cell.com/neuron/fulltext/S0896-6273(24)00925-5
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Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease

1
1. scibot 17 Oct 2025
  
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  DOI: 10.1038/s41398-025-03588-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12500900/
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Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease

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1. scibot 16 Oct 2025
  
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  DOI: 10.1186/s13024-025-00893-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12516900/
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The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.devcel.2025.09.012
  
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sciencedirect.com/science/article/pii/S1534580725005726
Sep 2025
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MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer’s disease

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1. scibot 18 Sep 2025
  
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  DOI: 10.1101/2025.09.05.674298
  
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biorxiv.org/content/10.1101/2025.09.05.674298v1
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Bazi Bushen improves cognitive dysfunction in 5×FAD mice by targeting amyloid pathology, neuroinflammation and cellular senescence

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1. scibot 13 Sep 2025
  
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  DOI: 10.1016/j.jep.2025.120586
  
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sciencedirect.com/science/article/pii/S0378874125012784
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Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116109
  
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sciencedirect.com/science/article/pii/S2211124725008800
Jul 2025
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A lysosomal surveillance response to stress extends healthspan

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1. scibot 12 Jul 2025
  
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  DOI: 10.1038/s41556-025-01693-y
  
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nature.com/articles/s41556-025-01693-y
Jun 2025
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Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

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1. scibot 17 Jun 2025
  
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  DOI: 10.1038/s41593-025-01973-8
  
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nature.com/articles/s41593-025-01973-8
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TNFR2 contributes to synaptic potentiation failure in hippocampal synapses and memory loss in a familial Alzheimer’s disease mouse model

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.bbi.2025.06.019
  
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sciencedirect.com/science/article/pii/S0889159125002363
May 2025
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Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.neuron.2025.04.027
  
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sciencedirect.com/science/article/pii/S0896627325003101
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Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice

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1. scibot 21 May 2025
  
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  DOI: 10.1186/s13195-025-01736-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12039073/
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A novel carbamate-based hybrid derivative with anti-neuroinflammatory properties as a selective butyrylcholinesterase inhibitor for Alzheimer's disease therapy

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.bioorg.2025.108551
  
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sciencedirect.com/science/article/pii/S0045206825004316
Apr 2025
elifesciences.org elifesciences.org

Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease

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1. scibot 03 Apr 2025
  
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  DOI: 10.7554/eLife.105347.1
  
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elifesciences.org/reviewed-preprints/105347
Mar 2025
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Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer’s Disease Spectrum

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1. scibot 08 Mar 2025
  
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  DOI: 10.21203/rs.3.rs-5930673/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844643/
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The compound... : Neural Regeneration Research

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  DOI: 10.4103/NRR.NRR-D-23-01890
  
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journals.lww.com/nrronline/fulltext/2025/11000/the_compound.34.aspx
Feb 2025
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GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115343
  
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Oct 2024
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Compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5 × FAD mice

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1. scibot 04 Oct 2024
  
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  DOI: 10.1016/j.lfs.2024.123085
  
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sciencedirect.com/science/article/pii/S0024320524006751
Sep 2024
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Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

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1. scibot 25 Sep 2024
  
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  RRID:AB_2564653
  
  DOI: 10.1016/j.immuni.2018.02.016
  
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sciencedirect.com/science/article/pii/S107476131830075X
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Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease

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1. scibot 12 Sep 2024
  
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  AB_2564653
  
  DOI: 10.3233/ADR-240026
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11380283/
Aug 2024
www.tandfonline.com www.tandfonline.com

Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer’s disease

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1. scibot 13 Aug 2024
  
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  803,001
  
  DOI: 10.1080/01616412.2021.1893566
  
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  803,001, 6E10, 1:200 dilutions, from BioLegend
  
  DOI: 10.1080/01616412.2021.1893566
  
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tandfonline.com/doi/full/10.1080/01616412.2021.1893566
academic.oup.com academic.oup.com

Infiltrating Hematogenous Macrophages Aggregate Around β-Amyloid Plaques in an Age- and Sex-Dependent Manner in a Mouse Model of Alzheimer Disease

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  mouse anti-β-amyloid
  
  DOI: 10.1093/jnen/nlaa093
  
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academic.oup.com/jnen/article-abstract/79/11/1147/5917814
Jul 2024
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Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice

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1. scibot 30 Jul 2024
  
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  AB_2564653
  
  DOI: 10.1016/j.jare.2024.07.024
  
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sciencedirect.com/science/article/pii/S2090123224003096
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Lack of inflammation or immune response in cyst tissue of patients with symptomatic non-hydrocephalic pineal cysts

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1. scibot 20 Jul 2024
  
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  AB_2564653
  
  DOI: 10.1016/j.jns.2024.123111
  
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sciencedirect.com/science/article/pii/S0022510X24002466
Mar 2024
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Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease

2
1. scibot 21 Mar 2024
  
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  DOI: 10.1016/j.ebiom.2024.105079
  
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  DOI: 10.1016/j.ebiom.2024.105079
  
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Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model

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Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

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A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease

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Sep 2023
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Endothelial senescence alleviates cognitive impairment in a mouse model of Alzheimer's disease

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Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

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PIIS2211124723009671-html.html

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Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment

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Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice

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Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model

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Apr 2023
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Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice

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Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease

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INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

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Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models

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Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease

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Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease

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A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer

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Aug 2022
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Genetic Inhibition of PDK1 Robustly Reduces Plaque Deposition and Ameliorates Gliosis in the 5×FAD Mouse Model of Alzheimer’s Disease

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Jun 2022
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The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment

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awac113-html.html

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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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Mar 2022
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BPS Publications

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Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer's disease

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Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

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Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults

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Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model

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BPS Publications

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Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle

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Sep 2021
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Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

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Aug 2021
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iPSC-derived human microglia-like cells to study neurological diseases

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Untitled document

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Untitled document

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Untitled document

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Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

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Jun 2021
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SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

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  DOI: 10.1016/j.celrep.2021.109259
  
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PSD-95 protects synapses from β-amyloid

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Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease

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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

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Peptide Interference with APP and Tau Association: Relevance to Alzheimer’s Disease Amelioration

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  DOI: 10.3390/ijms21093270
  
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Oct 2020
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14,15-epoxyeicosatrienoic acid alleviates pathology in a mouse model of Alzheimer’s disease

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  DOI: 10.1523/JNEUROSCI.1246-20.2020
  
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Sep 2020
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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

1
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Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

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  DOI: 10.7554/eLife.52612
  
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A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance

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A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

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alzres.biomedcentral.com/articles/10.1186/s13195-020-00617-2
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Extracellular vesicles: where the amyloid precursor protein carboxyl‐terminal fragments accumulate and amyloid‐β oligomerizes

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  DOI: 10.1096/fj.202000823R
  
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Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease

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  anti-β-amyloid
  
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Jan 2020
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Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

1
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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

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  DOI: 10.1016/j.neuron.2019.12.015
  
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Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans

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  DOI: 10.1016/j.cub.2019.06.031
  
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A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

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  DOI: 10.1016/j.cmet.2019.06.005
  
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Untitled document

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  DOI: 10.1111/bph.14688
  
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Untitled document

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  DOI: 10.1016/j.neuron.2019.01.014
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.095
  
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A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's‐associated pathologies

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  RRID:AB_2564653
  
  DOI: 10.1111/jnc.14647
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14647
Nov 2018
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Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

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Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe×PS1Δe9 transgenic mouse model of Alzheimer's disease

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onlinelibrary.wiley.com/doi/10.1111/jnc.14251/full
Nov 2017
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A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers

1
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onlinelibrary.wiley.com/doi/10.1111/jnc.14118/full
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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

1
1. scibot 08 Nov 2017
  
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Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease

1
1. scibot 08 Nov 2017
  
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