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Engineering T Cells with a Tumor-Reactive Chimeric T Cell Receptor Reduces Exhaustion and Promotes Persistence to Elicit Enhanced Antitumor Responses

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0777
  
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aacrjournals.org/cancerres/article/86/11/2688/785304/Engineering-T-Cells-with-a-Tumor-Reactive-Chimeric
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B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

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1. scibot 06 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.003
  
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sciencedirect.com/science/article/pii/S1074761326002542
Jun 2026
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Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection

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1. scibot 26 Jun 2026
  
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  DOI: 10.1016/j.immuni.2026.06.001
  
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sciencedirect.com/science/article/pii/S1074761326002311
May 2026
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Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer

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1. scibot 20 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.038
  
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sciencedirect.com/science/article/pii/S0092867426005052
Apr 2026
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Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117303
  
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sciencedirect.com/science/article/pii/S2211124726003815
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

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1. scibot 09 Apr 2026
  
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  DOI: 10.1158/1078-0432.CCR-24-3455
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13056295/
Mar 2026
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Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117062
  
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sciencedirect.com/science/article/pii/S2211124726001403
Nov 2025
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Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.004
  
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sciencedirect.com/science/article/pii/S1074761325004340
Oct 2025
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Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.005
  
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sciencedirect.com/science/article/pii/S1535610825003976
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2025.09.30.679035v1.full-html.html

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1. scibot 07 Oct 2025
  
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  DOI: 10.1101/2025.09.30.679035
  
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54.241.53.176/1390f297109f2e16a9738b79abd402ec0b331d3c/2025.09.30.679035v1.full-html.html
Aug 2025
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Lymphoma accelerates T cell and tissue aging

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.023
  
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sciencedirect.com/science/article/pii/S1535610825003290
Jul 2025
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Tumor integrin-targeted glucose oxidase enzyme promotes ROS-mediated cell death that combines with interferon alpha therapy for tumor control

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0163
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695183/
Apr 2025
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The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function

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1. scibot 01 Apr 2025
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.celrep.2025.115456
  
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sciencedirect.com/science/article/pii/S221112472500227X
Mar 2025
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Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.017
  
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sciencedirect.com/science/article/pii/S1074761325000846
Feb 2025
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Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer

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1. scibot 07 Feb 2025
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.ccell.2025.01.007
  
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sciencedirect.com/science/article/pii/S153561082500025X
Jan 2025
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Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma

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1. scibot 16 Jan 2025
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.xcrm.2024.101900
  
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sciencedirect.com/science/article/pii/S2666379124006712
Dec 2024
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Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity

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1. scibot 29 Dec 2024
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.ccell.2024.12.001
  
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cell.com/cancer-cell/abstract/S1535-6108(24)00476-8
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Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion

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1. scibot 28 Dec 2024
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.immuni.2024.11.026
  
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sciencedirect.com/science/article/pii/S1074761324005417
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Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.021
  
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sciencedirect.com/science/article/pii/S1074761324005363
Oct 2024
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Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis

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1. scibot 02 Oct 2024
  
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  AB_2566158
  
  DOI: 10.1016/j.ebiom.2024.105347
  
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sciencedirect.com/science/article/pii/S2352396424003839
Sep 2024
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Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation

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1. scibot 15 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114724
  
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sciencedirect.com/science/article/pii/S2211124724010751
Aug 2024
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Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114632
  
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sciencedirect.com/science/article/pii/S2211124724009823
Jul 2024
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Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

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1. scibot 25 Jul 2024
  
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  AB_2566158
  
  DOI: 10.1016/j.immuni.2024.06.014
  
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sciencedirect.com/science/article/pii/S1074761324003200
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Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis

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1. scibot 18 Jul 2024
  
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  DOI: 10.1126/science.adh5548
  
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science.org/doi/10.1126/science.adh5548
Mar 2024
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ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+ T cells in low arginine condition

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1. scibot 27 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113995
  
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sciencedirect.com/science/article/pii/S2211124724003231
Nov 2023
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The antitumor activities of anti-CD47 antibodies require Fc-FcγR interactions

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.ccell.2023.10.007
  
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sciencedirect.com/science/article/pii/S153561082300363X
Oct 2023
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Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors

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1. scibot 14 Oct 2023
  
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  RRID:AB_2566158
  
  DOI: 10.1101/2023.08.11.553007
  
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  DOI: 10.1101/2023.08.11.553007
  
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52.53.155.43/7eb24570d443d458f8fd7700f91970ed0d945838/2023.08.11.553007v1.full-html.html
Mar 2023
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Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

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1. scibot 16 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112250
  
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sciencedirect.com/science/article/pii/S2211124723002619
Jan 2023
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Immunoediting instructs tumor metabolic reprogramming to support immune evasion

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1. scibot 04 Jan 2023
  
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  DOI: 10.1016/j.cmet.2022.12.003
  
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sciencedirect.com/science/article/pii/S155041312200540X
Nov 2022
www.cell.com www.cell.com

Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.ccell.2022.11.002
  
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cell.com/cancer-cell/fulltext/S1535-6108(22)00549-9
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Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis

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1. scibot 10 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111611
  
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sciencedirect.com/science/article/pii/S2211124722014802
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Isolating and targeting a highly active, stochastic dendritic cell subpopulation for improved immune responses

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1. scibot 03 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111563
  
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sciencedirect.com/science/article/pii/S2211124722014243
Mar 2022
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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1. scibot 26 Mar 2022
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.molcel.2022.02.033
  
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sciencedirect.com/science/article/pii/S1097276522002076
Dec 2021
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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

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1. scibot 07 Dec 2021
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.cell.2021.11.018
  
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sciencedirect.com/science/article/pii/S0092867421013337
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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

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1. scibot 01 Dec 2021
  
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  RRID:AB_2566158
  
  DOI: 10.1016/j.celrep.2021.110061
  
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sciencedirect.com/science/article/pii/S2211124721015473
Nov 2021
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Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans

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1. scibot 05 Nov 2021
  
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  DOI: 10.7554/eLife.70554
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8562996/
Jul 2021
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Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

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1. scibot 07 Jul 2021
  
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  DOI: 10.1016/j.immuni.2021.06.007
  
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sciencedirect.com/science/article/pii/S107476132100251X
May 2021
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The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

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1. scibot 21 May 2021
  
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  DOI: 10.1016/j.ccell.2021.04.016
  
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cell.com/cancer-cell/fulltext/S1535-6108(21)00224-5
Apr 2021
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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

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1. scibot 01 Apr 2021
  
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  DOI: 10.1016/j.immuni.2021.03.007
  
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sciencedirect.com/science/article/pii/S1074761321001199
Oct 2020
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Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection

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1. scibot 08 Oct 2020
  
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  DOI: 10.1016/j.celrep.2020.108232
  
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Jan 2020
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The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.08.013
  
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